Kasun Wekasinghe, Stephanie A. Castillo, Jaina R. Bemis and Aaron J. Teator*,
{"title":"","authors":"Kasun Wekasinghe, Stephanie A. Castillo, Jaina R. Bemis and Aaron J. Teator*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c04964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Tianxiao Sun, Bin Wu*, Shimao Deng, Yu-Jie Guo, Ji-Lei Shi, Xing Zhang, Xiaofeng Shi, Guannan Qian, Jian Wang, Piero Pianetta, Jigang Zhou*, Yu-Guo Guo* and Yijin Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.4c14571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Rao, Domenico Gioffrè, Marcel Levien, Michael Wörle, Pragati Pandey, Marinella Mazzanti, Christophe Copéret and Lyndon Emsley*,
{"title":"","authors":"Yu Rao, Domenico Gioffrè, Marcel Levien, Michael Wörle, Pragati Pandey, Marinella Mazzanti, Christophe Copéret and Lyndon Emsley*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c04452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Augustin Braun, Charles J. Titus, Leland B. Gee, Michael L. Baker, Max D. J. Waters, James J. Yan, Sang-Jun Lee, Dennis Nordlund, William B. Doriese, Galen C. O’Neil, Daniel R. Schmidt, Daniel S. Swetz, Joel N. Ullom, Kent D. Irwin and Edward I. Solomon*,
{"title":"","authors":"Augustin Braun, Charles J. Titus, Leland B. Gee, Michael L. Baker, Max D. J. Waters, James J. Yan, Sang-Jun Lee, Dennis Nordlund, William B. Doriese, Galen C. O’Neil, Daniel R. Schmidt, Daniel S. Swetz, Joel N. Ullom, Kent D. Irwin and Edward I. Solomon*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c05261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Qilong Cui, Hongwei Shou, Chuanqiang Wu, Bijun Tang, Wen Zhu, Yuyang Cao, Wei Jiang, Pengjun Zhang, Ruijie Wang, Zhanfeng Liu, Shiqiang Wei, Shuangming Chen, Binghui Ge, Xiaojun Wu*, Zheng Liu* and Li Song*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c04546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazutaka Ikeda*, Yoshihiro Shimizu, Tessui Nakagawa, Akihiko Machida, Hyunjeong Kim, Kouji Sakaki, Koji Ohara, Hidetoshi Ohshita and Toshiya Otomo,
{"title":"","authors":"Kazutaka Ikeda*, Yoshihiro Shimizu, Tessui Nakagawa, Akihiko Machida, Hyunjeong Kim, Kouji Sakaki, Koji Ohara, Hidetoshi Ohshita and Toshiya Otomo, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c04566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei Wang, Si-Shun Yan, Yi Liu, Jia-Shun Zhu, Jing-Wei Yang, Jin-Cheng Xu, Yang-Yi Tao, Jin-Chan Li, Lei Song, Jian-Heng Ye, Da-Gang Yu
{"title":"Photocatalytic 1,2-Dicarboxylation of Unactivated Alkynes with CO<sub>2</sub>.","authors":"Wei Wang, Si-Shun Yan, Yi Liu, Jia-Shun Zhu, Jing-Wei Yang, Jin-Cheng Xu, Yang-Yi Tao, Jin-Chan Li, Lei Song, Jian-Heng Ye, Da-Gang Yu","doi":"10.1021/jacs.5c05537","DOIUrl":"10.1021/jacs.5c05537","url":null,"abstract":"<p><p>The carboxylation of widely available raw materials with CO<sub>2</sub> represents a highly desirable transformation in synthetic chemistry, enabling the streamlined synthesis of valuable carboxylic acids. While the photocatalytic carboxylation of activated unsaturated compounds with CO<sub>2</sub> has emerged as a powerful strategy for accessing diverse carboxylated products, the direct carboxylation of unactivated alkynes with CO<sub>2</sub> remains a formidable challenge due to the intrinsic inertness of both aliphatic alkynes and CO<sub>2</sub>. Herein, we report the first visible-light photocatalytic 1,2-dicarboxylation of unactivated alkynes with CO<sub>2</sub>, providing a versatile platform for synthesizing structurally diverse succinic acid derivatives. This method exhibits good functional group tolerance and high chemoselectivity under mild reaction conditions. Mechanistic investigations indicated that the <i>in situ</i> generated carbon dioxide radical anion (CO<sub>2</sub><sup>•-</sup>) might initiate the first hydrocarboxylation of unactivated alkynes to deliver a key acrylate intermediate, which could undergo a second hydrocarboxylation process to selectively yield succinic acid derivatives. The synthetic utility of this protocol is further demonstrated by constructing bioactive molecules and CO<sub>2</sub>-based polyesters.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":" ","pages":""},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single-Component High-Performance Adhesives Enabled by Synergistic Supramolecular and Covalent Polymerization.","authors":"Yan Shao, Wen Li, Massimo Cametti, Zoran Džolić, Zeyang Ding, Zairan Yang, Ying Xie, Shimei Jiang","doi":"10.1021/jacs.5c06302","DOIUrl":"https://doi.org/10.1021/jacs.5c06302","url":null,"abstract":"<p><p>The development of high-strength supramolecular adhesives from a single small molecule is a highly compelling research goal, as it offers the potential for lightweight, reversible, and stimuli-responsive bonding systems. However, achieving such adhesives presents significant challenges. Herein, we present a novel tripodal multifunctional molecule, <b>BTA-C7</b>, designed to exploit a synergistic supramolecular and covalent polymerization strategy to achieve a remarkable adhesive performance. <b>BTA-C7</b> features a central benzene-1,3,5-tricarboxamide (BTA) core from which cyanostilbene moieties extend, each terminating in a benzo-crown-ether macrocycle. Under ambient conditions, while the highly directional hydrogen bonding between tripodal amide groups induces one-dimensional (1D) stacked arrays, the terminal benzo-crown-ether macrocycles facilitate the assemblies of the 1D chains, thereby promoting the formation of supramolecular networks exhibiting a baseline adhesion of 2.28 MPa as measured by lap-shear tests. Notably, under ultraviolet (UV) irradiation, the supramolecular networks undergo additional covalent photo-cross-linking through a [2 + 2] cycloaddition reaction, facilitated by the supramolecular confinement of cyanostilbene moieties. This process significantly enhances the adhesion strength to 5.18 MPa. Comparative studies with model compounds <b>BTA-O7</b> (devoid of crown ether moieties, replaced by acyclic glycol chains) and <b>BTE-C7</b> (with amide units replaced by ester groups) reveal that amide and crown ether units are indispensable for both supramolecular networks and covalent cross-linking.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":" ","pages":""},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gram-Scale Total Synthesis of Illisimonin A.","authors":"Liangchao Zhu, Jinrui Li, Zhaohong Lu","doi":"10.1021/jacs.5c07921","DOIUrl":"https://doi.org/10.1021/jacs.5c07921","url":null,"abstract":"<p><p>Illisimonin A, a structurally complex sesquiterpenoid isolated from the Illicium genus, possesses a 5/5/5/5/5 pentacyclic scaffold featuring seven contiguous, fully substituted chiral quaternary carbon centers. Herein, we report a gram-scale total synthesis of (±)-Illisimonin A achieved in 14 steps. The strategic approach features several key transformations: (1) a pentafulvene-involved intramolecular [6 + 2] cycloaddition that rapidly assembles the linear 5/5/5 tricyclic core, (2) a pentafulvene-involved intramolecular alkylation enabling polycyclic framework construction, (3) a nitroso-Diels-Alder reaction for precise oxidation state installation, and (4) a late-stage Ru-catalyzed oxidative lactonization.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":" ","pages":""},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiming Wang, Chen Wang, Yunlong Zheng, Heng Hu, Yao Chen* and Yuan Lu*,
{"title":"","authors":"Yiming Wang, Chen Wang, Yunlong Zheng, Heng Hu, Yao Chen* and Yuan Lu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 25","pages":"2305–2315 XXX-XXX"},"PeriodicalIF":14.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c05406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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