Maria Del Pilar Bayona Molano, Joseph Boateng, Nisreen Ezuddin, Muhammad Usman Shahid
{"title":"Transperineal Mechanical Thrombectomy and Thrombolysis for Hematometrocolpos in a Pediatric Patient with Distal Vaginal Atresia.","authors":"Maria Del Pilar Bayona Molano, Joseph Boateng, Nisreen Ezuddin, Muhammad Usman Shahid","doi":"10.1016/j.jvir.2025.08.012","DOIUrl":"10.1016/j.jvir.2025.08.012","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul Mondon, Jean-Baptiste Pialat, Sylvain Grange, Joris Lavigne, Anthony Viste, Nicolas Stacoffe
{"title":"Percutaneous Reduction and Screw Fixation of Unstable Pelvic Fractures: Feasibility in IR.","authors":"Paul Mondon, Jean-Baptiste Pialat, Sylvain Grange, Joris Lavigne, Anthony Viste, Nicolas Stacoffe","doi":"10.1016/j.jvir.2025.08.013","DOIUrl":"10.1016/j.jvir.2025.08.013","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Teaching IR as an Independent Clinical Discipline.","authors":"Miguel Ángel De Gregorio, Masao Yamamoto-Ramos","doi":"10.1016/j.jvir.2025.08.011","DOIUrl":"10.1016/j.jvir.2025.08.011","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis Jacquier, Vania Tacher, Vincent Vidal, Hicham Kobeiter, Alain Luciani, Louis Boyer
{"title":"Response to \"2024 Global Statement Defining IR-Have We Reached the Tipping Point?\"","authors":"Alexis Jacquier, Vania Tacher, Vincent Vidal, Hicham Kobeiter, Alain Luciani, Louis Boyer","doi":"10.1016/j.jvir.2025.08.002","DOIUrl":"10.1016/j.jvir.2025.08.002","url":null,"abstract":"","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bedros Taslakian, Tarub Mabud, Mukundan Attur, Erin F Alaia, Jonathan Samuels, William Macaulay, Danibel Ramos, Christiana Salami, Shu Liu, Elizabeth M Morris, Ryan Hickey
{"title":"A Prospective Single-Arm Trial of Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: Clinical and Biomarker Outcomes.","authors":"Bedros Taslakian, Tarub Mabud, Mukundan Attur, Erin F Alaia, Jonathan Samuels, William Macaulay, Danibel Ramos, Christiana Salami, Shu Liu, Elizabeth M Morris, Ryan Hickey","doi":"10.1016/j.jvir.2025.08.009","DOIUrl":"10.1016/j.jvir.2025.08.009","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and effectiveness of genicular artery embolization (GAE) and its longitudinal effects on biomarkers implicated in knee osteoarthritis (KOA) pathogenesis.</p><p><strong>Materials and methods: </strong>This was a prospective, single-arm clinical trial of patients with symptomatic KOA resistant to conservative therapy for >3 months. Twenty-five patients who underwent GAE using 250-μm permanent microspheres were enrolled. Patient-reported outcome measures were evaluated at baseline and 1, 3, and 12 months following GAE. Blood samples were collected for biomarker analysis. Magnetic resonance (MR) imaging was performed at baseline and 3 months after GAE. The primary endpoint was the clinical success rate at 12 months, defined as 4 point decrease in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score. Baseline and follow-up outcomes were analyzed using the Wilcoxon matched-pairs signed-rank test.</p><p><strong>Results: </strong>The technical success was 100%, with no severe adverse events. The clinical success rate was 62%. The mean visual analog scale pain score for the target knee decreased by 48.5% at 1 month, 50.8% at 3 months, and 55.4% at 12 months (P < .001). WOMAC pain scores improved by 39.6% at 1 month, 50.1% at 3 months, and 43.7% at 12 months (P < .001). There was a statistically significant decrease in the serum levels of vascular endothelial growth factor (VEGF) and interleukin-1 receptor antagonist (IL-1Ra) at 12 months. The remaining biomarkers showed no significant change.</p><p><strong>Conclusions: </strong>GAE is a safe treatment for symptomatic KOA, providing clinically significant pain relief for a subset of patients. The observed reductions in serum VEGF and IL-1Ra levels following GAE may contribute to local pain relief and decreased inflammation in the knee joints.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Yurui Lim, Saebeom Hur, Lyo Min Kwon, Maxim Itkin
{"title":"Mesenteric Lymphangiography as a New Diagnostic and Therapeutic Tool for Refractory Chylous Lymphatic Leakages and Protein-Losing Enteropathy.","authors":"David Yurui Lim, Saebeom Hur, Lyo Min Kwon, Maxim Itkin","doi":"10.1016/j.jvir.2025.08.008","DOIUrl":"10.1016/j.jvir.2025.08.008","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether mesenteric lymphangiography (mLAG) is technically feasible and clinically useful for patients with refractory chylous ascites, chylothorax, and protein-losing enteropathy (PLE).</p><p><strong>Materials and methods: </strong>A retrospective study of 35 patients (male, 16; female, 19; mean age, 56 years; range, 20-78 years) who underwent mLAG at 2 institutions between March 2016 and July 2022 was performed. mLAG was performed via intraoperative and/or percutaneous approaches. Imaging findings were categorized into 3 types: Type 0 (technical failure), Type 1 (limited to mesentery), or Type 2 (central propagation). Auxiliary findings including lymphangiectasia, reflux, and leakage were recorded. Interventions included mesenteric lymph node embolization (mLNE), retroperitoneal lymph node embolization, lymphoplasty, and lymphovenous shunt creation.</p><p><strong>Results: </strong>Among 35 patients, 27 presented with refractory chylous ascites and/or chylothorax and 8 with PLE. Of the 35 patients, mLAG was performed percutaneously in 21 (60%) patients, intraoperatively in 9 (26%), and both percutaneously and intraoperatively in 5 (14%) patients. The findings were classified as Type 0 in 4 (11%), Type 1 in 8 (23%), and Type 2 in 23 (66%). Of 35 patients, the auxiliary findings of lymphangiectasia (E), reflux (R), and leakage (L) were observed in 20% (n = 7), 23% (n = 8), and 6% (n = 2), respectively. mLNE was performed in 14 patients. Clinical improvement was achieved in 57% (20 of 35) of the patients. One patient developed bowel wall edema post-mLNE; no other severe adverse event was reported.</p><p><strong>Conclusions: </strong>mLAG is technically feasible and safe. It can be a useful tool to image the mesenteric lymphatics or perform mesenteric lymphatic embolization.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew M Niemeyer, Yifan Wang, Maximillian J Carlino, Lobna Elkhadragy, Odile David, Luke R Jordan, Andrew J Lipnik, Daniel Blanco, Vera Mehta, Evelyn Sambora, Lawrence B Schook, Ketan Y Shah, Russell O Simpson, Ron C Gaba, Kyle M Schachtschneider
{"title":"Biodistribution of Macroaggregated Albumin after Tumor Model Development and Characterization in a Porcine Lung Cancer Model.","authors":"Matthew M Niemeyer, Yifan Wang, Maximillian J Carlino, Lobna Elkhadragy, Odile David, Luke R Jordan, Andrew J Lipnik, Daniel Blanco, Vera Mehta, Evelyn Sambora, Lawrence B Schook, Ketan Y Shah, Russell O Simpson, Ron C Gaba, Kyle M Schachtschneider","doi":"10.1016/j.jvir.2025.08.007","DOIUrl":"10.1016/j.jvir.2025.08.007","url":null,"abstract":"<p><strong>Purpose: </strong>To demonstrate that intratracheal infusion of an adenoviral vector carrying Cre recombinase (AdCre) induces lung tumors in the Oncopig and verify that bronchial arterial yttrium-90 transarterial radioembolization (TARE) is the optimal infusion route for lung cancer.</p><p><strong>Materials and methods: </strong>Three transgenic Oncopigs harboring Cre-inducible TP53<sup>R167H</sup> and KRAS<sup>G12D</sup> mutations underwent tumor induction via intratracheal AdCre infusion. Tumors were characterized with 2- and 4-week computed tomography (CT) and pathology. Five additional Oncopigs underwent tumor induction followed by transarterial technetium-99m (<sup>99m</sup>Tc) macroaggregated albumin (MAA) infusion from bronchial and pulmonary arteries targeting the same tumor with 7 days between procedures. <sup>99m</sup>Tc MAA biodistribution was quantified and compared using single photon emission computed tomography (SPECT).</p><p><strong>Results: </strong>Tumor induction was successful in all 3 Oncopigs. Mean tumor size 2 weeks after induction was 2.9 cm × 2.2 cm. Pathology revealed peribronchiolar chronic inflammation, large mass-forming inflammatory cell lesions, and KRAS positivity. Tumor induction was successful in 4 of 5 additional Oncopigs, with successful <sup>99m</sup>Tc MAA tumor targeting from bronchial and pulmonary arteries in all 4 tumor-bearing Oncopigs. Mean tumor-to-normal ratio after bronchial arterial <sup>99m</sup>Tc MAA infusion was significantly higher than that after pulmonary arterial infusion (8.10 [SD ± 4.30] vs 2.40 [SD ± 2.15]; P = .032). Esophageal (0.79 [SD ± 0.80] vs 0.20 [SD ± 0.16]; P = .20), pericardial (8.83 [SD ± 5.34] vs 5.87 [SD ± 5.15]; P = .43), and spinal cord (0.08 [SD ± 0.09] vs 0.08 [SD ± 0.08]; P = 1.0) activities were low and not statistically different between vascular beds. Renal and brain shunt percentages were negligible.</p><p><strong>Conclusions: </strong>Lung cancer may be generated in the Oncopig and may be used to characterize biodistribution after transarterial targeting. Bronchial arterial TARE should be prioritized on the basis of higher tumor-to-normal biodistribution.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeremy P Harris, Christina Boyd, Mengying Shi, Michael Reilly, Aaron Simon, Steven N Seyedin, Wen-Pin Chen, Misako Nagasaka, Rupali Nabar, Nadine Abi-Jaoudeh
{"title":"Pilot Study of Combining Stereotactic Body Radiation Therapy with Pulsed Field Ablation for Oligometastatic/Oligoprogressive Lung Tumors.","authors":"Jeremy P Harris, Christina Boyd, Mengying Shi, Michael Reilly, Aaron Simon, Steven N Seyedin, Wen-Pin Chen, Misako Nagasaka, Rupali Nabar, Nadine Abi-Jaoudeh","doi":"10.1016/j.jvir.2025.08.005","DOIUrl":"10.1016/j.jvir.2025.08.005","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility of combining pulsed field ablation through irreversible electroporation (IRE) or pulsed electric field (PEF) with stereotactic body radiation therapy (SBRT) delivered within 15 days for lung tumors.</p><p><strong>Materials and methods: </strong>A prospective pilot study was designed for the treatment of lung tumors with pulsed field ablation followed by 12 Gy in 1 fraction. Percutaneous ablation via paired electrode probes (IRE) or a single-probe system (PEF) was allowed on the trial; the intent was complete ablation. Patients with oligometastatic or oligoprogressive cancer of any histology and 1-3 lung tumor targets of 1-6 cm were included. The primary end point was feasibility, while secondary end points were safety, local failure, progression-free survival, overall survival, and changes in lung function. This trial was registered with ClinicalTrials.gov (NCT05555342).</p><p><strong>Results: </strong>Six patients with 8 tumors were enrolled and treated, including 3 ultracentral, 2 central, and 3 peripheral tumors. All patients completed treatment with PEF ablation (n = 0 with IRE) and SBRT, and 1 had a Grade ≥3 adverse event related to postprocedural extubation. Other adverse events were of Grade 1 (n = 3). There were no significant changes from baseline to 3 months in forced vital capacity (FVC, P = .68), forced expiratory volume in 1 second (FEV1, P = .16), or diffusing capacity of the lung for carbon monoxide (DLCO, P = .30). The median follow-up was 19 months, and there were 3 local failures in 2 patients. The 12-month rate of local failure was 37.5% (95% CI, 7%-69%), progression-free survival was 17% (95% CI, 3%-99%), and overall survival was 83% (95% CI, 58%-100%).</p><p><strong>Conclusions: </strong>Combining pulsed field ablation in this pilot trial was feasible and well-tolerated.</p>","PeriodicalId":49962,"journal":{"name":"Journal of Vascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}