Journal of Veterinary Internal Medicine最新文献

{"title":"Erratum to “Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial”","authors":"","doi":"10.1111/jvim.70212","DOIUrl":"https://doi.org/10.1111/jvim.70212","url":null,"abstract":"<p>S. A. Jablonski, S. B. Shropshire, V. E. Watson, et al., “Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial,” <i>Journal of Veterinary Internal Medicine</i> 39, no. 4 (2025): e70147, https://doi.org/10.1111/jvim.70147.</p><p>In the above-mentioned article, in Section 4 Discussion, second paragraph, lines five, six, and seven the word “dogs” should be replaced with “humans.” The sentences should be as follows.</p><p>“In humans with IBD, the prevalence of baseline hypovitaminosis D has been reported to range from 35% to 100% in humans with CD, and 45% to 50% in humans with UC [27]. Subsequently, several clinical trials have been performed evaluating various vitamin D treatments in humans with both CD and UC, some of which have shown positive benefits such as improvements in clinical activity index scores, reductions in inflammatory markers [13], and reduced utilizations of healthcare [14]. An additional placebo-controlled, randomized, clinical trial of 94 humans with CD found that the clinical relapse rate was lower in humans treated with cholecalciferol compared to humans treated with placebo, though the difference was not statistically different (<i>p</i> = 0.06) [28].”</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Outpatient Pain Management in Dogs With Mild to Moderate Pancreatitis Using a Novel Wearable Device for Continuous Hydromorphone Delivery","authors":"Caylen Erger,&nbsp;Katie D. Mauro,&nbsp;Isabel Mendoza-White,&nbsp;Marilyn Brink,&nbsp;Susanne Heartsill,&nbsp;Harry Cridge","doi":"10.1111/jvim.70217","DOIUrl":"https://doi.org/10.1111/jvim.70217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Inpatient management for pancreatitis might be costly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Describe a standardized outpatient protocol for pancreatitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Nineteen client-owned dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-arm prospective observational study. Inclusion criteria included ≥ 2 clinical signs of pancreatitis, an abnormal SNAP cPL, no evidence of mechanical obstruction, and no significant comorbidities. All dogs received: fuzapladib (0.4 mg/kg IV q24 h for 3 days), subcutaneous fluids (up to 20 mL/kg/d SQ), hydromorphone (0.01 mg/kg/h delivered by a wearable infusion device), anti-emetics (maropitant citrate &amp;/or ondansetron), and nutrition. Dogs were assessed every 24 h for 3 days via physical examination and calculation of modified clinical activity index (MCAI; indicator of severity) and Glasgow composite measure pain scale (GCMPS) scores (indicator of analgesic adequacy).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten of 19 dogs had a Spec cPL ≥ 400 μg/L and were considered to have suspected pancreatitis. Nine dogs had an abnormal SNAP cPL but Spec cPL &lt; 400 μg/L and were reported in the assessment of protocol complications only. In the suspected pancreatitis group, MCAI decreased from Day 0 to Day 2 (median: 6, IQR: 5, vs. median 3, IQR: 4.25). GCMPS decreased from Day 0 to Day 2 (median: 7.5, IQR: 7.75, vs. median 0, IQR: 2.75). 2/19 dogs were hospitalized, 1 dog due to relapsed clinical signs, and 1 dog at the owner's request. A cutaneous adverse reaction could not be ruled out in 1 dog.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>In this non-blinded study, most dogs were successfully treated on an outpatient basis. Mild to moderate cases of pancreatitis predominated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary Dwarfism and Adrenocorticotropic Hormone Deficiency in a White Swiss Shepherd Dog With LHX3 Mutation","authors":"Gaëlle Schils,&nbsp;Lisa Stammeleer,&nbsp;Sylvie Daminet","doi":"10.1111/jvim.70193","DOIUrl":"https://doi.org/10.1111/jvim.70193","url":null,"abstract":"<p>LHX3 mutation in dogs is associated with combined pituitary hormone deficiency. However, ACTH secretion is usually preserved. A 9-week-old female White Swiss Shepherd dog presented with growth retardation and was diagnosed with pituitary dwarfism due to LHX3 mutation. In the 2 years after diagnosis, the dog developed persistent lymphocytosis and eosinophilia. Endogenous ACTH measurement, ACTH stimulation test, and CRH stimulation test confirmed pituitary hypocortisolism. The dog was administered physiological doses of prednisolone, with improvement of activity levels. These findings are similar to scarce human reports and suggest that corticotrope function might decline over time in dogs with LHX3 mutations. Awareness and screening for ACTH deficiency in dwarf dogs is important in light of compatible clinical signs and laboratory abnormalities, as treatment with glucocorticoids improves the quality of life of these dogs.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal and Clinical Profiles of Dogs With Chronic Enteropathies Treated With Bile Acid Sequestrants for 5–47 Months: A Retrospective Case Series","authors":"Linda Toresson,&nbsp;Amanda B. Blake,&nbsp;Chi-Hsuan Sung,&nbsp;Gunilla Olmedal,&nbsp;Ulrika Ludvigsson,&nbsp;Paula R. Giaretta,&nbsp;M. Katherine Tolbert,&nbsp;Jan S. Suchodolski","doi":"10.1111/jvim.70206","DOIUrl":"https://doi.org/10.1111/jvim.70206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bile acid (BA) malabsorption and BA diarrhea (BAD) are prevalent but underdiagnosed conditions in people with chronic diarrhea of multiple causes. Recent studies have shown BA dysmetabolism in dogs with chronic enteropathies (CE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Describe canine inflammatory bowel disease activity index (CIBDAI), dysbiosis index (DI) and fecal BA concentrations in healthy dogs and dogs with refractory or partially immunosuppressive-responsive CE or CE dogs requiring high doses of corticosteroids, treated with BA sequestrants (BAS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twenty-four CE dogs and 18 healthy dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective case series. Dogs with CE were treated with BAS as adjunctive treatment. Fecal BA was analyzed using liquid chromatography–tandem mass spectrometry. Fecal microbiota was assessed using DI. Response to treatment was defined as a decrease in CIBDAI category.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen of 24 dogs improved clinically after BAS treatment (cholestyramine, 44–133 mg/kg q12h; colesevelam, 7–24 mg/kg q12h; colestipole, 26 mg/kg q24h). Duration of treatment was 5–47 months. Median (range) CIBDAI decreased from 6.5 (4–13) to 3 (2–5) in responders. At baseline, responders had a higher median (range) percentage of fecal unconjugated primary BAs (93 [1–100]) versus non-responders (2.5 [0–95]) and healthy dogs (1.5 [0–19]). Dysbiosis index (median [range]) was higher in responders (4.2 [−4.7 to 9.0]) versus non-responders (−0.1 [−1.5 to 5.7]) and healthy dogs (−4.5 [−6.4 to −0.2]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Treatment with BAS as adjunctive treatment potentially may benefit some dogs with nonresponsive or partially immunosuppressive-responsive enteropathy or CE dogs requiring high doses of corticosteroids.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of Specific Lung Sounds Auscultation by Veterinarians for the Detection of Bronchopneumonia in Calves","authors":"Leticia Princisval,&nbsp;Antonio Boccardo,&nbsp;Davide Pravettoni,&nbsp;Salvatore Ferraro,&nbsp;Jean-François Valarcher,&nbsp;Viviani Gomes,&nbsp;Gilles Fecteau,&nbsp;Sébastien Buczinski","doi":"10.1111/jvim.70203","DOIUrl":"https://doi.org/10.1111/jvim.70203","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung auscultation is a common method for the routine diagnosis of calf bronchopneumonia. However, its repeatability among operators has been criticized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Determine agreement among veterinarians for specific lung sounds after a short tutorial to standardize the definition of lung sounds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Forty lung sounds from a larger dataset collected at 4 veal calf farms that housed 495–815 animals were submitted online to 10 different veterinarians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After a short tutorial on lung sound auscultation, the raters were asked to detect the presence of any abnormal sounds and to differentiate among wheezes, crackles, and bronchial sounds. Raw percentage of agreement (PA), Gwet's agreement coefficient type 1 (AC1), Krippendorff's alpha (<i>K</i>_a), and Fleiss kappa (<i>K</i>_Fleiss) were chosen as agreement indicators in the absence of a gold standard indicator to assess agreement. The different indicators were interpreted based on a priori reported benchmarks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The agreements were fair to good for almost all lung sound indicators. For the presence of any abnormal lung sound, the reported agreements (95% confidence intervals [CI]) were 0.781 (0.716–0.845), 0.646 (0.514–0.777), 0.403 (0.351–0.455), and 0.293 (0.137–0.493) for PA, AC1, <i>K</i>_a, and <i>K</i>_Fleiss, respectively. The same indicators were 0.769 (0.694–0.845), 0.615 (0.446–0.784), 0.426 (0.378–0.475), and 0.425 (0.293–0.563) for wheezes, 0.754 (0.685–0.823), 0.643 (0.503–0.782), 0.21 (0.146–0.275), and 0.208 (0.097–0.327) for crackles, and 0.636 (0.571–0.701), 0.345 (0.179–0.512), 0.182 (0.131–0.232), and 0.18 (0.081–0.279) for bronchial sound detections, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>Agreement among raters auscultating calf respiratory sounds was higher than previously reported. However, improvement is still possible to increase auscultation agreement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatopathy in a 4-Month-Old Holstein Calf After Transfusion With Plasma Containing Bovine Bosavirus","authors":"Simon F. Peek,&nbsp;Chelsea L. Holschbach,&nbsp;Alexandra J. Burton,&nbsp;Zuzanna W. Sikorska,&nbsp;LaTasha K. Crawford,&nbsp;Christopher D. Dunn,&nbsp;Tony L. Goldberg","doi":"10.1111/jvim.70208","DOIUrl":"https://doi.org/10.1111/jvim.70208","url":null,"abstract":"<p>We report on the identification of bovine bosavirus associated with a post-transfusion hepatopathy in a 4-month-old Holstein bull calf that was referred for enteritis and fever of unknown origin. Next-generation sequencing (NGS) of post-transfusion blood and liver tissue from the calf, alongside NGS of plasma from the donor, identified a bovine bosavirus. This virus has been previously identified in bovine calf serum, calves with mucosal disease, and the blood of bison but was of uncertain clinical importance. These findings have biosecurity implications for clinicians using bovine whole blood or plasma therapeutically and suggest the need for pre- or postharvest donor screening or biologic processing to prevent infection of recipients. The calf made a full clinical recovery.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Gene Profiling and Targeted Metabolomics in Fecal Samples of Dogs With Chronic Enteropathy With or Without Increased Dysbiosis Index","authors":"Chih-Chun Chen,&nbsp;Rachel Pilla,&nbsp;Linda Toresson,&nbsp;Chi-Hsuan Sung,&nbsp;Amanda B. Blake,&nbsp;Bruna Correa Lopes,&nbsp;Jonathan Turck,&nbsp;Albert E. Jergens,&nbsp;Stacie C. Summers,&nbsp;Stefan Unterer,&nbsp;Patricia Eri Ishii,&nbsp;Paula R. Giaretta,&nbsp;M. Katherine Tolbert,&nbsp;Jan S. Suchodolski","doi":"10.1111/jvim.70199","DOIUrl":"https://doi.org/10.1111/jvim.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In previous studies, only a subset of dogs with chronic enteropathy (CE) had an increased dysbiosis index (DI) or altered fecal metabolites or both, suggesting differences in underlying intestinal pathophysiology between these subsets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare microbial functional genes and fecal metabolites between healthy dogs with DI &lt; 0 (HC) and dogs with CE and DI &gt; 0 (increased DI-CE) or DI &lt; 0 (normal DI-CE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Retrospective cross-sectional study including 78 HC and 138 <span>CE</span> dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fecal microbiome was assessed by DNA shotgun sequencing. Dysbiosis index was quantified by qPCR. Targeted fecal metabolites, long-chain fatty acids, sterols, bile acids (BAs), and carbohydrates were measured using gas chromatography–mass spectrometry (GC–MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In permutational analysis of variance (PERMANOVA), functional gene profiles showed larger shifts in increased DI-CE (median <i>R</i>² [95% confidence interval (CI)] = 0.12 [0.08–0.17]) than normal DI-CE (0.02 [0.01–0.04]) compared with HC (adjusted-<i>p</i> &lt; 0.02), characterized by increased counts of carbohydrate and lipid degradation genes. Similarly, increased DI-CE (PERMANOVA, median <i>R</i>² [95% CI] = 0.23 [0.14–0.34]) had larger shifts in fecal metabolome than normal DI-CE (0.10 [0.04–0.20]; adjusted-<i>p</i> &lt; 0.02). Increased DI-CE had lower fecal unconjugated secondary BAs percentage (95% CI; HC, 88.4%–96.4%; normal DI-CE, 79.8%–99.0%; increased DI-CE, 28.1%–64.1%) and transporter-independent carbohydrates (combined ribose, xylose, rhamnose, and arabinose) concentrations (1.6–2.6; 0.7–1.8; 0.3–1.3 ng/mg; adjusted-<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Results indicate differences in fecal microbial gene profiles and metabolome in increased DI-CE versus normal DI-CE and HC, suggesting dogs with an increased DI have more severe intestinal changes in metabolic functions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Multi-Steroid Profiles of Cats With Hyperaldosteronism or Other Diseases: A Retrospective Study","authors":"Alice H. Watson,&nbsp;Lorna C. Gilligan,&nbsp;Angela E. Taylor,&nbsp;Wiebke Arlt,&nbsp;Harriet M. Syme","doi":"10.1111/jvim.70209","DOIUrl":"https://doi.org/10.1111/jvim.70209","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Multi-steroid profiles are proven to help with the diagnostic approach to adrenal disorders in humans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Compare liquid chromatography tandem mass spectrometry (LC–MS/MS) and radioimmunoassay (RIA) measurement of aldosterone in feline blood samples. Evaluate multi-steroid profiles in cats with hyperaldosteronism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Client-owned cats with low/normal aldosterone by RIA (low aldo, <i>n</i> = 15), high aldosterone by RIA (high aldo, <i>n</i> = 6) and overt primary hyperaldosteronism (PHA, <i>n</i> = 6).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Exploratory retrospective case–control study. Feline blood multi-steroid profiles were analyzed with LC–MS/MS and compared with results from a commercially available RIA in widespread clinical use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Aldosterone measurement by LC–MS/MS and RIA was strongly correlated (<i>r</i> = 0.93, <i>p</i> &lt; 0.001) but showed a bias of 56 (95% CI: 104–7) pmol/L, with RIA giving higher values. Creatinine concentration was not significantly associated with the discrepancy between methods (<i>p</i> = 0.95). Cats with PHA had significantly lower serum concentrations of cortisol and glucocorticoid precursors (17-hydroxyprogesterone, 11-deoxycortisol), testosterone, and significantly higher dihydrotestosterone and 5α-dihydroprogesterone concentrations than the low aldo group. Pregnenolone concentrations were significantly lower in the PHA group than in the high aldo group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>Quantification of aldosterone by either LC–MS/MS or RIA is adequate for PHA diagnosis in the clinical setting, with appropriate method-specific reference intervals. Cats with PHA had different concentrations of some steroids compared with the control groups, but overt steroid excess (other than aldosterone) was not observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Campylobacter upsaliensis From an Abscessed Hepatic Mass in a Dog","authors":"Tahj A. Boston,&nbsp;Sara D. Lawhon,&nbsp;Genna F. Aitee,&nbsp;Katie Como,&nbsp;Kimberley Sannajust,&nbsp;Christine L. Gremillion,&nbsp;Haley E. Dodson,&nbsp;Laura K. Bryan,&nbsp;Karen E. Russell","doi":"10.1111/jvim.70195","DOIUrl":"https://doi.org/10.1111/jvim.70195","url":null,"abstract":"<p>An 11-year-old male castrated Boston Terrier dog presented with acute onset lethargy and vomiting. On examination, the dog was febrile, tachycardic, and thought to have generalized abdominal pain. Abdominal ultrasonography identified a fluid-filled hepatic mass with suspected surrounding steatitis. Cytology from the hepatic mass indicated septic neutrophilic inflammation with extracellular and intracellular curved to spiral small bacterial organisms consistent with <i>Campylobacter</i> spp. The cytology results prompted appropriate isolation techniques composed of microaerophilic culture methods, which resulted in isolation of <i>Campylobacter upsaliensis</i>. Anaerobic and aerobic cultures also were performed and yielded no growth. Because of prognosis, the owner elected euthanasia, and necropsy identified a hepatocellular carcinoma as the underlying lesion for the abscessed hepatic mass.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Tracheal and Cranial Mediastinal Aspergillosis in a Young Otherwise Healthy Cat","authors":"Liliana M. Mutascio,&nbsp;J. Clifton Crooks","doi":"10.1111/jvim.70204","DOIUrl":"https://doi.org/10.1111/jvim.70204","url":null,"abstract":"<p>A 3.5-year-old castrated male domestic medium hair cat was evaluated for dry cough and labored breathing. A cranial mediastinal mass was seen on thoracic radiographs. On computed tomography, the mass displaced the cranial vena cava and dorsally displaced and compressed the intrathoracic trachea. The patient was taken to surgery for attempted mass removal. Intraoperatively, the mass was adhered to the cranial vena cava, aortic arch, left subclavian artery, and had partially engulfed the brachiocephalic trunk. The cat was euthanized and on necropsy the mass was found to invade the lumen of the vena cava and the tracheal lumen. An <i>Aspergillus lentulus</i> fungal granuloma was diagnosed histologically and by fungal culture and PCR. We highlight the difficulty in determining the extent of invasion with invasive aspergillosis and provide evidence that invasive aspergillosis can occur in otherwise healthy, young cats with no concurrent immunosuppressive treatments or comorbidities.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}