Journal of Veterinary Internal Medicine最新文献

{"title":"Long-Term Humoral Immune Response After West Nile Virus Convalescence in Horses in a Geographic Area of Multiple Orthoflavivirus Co-Circulation","authors":"Csenge Hanna Tolnai,&nbsp;Petra Forgách,&nbsp;András Marosi,&nbsp;Orsolya Fehér,&nbsp;Bettina Paszerbovics,&nbsp;Miklós Tenk,&nbsp;Zsombor Wagenhoffer,&nbsp;Orsolya Kutasi","doi":"10.1111/jvim.70176","DOIUrl":"https://doi.org/10.1111/jvim.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In the last three decades, West Nile virus (WNV, <i>Flaviviridae, Orthoflavivirus</i> genus) has become one of the most important encephalitic agents worldwide, causing substantial numbers of cases in humans and horses every year by re-emerging in endemic areas and emerging in new territories. It is considered that after natural WNV infection, humans and birds develop long-term immunoprotection, but data on immunoprotection in horses is scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>West Nile virus infection provides long-term humoral immunity in subclinically infected horses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Client-owned, naturally WNV subclinically infected non-WNV-vaccinated, healthy horses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective cohort study, anti-WNV neutralizing antibody (nAb) titers of 25 horses were monitored for 5 consecutive years in Hungary. Serum samples were collected annually. First, a WNV immunoglobulin G (IgG) ELISA was performed, followed by virus neutralization tests (VNT) for endemic orthoflaviviruses. A VNT titer &gt; 8 was considered positive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean WNV titer of horses was 260.64 ± 336.74 in 2019, 114.32 ± 107.36 in 2020, 95.38 ± 115.56 in 2021, 22.53 ± 25.71 in 2022 and 6.31 ± 5.15 in 2023. A significant decrease (<i>p</i> &lt; 0.001) in the nAb titers occurred over time. In 2023, 88% of the horses had WNV VNT titers below the cut-off value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Relevance</h3>\u0000 \u0000 <p>Our results showed a significant decrease in WNV titers over time. Because nAbs correlate best with orthoflavivirus protection, our findings suggest that horses might not be protected against re-infection. We recommend regular nAb titer testing or vaccination in endemic areas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog","authors":"Elber A. Soler Arias,&nbsp;Ricardo Rodas Elvir,&nbsp;Adrian F. Daly,&nbsp;Hans S. Kooistra","doi":"10.1111/jvim.70177","DOIUrl":"https://doi.org/10.1111/jvim.70177","url":null,"abstract":"<p>A 12-year-old, male Labrador Retriever was presented because of polyuria, polydipsia, polyphagia, joint pain, and physical features consistent with acromegaly. Circulating insulin-like growth factor-1 (IGF-1) concentration was increased (&gt; 1000 ng/mL; reference interval [RI], 42–449), suggestive of hypersomatotropism. An abnormal low-dose dexamethasone suppression test and increased circulating adrenocorticotropic (ACTH) concentration indicated pituitary-dependent hypercortisolism. Computed tomography identified an enlarged pituitary gland. Treatment with cabergoline initially decreased circulating IGF-1 and ACTH concentrations and urinary cortisol-to-creatinine ratio (UCCR), with a notable reduction in acromegalic physical features. However, 7 months after the start of cabergoline treatment, IGF-1, ACTH, and UCCR had increased again, although pituitary gland size remained stable. Because of worsening joint pain, euthanasia was performed. On necropsy, double immunohistochemistry identified pituitary tumor cells with cytoplasmic co-expression of both growth hormone (GH) and ACTH, consistent with a monomorphic plurihormonal macroadenoma. This case shows that concurrent hypersomatotropism and hypercortisolism can occur in dogs caused by a plurihormonal pituitary adenoma.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities","authors":"Callum N. Atkins,&nbsp;Caroline N. Hahn,&nbsp;Bruce C. McGorum","doi":"10.1111/jvim.70140","DOIUrl":"https://doi.org/10.1111/jvim.70140","url":null,"abstract":"<p>Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic. Nine hundred and fifty-six articles were identified, of which 158 were included in this review. The review covers the clinical presentation, etiology, diagnostic approaches, treatment strategies, and prognosis across different species. By integrating findings from multiple species, we aim to enhance understanding and inform future research and medical strategies regarding dysautonomia.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De Novo Missense Variant in Bovine WDR33 Associated With a Complex Syndromic Form of Cleft Palate With Pentalogy of Fallot and Internal Hydrocephalus","authors":"Marilena Bolcato,&nbsp;Giovanni Romito,&nbsp;Irene M. Häfliger,&nbsp;Arcangelo Gentile,&nbsp;Cord Drögemüller,&nbsp;Joana G. P. Jacinto","doi":"10.1111/jvim.70144","DOIUrl":"https://doi.org/10.1111/jvim.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cleft palate (CP) is a congenital defect characterized by an opening in the palate. Two crossbred paternal half-sibs with a complex syndrome including CP were identified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Characterize disease phenotype and evaluate the genetic cause of the observed syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Two affected calves, their parents, and 5576 control cattle genomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The affected animals were evaluated clinicopathologically. Paternal half-sibling trio-based whole genome sequencing (WGS) was performed using genomic DNA extracted from the blood of the two affected calves and both dams, and sperm of the common sire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cases were presented with a CP Veau II, permanent recumbency, strabismus, tachycardia, and tachypnea. Echocardiographic findings were consistent with tetralogy of Fallot associated with patent foramen ovale (pentalogy of Fallot). Necropsy examination identified hydrocephalus in addition to CP and confirmed the clinical diagnosis of pentalogy of Fallot. The calves were diagnosed with a complex syndromic form of CP with pentalogy of Fallot and hydrocephalus. Analysis of the breeding data showed that 19/45 recorded offspring of the sire were not viable. Genetic analysis identified a missense variant in <i>WDR33</i> that was heterozygous in both analyzed cases and in an estimated 40% of the paternal gametes of the mosaic founder, but absent in both dams and controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>This study alerts veterinarians and breeders to the potential occurrence of dominant de novo mutations in cattle and emphasizes that, in herds using a natural service sire, the consequences of an asymptomatic germline mosaic can be important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal Autonomic Seizures Manifesting With Prevailing Signs of Gastrointestinal Disorder in Dogs","authors":"Solene Diop,&nbsp;Elsa Lyon,&nbsp;Nicolas Van Caenegem,&nbsp;Catherine Escriou,&nbsp;Valérie Freiche,&nbsp;Stéphane Blot","doi":"10.1111/jvim.70158","DOIUrl":"https://doi.org/10.1111/jvim.70158","url":null,"abstract":"<p>In human medicine, focal seizures can clinically express as autonomic signs, such as gastrointestinal dysfunction, cardiovascular changes, and variation of pupillary size; but little is known about possible presentations of autonomic seizures in veterinary medicine. Three dogs were presented for recurrent episodes characterized by hypersalivation, vomiting, retching, and signs of abdominal discomfort. Neurological examinations were normal between episodes. Electroencephalographic (EEG) recordings identified ictal or interictal epileptiform discharges in all dogs. Based on clinical signs and EEG findings, a diagnosis of focal autonomic seizures was made. There was a notable positive response of clinical signs to antiepileptic treatment. These cases highlight the diverse clinical presentations of focal autonomic seizures in dogs and emphasize the diagnostic value of EEG in these cases.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Serum Proteomic Profiles at Different Stages of Pregnancy Toxemia in Goats","authors":"Murat Uztimür,&nbsp;Cennet Nur Ünal,&nbsp;Gürler Akpınar","doi":"10.1111/jvim.70139","DOIUrl":"https://doi.org/10.1111/jvim.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In human medicine, serum proteome profiles are used to differentiate metabolic diseases and evaluate their pathophysiology. Understanding the serum proteome profiles of goats with pregnancy toxemia might help identify the proteomes and pathways responsible for the development of this disease and improve diagnosis and treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Aim</h3>\u0000 \u0000 <p>Determine biomarkers that differentiate healthy goats from goats with subclinical pregnancy toxemia (SPT) and clinical pregnancy toxemia (CPT) using serum proteome analysis. In addition, serum protein differences were evaluated to distinguish between SPT and CPT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Thirty-five hair goats were included, with 15 in the SPT group, 10 in the CPT group, and 10 in the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The cross-sectional study was conducted with animals from goat farms in Bingol, Türkiye, between December 2023 and May 2024. Serum samples were investigated using mass spectrometry-based proteomic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Proteomic profiles showed significant variation in relative protein abundance. Twenty-five proteins were significantly (<i>p</i> ≤ 0.01) differentially expressed between animals with pregnancy toxemia and those of the control group, with ≥ 2-fold changes in abundance. Proteins involved in cellular, biological, and molecular processes, including processes related to reactive oxygen species, cytokine activation, acute phase response signaling, lipid metabolism, and antimicrobial activity were altered in animals with pregnancy toxemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>The proteomic candidates identified are biomarkers that may facilitate the diagnosis, treatment, and management of pregnancy toxemia in goats. Serum proteomic biomarkers could be used in rapid tests in the future and may improve the management of pregnancy toxemia on farms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial","authors":"Sara A. Jablonski,&nbsp;Sarah B. Shropshire,&nbsp;Victoria E. Watson,&nbsp;Alison C. Manchester,&nbsp;Harry Cridge,&nbsp;Elizabeth M. Lennon,&nbsp;M. Katherine Tolbert","doi":"10.1111/jvim.70147","DOIUrl":"https://doi.org/10.1111/jvim.70147","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The effects of vitamin D supplementation are unknown in dogs with protein-losing enteropathy (PLE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the safety, efficacy, and clinical benefit of orally administered cholecalciferol in dogs with PLE and decreased serum concentrations of 25OHD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twenty-eight dogs with PLE, decreased 25OHD, and serum ionized calcium (iCa) &gt; 1.0 mmol/L (<i>n</i> = 15 treated with cholecalciferol, <i>n</i> = 13 treated with placebo).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective, double-blinded, randomized, controlled trial. Dogs randomized to receive 400 IU/kg cholecalciferol or placebo PO daily along with standard therapy for 6 weeks. Clinical and biochemical variables were measured at baseline (T0) and monitored at 2 (T1), 4 (T2), and 6 (T3) weeks postmedication initiation. Clinical and biochemical variables were also measured 6 weeks following discontinuation of study medication (T4). Variables were compared in dogs with PLE receiving cholecalciferol versus placebo at T0–T4 using Student's <i>t</i> test or Mann–Whitney U tests and a mixed-effects model. Correlations between 25OHD and clinical and biochemical variables were also performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Dogs with PLE treated with cholecalciferol had higher 25OHD concentrations at T2 compared to dogs treated with placebo (225 nmol/L, range 72–434 vs. 80 nmol/L, range 31–254 nmol/L; <i>p</i> = 0.004). Clinical and biochemical variables did not otherwise differ between dogs with PLE treated with cholecalciferol versus placebo at T0–T4. Serum albumin correlated with 25OHD at T0–T3(<i>p</i> &lt; 0.005 for all comparisons). Hypervitaminosis D without ionized hypercalcemia occurred in five dogs (18%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>While PLE dogs treated with cholecalciferol had higher 25OHD concentrations at study timepoints, a clinical benefit of supplementation was not observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Proteinuria in Dogs With Immune-Mediated Disease","authors":"James C. Barton,&nbsp;Alexander J. German,&nbsp;Erin M. O'Connell","doi":"10.1111/jvim.70162","DOIUrl":"https://doi.org/10.1111/jvim.70162","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Proteinuria is associated with autoimmune diseases in humans. There is minimal evidence in the veterinary literature on proteinuria and its association with immune-mediated disease in dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>Renal proteinuria is common in dogs with immune-mediated disease. Dogs presenting with pyrexia or immune-mediated polyarthritis (IMPA) are more likely to have proteinuria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>One hundred and forty-four dogs with primary immune-mediated diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective, observational study. Data collected included signalment, travel outside the United Kingdom, duration of clinical signs, diagnosis, urinalysis, and urine protein–creatinine ratio (UPCR). Non-proteinuric, mild proteinuria, moderate proteinuria, and severe proteinuria were defined as UPCR &lt; 0.5; ≥ 0.5–1; ≥ 1–2; ≥ 2, respectively. Exclusion criteria included azotemia, hypoalbuminemia (&lt; 2.0 g/dL), foreign travel, active urine sediment or positive culture, glucocorticoid therapy for greater than 24 h prior to presentation, or medication known to influence UPCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-seven dogs were non-proteinuric (47%; 95% confidence interval [95% CI]: 38%, 55%), 25 mildly proteinuric (17%; 95% CI: 9%, 26%), 15 moderately proteinuric (10%; 95% CI: 2%, 19%), and 37 severely proteinuric (26%; 95% CI: 17%, 34%). On multiple logistic regression analysis, female dogs (odds ratio [OR]: 3.24; 95% CI: 1.49, 7.42), individuals with pyrexia (OR: 6.59; 95% CI: 3.00, 15.37), or hemoglobinuria (OR: 27.21; 95% CI: 4.79, 516.56) were more likely to have proteinuria. There was an association between steroid-responsive meningitis-arteritis and the magnitude of proteinuria on multiple linear regression (<i>p</i> = 0.025); this was not confirmed on multiple logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Proteinuria is common in dogs with immune-mediated disease and can be severe. Screening for proteinuria could be considered part of the diagnostic assessment for dogs with immune-mediated disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for “Prognostic Potential of Copper, Zinc, Copper/Zinc Ratio, Cobalamin, and Serum Amyloid A in Cats With Panleukopenia”","authors":"","doi":"10.1111/jvim.70127","DOIUrl":"https://doi.org/10.1111/jvim.70127","url":null,"abstract":"<p>\u0000 <span>Yanar, KE</span>, <span>Baysal, S</span>, <span>Ulaş, N</span>, <span>Aktaş, MS</span>, <span>Timurkan, MÖ</span>, <span>Aydın, H</span>. <span>Prognostic potential of copper, zinc, copper/zinc ratio, cobalamin, and serum amyloid A in cats with panleukopenia</span>. <i>J Vet Intern Med.</i> <span>2024</span> May-Jun; <span>38</span>(<span>3</span>): <span>1535</span>-<span>1541</span>. doi: https://doi.org/10.1111/jvim.17077. Epub 2024 Apr 13. PMID: 38613433; PMCID: PMC11099764\u0000 </p><p>In the above-mentioned article, there is a labeling error in Figure 3. In the ROC plot, the x-axis was inadvertently labeled as “specificity” instead of the correct term “1 – specificity.” This error was an unintentional typographical oversight during figure preparation. The corrected Figure 3 is included below.</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144219973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers of Hepatic Insulin Clearance and Their Association With Steatosis in Hyperinsulinaemic Horses","authors":"Miranda Dosi,&nbsp;Laura Scott,&nbsp;Holly Payne,&nbsp;Jacqueline Poldy,&nbsp;John Keen,&nbsp;Bruce McGorum,&nbsp;Alexandra Malbon,&nbsp;Ruth Morgan","doi":"10.1111/jvim.70143","DOIUrl":"https://doi.org/10.1111/jvim.70143","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyperinsulinaemia (HI) is an important feature of Equine Metabolic Syndrome (EMS). It has been suggested that reduced hepatic clearance of insulin contributes to HI, particularly in humans affected by metabolic dysfunction-associated steatotic liver disease (MASLD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>In obese horses with HI, insulin clearance is impaired and associated with MASLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Tissue samples were collected at post-mortem from clinically well-characterized horses with HI (<i>n</i> = 13; basal insulin &gt; 20 mIU/l) and without HI (control; <i>n</i> = 20).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective observational study. Molecular drivers of hepatic clearance (CAECAM-1, an insulin chaperone protein and IDE-Insulin Degrading Enzyme) were quantified by RT-qPCR and activity, respectively, in liver tissue. Fixed liver sections stained with hematoxylin and eosin (H&amp;E) were assigned a histological score by two blinded observers using an equine liver disease score and a human MASLD score. Triglyceride (TG) content in liver sections, serum liver enzymes, ACTH, basal insulin, and serum triglycerides were also measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>IDE activity was 2.73 (IQR 4.00 activity/mg of protein) in HI horses and 2.18 (IQR 0.55) in controls (<i>p</i> = 0.07). IDE activity correlated negatively with insulin (rho = 0.561, <i>p</i> = 0.04) but not with liver or serum TG. CEACAM-1 gene expression was higher in the HI group (2.09 ± 1.79 folds) than in controls (0.69 ± 0.62, <i>p</i> = 0.03). Liver disease and MASLD scores were no different between groups, whereas triglyceride liver content was higher in horses with HI (504.83 IQR 217.51 nmol/g) compared to controls (363.58 IQR 67.32 nmol/g, <i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Relevance</h3>\u0000 \u0000 <p>MASLD is not consistently present in HI horses, but CAECAM-1 expression is higher.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144219971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}