Journal of Veterinary Internal Medicine最新文献

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Correction to “Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler” 修正“用脉冲波多普勒分析肾内静脉血流的预后价值”。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-11-06 DOI: 10.1111/jvim.70266
{"title":"Correction to “Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler”","authors":"","doi":"10.1111/jvim.70266","DOIUrl":"10.1111/jvim.70266","url":null,"abstract":"<p>T. Morita, H. Terukina, and M. Yamasaki, “Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler,” <i>Journal of Veterinary Internal Medicine</i> 39 (2025): e70260. https://doi.org/10.1111/jvim.70260.</p><p>In the above-mentioned article, the title of the article is incorrect and needs to be changed as below:</p><p>Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler Ultrasonography in Dogs with Myxomatous Mitral Valve Disease</p><p>The original article has also been corrected.</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Characteristics, Nutritional Recommendations, and Medical Interventions of 58 Dogs With Protein-Losing Enteropathy Presenting to a Veterinary Nutrition Service” 更正“58只向兽医营养服务机构报告的蛋白质丧失性肠病犬的特征、营养建议和医疗干预”。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-11-06 DOI: 10.1111/jvim.70264
{"title":"Correction to “Characteristics, Nutritional Recommendations, and Medical Interventions of 58 Dogs With Protein-Losing Enteropathy Presenting to a Veterinary Nutrition Service”","authors":"","doi":"10.1111/jvim.70264","DOIUrl":"10.1111/jvim.70264","url":null,"abstract":"<p>C. M. Margrey, A. W. Rollins, M. K. Tolbert, M. Murphy, X. Zhu, and S. M. Schmid, “Characteristics, Nutritional Recommendations, and Medical Interventions of 58 Dogs With Protein-Losing Enteropathy Presenting to a Veterinary Nutrition Service,” <i>Journal of Veterinary Internal Medicine</i> 39 (2025): e70247, https://doi.org/10.1111/jvim.70247.</p><p>In the above-mentioned article, Table 3, columns T2 and T3 have the following corrections.</p><p>Column T3, Number of Dogs, row <i>Enterococcus faecium</i> NCIMB 30183, the value is 7, not 14.6.</p><p>Column T3, %, row <i>Enterococcus faecium</i> NCIMB 30183, the value is 15 not 10.</p><p>Column T2, %, row <i>Enterococcus faecium</i> SF68<sup>C</sup>, the value is 2, not 2.4.</p><p>Column T2, %, row Other, the value is 2, not 2.4.</p><p>The correct table is displayed here.</p><p>The authors apologize for these errors.</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Characterization of Post-Ictal Clinical Signs in Dogs With Idiopathic Epilepsy: A Questionnaire-Based Study” 更正“特发性癫痫犬的发作后临床症状特征:一项基于问卷的研究”。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-11-06 DOI: 10.1111/jvim.70265
{"title":"Correction to “Characterization of Post-Ictal Clinical Signs in Dogs With Idiopathic Epilepsy: A Questionnaire-Based Study”","authors":"","doi":"10.1111/jvim.70265","DOIUrl":"10.1111/jvim.70265","url":null,"abstract":"<p>A. Nagendran, J. A. Nettifee, D. Carter, and K. R. Muñana, “Characterization of Post-Ictal Clinical Signs in Dogs With Idiopathic Epilepsy: A Questionnaire-Based Study,” <i>Journal of Veterinary Internal Medicine</i> 39, no. 1 (2025): e17302, https://doi.org10.1111/jvim.17302.</p><p>In the article cited above, minor discrepancies were found in the Abstract (“Results”) when compared to the Results in section 4.1 (“POST-ICTAL SIGNS”).</p><p>The corrected sections are shown below; there is no impact on the conclusions of this study.</p><p>In the abstract, these sentences</p><p>Median duration of PI signs was 30 minutes (range, 5–4320 minutes). The most common PI signs reported were disorientation (50/79) and wobbliness or clumsiness (49/79).</p><p>Should be changed to</p><p>Median duration of PI signs was 30 minutes (range, <b>1–4320</b> minutes). The most common PI signs reported were disorientation (<b>71/79</b>) and wobbliness or clumsiness (<b>67/79</b>).</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Reversible Cardio-Renal-Cerebral Syndrome in a Dog: A Case Report” 修正“狗的可逆性心-肾-脑综合征:一例报告”。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-28 DOI: 10.1111/jvim.70263
{"title":"Correction to “Reversible Cardio-Renal-Cerebral Syndrome in a Dog: A Case Report”","authors":"","doi":"10.1111/jvim.70263","DOIUrl":"10.1111/jvim.70263","url":null,"abstract":"<p>G. Candelario, G. Kramer, B. Williams, S. Siess, N. Gaudette, and L. Patterson Rosa, “Reversible Cardio-Renal-Cerebral Syndrome in a Dog: A Case Report,” <i>Journal of Veterinary Internal Medicine</i> 39 (2025): e70249, https://doi.org/10.1111/jvim.70249.</p><p>In the above mentioned article, author name Samantha Seies has been corrected to Samantha Siess.</p><p>The original article has also been corrected to reflect this change.</p><p>We apologize for this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2025 ACVIM Forum Research Abstract Program 2025 ACVIM论坛研究摘要计划。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-17 DOI: 10.1111/jvim.70258
{"title":"2025 ACVIM Forum Research Abstract Program","authors":"","doi":"10.1111/jvim.70258","DOIUrl":"10.1111/jvim.70258","url":null,"abstract":"<p>The American College of Veterinary Internal Medicine (ACVIM) Forum and the Journal of Veterinary Internal Medicine (JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opinions expressed in the abstracts are those of the author(s) and may not represent the views or position of the ACVIM. The authors are solely responsible for the content of the abstracts.</p><p><b>2025 ACVIM Forum</b></p><p><b>June 18–October 31, 2025</b></p><p><b>Research Abstract Oral Program</b></p><p><b>Index of Abstracts</b></p><p><b>Research Abstract Poster Program</b></p><p><b>Index of Abstracts</b></p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Value of Various Histological Factors in Cutaneous and Subcutaneous Mast Cell Tumors in 197 Dogs 197例犬皮肤和皮下肥大细胞瘤中各种组织学因素的临床价值。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-15 DOI: 10.1111/jvim.70244
Katherine Boyd, Melanie Dobromylskyj, Imogen Schofield, Dan O'Neill, Celia Figueroa, Owen Davies
{"title":"Clinical Value of Various Histological Factors in Cutaneous and Subcutaneous Mast Cell Tumors in 197 Dogs","authors":"Katherine Boyd,&nbsp;Melanie Dobromylskyj,&nbsp;Imogen Schofield,&nbsp;Dan O'Neill,&nbsp;Celia Figueroa,&nbsp;Owen Davies","doi":"10.1111/jvim.70244","DOIUrl":"10.1111/jvim.70244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Many histological tests have been correlated with outcome in mast cell tumors (MCTs)in dogs, but their statistical independence is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the clinical value of histological factors in the prognostication of dogs with MCTs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>One hundred and ninety-seven dogs with 199 histologically diagnosed cutaneous (<i>n</i> = 153) and subcutaneous (<i>n</i> = 43) MCTs treated surgically in primary care practice. All had a commercial prognostic panel performed (Patnaik and Kiupel grade, mitotic count, Ki67, AgNOR, KiAg, <i>c-kit</i> mutation in exons 8 and 11 and KIT localization).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cohort study identifying dogs from searching a commercial laboratory's records (January 2017–August 2020). Follow-up was collected from clinical records. Outcome measures included MCT specific survival (MSS) and recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multivariable Cox proportional hazard regression identified only mitotic count &gt; 5 (HR 10.2; 95% CI 3.2–32.8; <i>p</i> &lt; 0.001) predicted poorer MSS across all MCTs. In Patnaik grade I or II and Kiupel low-grade cutaneous MCTs, only <i>c-kit</i> mutation in exon 11 (HR 20.8; 95% CI 1.80–224.8; <i>p</i> = 0.015) predicted MSS. A <i>c-kit</i> mutation in exon 11 (HR 10.0; 95% CI 3.0–32.9; <i>p &lt;</i> 0.001), age, and histological tumor free margins &lt; 2 mm independently predicted cutaneous and subcutaneous MCT recurrence. In Patnaik grade I or II, and Kiupel low-grade cutaneous MCTs, <i>c-kit</i> mutation in exon 11 (HR 23.20; 95% CI 2.3–231.3; <i>p</i> = 0.007) and AgNOR (HR 13.73; 95% CI 1.6–115.6; <i>p</i> = 0.016) predicted MCT recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>This study suggests a comparatively greater role of <i>c-kit</i> mutations in exon 11 and AgNOR in the prognostication of MCTs, while Ki67 appears less important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation n -丁基东莨菪碱和甲硝唑钠对主动脉瓣和二尖瓣反流温血马心率、血压和超声心动图测量的影响
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-10 DOI: 10.1111/jvim.70254
Alexander Dufourni, Marie Demeyere, Ingrid Vernemmen, Glenn Van Steenkiste, Lize-Maria Verhaeghe, Gunther van Loon, Annelies Decloedt
{"title":"Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation","authors":"Alexander Dufourni,&nbsp;Marie Demeyere,&nbsp;Ingrid Vernemmen,&nbsp;Glenn Van Steenkiste,&nbsp;Lize-Maria Verhaeghe,&nbsp;Gunther van Loon,&nbsp;Annelies Decloedt","doi":"10.1111/jvim.70254","DOIUrl":"https://doi.org/10.1111/jvim.70254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Administration of N-butylscopolammonium bromide (NBB) with metamizol sodium (NBBM) causes tachycardia and hypertension, and has been associated with accentuated cardiac murmurs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the effect of a pharmacological challenge using NBBM on valvular regurgitation and cardiac murmurs in horses with aortic (AR) and mitral valve regurgitation (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twenty Warmblood horses with AR and 20 with MR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cardiac auscultation and two-dimensional (2D), M-mode, color flow, pulsed wave Doppler flow, and tissue Doppler echocardiography were performed with simultaneous ECG recording and non-invasive blood pressure measurements during rest and pharmacological challenge using 0.2 mg/kg NBB and 25 mg/kg metamizol sodium. Cardiac dimensions and functional parameters were assessed. Regurgitant jet size was subjectively evaluated, and jet area was measured. Data at rest and during pharmacological challenge were compared using repeated measures analysis or related samples Wilcoxon signed rank test. <i>p</i>-values were adjusted using the Benjamini-Hochberg method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with rest, pharmacological challenge resulted in decreased atrial and ventricular dimensions and increased aortic and pulmonary dimensions (<i>P</i><sub>BHa</sub> ≤ 0.02). Left ventricular end-diastolic diameter decreased in horses with AR (<i>P</i><sub>BHa</sub> &lt; 0.02) but not in horses with MR. Pharmacological challenge resulted in increased median cardiac murmur intensity (<i>P</i><sub>BHa</sub> = 0.03 and <i>P</i><sub>BHa</sub> &lt; 0.02) and jet area (<i>P</i><sub>BHa</sub> ≤ 0.02 and <i>P</i><sub>BHa</sub> = 0.03) in horses with AR and MR, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Pharmacological challenge with NBBM affects cardiac chamber sizes, regurgitant jet, and cardiac murmur intensity in horses with AR and MR. Influences on heart rate and blood pressure should be considered during longitudinal follow-up examinations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to “Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls” 对“与健康对照组相比,失蛋白肠病犬免疫系统成分的评估”的勘误。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-09 DOI: 10.1111/jvim.70262
{"title":"Erratum to “Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls”","authors":"","doi":"10.1111/jvim.70262","DOIUrl":"10.1111/jvim.70262","url":null,"abstract":"<p>E. Moore, K. Thelen Strong, and S. A. Jablonski, “Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls,” <i>Journal of Veterinary Internal Medicine</i> 39, no. 5 (2025): e70245, https://doi.org/10.1111/jvim.70245.</p><p>In the above-mentioned article, Figure 1 (A–C) and Figure 3 (A–E) had labeling errors. There were no methodological errors. The correct figures are displayed here.</p><p>We apologize for the errors.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of the Sodium-Glucose Cotransporter-2 Inhibitor Velagliflozin on Insulin Concentrations in Horses With Insulin Dysregulation 钠-葡萄糖共转运蛋白-2抑制剂Velagliflozin对胰岛素失调马胰岛素浓度的影响。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-08 DOI: 10.1111/jvim.70256
Kristen Thane, Rebecca Voth, Rebecca Klee, Tobias Warnken, Victor Chukwu, Nicholas Frank
{"title":"Effects of the Sodium-Glucose Cotransporter-2 Inhibitor Velagliflozin on Insulin Concentrations in Horses With Insulin Dysregulation","authors":"Kristen Thane,&nbsp;Rebecca Voth,&nbsp;Rebecca Klee,&nbsp;Tobias Warnken,&nbsp;Victor Chukwu,&nbsp;Nicholas Frank","doi":"10.1111/jvim.70256","DOIUrl":"10.1111/jvim.70256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are promising treatments to manage hyperinsulinemia in horses with insulin dysregulation (ID).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>The SGLT2i velagliflozin decreases insulin concentration in horses with ID.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Privately-owned adult horses (<i>n</i> = 37) with laboratory-confirmed ID (low-dose oral sugar test insulin concentration &gt; 75 μIU/mL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Double-blind randomized placebo-controlled trial. Horses received placebo (<i>n</i> = 19) or velagliflozin 0.3 mg/kg PO q24h (<i>n</i> = 18) for 20 weeks (Study Period 1, SP1) immediately followed by a 20-week open-label trial where all animals received velagliflozin (SP2). Analysis of resting insulin, glucose, and triglyceride concentrations and body condition score (BCS) was performed between treatment groups and study periods using a Mann–Whitney <i>U</i> test. For SP1, analysis of changes in biochemical analytes over time was performed using generalized linear mixed effects models (GLMM). Data are reported as median (interquartile range).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In SP1, GLMM indicated a significant effect of treatment on insulin concentration (71 [33–131] μIU/mL in horses receiving velagliflozin and 157 [82–298] μIU/mL in horses receiving placebo; <i>p</i> &lt; 0.0001). The average (95% confidence interval [CI]) effect of velagliflozin treatment on insulin concentration was 155 (90–219) μIU/mL. Horses receiving placebo in SP1 had lower insulin (50 [26–99] μIU/mL) during SP2 (<i>p</i> &lt; 0.0001). All horses experienced a transient increase in serum triglyceride concentration during velagliflozin treatment with no clinical abnormalities reported. In SP1, larger decreases in BCS occurred in horses receiving velagliflozin (median BCS 1 point lower than baseline; <i>p</i> = 0.02) than those receiving placebo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Velagliflozin significantly decreased resting insulin concentrations in horses with ID.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Owner-Reported Clinical Signs and Fecal Occult Blood Tests as Predictors of Equine Gastric Ulcer Syndrome in Competition Dressage Horses 评价马主报告的临床症状和粪便潜血测试作为马术比赛马胃溃疡综合征的预测因子。
IF 2.2 2区 农林科学
Journal of Veterinary Internal Medicine Pub Date : 2025-10-07 DOI: 10.1111/jvim.70248
Thibault Frippiat, Maëlle Bonhomme, Sue Dyson, Dominique-Marie Votion
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