Journal of Veterinary Internal Medicine最新文献

{"title":"2025 ACVIM Forum Research Abstract Program","authors":"","doi":"10.1111/jvim.70258","DOIUrl":"10.1111/jvim.70258","url":null,"abstract":"<p>The American College of Veterinary Internal Medicine (ACVIM) Forum and the Journal of Veterinary Internal Medicine (JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opinions expressed in the abstracts are those of the author(s) and may not represent the views or position of the ACVIM. The authors are solely responsible for the content of the abstracts.</p><p><b>2025 ACVIM Forum</b></p><p><b>June 18–October 31, 2025</b></p><p><b>Research Abstract Oral Program</b></p><p><b>Index of Abstracts</b></p><p><b>Research Abstract Poster Program</b></p><p><b>Index of Abstracts</b></p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Value of Various Histological Factors in Cutaneous and Subcutaneous Mast Cell Tumors in 197 Dogs","authors":"Katherine Boyd,&nbsp;Melanie Dobromylskyj,&nbsp;Imogen Schofield,&nbsp;Dan O'Neill,&nbsp;Celia Figueroa,&nbsp;Owen Davies","doi":"10.1111/jvim.70244","DOIUrl":"10.1111/jvim.70244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Many histological tests have been correlated with outcome in mast cell tumors (MCTs)in dogs, but their statistical independence is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the clinical value of histological factors in the prognostication of dogs with MCTs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>One hundred and ninety-seven dogs with 199 histologically diagnosed cutaneous (<i>n</i> = 153) and subcutaneous (<i>n</i> = 43) MCTs treated surgically in primary care practice. All had a commercial prognostic panel performed (Patnaik and Kiupel grade, mitotic count, Ki67, AgNOR, KiAg, <i>c-kit</i> mutation in exons 8 and 11 and KIT localization).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cohort study identifying dogs from searching a commercial laboratory's records (January 2017–August 2020). Follow-up was collected from clinical records. Outcome measures included MCT specific survival (MSS) and recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multivariable Cox proportional hazard regression identified only mitotic count &gt; 5 (HR 10.2; 95% CI 3.2–32.8; <i>p</i> &lt; 0.001) predicted poorer MSS across all MCTs. In Patnaik grade I or II and Kiupel low-grade cutaneous MCTs, only <i>c-kit</i> mutation in exon 11 (HR 20.8; 95% CI 1.80–224.8; <i>p</i> = 0.015) predicted MSS. A <i>c-kit</i> mutation in exon 11 (HR 10.0; 95% CI 3.0–32.9; <i>p &lt;</i> 0.001), age, and histological tumor free margins &lt; 2 mm independently predicted cutaneous and subcutaneous MCT recurrence. In Patnaik grade I or II, and Kiupel low-grade cutaneous MCTs, <i>c-kit</i> mutation in exon 11 (HR 23.20; 95% CI 2.3–231.3; <i>p</i> = 0.007) and AgNOR (HR 13.73; 95% CI 1.6–115.6; <i>p</i> = 0.016) predicted MCT recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>This study suggests a comparatively greater role of <i>c-kit</i> mutations in exon 11 and AgNOR in the prognostication of MCTs, while Ki67 appears less important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12528809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation","authors":"Alexander Dufourni,&nbsp;Marie Demeyere,&nbsp;Ingrid Vernemmen,&nbsp;Glenn Van Steenkiste,&nbsp;Lize-Maria Verhaeghe,&nbsp;Gunther van Loon,&nbsp;Annelies Decloedt","doi":"10.1111/jvim.70254","DOIUrl":"https://doi.org/10.1111/jvim.70254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Administration of N-butylscopolammonium bromide (NBB) with metamizol sodium (NBBM) causes tachycardia and hypertension, and has been associated with accentuated cardiac murmurs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the effect of a pharmacological challenge using NBBM on valvular regurgitation and cardiac murmurs in horses with aortic (AR) and mitral valve regurgitation (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twenty Warmblood horses with AR and 20 with MR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cardiac auscultation and two-dimensional (2D), M-mode, color flow, pulsed wave Doppler flow, and tissue Doppler echocardiography were performed with simultaneous ECG recording and non-invasive blood pressure measurements during rest and pharmacological challenge using 0.2 mg/kg NBB and 25 mg/kg metamizol sodium. Cardiac dimensions and functional parameters were assessed. Regurgitant jet size was subjectively evaluated, and jet area was measured. Data at rest and during pharmacological challenge were compared using repeated measures analysis or related samples Wilcoxon signed rank test. <i>p</i>-values were adjusted using the Benjamini-Hochberg method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with rest, pharmacological challenge resulted in decreased atrial and ventricular dimensions and increased aortic and pulmonary dimensions (<i>P</i>_BHa ≤ 0.02). Left ventricular end-diastolic diameter decreased in horses with AR (<i>P</i>_BHa &lt; 0.02) but not in horses with MR. Pharmacological challenge resulted in increased median cardiac murmur intensity (<i>P</i>_BHa = 0.03 and <i>P</i>_BHa &lt; 0.02) and jet area (<i>P</i>_BHa ≤ 0.02 and <i>P</i>_BHa = 0.03) in horses with AR and MR, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Pharmacological challenge with NBBM affects cardiac chamber sizes, regurgitant jet, and cardiac murmur intensity in horses with AR and MR. Influences on heart rate and blood pressure should be considered during longitudinal follow-up examinations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls”","authors":"","doi":"10.1111/jvim.70262","DOIUrl":"10.1111/jvim.70262","url":null,"abstract":"<p>E. Moore, K. Thelen Strong, and S. A. Jablonski, “Evaluation of Immune System Components in Dogs With Protein-Losing Enteropathy Compared to Healthy Controls,” <i>Journal of Veterinary Internal Medicine</i> 39, no. 5 (2025): e70245, https://doi.org/10.1111/jvim.70245.</p><p>In the above-mentioned article, Figure 1 (A–C) and Figure 3 (A–E) had labeling errors. There were no methodological errors. The correct figures are displayed here.</p><p>We apologize for the errors.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Sodium-Glucose Cotransporter-2 Inhibitor Velagliflozin on Insulin Concentrations in Horses With Insulin Dysregulation","authors":"Kristen Thane,&nbsp;Rebecca Voth,&nbsp;Rebecca Klee,&nbsp;Tobias Warnken,&nbsp;Victor Chukwu,&nbsp;Nicholas Frank","doi":"10.1111/jvim.70256","DOIUrl":"10.1111/jvim.70256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are promising treatments to manage hyperinsulinemia in horses with insulin dysregulation (ID).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>The SGLT2i velagliflozin decreases insulin concentration in horses with ID.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Privately-owned adult horses (<i>n</i> = 37) with laboratory-confirmed ID (low-dose oral sugar test insulin concentration &gt; 75 μIU/mL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Double-blind randomized placebo-controlled trial. Horses received placebo (<i>n</i> = 19) or velagliflozin 0.3 mg/kg PO q24h (<i>n</i> = 18) for 20 weeks (Study Period 1, SP1) immediately followed by a 20-week open-label trial where all animals received velagliflozin (SP2). Analysis of resting insulin, glucose, and triglyceride concentrations and body condition score (BCS) was performed between treatment groups and study periods using a Mann–Whitney <i>U</i> test. For SP1, analysis of changes in biochemical analytes over time was performed using generalized linear mixed effects models (GLMM). Data are reported as median (interquartile range).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In SP1, GLMM indicated a significant effect of treatment on insulin concentration (71 [33–131] μIU/mL in horses receiving velagliflozin and 157 [82–298] μIU/mL in horses receiving placebo; <i>p</i> &lt; 0.0001). The average (95% confidence interval [CI]) effect of velagliflozin treatment on insulin concentration was 155 (90–219) μIU/mL. Horses receiving placebo in SP1 had lower insulin (50 [26–99] μIU/mL) during SP2 (<i>p</i> &lt; 0.0001). All horses experienced a transient increase in serum triglyceride concentration during velagliflozin treatment with no clinical abnormalities reported. In SP1, larger decreases in BCS occurred in horses receiving velagliflozin (median BCS 1 point lower than baseline; <i>p</i> = 0.02) than those receiving placebo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Velagliflozin significantly decreased resting insulin concentrations in horses with ID.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Owner-Reported Clinical Signs and Fecal Occult Blood Tests as Predictors of Equine Gastric Ulcer Syndrome in Competition Dressage Horses","authors":"Thibault Frippiat,&nbsp;Maëlle Bonhomme,&nbsp;Sue Dyson,&nbsp;Dominique-Marie Votion","doi":"10.1111/jvim.70248","DOIUrl":"10.1111/jvim.70248","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Equine gastric ulcer syndrome (EGUS) adversely affects the health, welfare, and performance of sports horses, requiring gastroscopy for definitive diagnosis. Owners frequently consider girth aversion as highly suggestive of EGUS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate whether owner-reported clinical signs or fecal occult blood tests (FOBTs) can help identify horses needing gastroscopy for EGUS diagnosis or monitoring treatment, thereby reducing unnecessary procedures in unaffected horses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Eighty competition dressage horses referred by veterinarians for EGUS evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Case–control study including questionnaire, clinical examination, gastroscopy, and FOBT. Based on gastroscopic findings, horses were classified as cases (presenting equine squamous gastric disease, equine glandular gastric disease, or both) or controls (no lesions). Nineteen horses underwent a follow-up examination after EGUS treatment. Predictive values of clinical signs and fecal hemoglobin were assessed using the Wilson–Brown method, and group differences were analyzed using Mann–Whitney and Fisher's exact tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-five horses (69%) had EGUS. The most commonly reported clinical signs in this cohort included girth aversion (78%), poor performance (33%), and weight loss (30%), with no differences between groups (<i>p</i> = 0.44–0.99). Neither clinical signs nor FOBT had sufficient sensitivity or specificity for EGUS screening. Among the 19 horses reevaluated after treatment, resolution of clinical signs did not reliably predict mucosal healing, with poor agreement between owner-reported clinical response and gastroscopic outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>In competition dressage horses, owner-reported clinical signs and FOBT results are unreliable predictors of EGUS or treatment outcomes. Gastroscopy remains essential for accurately diagnosing and monitoring EGUS in sports horses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler","authors":"Tomoya Morita,&nbsp;Hiroki Terukina,&nbsp;Masahiro Yamasaki","doi":"10.1111/jvim.70260","DOIUrl":"10.1111/jvim.70260","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The predictive value of intrarenal Doppler ultrasonography (IRD) analysis using pulsed-wave Doppler for survival in dogs with myxomatous mitral valve disease (MMVD) remains unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Impaired IRD indices, such as a high venous impedance index (VII), are associated with a short survival time in dogs with MMVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Seventy-one client-owned dogs with MMVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective cohort study. Dogs diagnosed with various stages of MMVD between July 2019 and February 2024 were enrolled. Echocardiography and an IRD analysis were performed. Resistance index and VII were estimated using the following formula: (maximum flow velocity—minimum flow velocity)/maximum flow velocity from renal interlobar arteries and veins, respectively. Intrarenal venous flow waveforms were categorized into continuous and discontinuous patterns. Discontinuous IRVF pattern is defined as a minimum velocity of 0. The primary endpoint was defined as a composite of cardiac- and renal-related death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the follow-up period, 18 dogs met the primary endpoint. A multivariable Cox proportional hazard analysis adjusted for the Mitral INsufficiency Echocardiographic score and plasma creatinine concentrations identified VII &gt; 0.37 (hazard ratio, at least 4.62; 95% CI, 1.47–14.56) and discontinuous intrarenal venous pattern (hazard ratio, at least 3.62; 95% CI, 1.22–10.73) as an independent predictors of cardiac- and renal-related death. No association between resistance index and outcomes was observed in the multivariable analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Worse outcomes in dogs with MMVD could be predicted by an intrarenal venous flow analysis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Rapid, Low-Cost Broth Turbidity Test for Detecting Ampicillin-Resistant Lower Urinary Tract Infections in Dogs and Cats","authors":"W. Cooper Brookshire,&nbsp;Larry Ballard,&nbsp;Anna Collinsgru,&nbsp;Josh Burnette,&nbsp;Khadija Ferdous,&nbsp;Joo You Park,&nbsp;Keun Seok Seo","doi":"10.1111/jvim.70259","DOIUrl":"10.1111/jvim.70259","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Effective treatment of urinary tract infections (UTIs) in dogs and cats relies on timely recognition of antimicrobial resistance, but traditional microbiological culture and susceptibility testing require 48–72 h and can be cost-prohibitive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate a novel, low-cost broth turbidity test for detecting ampicillin-resistant UTIs in dogs and cats compared to the gold standard microbiological methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>One hundred sixty urine samples from 145 dogs and 15 cats at the Mississippi State University College of Veterinary Medicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From September 2023 to February 2024, urine samples were tested using an ampicillin-supplemented Mueller–Hinton broth turbidity test and gold standard culture with Sensititre MIC plates. Sensitivity, specificity, Cohen's <i>κ</i>, and McNemar's test were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The broth turbidity test showed 89.47% sensitivity (95% CI: 66.86%–98.72%) and 100% specificity (95% CI: 97.42%–100%) for the detection of ampicillin-resistant organisms in the urine, with substantial agreement (<i>κ</i> = 0.94, <i>p</i> &lt; 0.001) and no classification difference (<i>p</i> = 0.500). Notably, all 36 samples with ampicillin-susceptible organisms identified by the gold standard cultures test were correctly identified as negative for ampicillin resistance by the broth turbidity test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The broth turbidity test's simplicity and affordability make it a promising tool for in-house use by veterinary practitioners to guide first-line therapy decisions, though its sensitivity could be limited in cases with low bacterial loads or confounding factors such as recent antibiotic administration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment With Remdesivir Alone or in Combination With GS-441524 in Cats With Ocular Involvement of Feline Infectious Peritonitis: An Observational Case Series","authors":"Amy L. M. M. Andrews,&nbsp;Eneko Izaguirre,&nbsp;Jodie Green,&nbsp;Emma Scurrell,&nbsp;Savina Gogova,&nbsp;Sarah Tayler,&nbsp;Christiane Kafarnik","doi":"10.1111/jvim.70253","DOIUrl":"10.1111/jvim.70253","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Remdesivir and GS-441524 have successfully treated cats with feline infectious peritonitis (FIP) but the changes in associated signs of ocular disease are not reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Evaluate the response of FIP-associated signs of ocular disease before and after treatment with remdesivir, GS-441524, or both.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Sixty-one cats diagnosed with FIP by the Internal Medicine services between October 2021 and December 2022 that were treated with injectable, oral, or a combination of anti-viral therapies were reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Observation study. Signalment, associated signs of ocular disease, treatment, outcome, and follow-up of affected cats were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Associated signs of ocular disease in cats with FIP were diagnosed in 33% (20/61) cats, with a median follow-up of 55 days (IQR 47.3–90.8, range: 16–1071 days) in 11 cats with FIP. Ocular changes were all associated with uveitis, of which 20% (4/20) had anterior uveitis, 25% (5/20) had posterior uveitis, and 55% (11/20) had panuveitis. Ocular disease occurred in effusive (11/20; 55%) and non-effusive (9/20; 45%) FIP and was bilateral in 70% (14/20) cats. All cats started an 84-day course of treatment, with the majority (17/20; 85%) receiving remdesivir in the initial period. Of those, 70% (12/17) received a high dose of 15–20 mg/kg/day. Eleven cats with uveitis had long-term follow-up nine (9/11; 82%) of these had resolution of uveitis. Eighty-seven percent (13/15) of cases with anterior uveitis received topical anti-inflammatory medication. Eighty percent (16/20) of cats survived.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>Cats with FIP commonly have ocular involvement. Associated uveitis responded to remdesivir or GS-441524 treatment effectively in 82% of cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Cardio-Renal-Cerebral Syndrome in a Dog: A Case Report","authors":"Gianira Candelario,&nbsp;George Kramer,&nbsp;Brienne Williams,&nbsp;Samantha Seies,&nbsp;Nikki Gaudette,&nbsp;Laura Patterson Rosa","doi":"10.1111/jvim.70249","DOIUrl":"10.1111/jvim.70249","url":null,"abstract":"<p>A 14-year-old miniature Pinscher was presented with azotemia, severe hyperkalemia, and oliguria caused by decompensation of chronic renal disease, along with bradycardia resulting from third-degree atrioventricular (AV) block. Supportive medical treatment was instituted for the oliguria, azotemia, and hyperkalemia. Within 12 h of hospitalization, multifocal central neurologic signs developed, including nystagmus, quadriparesis, decreased mentation, and ventral neck flexion. A diagnosis of cardiorenal cerebral syndrome was made. A transvenous permanent pacemaker was placed to improve cardiac output. Within 24 h, clinical signs improved, and the patient was discharged from the hospital on day three.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}