Journal of Veterinary Internal Medicine最新文献

{"title":"RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS","authors":"","doi":"10.1111/jvim.17231","DOIUrl":"10.1111/jvim.17231","url":null,"abstract":"<p><b><i>5–7 September 2024</i></b></p><p><b>Cité Centre de Congrès</b></p><p><b>Lyon, France</b></p><p><i>The European College of Veterinary Internal Medicine – Companion Animals (ECVIM-CA) Congress and the Journal of Veterinary Internal Medicine (JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opinions expressed in the abstracts are those of the author(s) and may not represent the views or position of the ECVIM-CA. The authors are solely responsible for the content of the abstracts</i>.</p><p>\u0000 </p><p>\u0000 </p><p><b>ESVC – European Society of Veterinary Cardiology</b></p><p><b>ESVC</b>—<b>European Society of Veterinary Cardiology</b></p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3537-3694"},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele","authors":"Itsuma Nagao,&nbsp;Tomoki Motegi,&nbsp;Yuko Goto-Koshino,&nbsp;Masaya Tsuboi,&nbsp;Naohiro Takahashi,&nbsp;James K. Chambers,&nbsp;Kazuyuki Uchida,&nbsp;Kenji Baba,&nbsp;Hirotaka Tomiyasu,&nbsp;Masaru Okuda","doi":"10.1111/jvim.17157","DOIUrl":"10.1111/jvim.17157","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gallbladder mucocele (GBM) is a common disease in the canine gallbladder. Although the pathogenesis of GBM remains unclear, we recently reported that the excessive accumulation of mucin in the gallbladder is not a result of overproduction by gallbladder epithelial cells (GBECs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Changes in the function of GBECs other than the production of mucin are associated with the pathogenesis of GBM. We performed an RNA sequencing (RNA-seq) analysis to comprehensively search for abnormalities in gene expression profiles of GBECs in dogs with GBM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Fifteen dogs with GBM and 8 dogs euthanized for reasons other than gallbladder disease were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The GBECs were isolated from gallbladder tissues to extract RNA. The RNA-seq analysis was performed using the samples from 3 GBM cases and 3 dogs with normal gallbladders, and the gene expression profiles were compared between the 2 groups. Differences in mRNA expression levels of the extracted differentially expressed genes (DEGs) were validated by quantitative reverse transcription polymerase chain reaction (RT-qPCR) using samples of 15 GBM cases and 8 dogs with normal gallbladders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparison of gene expression profiles by RNA-seq extracted 367 DEGs, including <i>ANO1</i>, a chloride channel associated with changes in mucin morphology, and <i>HTR4</i>, which regulates the function of chloride channels. The <i>ANO1</i> and <i>HTR4</i> genes were confirmed to be downregulated in the GBM group by RT-qPCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Our results suggest that GBM may be associated with decreased function of chloride channels expressed in GBECs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3031-3037"},"PeriodicalIF":2.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based veterinary medicine—potential, practice, and pitfalls","authors":"Gary Block","doi":"10.1111/jvim.17239","DOIUrl":"10.1111/jvim.17239","url":null,"abstract":"<p>Understanding and incorporating evidence-based veterinary medicine (EBVM) into clinical practice and research continues to pose a challenge for our profession despite over 2 decades of increasing awareness of this concept. Reasons for this include a lack of understanding of its importance to the practice of medicine, veterinary literature that often fails to adhere to evidence-based standards, inadequate attention to teaching EBVM at the university level, and the inherent reluctance of clinicians to alter historical practice styles. For many practitioners, EBVM continues to be an abstract concept they believe requires advanced training in statistics and epidemiology resulting in them relying on less robust sources for clinical guidance. This unfortunately results in suboptimal care for our patients and delayed medical advancements for our profession. As part of the 20th anniversary of the founding of the Evidence-Based Veterinary Medicine Association (EBVMA), we are refocusing our efforts to highlight the need for dedicated teaching of EBVM at the university level, for rigorous adherence to established research reporting guidelines, for expansion of EBVM infrastructure, and for the provision of easily accessible tools that permit clinicians to incorporate EBVM into their daily practice. As the quality of veterinary literature improves, so too will development of more effective clinical practice guidelines that ultimately can be widely adopted if they are flexible enough to support the triadic relationship between veterinarians, our clients and our patients. Ultimately, EBVM is not an end unto itself, but rather a means to improve the quality of care we provide our patients.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3261-3271"},"PeriodicalIF":2.1,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum electrolyte abnormalities in cats with chronic inflammatory enteropathy","authors":"Iona Baker,&nbsp;Romy Heilmann,&nbsp;Ramona Knoll,&nbsp;Berenice Schneider,&nbsp;Yuvani Bandara,&nbsp;Simon Priestnall,&nbsp;Aarti Kathrani","doi":"10.1111/jvim.17242","DOIUrl":"10.1111/jvim.17242","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Limited information is available on electrolyte abnormalities in cats with chronic inflammatory enteropathy (CIE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Report the prevalence of electrolyte abnormalities in cats with CIE compared to other gastrointestinal disorders, and determine their association with disease and outcome variables in cats with CIE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Three hundred twenty-eight client-owned cats from 2 referral hospitals: CIE (132), alimentary small cell lymphoma (29), acute gastroenteritis (48), and healthy controls (119).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective study comparing serum electrolyte concentrations at time of diagnosis among the 4 groups of cats, and associations with clinical signs, intestinal mucosal fibrosis scores, treatment subclassification and outcome in CIE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cats with CIE had lower sodium and higher potassium concentrations and lower sodium: potassium ratios compared with healthy cats (<i>P</i> &lt; .001, <i>P</i> = .01, and <i>P</i> &lt; .001, respectively). Cats with CIE and a duodenal mucosal fibrosis score of 2 had lower sodium and lower total calcium concentrations compared with cats that had a score of 0 (<i>P</i> = .02 and <i>P</i> = .01). Cats with CIE and a colonic mucosal fibrosis score of 1 had higher potassium concentrations and lower sodium: potassium ratios compared with cats that had a score of 0 (<i>P</i> = .03 and <i>P</i> = .01). Cats with CIE that died as a result of their disease had higher potassium concentrations and lower sodium: potassium ratios compared to cats that were alive (<i>P</i> = .02 and <i>P</i> = .01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Electrolyte abnormalities occur with CIE and, in particular, in cats with higher fibrosis scores and worse outcomes. Further research should aim to determine the pathogenesis of these findings and identify novel therapeutic targets for cats with CIE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3038-3049"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings 36th Symposium ESVN-ECVN 12th-14th September 2024","authors":"","doi":"10.1111/jvim.17225","DOIUrl":"10.1111/jvim.17225","url":null,"abstract":"&lt;p&gt;&lt;i&gt;The European College of Veterinary Neurology (ECVN) Symposium and the Journal of Veterinary Internal Medicine (JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opinions expressed in the abstracts are those of the author(s) and may not represent the views or position of the ECVN. The authors are solely responsible for the content of the abstracts&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESIDENTS DAY PROGRAM&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;12 SEP 2024 | THURSDAY&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;ESVN-ECVN 36th Symposium: Neuro-Ophthalmology&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;PROGRAM&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;13 SEP 2024 | FRIDAY&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Consensus Statements of the European College of Veterinary Neurology (ECVN) provide the veterinary community with up-to-date information on the pathophysiology, diagnosis, and treatment of clinically important animal diseases. The ECVN Board oversees selection of relevant topics, identification of panel members for each topic with the expertise to draft the statements, and other aspects of assuring the integrity of the process. The statements are derived from evidence-based medicine whenever possible and the panel offers interpretive comments when such evidence is inadequate or contradictory. A draft is prepared by the panel, followed by solicitation of input by the ECVN membership which may be incorporated into the statement. It is then submitted to the Journal of Veterinary Internal Medicine, where it is edited prior to publication. The authors are solely responsible for the content of the statements&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Royal (Dick) School of Veterinary Medicine, University of Edinburgh, Easter Bush Campus, EH25 9RG&lt;/b&gt;&lt;/p&gt;&lt;p&gt;This talk will focus on ocular and orbital causes of blindness (i.e., excluding central causes of acute blindness).&lt;/p&gt;&lt;p&gt;This will need to be severe to cause blindness (as opposed to visual deficits). Infectious causes include: Prototheca, Cryptococcosis, Histoplasma, Blastomycosis, Coccidiomycosis, Aspergillosis, Leishmania, Rabies, Distemper, FeLV/FIV, Toxoplasma, Neospora, Ehrlichia, Rickettsia, Babesia, Bartonella. Inflammatory or immune mediated causes include: a septic focus (e.g., pyometra), hyphaema (e.g., traumatic, Angiostrongylus, systemic hypertension, anti-coagulant poisoning), diabetes mellitus (e.g., acute cataract formation), Neoplasia—primary/secondary and Feline Infectious Peritonitis (FIP).&lt;/p&gt;&lt;p&gt;Hyperglycaemia associated with diabetes, and as glucose is a small molecule it will pass into the lens (along with all other tissues). Here it overwhelms the normal hexokinase pathway and excess is shunted to aldose reductase pathway where the end product is sorbitol (a large molecule and therefore trapped within lens capsule) resulting in osmotic draw and tumescent cataract formation. This can be exceptionally rapid where glycaemic control is poor, and may even result in lens capsule rupture and phacoclastic uveitis (requiring emergency intervention to save the globe).&lt;/p&gt;&lt;p&gt;Per","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3461-3536"},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus","authors":"Daniela Farke,&nbsp;Agnieszka Olszewska,&nbsp;Kathrin Büttner,&nbsp;Martin J. Schmidt","doi":"10.1111/jvim.17235","DOIUrl":"10.1111/jvim.17235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Not all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Fifty-three dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Cross-sectional study. Clinical signs and MRI findings were evaluated for an association of IVP &gt;12 mm Hg and syringomyelia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>High IVP was associated with obtundation OR 4.64 (95% CI 1.27-16.93) (<i>P</i> = .02), head tilt OR 6.42 (95% CI 1.08-37.97) (<i>P</i> = .04) and nystagmus OR 8.24 (95% CI 1.44-47.07) (<i>P</i> = .02). Pain was associated with syringomyelia OR 3.4 (95% CI 0.98-11.78) (<i>P</i> = .05). The number of affected ventricles was associated with high IVP OR 2.85 (95% CI 0.97-8.33) (<i>P</i> = .05) and syringomyelia OR 12.74 (95% CI 2.93-55.4) (<i>P</i> = .0007). Periventricular edema OR 24.46 (95% CI 4.54-131.77), OR 7.61 (95% CI 1.91-30.32) (<i>P</i> &lt; .0002, <i>P</i> = .004) and signal void sign OR 17.34 (95% CI 4.01-74.95), OR 4.18 (95% CI 1.16-15.02) (<i>P</i> &lt; .0001, <i>P</i> = .03) were associated with high IVP and syringomyelia. The probability for syringomyelia is lower with disruption of the internal capsule OR 0.19 (95% CI 0.05-0.72) (<i>P</i> = .01) and higher VBR OR 0.25 (95% CI 0.1-0.63) (<i>P</i> = .004).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Previously reported MRI findings are not predictive of high IVP. Clinical signs and MRI findings should be used to make a diagnosis of internal hydrocephalus in dogs with or without high IVP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3119-3128"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacodynamics of 2 dosages of orally administered esomeprazole in client-owned, healthy dogs: A prospective, crossover study","authors":"Abby Ostronic,&nbsp;Christine Gremillion,&nbsp;Song Zhang,&nbsp;Joerg M. Steiner,&nbsp;M. Katherine Tolbert,&nbsp;Emily N. Gould","doi":"10.1111/jvim.17233","DOIUrl":"10.1111/jvim.17233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Esomeprazole use is increasing in dogs, but the gastrointestinal adverse events associated with q12h dosing necessitate pharmacodynamic evaluation of a reduced dose and frequency of administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the efficacy of 2 doses of (q24h) esomeprazole in raising intragastric pH in dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Nine healthy, client-owned dogs, &gt;20 kg.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective, randomized, double blinded, crossover study. Esomeprazole (0.5 or 1 mg/kg q24h) was orally administered for up to 5 days per treatment arm, and the mean percentage time intragastric pH was ≥3 (MPT3) and ≥4 (MPT4) for 24 hours periods were compared to pretreatment pH using a continuous pH monitoring system. Dogs failing to reach pH goals (MPT3 ≥75%, MPT4 ≥66%) with once daily dosing received esomeprazole 1 mg/kg PO q12h to determine if a higher dose would improve acid suppression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant difference in the MPT3 or MPT4 was identified between treatments for any time point (<i>P</i> &gt; .05). Both doses increased the MPT pH ≥3 and 4 median [range] (0.5 mg/kg, 1 mg/kg) on days 1 (MPT3: 76.8% [44-100], 69.2% [28.2-100]; MPT4: 65.6% [16.7-99.3], 54.9% [14.9-93.3]; <i>P</i> = .0009) and 2 (MPT3:77.2% [27.4-100], 75.4% [49.4-89.5]; MPT4: 66.3% [15.5-100], 59.7% [33.8-81.2]; <i>P</i> = .0005) of PPI treatment compared to pretreatment (MPT3: 58.3% [0.02-93.9], 52.6% [6.1-94.7]; MPT4: 25.2% [0-86.8], 32.4% [1.8-89.3]). Six dogs (66%, [0.36, 0.97]) reached pH goals established in humans with q24h dosing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Both q24h PO esomeprazole doses were effective in raising intragastric pH, despite high intersubject variability, but 33% of dogs required q12h dosing to reach pH goals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3235-3241"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical findings, prognostic factors, and outcome of protein-losing nephropathy in cats: A retrospective study","authors":"Noam Sugar,&nbsp;Hilla Chen,&nbsp;Gilad Segev","doi":"10.1111/jvim.17240","DOIUrl":"10.1111/jvim.17240","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primary glomerular disease resulting in protein-losing nephropathy (PLN) is an uncommon cause of chronic kidney disease in cats, yet is important to recognize because it warrants specific treatment that impacts outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objective</h3>\u0000 \u0000 <p>Characterize clinicopathologic findings, prognostic indicators, and short- (≤30 days) and long-term survival of cats with PLN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Thirty-seven cats with naturally occurring PLN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medical records of cats with PLN admitted to a veterinary teaching hospital were retrospectively reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median age was 3 years (range, 1.5-11.5 years) and 17/37 (46%) were males. Short-term survival was 57%. The estimated median survival time of all cats was 424 days (95% confidence interval [CI], 0-1098 days). Common clinical signs included lethargy (57%), edema (46%) and weight loss (35%). Edema was more common in short-term survivors compared with nonsurvivors (odds ratio [OR], 0.21; 95% CI, 0.05-0.86-20.4; <i>P</i> = .04). Serum creatinine concentration at presentation was negatively associated with long-term survival (OR, 1.3; 95% CI, 1.03-1.52; <i>P</i> = .01). Administration of immunosuppressive and antiproteinuric medications was more common among short-term survivors compared with nonsurvivors (18/20 [90%] vs 9/16 [56%]; OR, 7.0; 95% CI, 1.2-40.8; <i>P</i> = .05 and 17/20 [85%] vs 7/16 [44%]; OR, 7.3; 95% CI, 1.5-35.2; <i>P</i> = .01, respectively). Partial or complete remission was documented in 11/31 (36%) cats and was associated with both short (OR, 3.3; 95% CI, 1.7-6.5; <i>P</i> &lt; .001) and long-term survival (<i>P</i> = .003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>Cats with PLN have a guarded prognosis, but achieving remission improves outcome. Cats presented with edema rather than azotemia are more likely to respond to treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3111-3118"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure","authors":"Cailey Banken,&nbsp;Autumn N. Harris,&nbsp;Rachel Conway,&nbsp;Eduardo J. Benjamin,&nbsp;Robin Shoemaker,&nbsp;Darcy Adin","doi":"10.1111/jvim.17238","DOIUrl":"10.1111/jvim.17238","url":null,"abstract":"<p>A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3255-3260"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen consumption, locomotory-respiratory coupling and exercise-induced pulmonary hemorrhage in horses during the Paso Fino gait","authors":"Shannon Massie,&nbsp;Renaud Léguillette,&nbsp;Warwick Bayly,&nbsp;Ray Sides,&nbsp;Angélica María Zuluaga-Cabrera","doi":"10.1111/jvim.17226","DOIUrl":"10.1111/jvim.17226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Workload associated with the high frequency Colombian Paso Fino gait has not been evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the oxygen consumption (V̇O₂), heart rate (HR), stride frequency: breathing ratio, and hematology associated with the Paso Fino gait, including whether exercise-induced pulmonary hemorrhage (EIPH) occurs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Eleven Paso Fino horses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective cohort study. Horses performed a standardized Paso Fino gait test across a wooden sounding board, simulating competition. V̇O₂ and ventilatory parameters (tidal volume [<i>V</i>_<i>T</i>]; peak inspiratory and expiratory airflows [PkV̇_I, PkV̇_E]; respiratory rate [RR], minute ventilation [V̇E]) were measured using a portable ergospirometry facemask. Heart rate was measured using electrocardiograms. Post-exercise lactate, hematocrit, bicarbonate, pH, electrolytes, and biochemistry concentrations were measured. EIPH was assessed via tracheobronchoscopy. Four horses completed a secondary high-intensity gallop to elicit peak V̇O₂ for comparative purposes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median [IQR] mean individual HR during the Paso Fino gait was 190 [178, 201] bpm. Relative V̇O₂ measured 49.8 [48.4, 59.5] mL/(kg min; <i>V</i>_<i>T</i> = 8.6 [8.0, 10.7] L; RR = 87.1 [75.4, 99.5] bpm; V̇E = 869 [740, 902] L/min; PkV̇_I = 33.4 [32.7, 37.2] L/s; PkV̇_E = 44.2 [40.3, 46.0] L/s). Horses took 2.8 [2.7, 2.9] strides/second and had a stride frequency: breathing ratio of 2.0 [1.8, 2.3]. Post-exercise blood lactate concentration and hematocrit measured 2.7 mmol/L and 50% respectively. Three horses showed endoscopic evidence of Grade-1 EIPH. The Paso Fino gait V̇O₂ and HR equaled 79% V̇O₂pk and 91% maximal HR, respectively, based on the high-intensity gallop.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>The Paso Fino gait represents submaximal exercise based on V̇O₂ &lt; V̇O₂pk and blood lactate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"38 6","pages":"3337-3345"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}