Journal of Veterinary Internal Medicine最新文献

{"title":"Leukoreduction in a dog with acute leukemia","authors":"Brenna Hanratty,&nbsp;Anna Hauck,&nbsp;Amanda Foskett,&nbsp;J. D. Foster","doi":"10.1111/jvim.17283","DOIUrl":"10.1111/jvim.17283","url":null,"abstract":"<p>A 9-year-old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-based treatment and had a survival time of 43 days before the owner elected humane euthanasia. To our knowledge, this report represents a case of acute leukemia in a dog treated with leukoreduction before starting chemotherapy.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for “Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy”","authors":"","doi":"10.1111/jvim.17262","DOIUrl":"10.1111/jvim.17262","url":null,"abstract":"<p>Agulla B, Villaescusa A, Sainz A, Díaz-Regañón D, Rodríguez-Franco F, Calleja-Bueno L, Olmeda P, García-Sancho M. Peripheral and intestinal T lymphocyte subsets in dogs with chronic inflammatory enteropathy. <i>J Vet Intern Med</i>. 2024; 38:1437. doi:10.1111/jvim.17036.</p><p>In the article cited above, there is an error in section 2.5 Statistical Analysis within section 2 Materials and Methods. The study used the Wilcoxon scores (rank-sum) test—equivalent to the Mann-Whitney U-test—which is appropriate for comparing 2 independent groups. It was incorrectly referred to as the Wilcoxon's signed rank test, which is meant for paired data. This was a labeling mistake, not a methodological one.</p><p>We apologize for the error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of a percutaneous cystostomy tube as an adjunctive treatment option for dogs with idiopathic functional outflow tract obstruction","authors":"Zoe P. Greenfield,&nbsp;Allyson C. Berent,&nbsp;Chick W. Weisse","doi":"10.1111/jvim.17275","DOIUrl":"10.1111/jvim.17275","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Functional outflow tract obstruction (FOO) remains a challenging disease to manage in male dogs. Cystostomy tubes have been used to relieve urethral obstruction while allowing time to achieve effective medical management, avoiding the need for emergency visits and repeat urinary catheterizations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To describe a series of dogs with FOO and categorize the most successful management strategies including medical management alone or with the support of cystostomy tubes for urinary diversion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twelve client-owned dogs with FOO were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Medical records of dogs presented from August 2012 to September 2021 with a presumptive diagnosis of FOO were retrospectively reviewed and findings recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven dogs were managed with a cystostomy tube and 5/7 (71%) had a good-excellent outcome. Five dogs were managed without a tube and 1/5 (20%) had a good outcome. Eight dogs were refractory to medical management; 5 managed with a cystostomy tube and 3/5 (60%) had a good-excellent outcome; 3 managed without a cystostomy tube and 0/3 had a good or excellent outcome. Overall, dogs with cystostomy tubes had better outcomes but also had mild, moderate, and severe complications (100%, 71%, and 71%, respectively) reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Most dogs that received a percutaneous cystostomy tube as part of their management plan had a good to excellent outcome, particularly when compared to those that did not, despite the high rate of tube-related complications. Percutaneous cystostomy tubes could be considered early during management for FOO to improve overall outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing the Ellik bladder evacuator during cystoscopic retrieval of urocystoliths in 12 dogs","authors":"John Shamoun,&nbsp;Shelly L. Vaden,&nbsp;Allison R. Kendall,&nbsp;Patricia L. Secoura","doi":"10.1111/jvim.17280","DOIUrl":"10.1111/jvim.17280","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Urocystolithiasis is a common problem in dogs; many canine uroliths are resistant to medical dissolution. Novel management options would expand, and in some cases improve, current urolith retrieval strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>To describe a previously unreported technique by the Ellik bladder evacuator (EE) to assist in minimally invasive, cystoscopic retrieval of canine cystoliths.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Twelve client-owned dogs presented with urocystolithiasis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective study, dog demographics, procedure type and duration, and clinical outcomes of dogs undergoing cystoscopic cystolith retrieval utilizing the EE are described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve dogs underwent 13 cystoscopic procedures utilizing EE for cystolith retrieval. The EE was used in accordance with previously described techniques via a custom-made adaptor. Ten dogs were spayed females; 8 different breeds were represented. In 8 of 13 procedures, transurethral cystoscopy alone by EE with or without wire basket or grasping forceps was performed with a median procedure duration of 36 minutes (range, 16-52). In the other 5 procedures, additional interventions (ie, laser lithotripsy, percutaneous perineal approach, urethral stricture ballooning, ethanol parathyroid ablation) were performed as indicated with a median procedure duration 110 minutes (range, 42-144). No complications were noted in association with the use of the EE; retrieval of cystoliths was complete in 12 of 13 procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Use of the EE during cystoscopy might aid in minimally-invasive retrieval of cystoliths. This work provides a starting point for additional discussion regarding its benefit relative to current interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical importance of borderline proteinuria in nonazotemic cats and evaluation of other risk factors for the development of chronic kidney disease","authors":"Femke Mortier,&nbsp;Sylvie Daminet,&nbsp;Sofie Marynissen,&nbsp;Joren Verbeke,&nbsp;Dominique Paepe","doi":"10.1111/jvim.17257","DOIUrl":"10.1111/jvim.17257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Borderline proteinuria is associated with decreased survival in cats with azotemic chronic kidney disease (CKD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Determine the clinical importance of borderline proteinuria in nonazotemic cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>A total of 201 healthy client-owned cats ≥7 years of age; 150 nonproteinuric (urinary protein : creatinine ratio [UPC] &lt;0.2) and 51 borderline proteinuric (UPC 0.2-0.4).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective study. Cats were thoroughly screened and subsequently examined every 6 months for 2 years. Kaplan-Meier curves were compared between nonproteinuric and borderline proteinuric cats. Univariable and multivariable Cox models were fit to determine the relationship between development of renal disease and potential risk factors such as age, sex, breed, weight, dental disease, blood pressure, serum creatinine concentration (sCrea), serum symmetric dimethylarginine concentration (sSDMA), blood urea nitrogen concentration, urine specific gravity (USG), and UPC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significantly more cats with borderline proteinuria at inclusion developed renal disease (International Renal Interest Society [IRIS] ≥ stage 2 CKD or renal proteinuria; log-rank <i>P</i> = .004) or died (log-rank <i>P</i> = .02) within 2 years, compared with nonproteinuric cats. In the multivariate analysis, IRIS stage 1 CKD (persistent USG &lt;1.035 or sSDMA &gt;14 μg/dL; hazard ratio [HR], 4.2; 95% confidence interval [CI], 2.0-8.8; <i>P</i> &lt; .001), sCrea ≥1.6 mg/dL (≥140 μmol/L; HR, 2.6; 95% CI, 1.1-6.4; <i>P</i> = .04), borderline proteinuria (HR, 2.5; 95% CI, 1.2-5.2; <i>P</i> = .01), and age at inclusion (HR, 1.3; 95% CI, 1.2-1.5; <i>P</i> &lt; .001) were significantly associated with diagnosis of renal disease 6 months later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Borderline proteinuria should receive more attention in healthy mature adult and senior cats because it is associated with renal disease and death.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals","authors":"Donatienne L. Castelain,&nbsp;Alexander Dufourni,&nbsp;Mathilde L. Pas,&nbsp;Jade Bokma,&nbsp;Eva de Bruijn,&nbsp;Ellen Paulussen,&nbsp;Laurence Lefère,&nbsp;Gunther van Loon,&nbsp;Bart Pardon","doi":"10.1111/jvim.17269","DOIUrl":"10.1111/jvim.17269","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The care of sick neonatal foals is labor-intensive and costly. Prediction of risk of death upon admission is often difficult but might support decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine diseases and risk factors associated with death in neonatal hospitalized foals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Two hundred twenty-two hospitalized foals, ≤7 days old.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective cohort study. Clinical and laboratory variables were evaluated for their association with death by means of Cox survival analysis and by classification and regression tree (CART) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most prevalent diseases were sepsis (43.9%), enteritis (14.0%), and omphalitis (9.0%). Case fatality rate was 33.3%. Neonatal sepsis significantly increased the risk of death (hazard ratio [HR] = 1.9; 95% confidence interval [CI] = 1.2-3.0; <i>P</i> = .009). Multivariable Cox regression in foals ≤7 days old revealed comatose mental state (HR = 2.9; 95% CI = 1.1-8.1; <i>P</i> = .04), L-lactatemia (≥373.8 mg/L [4.2 mmol/L]; HR = 4.4; 95% CI = 1.7-11.7; <i>P</i> = .003) and increased serum amyloid A (SAA; ≥2054 μg/mL; HR = 3.9; 95% CI = 1.2-12.7; <i>P</i> = .02) as risk factors for death, with a sensitivity and specificity of 7.5% and 95.7%, respectively. The CART analysis highlighted L-lactatemia, comatose mental state, and hypercapnia as risk factors for death, with a sensitivity of 38.1% and specificity of 86.1% after validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>In this study sample, sepsis was associated with the highest risk of death. Identified risk factors such as SAA, L-lactate, and comatose mental state might guide veterinarians and owners in better decision-making for economic or welfare reasons. Frequently measured laboratory variables, such as blood glucose concentration and Immunoglobulin G, were not sensitive and specific enough to provide reliable decision support for survival estimation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of age and sex on reference intervals for cobalamin, homocysteine, and serum and urinary methylmalonic acid in healthy adult dogs","authors":"Anna-Lena Proksch,&nbsp;Sophia Schaefer,&nbsp;Vanessa Dreller,&nbsp;Judith Langenstein,&nbsp;Ralph Fingerhut,&nbsp;Natali Bauer,&nbsp;Andreas Moritz","doi":"10.1111/jvim.17250","DOIUrl":"10.1111/jvim.17250","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In dogs, data on reference intervals (RIs) for cobalamin, markers of metabolism (markersB₁₂met), age and sex effects are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>Establish RI for serum cobalamin, homocysteine, and methylmalonic acid (sMMA) concentrations, urinary methylmalonic acid-to-creatinine ratio (uMMA:crea), and determine effects of sex and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective study using healthy dogs (1-10 years). Cobalamin and markersB₁₂met were determined using chemiluminescence immunoassay (cobalamin) and liquid chromatography/tandem mass spectrometry (homocysteine, sMMA, uMMA:crea). In dogs with outlying data, changes in health, markersB₁₂met, and onset of gastrointestinal signs were reevaluated after 9-15 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve of 120 healthy dogs had abnormal uMMA:crea ratios. No other cobalamin analyte outliers were found. Outlying data re-examination (odRE) was performed in 10/12 dogs. Chronic gastrointestinal signs occurred in 64% of odRE-dogs, whereas 36% remained healthy. In total, 112 dogs (67 females, 45 males; median ages, 3.5 and 3.75 years, respectively) were included in RI analyses. Reference intervals were 178.5-851 pmol/L (cobalamin), 5.8-29.0 μmol/L (homocysteine), 45.3-159.5 μg/L (sMMA), and ≤22.4 mg/g (uMMA:crea). Only age affected cobalamin concentrations (significant decrease). Compared by sex and neuter status, intact male dogs had significantly higher uMMA:crea ratios (median, 13.5; range, 1.9-83.6 mg/g) than the other groups (median, 2.5; range, 0.7-9.7 mg/g; <i>P</i> &lt; .0001). Sex-specific RI were ≤58.9 mg/g (intact male) vs ≤5.2 mg/g (females and neutered males).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>Intact male dogs had significantly higher uMMA:crea ratios than the other groups. Thus, sex-specific RI are recommended for uMMA:crea. Because of the wide distribution of uMMA:crea ratios, careful interpretation in intact male dogs is advised.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding “Value of repeated health screening in 259 apparently healthy mature adult and senior cats followed for 2 years”","authors":"Femke Mortier,&nbsp;Sylvie Daminet,&nbsp;Sofie Marynissen,&nbsp;Pascale Smets,&nbsp;Dominique Paepe","doi":"10.1111/jvim.17272","DOIUrl":"10.1111/jvim.17272","url":null,"abstract":"<p>Thank you for allowing us to respond to the letter to the editor by McKenzie, which presents us with the opportunity for additional dialog on the topic of routine health screening in older cats.</p><p>We would first like to clarify that the purpose of our study was to determine whether routine health screening has value with regard to the detection of disease in older cats that are apparently healthy to the owner, as is stated in the article. Our study was not designed to determine whether detection and subsequent treatment of abnormalities found during routine health examinations decrease mortality, nor to calculate which long-term financial benefits or burdens these health examinations cause cat owners. By describing which diseases can be detected with health screening in a population of apparently healthy older cats, owners can be better informed about the chance of disease being detected in their cats, so that they can make informed decisions about whether or not to have a health examination performed. We agree with McKenzie that it would be very interesting to have additional prospective studies to determine the long-term health benefits and costs associated with routine health screening in older cats, but examining these aspects was outside the scope of our study.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding “Value of repeated health screening in 259 apparently healthy mature adult and senior cats followed for 2 years”","authors":"Brennen McKenzie","doi":"10.1111/jvim.17271","DOIUrl":"10.1111/jvim.17271","url":null,"abstract":"<p>The article by Mortier et al. is a well-written report of a useful study that provides important epidemiologic data regarding detection of common health conditions in mature and senior cats. However, the authors imply at several points that screening apparently healthy cats is necessarily beneficial, that it is worthwhile as long as abnormalities are detected, and that their results “argue for greater health screening in cats ≥7 years of age” because “all cats [of this age] would benefit.”</p><p>This is an oversimplified and potentially misleading characterization of screening programs and of the findings. It ignores many factors that influence the likelihood of achieving the true goals of screening, which are to decrease mortality and other negative impacts of disease and improve patient outcomes.</p><p>The current study does not provide evidence that the screening employed would meet those aims, or that the benefits of such a program would exceed the harms. Demonstrating such benefits would require comparing outcomes in cats that are screened with those that are not. Although it is plausible that detection of disease before observable clinical signs might lead to better outcomes, this outcome cannot be assumed, and it may not turn out to be true. Screening often has been shown to result in overdiagnosis and net harm in humans,<span>¹</span> and the same may be true in veterinary patients.<span>²</span> This study also does not answer the crucial question of whether outcomes for the subjects would be better, on average, if the conditions identified are diagnosed when still occult or at a later time when the cats present with clinical signs.<span>³</span></p><p>Finding the optimal balance between screening that not only detects abnormalities but improves clinical outcomes and the alternative (ie, increased misdiagnosis, overdiagnosis, cost of care, and potential direct patient harm) requires evidence not available in this report. This includes evidence that earlier detection and intervention results in better outcomes and, ideally, prospective studies comparing long-term outcomes in patients with and without screening. Evidence in human medicine shows that screening benefits some patients, harms others, and can substantially increase healthcare costs and, without adequate information, it is impossible to determine whether the net impact of screening in veterinary patients is beneficial, harmful, or neutral.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for “Evaluation of a urine dipstick protein to urine specific gravity ratio for the detection of proteinuria in dogs and cats”","authors":"","doi":"10.1111/jvim.17263","DOIUrl":"10.1111/jvim.17263","url":null,"abstract":"<p>\u0000 <span>Barchilon, M</span>, <span>Perez-Nieves, N</span>, <span>Palerme, J-S</span>. <span>Evaluation of a urine dipstick protein to urine specific gravity ratio for the detection of proteinuria in dogs and cats</span>. <i>J Vet Intern Med</i>. <span>2024</span>; <span>38</span>(<span>2</span>): <span>1060</span>-<span>1067</span>. doi:10.1111/jvim.17001.</p><p>In the article cited above, the authors have determined that the X axis is mislabeled in Figures 3 and 4. The corrected versions are shown below.</p><p>The authors regret this error.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}