Journal of Veterinary Internal Medicine最新文献

{"title":"Association Between Adrenocorticotropic Hormone Concentration and Clinical Signs of Pituitary Pars Intermedia Dysfunction in Swiss and Austrian Equids","authors":"Nathalie Fouché,&nbsp;Camille Doras,&nbsp;Gertraud Schüpbach-Regula,&nbsp;Alexandre Scherer,&nbsp;Barbara Freudenschuss,&nbsp;Vinzenz Gerber","doi":"10.1111/jvim.70008","DOIUrl":"https://doi.org/10.1111/jvim.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There remains a scarcity of data concerning the relationship between the clinical signs associated with PPID and plasma ACTH concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Report the frequency of clinical signs in the study cohort and identify individual clinical signs or combinations of clinical signs associated with high ACTH concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Two hundred eighty equids were examined by private veterinarians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study of animals with clinical suspicion of PPID was conducted between August and November. Private practitioners completed an online questionnaire reporting detailed information, including signalment, owner-reported history, and clinical observations during the examination. Plasma ACTH concentrations of each animal were measured. Associations between clinical signs and ACTH concentrations were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Age, month, and specific clinical signs (hair coat abnormalities, laminitis, and supraorbital fat) were univariably associated with high ACTH concentrations. The first three dimensions of the multiple correspondence analysis (MCA) described the aggregation of clinical signs according to a known semiological typicity. Dimensions 1, 2, and 3 corresponded to features indicative of equine metabolic syndrome, early-stage PPID, and advanced PPID, respectively. Further regression analysis showed that Dimensions 1 and 3, as well as age, were significant predictors of high ACTH levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>The results indicate that particular clinical signs commonly associated with advanced stages of PPID are associated with high ACTH levels. Furthermore, in this data set, a phenotype compatible with metabolic syndrome was also linked to higher ACTH concentrations. These findings underscore the importance of seeking more sensitive biomarkers for the diagnosis of early PPID.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transesophageal Echocardiography-Related Complications During Mitral Valve Repair in Dogs","authors":"Kentaro Kurogochi,&nbsp;Arane Takahashi,&nbsp;Yasuyuki Nii,&nbsp;Tomoya Suzuki,&nbsp;Masashi Mizuno,&nbsp;Masami Uechi","doi":"10.1111/jvim.70037","DOIUrl":"https://doi.org/10.1111/jvim.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Transesophageal echocardiography (TEE) is an indispensable modality in cardiac surgery; however, the complications associated with its use in veterinary clinical settings remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>To investigate the complications associated with TEE probe manipulation during mitral valve repair in dogs and identify the risk factors for new mucosal injuries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>This prospective study evaluated 60 client-owned dogs that underwent TEE to support mitral valve repair.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Esophageal endoscopy was performed twice—once after anesthesia induction and once before extubation—to assess esophageal mucosal injuries during the procedure. The type of injury was classified as ‘complex’ (intramural hematoma and mucosal laceration), ‘minor’ (petechiae and ecchymosis), or ‘minute’ (visible only on narrowband imaging) lesions. During the surgery, TEE was performed three times. Hemodynamics were evaluated before the initial TEE insertion and immediately after it was removed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 60 dogs, newly detected mucosal lesions were observed in 20 dogs and classified as ‘minor’ in four and ‘minute’ in 16 dogs. These ‘minute’ lesions were not visible with conventional endoscopy, and no ‘complex’ lesions were identified. No significant factors were associated with the presence of mucosal lesions. After TEE insertion, systolic blood pressure decreased from 95 ± 13 mmHg to 92 ± 11 mmHg (<i>p</i> = 0.008), and heart rate decreased from 128 ± 25 bpm to 123 ± 24 bpm (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Intraoperative TEE results in a low incidence of esophageal mucosal injuries. Hemodynamic changes could occur during TEE manipulation, underscoring the need for close monitoring.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Study on the Relationship Between Idiopathic Epilepsy and Sleep in Dogs","authors":"Alejandra Mondino,&nbsp;Julie Nettifee,&nbsp;Karen R. Muñana","doi":"10.1111/jvim.70026","DOIUrl":"https://doi.org/10.1111/jvim.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The bidirectional relationship between epilepsy and sleep is well characterized in humans but has not been thoroughly explored in dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Evaluate sleep differences between dogs with idiopathic epilepsy and healthy controls and determine associations among epilepsy characteristics, antiseizure medications (ASMs), and sleep.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Sixty-four dogs with idiopathic epilepsy and 64 non-epileptic control dogs matched by age, breed, and sex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Owners of all dogs completed an online survey that included questions regarding signalment, epilepsy history if applicable, and sleep. Owners of epileptic dogs were asked whether their dogs experienced changes in sleep after a seizure. Sleep scores were calculated using the Sleep and Nighttime Restlessness Evaluation (SNoRE) questionnaire, consisting of two factors: “sleep quality” and “sleep interruptions caused by dreaming.” Data were analyzed for differences in sleep scores between epileptic and control dogs and any effects of seizure frequency, cluster seizures, and ASMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences in sleep scores were identified between epileptic dogs and controls (median, 12 vs. 8, respectively; <i>p</i> &lt; 0.001), driven by poorer sleep quality in the epileptic group. No significant associations were found between sleep scores and seizure frequency, clusters, or ASM use. Fifty-nine percent of dog owners noticed changes in sleep patterns after a seizure, most often increased sleep duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Dogs with idiopathic epilepsy experience negative changes in sleep, emphasizing the importance of monitoring and managing sleep disturbances in this cohort. Larger, multicenter studies controlling for confounding factors are needed to better understand the impact of epilepsy on sleep.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for “The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds”","authors":"","doi":"10.1111/jvim.70061","DOIUrl":"https://doi.org/10.1111/jvim.70061","url":null,"abstract":"<p>\u0000 <span>Stacey Sullivan</span>, <span>David Redden</span>, <span>Froydis Hardeng</span>, <span>Malin Sundqvist</span>, <span>Michelle Kutzler</span> <i>J Vet Intern Med.</i> <span>2025</span>; <span>39</span>( <span>1</span>). https://doi.org/10.1111/jvim.17281.\u0000 </p><p>In the article cited above, in the Results section of the Abstract the second sentence erroneously states, “1 or 2 FGF4L2 copies.” This should state “0 or 1 FGF4L2 copies.” This concept is correctly stated in the main body of the article.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic Primary Hypothyroidism Associated With Sulfamethoxazole-Trimethoprim Treatment of Nocardiosis in a Cat","authors":"Deborah Alexander,&nbsp;Gustavo C. Cobucci,&nbsp;Cassia C. da Motta,&nbsp;Gabriela de C. Cid,&nbsp;Lana S. Belizzi,&nbsp;Amanda C. de Jesus,&nbsp;Heloisa J. Souza,&nbsp;Mark E. Peterson","doi":"10.1111/jvim.70045","DOIUrl":"https://doi.org/10.1111/jvim.70045","url":null,"abstract":"<p>A 9-year-old mixed breed cat with a history of recurrent ulcerated skin lesions was diagnosed with nocardiosis. Three months after initiating potentiated sulfonamide treatment, the cat developed goitrous hypothyroidism, characterized by palpable enlargement of both thyroid lobes, low serum concentrations of total thyroxine (T4) and free thyroxine (fT4), and high serum thyroid-stimulating hormone (TSH) concentration. Thyroid scintigraphy identified symmetrical enlargement of both thyroid lobes, with increased radionuclide (^99mTc-pertechnetate) uptake. Upon discontinuation of trimethoprim-sulfa, serum concentrations of T4, fT4, and TSH returned to normal, confirming the diagnosis of iatrogenic, drug-induced thyroid dyshormonogenesis leading to hypothyroidism. A skin lesion was surgically removed, and microscopy disclosed branched filaments along with characteristic Gram-positive coccobacilli and Splendore-Hoeppli phenomenon. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), the clinical isolate was identified as <i>Nocardia puris</i>.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protothecosis in Dogs: A Narrative Review","authors":"Tomasz Jagielski,&nbsp;Angelika Proskurnicka,&nbsp;Mateusz Iskra,&nbsp;Sylwia Wronka,&nbsp;Zofia Bakuła,&nbsp;Patrizia Danesi,&nbsp;Marconi Rodrigues de Farias,&nbsp;Fábio Vinícius Ramos Portilho,&nbsp;Márcio Garcia Ribeiro,&nbsp;Uwe Rösler,&nbsp;Rui Kano,&nbsp;Richard Malik","doi":"10.1111/jvim.70025","DOIUrl":"https://doi.org/10.1111/jvim.70025","url":null,"abstract":"<p>Protothecosis is a rare and unusual disease that affects both humans and animals, including dogs. The causative agents are unicellular, achlorophyllous, “yeast-like” microalgae of the genus <i>Prototheca</i> (Trebouxiophyceae, Chlorophyta). Although usually saprophytic, <i>Prototheca</i> may, under conditions of immunologic compromise, become pathogenic and even lethal to the host. We present a synthesis of the current literature on protothecosis, with special emphasis on disease features in the dog. Five open-access scientific journal repositories were searched two times by two independent reviewers for original studies (including case reports, standard articles, and conference abstracts) pertaining to cases of protothecosis in dogs. Findings about protothecosis cases in dogs (e.g., animal metrics, type of infection, implemented treatment, and treatment outcome) were synthesized in independent data tables. Eighty studies describing 125 cases of protothecosis in dogs qualified for final analysis. Based on this investigation, protothecosis in dogs can be defined as an emerging disease that poses a serious challenge to the veterinary profession in terms of both diagnosis and management. In general, clinical signs and physical findings most often are referable to the gastrointestinal tract (<i>n</i> = 68; 54.4%). Yet the most common clinical manifestation in dogs is disseminated systemic infection (<i>n</i> = 84; 67.2%), including clinical signs referable to inflammation affecting more than one organ. We emphasize the complexity of <i>Prototheca</i> infection in dogs by summarizing clinical and laboratory findings from 125 cases of <i>Prototheca</i> infection in dogs published over the last half-century.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Dearterialization for Nonresectable Liver Tumors in Five Dogs and Two Cats","authors":"Michelle T. Nguyen,&nbsp;Chick Weisse,&nbsp;Stacy Kaneko","doi":"10.1111/jvim.70023","DOIUrl":"https://doi.org/10.1111/jvim.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Some massive or nodular liver tumors can make surgical resection dangerous. Transarterial embolization and chemoembolization recently have been evaluated in dogs and cats, but multinodular or diffuse tumors make selective embolization difficult, impractical, and may require multiple anesthetic events. Hepatic dearterialization in humans has been shown to be safe and sometimes successful in promoting temporary tumor regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Retrospective review of patients with nodular, diffuse, or non-resectable massive liver tumors that underwent transarterial coil embolization of the hepatic artery from the origin of the gastroduodenal artery to the proximal hepatic artery was performed. Data recorded included patient signalment, clinical signs, serum biochemical changes, cross-sectional imaging results, complications, and response to treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven patients (five dogs and two cats) underwent transarterial hepatic dearterialization and were included. All patients had increased pretreatment hepatocellular enzyme activities 24 h after surgery. All patients survived to discharge and five were discharged within 24 h after treatment. Two patients experienced mild short-term vomiting and anorexia, one of which required repeat hospitalization. Repeat laboratory testing approximately 6 weeks after treatment indicated decreased ALT and AST activities in 5/6 and 4/5 patients, respectively. Repeat imaging identified tumor regression in 3/4 patients evaluated by computed tomography (CT). Survival time ranged from 50 to 505 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hepatic dearterialization should be further investigated as a palliative management option for multinodular and diffuse liver tumors because it may provide a minimally invasive, safe, and palliative option based on the observation that all patients survived to discharge and tumor regression was noted in three animals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for “Pre-clinical enteropathy in healthy soft-coated wheaten terriers”","authors":"","doi":"10.1111/jvim.70034","DOIUrl":"https://doi.org/10.1111/jvim.70034","url":null,"abstract":"<p>M. K. Tolbert, J. Darrow, L. Grubb, S. Fitzgerald, R. Bergee, J. Price, M. Mariano, M. Hong, C.-H. Sung, T. Hill, J. M. Steiner and J. S. Suchodolski. Pre-clinical enteropathy in healthy soft-coated wheaten terriers. <i>Journal of Veterinary Internal Medicine</i>. 39, no. 2 (2025): e17293.</p><p>In the above mentioned article, Table 2, column “Healthy, non-SCWT” n should equal 10.</p>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroid Administration Enhances the Glycemic, Insulinemic, and Incretin Responses to a High-Protein Mixed Meal in Adult Horses","authors":"Allison T. Palmer,&nbsp;Mauria R. Watts,&nbsp;Kathryn J. Timko,&nbsp;Erin F. Pinnell,&nbsp;Katelyn A. Keefer,&nbsp;Olivia Gorman,&nbsp;Laura D. Hostnik,&nbsp;Teresa A. Burns","doi":"10.1111/jvim.17305","DOIUrl":"https://doi.org/10.1111/jvim.17305","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Corticosteroids are used routinely in horses and induce insulin dysregulation (ID). Nutrition is important for ID management and includes low nonstructural carbohydrate (NSC) diets and, often, high-protein ration balancers (RB). Insulin and incretin secretion increase after high-protein meals; corticosteroids may influence these effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis</h3>\u0000 \u0000 <p>A high-protein mixed meal will induce hyperinsulinemia and increased concentrations of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) in horses with ID; dexamethasone (DEX) will amplify this effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Five horses with naturally occurring ID.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Horses underwent an IV glucose tolerance test and a feed challenge test (FCT; 1 kg RB). Tests were repeated after DEX administration (0.08 mg/kg PO q24h, 7 days). Insulin, glucose, and incretin dynamics were compared pre- and post-DEX.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Corticosteroids exacerbated post-prandial hyperinsulinemia and hyperglycemia after a high-protein meal. The FCT area under the curve for insulin (AUC_INS) after DEX was significantly higher than baseline (558 ± 182 μIU/mL × min vs. 257 ± 93.9 μIU/mL × min; <i>p</i> = 0.03). The maximum concentration of GIP (C_maxGIP) after DEX (381 ± 70.6 pg/mL) was significantly higher than baseline (262 ± 13.7 pg/mL; <i>p</i> = 0.013). The AUC for GLP-1 (AUC_GLP-1; 31.1 ± 15.2 vs. 50 ± 20.2 pg/mL; <i>p</i> = 0.19) and the C_max of GLP-1 (C_maxGLP-1; 39.1 ± 25.3 vs. 29.6 ± 12.2 pg/mL; <i>p</i> = 0.32) did not differ between DEX and baseline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Importance</h3>\u0000 \u0000 <p>Metabolic responses to a high-protein mixed meal were exacerbated by corticosteroids. Horses receiving corticosteroids had larger GIP responses, which may enhance post-prandial hyperinsulinemia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.17305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Quality of Histopathologic Specimens Obtained via Small Intestinal Endoscopic Biopsy in Dogs and Cats","authors":"Ko Nakashima,&nbsp;Kazuhiro Kojima,&nbsp;Yoshinori Takeuchi,&nbsp;Manami Ito,&nbsp;Isao Matsumoto,&nbsp;Takahiro Ushigusa,&nbsp;Hiroshi Ohta,&nbsp;Kazuyuki Uchida","doi":"10.1111/jvim.70059","DOIUrl":"https://doi.org/10.1111/jvim.70059","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The factors affecting the quality of histopathologic specimens obtained via small intestinal endoscopic biopsy (SIEB) remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Hypothesis/Objectives</h3>\u0000 \u0000 <p>To identify factors related to the quality of histopathologic specimens obtained via SIEB.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Animals</h3>\u0000 \u0000 <p>Histopathologic duodenal and ileal specimens were obtained from 116 dogs and 38 cats that underwent SIEB for diagnostic purposes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analyzed 3354 individual histopathologic specimens scored using the grading system of histopathologic adequacy (GSHA). A lower GSHA score indicates lower quality specimens. Univariate and multivariate ordinal logistic models were used to assess the relationship between the GSHA score of the specimens and various explanatory factors, including fixation method, biopsy forceps size, biopsy site, and histopathologic diagnosis. The generalized estimating equation method was used to account for the clustering of specimens among animals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multivariate models using the specimens showed that filter paper fixation of endoscopic samples resulted in a higher GSHA score than floating fixation in both dogs (ordinal odds ratio [OR]: 0.19; 95% confidence interval [CI]: 0.15–0.25) and cats (ordinal OR: 0.19; 95% CI: 0.13–0.29). In dogs, the scores were lower for duodenal specimens than for ileal specimens and for specimens obtained using smaller forceps. In cats, the scores were lower for ileal specimens than for duodenal specimens and for older animals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Clinical Importance</h3>\u0000 \u0000 <p>The quality of histopathologic specimens obtained via SIEB is influenced by the fixation method. Additionally, other factors differ between dogs and cats. These results contribute to improved SIEB practices in veterinary medicine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}