Effects of Plasma and Hetastarch Administration on Colloid Oncotic Pressure and Coagulation Variables in Dairy Calves and Goats

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-05-15 DOI:10.1111/jvim.70079

Sarah Woods Cuneo, Bailey A. Abi-Nader, Sarah J. Blasczynski, Munashe Chigerwe

{"title":"Effects of Plasma and Hetastarch Administration on Colloid Oncotic Pressure and Coagulation Variables in Dairy Calves and Goats","authors":"Sarah Woods Cuneo, Bailey A. Abi-Nader, Sarah J. Blasczynski, Munashe Chigerwe","doi":"10.1111/jvim.70079","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Transfusion with fresh frozen plasma (FFP) or hetastarch 6% (HES) is an option for managing decreased colloid oncotic pressure (COP) associated with hypoproteinemia. The effectiveness of HES compared to plasma has not been reported in calves and goats.</p>\n </section>\n \n <section>\n \n <h3> Hypothesis</h3>\n \n <p>Hetastarch increases COP to levels similar to FFP. There will be no significant adverse clinicopathological changes after administration of HES.</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Seven healthy preweaned calves and 7 juvenile goats from university herds.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Cohort, clinical trial in a two-way crossover design. Hetastarch and FFP were administered intravenously at 10 and 20 mL/kg, respectively, once. Plasma COP was measured re-transfusion, at 0, 1, 2, 4, 6, 12, 24, 36, 72 h, and 7 days after each transfusion. Coagulation variables were analyzed pre-transfusion, at 0, 24, and 72 h after transfusion. The effects of treatment and time on COP and coagulation variables were determined by multivariate analysis of variance.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Transfusion with FFP and HES increased the COP in calves and goats, with FFP increasing the COP to a greater magnitude in calves (least square mean difference of 1.6 vs. 1 mmHg; <i>p</i> = 0.03) but not in goats (least square mean difference of 3.0 vs. 3.0 mmHg; <i>p</i> = 0.99). There were no significant changes (<i>p</i> > 0.05) in coagulation variables detected after transfusion with FFP or HES.</p>\n </section>\n \n <section>\n \n <h3> Conclusions and Clinical Importance</h3>\n \n <p>Hetastarch is an alternative colloid to FFP in calves and goats. Adverse changes were not observed in goats and calves after HES administration.</p>\n </section>\n </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 3","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70079","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Internal Medicine","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jvim.70079","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Transfusion with fresh frozen plasma (FFP) or hetastarch 6% (HES) is an option for managing decreased colloid oncotic pressure (COP) associated with hypoproteinemia. The effectiveness of HES compared to plasma has not been reported in calves and goats.

Hypothesis

Hetastarch increases COP to levels similar to FFP. There will be no significant adverse clinicopathological changes after administration of HES.

Animals

Seven healthy preweaned calves and 7 juvenile goats from university herds.

Methods

Cohort, clinical trial in a two-way crossover design. Hetastarch and FFP were administered intravenously at 10 and 20 mL/kg, respectively, once. Plasma COP was measured re-transfusion, at 0, 1, 2, 4, 6, 12, 24, 36, 72 h, and 7 days after each transfusion. Coagulation variables were analyzed pre-transfusion, at 0, 24, and 72 h after transfusion. The effects of treatment and time on COP and coagulation variables were determined by multivariate analysis of variance.

Results

Transfusion with FFP and HES increased the COP in calves and goats, with FFP increasing the COP to a greater magnitude in calves (least square mean difference of 1.6 vs. 1 mmHg; p = 0.03) but not in goats (least square mean difference of 3.0 vs. 3.0 mmHg; p = 0.99). There were no significant changes (p > 0.05) in coagulation variables detected after transfusion with FFP or HES.

Conclusions and Clinical Importance

Hetastarch is an alternative colloid to FFP in calves and goats. Adverse changes were not observed in goats and calves after HES administration.

查看原文本刊更多论文

血浆和hetarch给药对犊牛和山羊胶体瘤压和凝血指标的影响

背景：新鲜冷冻血浆（FFP）或6% hetastarch （HES）输注是治疗与低蛋白血症相关的胶体肿瘤压（COP）降低的一种选择。与血浆相比，HES在小牛和山羊中的有效性尚未见报道。假设Hetastarch使COP升高到与FFP相似的水平。给药后没有明显的不良临床病理改变。动物：7头健康的未断奶犊牛和7只来自大学牧群的小山羊。方法采用双交叉设计的队列、临床试验。Hetastarch和FFP分别以10和20 mL/kg的剂量静脉滴注1次。在每次输血后0、1、2、4、6、12、24、36、72 h和7天分别测量血浆COP。分析输血前、输血后0、24和72 h的凝血指标。通过多变量方差分析确定治疗和时间对COP和凝血变量的影响。结果输血FFP和HES可增加犊牛和山羊的COP，其中FFP对犊牛COP的增加幅度更大(最小二乘平均差为1.6 vs. 1 mmHg；p = 0.03)，但山羊没有(最小二乘平均差为3.0 vs. 3.0 mmHg；p = 0.99)。两组输血后凝血指标无显著差异（p > 0.05）。结论及临床意义Hetastarch是犊牛和山羊中FFP的替代胶体。施用HES后，山羊和犊牛未观察到不良变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.