Evaluation of Hyperlipasemia and Clinical Signs in 106 Dogs After Hospitalization for Acute Pancreatitis: Results From a Combined Retrospective and Prospective Follow-Up Study

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-08-01 DOI:10.1111/jvim.70188

Peter H. Kook

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Abstract

Background

No data after hospitalization for acute pancreatitis (AP) in dogs comparing clinical signs to lipase results exists.

Objectives

Evaluate disease severity, lipase activity, and pancreatic lipase immunoreactivity (PLI) after hospitalization for suspected AP.

Animals

One hundred and six client-owned dogs with a minimum of one re-check 2 weeks after hospitalization for AP.

Methods

Combined retrospective and prospective study. Clinical signs graded using a clinical disease activity score (CDAS = CIBDAI complemented by abdominal pain) were compared to DGGR-lipase activity (LIPC Roche) and PLI (SpecPL) at 2 weeks (t₂, n = 106) after discharge. Additional re-checks were available 6 weeks (t₃, n = 56), 12 weeks (t₄, n = 24), and 24 weeks (t₅, n = 13) after discharge.

Results

Lipase activity and PLI correlated strongly at all time points (r_s 0.863–0.937, p < 0.0001). Discordant results in regard to published reference intervals (RI) were rare (2.8% at t₂, 1.7% at t₃, 4.2% at t₄, 0% at t₅) and seemed clinically irrelevant. Dogs with still elevated lipase activity and PLI at t₂ (24/106.22.6%) and t₃ (21/56.37.5%) were significantly older compared to dogs with lipase within RI. Weak and moderate correlation between CDAS and lipase activity/PLI was found only at t₂ (r_s 0.391, p = 0.0009; r_s 0.279, p = 0.004) and t₅ (r_s 0.603, p = 0.032; r_s 0.57 p = 0.045). Most dogs (79.2%) with still elevated lipase at t₂ had no or minimal clinical signs (CDAS 0–3). The same applied to all later re-checks.

Conclusion and Clinical Importance

Both lipase assays did not differ when compared to clinical status. Most dogs with hyperlipasemia after hospitalization for AP have no or minimal clinical signs.

Abstract Image

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106只狗急性胰腺炎住院后高脂血症和临床症状的评估：来自回顾性和前瞻性随访研究的结果

背景：目前尚无犬急性胰腺炎（AP）住院后临床体征与脂肪酶结果比较的数据。目的评估疾病严重程度、脂肪酶活性、实验动物106只客户犬在AP住院2周后至少复查1次。方法回顾性与前瞻性研究相结合。在出院后2周（t2, n = 106），将临床疾病活动度评分（CDAS = CIBDAI并伴有腹痛）的临床体征与dggr -脂肪酶活性（LIPC - Roche）和PLI （SpecPL）进行比较。出院后6周（t3, n = 56）、12周（t4, n = 24）和24周（t5, n = 13）复查。结果脂肪酶活性与PLI在各时间点呈较强相关性（rs 0.863-0.937, p < 0.0001）。关于已发表的参考区间（RI）的不一致结果很少（t2为2.8%，t3为1.7%，t4为4.2%，t5为0%），并且似乎与临床无关。脂肪酶活性和PLI在t2（24/106.22.6%）和t3（21/56.37.5%）仍然升高的狗与RI内脂肪酶的狗相比显着变老。CDAS与脂肪酶活性/PLI仅在t2时存在弱和中度相关性(rs 0.391, p = 0.0009；rs 0.279, p = 0.004)和t5 (rs 0.603, p = 0.032;Rs 0.57 p = 0.045)。大多数（79.2%）在t2时脂肪酶仍然升高的狗没有或只有轻微的临床症状（CDAS 0-3）。这同样适用于所有后来的重新检查。结论及临床意义两种脂肪酶检测方法与临床状态比较无明显差异。大多数患有高脂血症的狗在AP住院后没有或只有很少的临床症状。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.