Journal of Voice最新文献

{"title":"From Screening to Precision: Searching for Voice Disorder-Specific Acoustic and Auditory-Perceptual Metrics.","authors":"Eric J Hunter, Lady Catherine Cantor-Cutiva, Patrick R Walden","doi":"10.1016/j.jvoice.2025.09.007","DOIUrl":"10.1016/j.jvoice.2025.09.007","url":null,"abstract":"<p><strong>Background: </strong>Acoustic and auditory-perceptual parameters are common tools for screening clinically significant voice disorders. However, the potential for disorder-specific acoustic signatures that support clinical differential diagnosis remains largely unrealized. Additionally, the robustness of acoustic patterns across different speech materials requires clarification to inform flexible, evidence-based clinical protocols and emerging machine learning applications.</p><p><strong>Methods: </strong>This study investigated disorder-specific metrics and speech material consistency using the Perceptual Voice Qualities Database. Generalized Linear Models examined associations between 14 acoustic parameters and common voice pathologies [Vocal Fold Paralysis (VFP), Atrophy, Lesions, and Muscle Tension Dysphonia (MTD)]. Principal component analysis (PCA) integrated acoustic and auditory-perceptual measures to identify multidimensional voice quality patterns, while Receiver Operating Characteristic (ROC) curves evaluated discriminative performance across sustained vowels and connected speech.</p><p><strong>Results: </strong>Two primary principal components emerged: PC1 (34.7% variance) integrating general voice quality and perceptual ratings, and PC2 (17.3% variance) contrasting temporal stability with harmonic structure. Distinct disorder-specific patterns were identified: VFP demonstrated strong discriminative performance on both components (AUC ≥ 0.75), while Atrophy, Lesions, and MTD showed moderate associations with PC1 (AUC = 0.52-0.66). Preliminary analysis revealed characteristic patterns for Parkinson's disease across both components. Importantly, acoustic patterns remained consistent across speech materials, supporting task-flexible clinical assessment protocols.</p><p><strong>Conclusion: </strong>Specific voice pathologies exhibit distinct acoustic-perceptual signatures that can be reliably identified through multidimensional analysis. These findings support a precision-based approach to voice assessment, moving beyond general screening toward disorder-specific diagnostic applications. The robustness of patterns across speech materials enables flexible clinical protocols, while the integration of acoustic and perceptual measures provides a foundation for enhanced diagnostic tools and machine learning applications.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Vitamin D Status and Voice Features in the Thai National Health Examination Survey.","authors":"Benyapa Ongphiphadhanakul, Wichai Aekplakorn, Pichatorn Suppakitjanusant, Boonsong Ongphiphadhanakul, La-Or Chailurkit, Nittaya Kasemkosin","doi":"10.1016/j.jvoice.2025.09.018","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.018","url":null,"abstract":"<p><strong>Objectives: </strong>Although vitamin D may affect human speech by influencing neuromuscular functions, related studies are limited and report discrepant findings because of small sample sizes and variations in voice parameters considered. This study investigated the relationship between vitamin D and voice parameters using the Extended Geneva Acoustic Parameter Set (eGeMAPs) in a randomly selected subpopulation (n = 480) of the Thai National Health Examination Survey.</p><p><strong>Methods: </strong>The /a/ voice samples provided by participants via smartphones were analyzed using the OpenSMILE Python package to extract 88 eGeMAPs features. Mass spectrometry was utilized to measure 25-OH-vitamin D (25(OH)D) levels. Subjects were divided into two groups. In Gr.1 (≤35 years, n = 98).</p><p><strong>Results: </strong>Stepwise multiple regression analysis identified 28 voice parameters significantly associated with 25(OH)D levels, independent of sex. The five most strongly associated voice parameters were mean spectral flux in voice segment, mean spectral flux, amplitude log ratio of the 3rd formant/F0, amplitude log ratio of the 2nd formant/F0, and equivalent sound levels. In Gr.2 (>35 years, n = 382), only the standard deviation of the falling slope of the fundamental frequency was associated with 25(OH)D levels, independent of sex.</p><p><strong>Conclusions: </strong>This work shows that vitamin D potentially influences neuromuscular functions associated with voice generation, particularly in younger individuals.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Cricothyroid Joint Type on Vocal Fold Elongation in Professional Male Singers and Non-singers.","authors":"Storck Claudio, Murer Rita, Honegger Flurin, Lieb Johanna","doi":"10.1016/j.jvoice.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.015","url":null,"abstract":"<p><strong>Objectives: </strong>The pitch of the singing voice can be influenced by changes in vocal fold length and resonance space. The aim of the study was to investigate differences in singing biomechanics in relation to the cricothyroid joint (CTJ) type between professional singers (PS) and non-singers (NS).</p><p><strong>Methods: </strong>We recruited 22 PS (all male; 11 tenors, 11 bass/baritones) and 20 NS (10 males and 10 females) and analyzed three-dimensional images of the larynx derived from high-resolution computed tomography (HRCT) scans obtained at the mean speaking fundamental frequency (F0) and one (F1) and two octaves (F2) above this pitch.</p><p><strong>Results: </strong>Sixteen of the PS (72%) had a type A CTJ and 6 (28%) had a type B/C CTJ. From F0 to F2, vocal fold elongation was 18% in all PS and 10% in all NS. In PS with a type A CTJ, the vocal fold elongation was 20% over two octaves (F0-F1: 15%; F1-F2: 5%), and in PS with a type B/C CTJ the elongation was 11% (F0-F1: 7%; F1-F2: 4%). In NS, vocal fold elongation was 10% over two octaves regardless of the type of CTJ (F0-F1: 7%; F1-F2: 3%).</p><p><strong>Conclusions: </strong>Male PS lengthen their vocal folds sufficiently in the first and second octaves, while NS do not lengthen them sufficiently enough to elevate the singing pitch. NS probably reduces the resonance space via laryngeal elevation in order to increase the singing voice.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Azerbaijani-Turkish Version of the Voice Symptom Scale (AT-VoiSS).","authors":"Fatemeh Fekar Gharamaleki, Elnaz Ghorbani, Jalal Ahadi, Zeinab Fathipour-Azar","doi":"10.1016/j.jvoice.2025.08.032","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.08.032","url":null,"abstract":"<p><strong>Objectives: </strong>Currently, there is no validated Azerbaijani-Turkish instrument specifically designed to comprehensively assess the multidimensional symptom profile of voice disorders in this language. This study aimed to translate the Azerbaijani-Turkish version of the Voice Symptom Scale (AT-VoiSS) to Azerbaijani-Turkish and evaluate its validity and reliability through cross-cultural adaptation.</p><p><strong>Study design: </strong>A cross-sectional and prospective validation design was adopted.</p><p><strong>Methods: </strong>After permission, the VoiSS was translated and culturally adapted into the Azerbaijani-Turkish language according to the standard methodology of forward-backward translation. Eight experts assessed content validity through the Content Validity Index (CVI). Face validity and the pilot study were assessed through cognitive interviewing with 20 voice patients. The study included 160 participants, with 80 having voice complaints and 80 not having voice complaints. Construct validity was obtained by comparing the total and subtotal scores with and without the voice complaint groups. The criterion validity was calculated by comparing the correlation of the total score of the AT-VoiSS with the Azerbaijani-Turkish version of voice-related quality of life (AT-VRQOL). The discriminant validity was evaluated by evaluating the area under the curve (AUC), sensitivity, specificity, and cutoff points. The internal consistency of AT-VoiSS was examined using Cronbach's alpha coefficient. To calculate the test-retest reliability coefficient, 30 participants completed the AT-VoiSS twice, including 20 with voice complaint disorders and 10 without voice complaints, at 2-week intervals.</p><p><strong>Results: </strong>Differences in the AT-VoiSS scores between participants with and without voice complaints were statistically significant (P < 0.001). The construct validity results showed significant differences in the scores between the two groups in three factor scores (P < 0.001). The criterion validity results showed that the total score of AT-VoiSS is negatively correlated with the AT-VRQOL results (r = -0.85, P < 0.001). The area under the curve value from the ROC curve was 100. The optimal cutoff point was 30.55, with a sensitivity of 100% and a specificity of 55%. The AT-VoiSS had high internal consistency, indicating excellent reliability (Cronbach's alpha coefficient = 0.99). A high degree of correlation was found between the scores obtained in the two administrations, indicating excellent test-retest reliability (r =0.98, P < 0.001).</p><p><strong>Conclusions: </strong>The AT-VoiSS is a valid, reliable, and sensitive scale that can assess patients with voice disorder symptoms in the Azerbaijani-Turkish population.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Being Perceived as Vocally Young in Older Adults.","authors":"Narumi Kojima, Yosuke Osuka, Keiko Motokawa, Ayako Edahiro, Hirohiko Hirano, Shuichi Awata, Hiroyuki Sasai","doi":"10.1016/j.jvoice.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.014","url":null,"abstract":"<p><strong>Objectives: </strong>To identify physiological, psychological, and lifestyle factors associated with being perceived as vocally young among community-dwelling older adults.</p><p><strong>Study design: </strong>Cross-sectional observational study.</p><p><strong>Methods: </strong>Participants were 1066 older adults (median age: 77.5 years) participating in the Itabashi Longitudinal Study on Aging in February-March, 2022. The outcome was self-reported frequency of being told one has a youthful voice, dichotomized into \"yes\" (often/sometimes) or \"no\" (rarely). Explanatory variables included sociodemographic characteristics, body water percentage, smoking status (current, former, never), alcohol consumption (current, former, never), respiratory disease history, grip strength, mental health (WHO-5), cognitive function, social interaction frequency, sleep duration, physical activity, oral health, and nutrient intake. Age- and gender-adjusted logistic regression models were examined associations with the outcome, with false discovery rate correction. Significant variables were entered into a multivariable model to assess their independent associations with the outcome.</p><p><strong>Results: </strong>Among participants, 55.3% reported often or sometimes being told they have a youthful voice. In age- and gender-adjusted analyses, greater social interaction frequency (OR = 2.60, 95% CI: 2.01-3.37, P < 0.001) and higher WHO-5 score (OR = 1.08 per point, 95% CI: 1.06-1.11, P < 0.001) were significantly associated. In multivariable analysis, both social interaction frequency (OR = 2.26, 95% CI: 1.74-2.94, P < 0.001) and WHO-5 score (OR = 1.05, 95% CI: 1.03-1.08, P < 0.001) remained significant.</p><p><strong>Conclusions: </strong>Frequent social interactions and better mental well-being are independently associated with being perceived as vocally young. These findings suggest that psychosocial factors contribute meaningfully to perceived vocal youthfulness, supporting the development of multidimensional programs for older adults that promote mental well-being and social engagement.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamification of Tube Phonation: A Feasibility Study for Voice Therapy Practice.","authors":"Taketo Murai, Tatsuya Kitamura, Naoko Kawamura","doi":"10.1016/j.jvoice.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.008","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to turn home vocal exercise for people with voice problems into an engaging experience through gamification. A serious game designed for tube phonation was developed, and its effectiveness in encouraging adherence to prescribed vocal exercises was evaluated in healthy older adults.</p><p><strong>Serious game: </strong>The serious game is a slot machine game displayed on a tablet, connected to an Internet of Things (IoT) device and an accelerometer with a straw for tube phonation. It detects phonation by measuring the amplitude and frequency of the vibratory wave of a straw wall. The tablet connects to the IoT device via Bluetooth. When users maintain tube phonation for a specified duration, the slot machine reels start spinning. Users can stop the reels using buttons on the tablet, and their scores are calculated and stored.</p><p><strong>Methods: </strong>Sixteen participants (eight males and eight females) with a mean age of 68.6 years were divided into control and experimental groups. For 1 week, all participants practiced tube phonation at home, with instructions to complete three sets of 15 5-second tube phonations daily. The experimental group used the proposed game system, while the control group did not. An IoT device recorded phonation durations for both groups. Participants completed a postexperiment questionnaire.</p><p><strong>Results: </strong>The experimental group successfully maintained tube phonation durations exceeding 5 seconds throughout the week, while the control group's durations varied, often falling below 5 seconds. However, both groups believed that they had followed the phonation instructions. In the survey, the experimental group expressed a more positive attitude toward long-term home vocal exercises.</p><p><strong>Conclusions: </strong>The serious game shows promise for promoting correct and consistent daily vocal exercises among patients, and is a valuable approach to voice rehabilitation.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Three-Dimensional Fine Structures of the Maculae Flavae of the Rat Vocal Fold Using the Correlative Light and Electron Microscopy.","authors":"Kiminobu Sato, Kiminori Sato, Mengya Mark, Xiaochuan Xu, Hirohito Umeno, Bernard Rousseau","doi":"10.1016/j.jvoice.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.010","url":null,"abstract":"<p><strong>Objectives: </strong>The comparative fine structures of the maculae flavae of the rat vocal fold (VF) were investigated using the correlative light and electron microscopy (CLEM) technique combined with transmission electron microscopy (TEM).</p><p><strong>Methods: </strong>Seven normal adult Sprague-Dawley rats were examined using the CLEM technique and TEM to investigate their fine structures.</p><p><strong>Results: </strong>Cobblestone-like polygonal cells (CPCs), vocal fold stellate cell-like cells (VFSCs), and fibroblast-like spindle cells (FSCs) were identified in the anterior and posterior maculae flavae of the rat VF under CLEM and TEM. The VFSCs had lipid droplets in their cytoplasm under TEM. Microfibrils, collagen fibrils, and amorphous material were observed surrounding the periphery of the cytoplasm of the VFSCs, indicating that they synthesize extracellular matrices. Cell aggregations with CPCs were identified in the maculae flavae, indicating there is a complex cross-talk between the adhesion machinery and chemical signaling pathways.</p><p><strong>Conclusion: </strong>The comparative fine structures of the cells in the maculae flavae suggested heterogeneity among the cells in the maculae flavae of the rat VF. The cellular components in the maculae flavae of the rat vocal folds (VFs) are similar to those in human maculae flavae, suggesting that rat VFs serve as a suitable model for animal experiment studies. The CLEM technique combined with TEM is a valuable tool for evaluating the fine structures of the VFs in small species and holds promise for future applications in animal studies of VF morphology and function.</p><p><strong>Level of evidence: </strong>NA.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giving Voice to Children's Vocal Health: Assessment of Parents' Knowledge Before and After the Online Course.","authors":"Amanda Gabriela de Oliveira, Eliana Maria Gradim Fabbron","doi":"10.1016/j.jvoice.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.009","url":null,"abstract":"<p><strong>Introduction: </strong>Dysphonia in children may arise from exposure to inefficient vocal behaviors in primary social environments, particularly within the family context, and it is common for affected children to remain unaware of their vocal impairment. However, there are no studies focused on guiding parents or caregivers on how to deal with this issue, aiming for the success of therapeutic prognosis or the prevention of voice disorders in children. Furthermore, distance education has become a favorable resource currently.</p><p><strong>Objective: </strong>To evaluate the change in parents' knowledge before and after completing an online course titled \"Giving voice to children's vocal health.\"</p><p><strong>Materials and methods: </strong>Following the development of the course, parents and caregivers of children aged 4 to 11 years, both with and without vocal complaints, were invited to participate in the study. The parents completed the online course, which had an estimated duration of eight hours. Supplementary materials were provided to support parent-child activities at home, and the course incorporated interactive questions designed for joint participation. An online assessment of the course content was administered to the parents within one week prior to the intervention and up to two weeks after its completion.</p><p><strong>Data analysis: </strong>A descriptive percentage analysis of the precourse and postcourse tests of the participants was conducted, and inferential analysis was also performed to compare parents' performance on the precourse and postcourse tests using Sigma® 3.5 software, adopting a significance level of 0.05 (P ≤ 0.05) and using the Student's paired t test.</p><p><strong>Results: </strong>A total of 15 parents participated. After completing the course, parents showed a higher percentage of correct answers in the postcourse test in most questions. The average percentage of correct answers for all questions increased from 73% to 93%. There was a statistically significant increase in average correct answers comparing the precourse and postcourse test (P < 0.001).</p><p><strong>Conclusion: </strong>The completion of the course contributed to the expansion of knowledge for parents/caregivers and their children about children's vocal health.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voice of Mind, a Deep Learning Model for Depression and Anxiety Assessment From Acoustic and Lexical Vocal Biomarkers.","authors":"S Regondi, F Roncone, V Colombo, R Pugliese, E Bagli, G Russo, A Panella, M Radavelli, S Bolognini","doi":"10.1016/j.jvoice.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.09.012","url":null,"abstract":"<p><strong>Objective: </strong>To develop a deep learning model to assess anxiety and depression from acoustic and lexical biomarkers able to analyze Italian psychotherapy recordings and classify three distinct conditions: depression, anxiety, and no pathology.</p><p><strong>Method: </strong>Five patients diagnosed with either Major Depressive Disorder or Generalized Anxiety Disorder were selected from psychotherapy sessions conducted at RAM Psyche. A total of seven audio recordings were manually analyzed by a clinical psychologist using the DASS-21 scale, resulting in over 1000 audio segments labeled for psychopathological content. From these recordings, acoustic features and lexical markers were extracted. These features were processed through a hybrid architecture combining a Convolutional Neural Network for Mel spectrogram analysis and a Multi-Layer Perceptron for integrating lexical and acoustic inputs. Three model variants (VOM 1.1, 1.2, and 1.3) were trained and evaluated using two custom datasets (DVOM2, DVOM3), including both internal patient audio and external neutral voices.</p><p><strong>Results: </strong>The model successfully classified segments into depression, anxiety, and no pathology with promising results. Feature importance analysis revealed that prosodic cues such as lower pitch, reduced intensity, and increased pauses were highly predictive of depression, while lexical richness and adverb usage were associated with both disorders. Among the model variants, VOM 1.1 showed balanced performance across all three classes, particularly excelling in detecting depression and no pathology. In contrast, VOM 1.2 prioritized depression and anxiety detection, occasionally misclassifying ambiguous cases as symptomatic, suggesting a heightened sensitivity to subtle pathological cues. VOM 1.3 while maintaining a strong classification performance, demonstrated improved robustness on external neutral voices.</p><p><strong>Conclusions: </strong>The Voice of Mind model demonstrates the feasibility of using speech data to support mental health diagnostics. Its capacity to distinguish between depression and anxiety, while maintaining generalization across nonpathological voices, suggests its potential as a clinical decision-support tool.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Auditory-Perceptual Evaluation Indexes, CAPE-V and GRBAS (Machine Learning), in Patients With Parkinson's Disease.","authors":"Payam Saadat, Hassan Khoramshahi, Karaneh Mahdavi, Fatemeh Zahedi, Akram Ahmadi, Hossein-Ali Nikbakht","doi":"10.1016/j.jvoice.2025.08.041","DOIUrl":"https://doi.org/10.1016/j.jvoice.2025.08.041","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the effectiveness of two auditory-perceptual voice assessment tools, GRBASZero (an AI-based application) and Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V), in evaluating voice impairments in patients with Parkinson's disease (PD). The research sought to determine the sensitivity and reliability of these tools across different stages of PD severity, focusing on parameters such as overall severity, roughness, breathiness, strain, loudness, and pitch.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 44 PD patients, categorized by disease severity using the Hoehn and Yahr scale. Voice samples were collected through sustained vowels /a/. Trained speech-language pathologists (SLP) performed CAPE-V assessments, while GRBASZero evaluations were conducted using an AI application, while GRBASZero evaluations were conducted using an AI application. Statistical analyses included the Kruskal-Wallis test and correlation tests to compare the tools' performance.</p><p><strong>Results: </strong>This study showed that CAPE-V has higher sensitivity in identifying voice disorders at all stages of the disease (all P values < 0.05), while GRBASZero only detects Breathiness and Strain parameters at advanced stages (P = 0.049 and P = 0.034, respectively). Analyses were performed based on the vowel /a/ and the common parameters of the two instruments. The findings highlight the importance of choosing the appropriate instrument based on the stage of the disease.</p><p><strong>Conclusion: </strong>CAPE-V is more comprehensive and sensitive for assessing voice impairments in PD patients across all disease stages, making it preferable for clinical and research use. GRBASZero, while useful for monitoring vocal strain and breathiness in advanced PD, lacks sensitivity in early stages. These findings highlight the importance of selecting appropriate tools for early diagnosis and monitoring of voice disorders in PD.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}