Korean Journal of Pathology最新文献

{"title":"Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study.","authors":"Hyun-Jin Son,&nbsp;Tae-Hwa Baek,&nbsp;Seung Yun Lee,&nbsp;Joo-Heon Kim,&nbsp;Dong-Wook Kang,&nbsp;Hye-Kyung Lee,&nbsp;Mee-Ja Park","doi":"10.4132/KoreanJPathol.2014.48.4.270","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.270","url":null,"abstract":"<p><strong>Background: </strong>Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.</p><p><strong>Methods: </strong>We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.</p><p><strong>Results: </strong>The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.</p><p><strong>Conclusions: </strong>This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"270-5"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinicopathological significance of epithelial mesenchymal transition associated protein expression in head and neck squamous cell carcinoma.","authors":"Kyu Ho Kim,&nbsp;Lucia Kim,&nbsp;Suk Jin Choi,&nbsp;Jee Young Han,&nbsp;Joon Mee Kim,&nbsp;Young Chae Chu,&nbsp;Young-Mo Kim,&nbsp;In Suh Park,&nbsp;Joo Han Lim","doi":"10.4132/KoreanJPathol.2014.48.4.263","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.263","url":null,"abstract":"<p><strong>Background: </strong>Epithelial mesenchymal transition (EMT) has an important role in invasion and metastasis of tumor cells. The purpose of this study was to evaluate the roles of EMT-associated proteins on progression and metastasis as a prognostic/predictive factor in curatively-resected (R0) head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>A total of 118 patients who received curative surgery for HNSCC at Inha University Hospital between January 1996 and December 2011 were included. We used protein immunohistochemistry to evaluate the expression of E-cadherin, vimentin, and EZH2 on tissue microarrays. Also, we reviewed all medical records and analyzed the relationship between the expression of EMT-associated proteins and prognosis.</p><p><strong>Results: </strong>The E-cadherin-negative group showed more moderate/poor differentiation of cancer cell type than the higher E-cadherin-expressing group (p=.016) and high EZH2 expression was significantly correlated with nodal metastasis (p=.012). Our results demonstrate a significant association between high expression of EZH2 and vimentin and presence of distant progression (p=.026). However, expression of E-cadherin, vimentin, and EZH2 was not significantly associated with overall survival.</p><p><strong>Conclusions: </strong>These findings suggest that an EMT-associated protein expression profile is correlated with aggressiveness of disease and prognosis, and could be a useful marker for determination of additional treatment in curatively-resected HNSCC patients.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"263-9"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status.","authors":"Jung Ho Kim,&nbsp;Jeong Mo Bae,&nbsp;Kyung-Ju Kim,&nbsp;Ye-Young Rhee,&nbsp;Younghoon Kim,&nbsp;Nam-Yun Cho,&nbsp;Hye Seung Lee,&nbsp;Mee Soo Chang,&nbsp;Gyeong Hoon Kang","doi":"10.4132/KoreanJPathol.2014.48.4.276","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.276","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs.</p><p><strong>Methods: </strong>Expression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight).</p><p><strong>Results: </strong>Among 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004).</p><p><strong>Conclusions: </strong>Loss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"276-82"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary myofibroma of the adult mandible: a case report and review of literature.","authors":"Yong-Moon Lee,&nbsp;Seung-Myoung Son,&nbsp;Kyoung Won Kim,&nbsp;Ok-Jun Lee","doi":"10.4132/KoreanJPathol.2014.48.4.307","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.307","url":null,"abstract":"Myofibroma is a rare benign neoplasm of myofibroblastic cells that can occur in either a solitary or multicentric form. Both forms were described as infantile myofibromatosis because of its multiplicity, typical age distribution (first decade of life), and frequent involvement of deep structures, including the central nervous system and visceral organs such as lung, heart, gastrointestinal tract, liver, kidney, and pancreas. 1 In contrast to the multicentric form, solitary myofibroma usually presents as a cu taneous or subcutaneous mass of the head and neck region. 2 In","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"307-10"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent thyroid papillary carcinoma in children under ten years old: report of two cases and literature review.","authors":"Byeong-Joo Noh,&nbsp;Ji-Youn Sung,&nbsp;Youn-Wha Kim,&nbsp;Yong-Koo Park","doi":"10.4132/KoreanJPathol.2014.48.4.297","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.297","url":null,"abstract":"<p><p>Papillary thyroid carcinoma (PTC) in children under ten years old is very rare. To date, 18 cases of PTC in children under ten years old (including our two cases) have been reported in Korea. Here, we describe two cases of recurrent PTC with follicular variant and conventional type in an 8-year-old boy and a 7-year-old boy, respectively, and discuss clinicopathologic and molecular characteristics that differ in pediatric patients from adults. </p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"297-301"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterotopic pancreas in omphalomesenteric duct remnant results in persistent umbilical discharge.","authors":"Eunhyang Park,&nbsp;Hyojin Kim,&nbsp;Kyu Whan Jung,&nbsp;Jin-Haeng Chung","doi":"10.4132/KoreanJPathol.2014.48.4.323","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.323","url":null,"abstract":"Umbilical discharge in infancy is a common pediatric problem and usually attributed to infection or an umbilical granuloma. However, it is important to investigate if such discharge is due to an underlying congenital abnormality such as umbilical hernia ulceration, urachal remnant, or omphalomesenteric duct remnant, because corrective surgical intervention may then be required. Omphalomesenteric duct remnant can cause umbilical discharge generally through patency between the gut and umbilicus. However, though rare, umbilical discharge may be due to the presence of heterotopic pancreas. The prevalence of omphalomesenteric duct remnant is only 2% of the population, and most of them remain asymptomatic. The present case is an infant with persistent umbilical discharge caused by heterotopic pancreatic tissue in a remnant omphalomesenteric duct. To the best of our knowledge, this is the first such case report in Korea. A 3-month-old female infant presented with persistent umbilical discharge since birth. The infant was born through normal vaginal delivery following an uneventful gestational period and had no congenital anomalies. She had been gaining weight well and had no family history of genitourinary or gastrointestinal problems. Ultrasonography of the abdomen revealed an isoechoic tract posterior to the umbilicus, and the diagnosis of urachal remnant was suspected. On physical examination, small droplets of clear fluid constantly discharged from a normallooking umbilicus. Laboratory examination results were within normal limits. Under general anesthesia, an incision was made below umbilicus. Surgical exploration showed a fibrous sinus posterior to the umbilicus which was attached to the inner aspect of the umbilicus and the outer wall of the ileum by a fi brous band. Fibrous tissue was excised close to both ends, and the rest was ligated by suture tie. The excised specimen was a 7×6×5-mm-sized whitish fibrous tissue. Histologically, the excised specimen included pancreatic tissue with some small intestinal mucosa and fibrous extracellular components (Fig. 1). Both exocrine and endocrine pancreatic tissues were observed, including acini, ducts, and islets of Langerhans. Acini were separated into lobules by connective tissue. Intercalated ducts were lined by simple low cuboidal epithelium (Fig. 2). The patient was discharged without any postoperative complications and is currently alive without any sequelae.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"323-6"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report.","authors":"Heae Surng Park,&nbsp;Yoon Sung Bae,&nbsp;Sun Och Yoon,&nbsp;Beom Jin Lim,&nbsp;Hyun Jun Hong,&nbsp;Jae Y Ro,&nbsp;Soon Won Hong","doi":"10.4132/KoreanJPathol.2014.48.4.335","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.335","url":null,"abstract":"Nuclear protein in testis (NUT) midline carcinomas are uncommon, recently described, fatal neoplasm that are characterized by rearrangement of the NUT gene on 15q14.1 Since the first case of NUT midline carcinoma was reported as an undifferentiated carcinoma with a t(15;19) translocation in 1991,2 more than 50 cases have been reported.3 Because of the unique chromosomal translocation and predilection for occurrence in midline structures, they have been termed NUT midline carcinomas. However, tumors outside the midline have been reported, including the salivary gland, bladder, and other sites.1,3,4,5 We encountered a case of NUT midline carcinoma confirmed by NUT specific immunohistochemistry (IHC) using cytologic and histologic specimens. Herein, we present the first case report on immunocytologic features of NUT midline carcinoma arising in the parotid gland.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"335-8"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of TWIST in Ovarian Epithelial Cancers.","authors":"Kyungbin Kim,&nbsp;Eun Young Park,&nbsp;Man Soo Yoon,&nbsp;Dong Soo Suh,&nbsp;Ki Hyung Kim,&nbsp;Jeong Hee Lee,&nbsp;Dong Hoon Shin,&nbsp;Jee Yeon Kim,&nbsp;Mee Young Sol,&nbsp;Kyung Un Choi","doi":"10.4132/KoreanJPathol.2014.48.4.283","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.283","url":null,"abstract":"<p><strong>Background: </strong>Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.</p><p><strong>Methods: </strong>We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters.</p><p><strong>Results: </strong>The expression of TWIST, E-cadherin, HIF1α, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1α expression and reduced E-cadherin expression. The altered HIF1α/TWIST/E-cadherin pathway was associated with lower overall survival (OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS.</p><p><strong>Conclusions: </strong>Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia-mediated EMT, which involves the HIF1α/TWIST/E-cadherin pathway may play an important role in the progression of OEC.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"283-91"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undifferentiated embryonal sarcoma in adult liver.","authors":"Won Ju Hong,&nbsp;Yu Na Kang,&nbsp;Koo Jeong Kang","doi":"10.4132/KoreanJPathol.2014.48.4.311","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.311","url":null,"abstract":"Undifferentiated embryonal sarcoma (UES) is the third most common primary malignant liver tumor in children, following hepatoblastoma and hepatocellular carcinoma. UES of the liver was first named by Stocker and Ishak in 1978,1 and the majority of patients at the time ranged from 6 to 10 years of age. \u0000 \u0000A recent review of the literature showed only 70 cases of UES in adults reported worldwide in 2008.2 This rare presentation is especially true for adults aged >60 years with only 14 cases of UES reported in this population until now.3,4,5,6,7 In Korea, eight cases of UES in adults have been reported: five cases were in women and four cases were in people older than 60 years.5,6,7,8 We present a new case of adult UES of the liver arising in a 67-year-old man. Like pediatric UES, the adult tumor has an unclear pathogenesis and poor prognosis.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"311-4"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signet-ring cell carcinoma of the distal common bile duct: report of a case.","authors":"Hyung Jun Kwon,&nbsp;Ghil-Suk Yoon,&nbsp;Yong Chul Kwon,&nbsp;Sang Geol Kim,&nbsp;Ji Yun Jeong","doi":"10.4132/KoreanJPathol.2014.48.4.315","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.4.315","url":null,"abstract":"Signet-ring cell carcinoma (SRCC) of the extrahepatic bile duct is a histologically distinct entity classified by the World Health Organization, in which cells containing intracytoplasmic mucin displacing the nucleus predominate.1 SRCC of the gastrointestinal tract is most commonly found in the stomach, and the impact of this histology on the prognosis is controversial.2,3 \u0000 \u0000Well to moderately differentiated adenocarcinoma is the most common histologic type and complete resection is the only potentially curative therapy for distal bile duct cancer.4 However SRCC of extrahepatic bile duct is extremely rare, so its clinico-pathological features and impact on the prognosis are not well known. To the best of our knowledge, only three cases of SRCC of the extrahepatic bile duct have been reported in the English literature.5,6,7 Herein, we present a case of SRCC originating from the epithelium of the distal extrahepatic bile duct.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 4","pages":"315-8"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.4.315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}