Laryngoscope最新文献_第3页

Safety and Efficacy of a Protocol for In-Office Pediatric Aural Foreign Body Removal.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-18 DOI: 10.1002/lary.32073

Dilan Prasad, Glenn Isaacson

{"title":"Safety and Efficacy of a Protocol for In-Office Pediatric Aural Foreign Body Removal.","authors":"Dilan Prasad, Glenn Isaacson","doi":"10.1002/lary.32073","DOIUrl":"https://doi.org/10.1002/lary.32073","url":null,"abstract":"Objectives: To examine the safety and efficacy of a step-by-step protocol for the office removal of aural foreign bodies (FB) in a pediatric population.Methods: All children presenting to an academic pediatric outpatient department were identified from a computerized collection of office notes and operative reports. FB removal was performed in a standard fashion including: (1) pre-procedure discussion with shared decision making, (2) restraint in a supine position with a trained second person holding the head, (3) FB removal using an operative microscope and instrumentation. A case was considered a failure if subsequent removal under sedation or general anesthesia was required.Results: 447 total cases (ears) were identified in 428 children (19 had bilateral FBs). 201/428 (47%) of children had previous attempts at FB removal elsewhere. 431/447 (96.4%) of FBs were successfully extracted in the office. 16/447 (3.6%) of FBs were removed in the operating room. Out of the 431 successful removals, two patients had minor complications (ear canal lacerations). No child suffered a more severe complication. The failed removal group was more likely to have a documented neurodevelopmental disorder (4/21 vs. 12/407, p = 0.0001).Conclusion: This protocol resulted in a high rate of successful FB removal, even in children with prior failed attempts. There were no significant ear injuries in this 22-year experience, which included children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. This approach should be considered by otolaryngologists who care for children in the office setting.Level of evidence: 3-Retrospective review.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Oral Swabs Be Used to Diagnose Nontuberculous Mycobacterial Cervicofacial Lymphadenitis?

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-18 DOI: 10.1002/lary.32062

Samuel H Willemse, Luc H E Karssemakers, Marjolijn A E M Oomens, Willem H Schreuder, Jean-Pierre T F Ho, Marion Kolader, Robin van Houdt, Martijn van der Kuip, Gina R Buijsers, Jan de Lange, Jerome A Lindeboom

{"title":"Can Oral Swabs Be Used to Diagnose Nontuberculous Mycobacterial Cervicofacial Lymphadenitis?","authors":"Samuel H Willemse, Luc H E Karssemakers, Marjolijn A E M Oomens, Willem H Schreuder, Jean-Pierre T F Ho, Marion Kolader, Robin van Houdt, Martijn van der Kuip, Gina R Buijsers, Jan de Lange, Jerome A Lindeboom","doi":"10.1002/lary.32062","DOIUrl":"https://doi.org/10.1002/lary.32062","url":null,"abstract":"Objective: We investigated the presence of mycobacteria in the oral cavity and oropharynx of children with nontuberculous mycobacterial (NTM) cervicofacial lymphadenitis compared to negative controls. Our aim was to evaluate whether oral cavity and oropharyngeal swab sampling could serve as a minimally invasive alternative to diagnostic sampling of excised lymph node tissue or punctate.Methods: Children who underwent surgery under general anesthesia due to a strong clinical suspicion of NTM cervicofacial lymphadenitis were enrolled in this multicenter cross-sectional study. The control group comprised children undergoing surgery under general anesthesia for reasons other than lymphadenopathy. The obtained oropharyngeal, dorsal tongue, and gingival swabs were subjected to mycobacterial polymerase chain reaction (PCR) analysis.Results: A total of 67 subjects were enrolled in this study, 31 of whom underwent surgery due to strong clinical suspicion of NTM cervicofacial lymphadenitis. Positive genus and Mycobacterium avium specific PCR results were found in one patient from the control group, and in none of the patients with (suspected) NTM cervicofacial lymphadenitis.Conclusion: Our in-house routine diagnostic PCR assay on oral and oropharyngeal swabs was not suitable as a minimally invasive alternative to diagnostic sampling of excised lymph node material or punctate. It remains unclear whether the oral cavity and oropharynx might be a portal of entry for mycobacteria in NTM cervicofacial lymphadenitis.Level of evidence: 2: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Case of Multi-etiology Conductive Hearing Loss from Cephalocele and Prolapsed Facial Nerve.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-18 DOI: 10.1002/lary.32055

Jane B Cleland, Kunjan B Patel, Paul M Bunch, Michele M Gandolfi

引用次数: 0

Oropharyngeal Cancer and the HPV Vaccine: Analysis of Social Media Content.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32076

Makayla R Matthews, Hasan Abdulbaki, William R Ryan, Trevor G Hackman, Zainab Farzal

{"title":"Oropharyngeal Cancer and the HPV Vaccine: Analysis of Social Media Content.","authors":"Makayla R Matthews, Hasan Abdulbaki, William R Ryan, Trevor G Hackman, Zainab Farzal","doi":"10.1002/lary.32076","DOIUrl":"https://doi.org/10.1002/lary.32076","url":null,"abstract":"Objective: Human Papillomavirus (HPV) is a well-documented cause of cervical, oropharyngeal, vaginal, vulvar, anal, and penile cancers, largely preventable with the HPV vaccine. We aim to characterize the most popular TikTok videos pertaining to HPV-associated cancers and vaccination with a focus on oropharyngeal cancer.Methods: Observational study of public social media content. The top 200 TikTok videos that appeared when searching for #HPVvaccine and #Gardasil individually were included and analyzed on the basis of creator characteristics, viewer reach, content, and accessibility. Characteristics of each video were counted if mentioned or listed in the caption.Results: Forty-four percent of videos originated from creators self-identifying as health care professionals and had an average of 129,525 (SD: 59,997) views. 72.0% were pro-vaccination, and 17.5% were specifically anti-vaccination. Only 14.0% mentioned all six types of HPV-related cancer (including oropharyngeal). Other mentions included HPV prevention (62.0%), transmission (31.0%), infection risk factors (12.0%), and vaccine side effects (23.0%), while only 7.5% specifically regarded vaccines as safe. 35.5% of creators identified the Gardasil vaccine as appropriate for both men and women.Conclusions: Medical professionals have a strong presence on TikTok and overwhelmingly support HPV vaccination for cancer prevention but miss the mark in associating high-risk HPV with non-cervical cancers, addressing vaccine safety, and clearly defining who is eligible for the HPV vaccine/Gardasil. Despite oropharyngeal cancer eclipsing cervical cancer as the most common HPV-related malignancy, there is still a dearth of online patient education about this disease and the potential treatment/prevention measures available.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolution of Multidisciplinary Head and Neck Cancer Treatment.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32064

Kevin J Contrera, Pooja D Reddy, Vanessa Helou, Jeffrey N Myers, Heath D Skinner, Renata Ferrarotto, Eugene N Myers

{"title":"The Evolution of Multidisciplinary Head and Neck Cancer Treatment.","authors":"Kevin J Contrera, Pooja D Reddy, Vanessa Helou, Jeffrey N Myers, Heath D Skinner, Renata Ferrarotto, Eugene N Myers","doi":"10.1002/lary.32064","DOIUrl":"https://doi.org/10.1002/lary.32064","url":null,"abstract":"Objective: The management of head and neck squamous cell carcinoma (HNSCC) has substantially changed over the past two centuries. This review explores the historical progression of HNSCC management focusing on the multidisciplinary treatment paradigm.Data sources: This review synthesizes data from historical and current clinical trials, books, scientific reports, public documents, and other written material relevant to HNSCC management.Review methods: Historical review.Results: Although surgery was initially the only treatment available, radiation, chemotherapy, and immunotherapy have expanded the treatment landscape for HNSCC. Despite continuous evolution, modern treatment of HNSCC remains rooted in a multidisciplinary, personalized approach. This review highlights the clinical pioneers who established the standards of care and the landmark trials that progressed it. The optimal timing, application, and extent of different treatments, including the role of neoadjuvant therapy, remain under study. Immunotherapy has improved outcomes for recurrent/metastatic mucosal HNSCC and cutaneous malignancies, although its role in the curative management of mucosal HNSCC is still materializing.Conclusions: Surgery and radiotherapy have made continued gains in reducing morbidity and treatment sequala. Platinum-based chemotherapy remains the mainstay of systemic therapy for HNSCC, but there has been accelerated growth in the application of immunotherapy and targeted therapy. Comprehensive head and neck cancer care depends on multidisciplinary management, usually requiring multiple treatment modalities while individualizing both the therapies and treatment goals. Additional phase III trials are needed to further define the optimal treatments for HNSCC.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Application of Bone Marrow Mesenchymal Stem Cells After Subglottic Injury: Animal Study.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32070

Ezzeldin Ibrahim, Alaa Hazem Gaafar, Radwa Ali Mehanna, Samar El Achy, Ashraf Hamza Taha

{"title":"Effect of Application of Bone Marrow Mesenchymal Stem Cells After Subglottic Injury: Animal Study.","authors":"Ezzeldin Ibrahim, Alaa Hazem Gaafar, Radwa Ali Mehanna, Samar El Achy, Ashraf Hamza Taha","doi":"10.1002/lary.32070","DOIUrl":"https://doi.org/10.1002/lary.32070","url":null,"abstract":"Objective: Acquired laryngotracheal stenosis (LTS) is notorious for recurrence and the need for repeated procedures to achieve a satisfactory outcome. This limitation is, at least partly, due to the suboptimal healing process of the airway following trauma. Consequently, innovative interventions are required to improve wound healing, which would reflect on improving the outcome of the management of LTS. The objective of this study is to examine the effect of the application of BM-MSCs in preventing subglottic acute stenosis following trauma.Methods: Twenty-four Sprague-Dawley rats were divided into three equal groups (n = 8): two intervention groups and one control group. Subglottic trauma was performed in the three groups. In the intervention groups, bone marrow-derived mesenchymal stem cells (BM-MSCs) were applied either systemically (TS group) or via local injection (TL group). Subglottic specimens from the three groups were compared by histopathological appearance, lamina propria (LP) thickness, and luminal anteroposterior (AP) diameter.Results: An intense inflammatory reaction was observed in the control specimens, while a mild inflammatory reaction was detected in the two intervention groups. The LP thickness and the AP diameter were significantly different between the control group and the two intervention groups.Conclusions: In the present animal model, stem cell application, either systemic or local application, can mitigate subglottic inflammation and stenosis after trauma.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinguished Peer Reviewers 2024.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32075

Samuel H Selesnick

引用次数: 0

Getting the Feeling? The Salience of Music Emotion with a Cochlear Implant.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32045

David R Friedmann, Emily Spitzer, Joshua Horton, Daniel Jethanamest, David Landsberger

{"title":"Getting the Feeling? The Salience of Music Emotion with a Cochlear Implant.","authors":"David R Friedmann, Emily Spitzer, Joshua Horton, Daniel Jethanamest, David Landsberger","doi":"10.1002/lary.32045","DOIUrl":"https://doi.org/10.1002/lary.32045","url":null,"abstract":"Objective: Music, like all forms of art, seeks to communicate emotional content to its audience. The signal provided by cochlear implants (CI) does not faithfully represent the psychophysical relationships inherent in music; however, it is unknown whether targeted musical emotions are conveyed through electric only stimulation with a cochlear implant.Methods: Twenty musical excerpts for which there was concordance among normal hearing (NH) listeners as to the emotion conveyed: (1) happy, (2) sad, (3) scary, or (4) peaceful were presented to cochlear implant (CI) subjects (n = 20) and age-matched NH controls (n = 8) through a specifically designed iPad application. The musical clips were original recordings of western music from various musical genres but not widely familiar to participants. Subjects also completed a music background questionnaire.Results: CI users identified the target emotion in only 57% of excerpts compared with NH listeners who correctly identified the target emotion in 76.9% of excerpts. Musical excerpts with the target emotion of happy were recognized in 84% of cases by CI users compared with 75% among NH controls while the remaining target emotions were much more difficult for CI users compared with NH raters. Length of CI experience, speech perception scores, and musical training or listening habits did not correlate with performance on this task.Conclusions: Current CI technology and processing strategies do not convey the range of emotions conveyed in music as recognized by normal hearing subjects. This difficulty may explain the reported lack of interest many patients have in music after CI despite a passion for music before onset of hearing loss.Level of evidence: 3 Laryngoscope, 2025.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining the Minimum Number of Examined Lymph Nodes for N1b Papillary Thyroid Cancer Patients.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32067

Liu Xiao, Wei Zhang, Yu Ma, Lin Li, Bin Liu

{"title":"Determining the Minimum Number of Examined Lymph Nodes for N1b Papillary Thyroid Cancer Patients.","authors":"Liu Xiao, Wei Zhang, Yu Ma, Lin Li, Bin Liu","doi":"10.1002/lary.32067","DOIUrl":"https://doi.org/10.1002/lary.32067","url":null,"abstract":"Background: This study aimed to evaluate the correlation between the number of examined lymph nodes (eLNs) and postoperative residual lateral LN disease in patients with papillary thyroid cancer (PTC) and lateral nodal metastasis (N1b) and determine the minimal threshold for the eLNs.Methods: Patients diagnosed with unilateral N1b PTC who underwent total thyroidectomy with therapeutic LN dissection of the central and lateral compartments between January 2012 and December 2022 were included. Multivariate logistic regression analyses were performed to identify the threshold number of eLNs that independently influenced the risk of residual lateral LN disease.Results: Residual lateral LN disease was identified in 56 (5.4%) of 1042 T1-2 patients and 74 (12.3%) of 602 T3-4 patients. When analyzed as a continuous variable, the number of eLNs in the lateral neck was independently associated with a reduced risk of residual lateral LN disease in both T1-2 (OR: 0.93; 95% CI: 0.90-0.97; p < 0.001) and T3-4 patients (OR: 0.94; 95% CI: 0.91-0.97; p < 0.001). As a categorical variable, the risk of residual lateral LN disease continued to decrease significantly until the number of eLNs reached 34 in T1-2 patients and 46 in T3-4 patients.Conclusion: Comprehensive preoperative imaging for LN status and systematic compartmental dissection of the affected levels are critical in managing N1b PTC. To minimize the risk of residual lateral LN disease, the minimum recommended number of eLNs in the lateral neck is 34 for T1-2 patients and 46 for T3-4 patients.Level of evidence: 4-retrospective cohort study.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival Associations of Timely Postoperative Radiotherapy Among Head and Neck Cancer High-Risk Subgroups.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-17 DOI: 10.1002/lary.32074

Lisa M Velez Velez, Timothy V Corpuz, Luke C Schwetschenau, Angela Mazul, Sean T Massa

{"title":"Survival Associations of Timely Postoperative Radiotherapy Among Head and Neck Cancer High-Risk Subgroups.","authors":"Lisa M Velez Velez, Timothy V Corpuz, Luke C Schwetschenau, Angela Mazul, Sean T Massa","doi":"10.1002/lary.32074","DOIUrl":"https://doi.org/10.1002/lary.32074","url":null,"abstract":"Objective: Effective implementation of timely postoperative radiation therapy (PORT) as a quality metric for head and neck squamous cell carcinoma (HNSCC) care may reduce survival disparities in subgroups with the highest risk of mortality-advanced stage and Black race. We sought to determine if the association between timely PORT and survival varies among clinical and demographic high-risk subgroups.Methods: In this retrospective cohort study using the National Cancer Database 2004-2020, patients with HPV-negative HNSCC treated with surgery and PORT were identified. The association between PORT delay greater than 6 weeks with overall survival was assessed by Cox proportional hazards models with interaction effects for race, overall stage, and PORT delay.Results: Among 54,035 patients included in the study, 62% (33491) had PORT delays. Black patients were more likely to have PORT delays (aOR 1.19, 95% CI: 1.10-1.27). Timely PORT was only associated with improved survival for all stage I patients and White stage IV patients (predicted mortality risk 2.53, 95% CI: 2.34-2.74 versus 2.88, 95% CI: 2.67-3.09, referenced to White, stage I). After adjusting for covariates, timely PORT was estimated to be associated with inferior overall survival in Black patients with stage IV disease although with low precision (predicted mortality risk 3.24, 95% CI: 2.87-3.66, versus 2.71, 95% CI: 2.47-2.98, referenced to White, stage I).Conclusion: Timely, guideline-adherent PORT may not reduce survival disparities in Black patients, especially those with advanced stage disease, suggesting other interventions are needed to address this disparity.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0