Legal Medicine最新文献_第7页

Preliminary study of mixed traces on cigarette butts and non-self DNA transfer, persistence, prevalence and recovery in different forensic scenarios 烟头混合痕迹与非自体DNA在不同法医场景中的转移、持续、流行和恢复的初步研究。

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.legalmed.2026.102803

Denise Gianfreda , Beatrice Corradini , Gianmarco Ferri , Francesca Ferrari , Ilaria Borciani , Rossana Cecchi , Anna Laura Santunione

{"title":"Preliminary study of mixed traces on cigarette butts and non-self DNA transfer, persistence, prevalence and recovery in different forensic scenarios","authors":"Denise Gianfreda , Beatrice Corradini , Gianmarco Ferri , Francesca Ferrari , Ilaria Borciani , Rossana Cecchi , Anna Laura Santunione","doi":"10.1016/j.legalmed.2026.102803","DOIUrl":"10.1016/j.legalmed.2026.102803","url":null,"abstract":"<div><div>Recent studies focus on the different ways in which DNA can be transferred from and individual to another or to a surface.</div><div>This work investigates how mixed DNA profiles can be generated on items commonly collected at the crime scene, specifically on cigarette butts. The aim is to determine how biological material exchanged during intimate contact (kissing or sharing a cigarette) can be secondarily transferred onto cigarettes, and how long non-self DNA persists and remains recoverable under different conditions and time intervals.</div><div>The preliminary experimental study involved one investigative couple: each volunteer smoked a cigarette at fixed intervals after kissing (from 0 to 120 min) and both partners smoked a shared cigarette.</div><div>DNA was extracted from cigarette butts immediately and after 30 days using the QIAamp DNA Investigator Kit on the QIAcube Connect. Quantification was performed with PowerQuant® System Kit and genetic profiles were obtained using PowerPlex® Fusion and Y23 Kits.</div><div>Results showed non-self DNA alleles up to 2 h after kissing, even in non-immediate extractions, partial Y-STRs profiles in female butts after 1 h: individual variability and degradation made interpretations harder. Based on preliminary findings, the study will be expanded including more partner pairs, more smoking devices and longer processing timeframes.</div><div>Our findings suggest the possibility of reconstructing transfer scenarios leading to mixed DNA traces on cigarette butts and of assessing a time window within which non-self DNA can be secondarily transferred to the cigarette, highlighting the impact of processing times and smoking device on DNA results.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102803"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological risk profiles in suicide: The forensic value of hair-based substance detection 自杀的毒理学风险概况：基于毛发的物质检测的法医价值。

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.legalmed.2026.102805

L. Tomassini , M. Lancia , R. Scendoni , A. Raimondi , A. Gili , K. Aroni , C. Gambelunghe

{"title":"Toxicological risk profiles in suicide: The forensic value of hair-based substance detection","authors":"L. Tomassini , M. Lancia , R. Scendoni , A. Raimondi , A. Gili , K. Aroni , C. Gambelunghe","doi":"10.1016/j.legalmed.2026.102805","DOIUrl":"10.1016/j.legalmed.2026.102805","url":null,"abstract":"<div><h3>Introduction</h3><div>Suicide is a major global cause of premature mortality and a critical public health concern. Chronic alcohol misuse and illicit drug use are well-established risk factors, but conventional post-mortem toxicology frequently fails to detect long-term substance exposure. Hair analysis represents a valuable forensic tool, enabling the reconstruction of pre-mortem behavioral patterns and offering insight into chronic substance use and its association with suicidal behavior.</div></div><div><h3>Materials and methods</h3><div>This retrospective study examined 74 suicide cases (59 males, 15 females) from 2023 to 2024. Hair samples were analyzed for ethyl glucuronide to assess chronic alcohol consumption and screened for psychoactive substances. Demographic data, previous suicide attempts, and methods of suicide were also considered.</div></div><div><h3>Results</h3><div>Chronic excessive alcohol use was identified in 75.7% of cases, with higher prevalence in females (93.3%) and individuals aged ≥ 65 years (88.9%). Illicit drugs were detected in 25.7% of cases, mainly cocaine (23.0%) and cannabis (17.6%). Polydrug use was found in 66.2% of subjects. Psychoactive drugs were frequently present: benzodiazepines in 63.5%, antidepressants in 36.5%, and antipsychotics in 10.8%. A prior suicide attempt was reported in 23.0% of individuals, with the highest rate among adolescents and young adults (29.4%).</div></div><div><h3>Discussion and conclusion</h3><div>These findings highlight age- and sex-specific toxicological patterns and support the forensic relevance of hair analysis in detecting chronic substance use. Integrating toxicological, clinical, and demographic data enhances post-mortem risk profiling and informs suicide prevention strategies targeting high-risk, underserved populations.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102805"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forensic implications of early postmortem changes in skeletal, cardiac, and smooth muscles following acute colchicine intoxication in rats 大鼠急性秋水仙碱中毒后早期死后骨骼、心脏和平滑肌变化的法医意义

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.legalmed.2026.102780

Dina Y. Hegab , Nabela I. El-Sharkawy , Gihan G. Moustafa , Taghred M. Saber , Mohamed M.M. Metwally , Yasmina M. Abd-Elhakim

{"title":"Forensic implications of early postmortem changes in skeletal, cardiac, and smooth muscles following acute colchicine intoxication in rats","authors":"Dina Y. Hegab , Nabela I. El-Sharkawy , Gihan G. Moustafa , Taghred M. Saber , Mohamed M.M. Metwally , Yasmina M. Abd-Elhakim","doi":"10.1016/j.legalmed.2026.102780","DOIUrl":"10.1016/j.legalmed.2026.102780","url":null,"abstract":"<div><div>Acute colchicine (CHC) poisoning can be fatal due to its narrow therapeutic index, involvement of multiple organ systems, and the lack of a specific antidote. This study investigated early postmortem biochemical, histopathological, and immunohistochemical changes in skeletal, smooth, and cardiac muscles within 24 h of death following acute CHC intoxication in rats. Sixty male Sprague Dawley rats were divided into control and CHC-intoxicated groups (n = 30 each). Controls received saline and were euthanized humanely; CHC rats received a single oral lethal dose (4.9 mg/kg b.wt) and died naturally within 8–10 h. Samples from the gastrocnemius muscle, intestine, and heart were collected at 0, 3, 6, 12, and 24 h postmortem. Tissue homogenates were analyzed for pH, CRP, Na<sup>+</sup>, K<sup>+</sup>, Ca<sup>++</sup>, LDH, ATP, glycogen, and lactic acid. Immunohistochemistry assessed cytochrome <em>c</em> oxidase (CcO) and Na<sup>+</sup>, K<sup>+</sup>-ATPase (NKA) expression. CHC intoxication significantly altered most biochemical markers in a time-dependent manner. pH, Na<sup>+</sup>, ATP, and glycogen decreased, while CRP, LDH, Ca<sup>++</sup>, K<sup>+</sup>, and lactic acid increased. CRP rose in the gastrocnemius and intestine but remained unchanged in the heart. CcO and NKA staining did not differ significantly between groups, though both declined with increasing postmortem interval (PMI). Several markers showed significant CHC-PMI interactions across tissues. Conclusively, acute CHC intoxication induced time-dependent biochemical changes in vital muscle tissues within 24 h PM. These findings underscore the forensic significance of understanding both toxicant-specific effects and PMI-related dynamics, enhancing the interpretation of muscle-based markers in suspected CHC poisoning cases.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102780"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forensic DNA phenotyping: Prediction of eye and hair colour and allelic frequency estimation in the Italian population for the development of a reference dataset 法医DNA表型：预测眼睛和头发的颜色和等位基因频率估计在意大利人口的参考数据集的发展。

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.legalmed.2026.102802

Giulia Fazio , Denise Gianfreda , Sara Amurri , Beatrice Corradini , Gianmarco Ferri , Francesca Ferrari , Ilaria Borciani , Carla Bini , Rossana Cecchi , Susi Pelotti , Anna Laura Santunione

{"title":"Forensic DNA phenotyping: Prediction of eye and hair colour and allelic frequency estimation in the Italian population for the development of a reference dataset","authors":"Giulia Fazio , Denise Gianfreda , Sara Amurri , Beatrice Corradini , Gianmarco Ferri , Francesca Ferrari , Ilaria Borciani , Carla Bini , Rossana Cecchi , Susi Pelotti , Anna Laura Santunione","doi":"10.1016/j.legalmed.2026.102802","DOIUrl":"10.1016/j.legalmed.2026.102802","url":null,"abstract":"<div><div>In recent years, Forensic DNA Phenotyping (FDP) has emerged as an innovative “DNA intelligence approach” aimed at predicting externally visible individual characteristics from biological traces collected at crime scenes or from biological samples of unidentified corpses or skeletal remains.</div><div>This study aims to analyse the allele frequency distribution of genetic markers involved in the prediction of eye and hair colour in an Italian population sample, to enhance the existing European dataset. A large cohort of Italian individuals with at least three generations of ancestry was recruited, ensuring representation of phenotypic variability. The 24 SNP markers included in the HIrisPlex panel were analysed using SNaPshot sequencing technique, and the genotypic data were uploaded to the FDP web tool validated for forensic use by the international VISAGE Consortium’s. This tool provides prediction probabilities for three eye colour categories (blue, brown, and intermediate) and four hair colour categories (black, blonde, brown, and red).</div><div>The results confirmed a high predictive accuracy for the Italian population as well; however, the complex genetic structure of intermediate phenotypic traits highlights the need for novel prediction models that include genetic markers associated with complex phenotypes. The strong north–south European gradient in eye colour, along with the hypothesis that variation in eye colour is associated with skin pigmentation and UV environmental adaptation, underscores the importance for further research. These should focus on novel genetic markers to refine the European dataset, in which the Italian population may be included to enhance the accuracy of predictive models.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102802"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three cases of drug-related death during treatment for stimulant-induced psychosis 兴奋剂性精神病治疗期间药物相关性死亡3例

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.legalmed.2026.102789

Tadashi Nishio, Yoko Toukairin, Tomoaki Hoshi, Tomomi Arai, Makoto Nogami

{"title":"Three cases of drug-related death during treatment for stimulant-induced psychosis","authors":"Tadashi Nishio, Yoko Toukairin, Tomoaki Hoshi, Tomomi Arai, Makoto Nogami","doi":"10.1016/j.legalmed.2026.102789","DOIUrl":"10.1016/j.legalmed.2026.102789","url":null,"abstract":"<div><div>Long-term use of stimulant drugs can cause schizophrenia-like psychotic symptoms including hallucinations and delusions in the syndrome known as stimulant-induced psychosis. Therefore, treatment for stimulant-induced psychosis follows the approach for schizophrenia and primarily involves the use of antipsychotic drugs that antagonize dopamine release. However, multiple studies suggest that pharmacotherapy and psychosocial therapy for stimulant-induced psychosis have limited therapeutic efficacy, leading to poor long-term prognosis characterized by recurrence and chronicity of psychiatric symptoms, social isolation, and an extremely high risk of suicide. Here we report three forensic autopsy cases of patients with stimulant-induced psychosis whose cause of death was considered to be due to overdose of prescription medications. All three patients had received treatment with antipsychotic drugs during their lifetimes, but they had poor medication adherence and had discontinued treatment. Two deaths were directly due to drug overdose (Case 1, chlorpromazine and quetiapine poisoning; Case 2, zotepine and tramadol poisoning). In the third case, the direct cause of death was hanging, but markedly elevated blood concentrations of quetiapine and trazodone suggested that drug intoxication may have contributed to death. Elucidating the pathophysiology of stimulant-induced psychosis and selecting and developing effective treatments are essential, and long-term mental health care and social support to prevent isolation are crucial for preventing unfortunate deaths.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102789"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective analysis of suicide cases in the province of Ferrara 费拉拉省自杀案例的回顾性分析

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.legalmed.2026.102793

Luca Diani , Giada Rovito , Irene Pradelle , Matilde Ruju , Rosa Maria Gaudio , Margherita Neri

{"title":"Retrospective analysis of suicide cases in the province of Ferrara","authors":"Luca Diani , Giada Rovito , Irene Pradelle , Matilde Ruju , Rosa Maria Gaudio , Margherita Neri","doi":"10.1016/j.legalmed.2026.102793","DOIUrl":"10.1016/j.legalmed.2026.102793","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2016, the Postgraduate School of Forensic Medicine of the University of Ferrara presented a paper at the Annual Congress of the AAFS that analyzed some characteristics of suicides in the territory of the Province of Ferrara between 1996 and July 2016. This presentation is intended to stand as an ideal follow-up to that work.</div><div>Since 2017, the number of suicides in Italy has been progressively decreasing and peaked in 2021 (0.40 per 10,000 inhabitants). In Emilia-Romagna, available data confirm a steady decline in the number of suicides since 2001.</div></div><div><h3>Materials and methods</h3><div>Records collecting necrosectorial activity of the Institute were retrospectively analyzed. During the period between August 2016 and April 2025, about 1000 autopsies were performed, 153 of which involved suicide cases. For each of these autopsies, factors regarding the people who committed suicide, as well as the suicide method and the type of activity carried out by the Institute pathologists were examined.</div></div><div><h3>Results and discussion</h3><div>Among deaths by suicide, 77% are male (118 vs 35), with percentages not dissimilar to those between 1996 and 2016.</div><div>The most frequently used suicide method is confirmed to be hanging (49%), followed by the use of firearms (15.6%) and precipitation (9.8%).</div><div>Suicide cases come to the attention of the Institute overwhelmingly at the request of the Judicial Authority (87.2%) with judicial autopsy performed in 60% of cases.</div><div>Thus, the data collected show that suicide trends have not changed over the past nine years and are in line with national data.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"81 ","pages":"Article 102793"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of a 200-SNP panel for individual identification and evaluation of genotyping performance using isolated cells 设计200-SNP面板，用于分离细胞的个体鉴定和基因分型性能评估

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.legalmed.2025.102759

Ryo Namba , Masaru Asari , Yuta Takahashi , Chisato Hoshina , Kanae Mori , Katsuhiro Okuda , Keiko Shimizu

{"title":"Design of a 200-SNP panel for individual identification and evaluation of genotyping performance using isolated cells","authors":"Ryo Namba , Masaru Asari , Yuta Takahashi , Chisato Hoshina , Kanae Mori , Katsuhiro Okuda , Keiko Shimizu","doi":"10.1016/j.legalmed.2025.102759","DOIUrl":"10.1016/j.legalmed.2025.102759","url":null,"abstract":"<div><div>We developed a novel next-generation sequencing-based genotyping panel for 200 single nucleotide polymorphism (SNP) loci, and evaluated the genotyping performance when using small amounts of DNA. We analyzed 1144 previously characterized autosomal SNPs, and selected 200 informative SNPs, based on the allele coverage ratio (ACR) and amplicon size, to minimize inter-locus depth of coverage imbalances. Analysis of the 200 SNPs was performed using 1 ng of DNA from 66 Japanese individuals. The average ACR of most of the SNP loci ranged from 0.85 to 0.95. We also detected 200-SNP genotypes using diluted DNA samples (500, 250, 125, 60, 30, and 15 pg/reaction), and found high ACRs and concordance from less than 100 pg of DNA: the concordances were as high as 95.7 % and 88.0 %, respectively, when 60 and 30 pg of DNA were used. Our method also showed higher inhibitory tolerance than other methods when humic acid was added to the initial amplification reaction for SNP genotyping. When genotyping in the presence of 10 ng/µL humic acid, no SNP profiles were detected, but profiles with more than 99 % concordance were recovered on addition of bovine serum albumin. The genotyping performance was also evaluated using small groups of cells (10, 5, 4, 3, and 2 cells/reaction) isolated by micromanipulation with micro-tweezers. High concordance was identified on analysis of three cells (96.1 %). The use of isolated cells allowed accurate determination of the sensitivity, indicating that our method is highly sensitive and can provide informative SNP profiles for individual identification.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"80 ","pages":"Article 102759"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MARK4 as a novel biomarker of acute myocardial ischemia-induced sudden cardiac death MARK4作为急性心肌缺血心源性猝死的新生物标志物

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-02-01 Epub Date: 2025-12-10 DOI: 10.1016/j.legalmed.2025.102766

Xing Ye , Guanghui Hong , Runting Dou , Zhimin Wang , Zijie Lin , Yu Shao , Jiajia Yang , Junyi Lin , Yiwen Shen

{"title":"MARK4 as a novel biomarker of acute myocardial ischemia-induced sudden cardiac death","authors":"Xing Ye , Guanghui Hong , Runting Dou , Zhimin Wang , Zijie Lin , Yu Shao , Jiajia Yang , Junyi Lin , Yiwen Shen","doi":"10.1016/j.legalmed.2025.102766","DOIUrl":"10.1016/j.legalmed.2025.102766","url":null,"abstract":"<div><div>Postmortem diagnosis of acute myocardial ischemia (AMI), especially early myocardial ischemia (EMI; ischemic insults occurring within minutes to a few hours, <6h), remains challenging due to nonspecific morphological changes. Microtubules affinity regulated kinase 4 (MARK4) is a serine/threonine kinase involved in the regulation of microtubule dynamics through the phosphorylation of microtubule-associated proteins. Emerging research has highlighted the significant involvement of MARK4 in cardiovascular diseases. The aim of this study is to evaluate whether MARK4 can serve as a postmortem diagnostic marker for sudden cardiac death (SCD) resulting from AMI. Using a mouse AMI model, hypoxia-treated AC16 cardiomyocytes, and human autopsy material (36 SCD hearts: 18 EMI, 18 myocardial infarction (MI) and 20 noncardiac controls), MARK4 expression was assessed by immunohistochemistry and western blotting, and diagnostic performance was examined by receiver operating characteristic (ROC) analysis. MARK4 expression increased with ischemia/hypoxia in vivo and in vitro, peaking at 3 h. Human myocardial MARK4 was significantly elevated in EMI and MI versus controls, independently of age and postmortem interval. ROC analysis discriminated EMI from controls with an AUC of 0.8028 for MARK4, outperforming cardiac troponin I (cTnI; AUC = 0.7556), and combining both markers improved diagnostic accuracy. In hypoxic AC16 cells, MARK4 overexpression increased cytochrome <em>c</em> and phosphorylated Drp1, suggesting a role in ischemia-related mitochondrial dysfunction. These results indicate MARK4 is a promising postmortem biomarker for AMI-induced SCD.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"80 ","pages":"Article 102766"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clitoral epidermal cyst after excision in an 8-year-old girl: the pivotal role of forensic medicine in the detection and care of female genital mutilation (FGM)-related complications 1例8岁女童阴蒂表皮囊肿切除术后：法医学在女性生殖器切割（FGM）相关并发症检测和护理中的关键作用

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-02-01 Epub Date: 2025-11-17 DOI: 10.1016/j.legalmed.2025.102757

Anaïs Du Fayet de la Tour , Quentin Ballouhey , Pierre Raguin , François Paraf

{"title":"Clitoral epidermal cyst after excision in an 8-year-old girl: the pivotal role of forensic medicine in the detection and care of female genital mutilation (FGM)-related complications","authors":"Anaïs Du Fayet de la Tour , Quentin Ballouhey , Pierre Raguin , François Paraf","doi":"10.1016/j.legalmed.2025.102757","DOIUrl":"10.1016/j.legalmed.2025.102757","url":null,"abstract":"<div><h3>Background</h3><div>Female genital mutilation (FGM) refers to socio-cultural practices involving the partial or total removal of a woman’s external genitalia for non-medical purposes. These procedures are associated with numerous short- and long-term physical and psychological complications. While such complications are relatively well documented in adults, pediatric cases remain insufficiently reported. Forensic physicians are often the first – and sometimes the only – healthcare providers to detect and document these complications, particularly in asylum contexts.</div></div><div><h3>Case presentation</h3><div>We report the case of an 8½-year-old Guinean girl with a history of type IIb FGM, examined by a forensic physician during an asylum application. The medico-legal examination revealed a 3 cm mobile mass at the clitoral site, causing pelvic pain and urinary dysfunction. Her father had allegedly threatened to perform a second excision. Protective measures were implemented in coordination with child welfare authorities before surgical intervention, which resulted in complete resection of the clitoral mass. Histopathology confirmed the diagnosis of an epidermoid cyst.</div></div><div><h3>Conclusions</h3><div>This case underscores the critical role of forensic physicians in identifying rare pediatric complications of FGM and initiating both protective and therapeutic interventions. By enabling surgical treatment and preventing long-term psychological harm, it highlights the integrative function of forensic medicine at the intersection of health, law, and child protection.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"80 ","pages":"Article 102757"},"PeriodicalIF":1.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autopsy case of sudden infant death caused by cardiac fibroma 心脏纤维瘤致婴儿猝死尸检一例。

IF 1.4 4区医学

Legal Medicine Pub Date : 2026-02-01 Epub Date: 2025-11-23 DOI: 10.1016/j.legalmed.2025.102760

Wataru Irie, Fumiko Satoh, Chizuko Sasaki, Eriko Ochiai, Maho Kondo, Satoshi Kamogawa, Yoshiya Saito

引用次数: 0