Luminescence最新文献_第5页

A Quantitative Analysis of Aspirin, Telmisartan, and Bisoprolol in Spiked Human Plasma Using Green Spectrofluorimetric Analysis 用绿色荧光光谱法定量分析加标人血浆中阿司匹林、替米沙坦和比索洛尔

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-18 DOI: 10.1002/bio.70149

Osama I. Abdel Sattar, Hamed H. M. Abuseada, Sherif Ramzy, Mahmoud M. Abuelwafa

{"title":"A Quantitative Analysis of Aspirin, Telmisartan, and Bisoprolol in Spiked Human Plasma Using Green Spectrofluorimetric Analysis","authors":"Osama I. Abdel Sattar, Hamed H. M. Abuseada, Sherif Ramzy, Mahmoud M. Abuelwafa","doi":"10.1002/bio.70149","DOIUrl":"https://doi.org/10.1002/bio.70149","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, precise and straightforward spectrofluorimetric method was developed for the determination of aspirin, telmisartan, and bisoprolol in spiked human plasma. Bisoprolol was measured directly by detecting its native fluorescence spectra at 301 nm following excitation at 230 nm, with no interference from aspirin or telmisartan. However, direct fluorescence detection of aspirin and telmisartan proved challenging because their native emission spectra at 406 and 375 nm overlapped. As a result, aspirin and telmisartan were measured utilizing synchronous fluorescence spectroscopy coupled with first-derivative spectroscopy, allowing for the entire resolution of their overlapping spectra and the measurement of aspirin and telmisartan at 416 and 349 nm, respectively. The method was validated according to the requirements outlined in ICH M10 for bioanalytical method validation. The approach demonstrated satisfactory linearity in the working ranges of 30–1000 ng/mL for aspirin, 50–900 ng/mL for telmisartan, and 75–1300 ng/mL for bisoprolol. The method was accurate and precise, and it was effectively used to measure the studied drugs in spiked plasma with minimal matrix influence. The method's greenness was further evaluated using the Green Analytical Procedure Index and the Analytical GREEnness metrics. The results showed that the employed procedure was environmentally friendly.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Judd–Ofelt Parameters for LiGd2-XYx:Eu3+ O3 Nanophosphor Synthesis by Combustion Method With Glycine as Fuel for Near UV Light Emitting Diode 甘氨酸为燃料燃烧法制备近紫外发光二极管用lid2 - xyx:Eu3+ O3纳米磷光体Judd-Ofelt参数的测定

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-13 DOI: 10.1002/bio.70129

Milind A. Patwardhan, Ritesh L. Kohale, Ritesh K. Jumale, Sarika A. Khapre, Rujuta K. Joshi, A. N. Yerpude

{"title":"Determination of Judd–Ofelt Parameters for LiGd2-XYx:Eu3+ O3 Nanophosphor Synthesis by Combustion Method With Glycine as Fuel for Near UV Light Emitting Diode","authors":"Milind A. Patwardhan, Ritesh L. Kohale, Ritesh K. Jumale, Sarika A. Khapre, Rujuta K. Joshi, A. N. Yerpude","doi":"10.1002/bio.70129","DOIUrl":"https://doi.org/10.1002/bio.70129","url":null,"abstract":"<div>\u0000 \u0000 <p>This paper introduces a combustion synthesis method utilizing glycine as an eco-friendly fuel for the synthesis of LiGd₂₋ₓYₓ:Eu<sup>3+</sup>O₃ nanophosphors. Glycine, being a naturally occurring amino acid, serves as a sustainable, renewable, and low-emission alternative to conventional fuels, minimizing the environmental impact of the synthesis process. The research focuses on analyzing Judd–Ofelt (JO) parameters to explore the luminescent properties and optical performance of the nanophosphors, with a specific emphasis on their application in near-ultraviolet (UV) light-emitting diodes (LEDs). The combustion method employed produces nanophosphors with exceptional optical characteristics while reducing both energy consumption and harmful emissions. The study includes the synthesis process, structural characterization, and photoluminescence analysis of the LiGd₂₋ₓYₓ:Eu<sup>3+</sup>O₃ nanophosphors. By applying JO theory, the JO parameter analysis provides valuable insights into the luminescent behavior, enabling the optimization of optical properties for improved performance in near-UV LED applications. The findings highlight the importance of JO parameter analysis in refining the luminescent efficiency of these nanophosphors. Moreover, the use of the combustion technique promotes the development of innovative materials for next-generation optoelectronic devices. This work contributes to the understanding of nanophosphor synthesis and offers potential solutions for energy-efficient, environmentally friendly lighting, addressing the increasing demand for sustainable technologies in lighting and optoelectronics.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green and Sensitive Investigation for Estimation of Anticancer Medication in Raw Material and Dosage Form: Greenness Assessment Consideration 抗癌药物原料和剂型评价的绿色敏感研究：绿色评价的考虑

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-10 DOI: 10.1002/bio.70141

Samah Abo El Abass, Manal A. Alossaim, Taibah Aldakhil, Alanoud M. Aldawsari, Fay F. Alanzi

{"title":"Green and Sensitive Investigation for Estimation of Anticancer Medication in Raw Material and Dosage Form: Greenness Assessment Consideration","authors":"Samah Abo El Abass, Manal A. Alossaim, Taibah Aldakhil, Alanoud M. Aldawsari, Fay F. Alanzi","doi":"10.1002/bio.70141","DOIUrl":"https://doi.org/10.1002/bio.70141","url":null,"abstract":"<div>\u0000 \u0000 <p>Larotrectinib or VITRAKVI is a first-generation pan–tropomyosin-related kinase (TRK) inhibitor. It is a highly selective, tumor-agnostic agent which has been approved in both adult and pediatric patients. Three different analytical methods for estimation of such important drug were developed. Two simple spectrophotometric methods were developed: Method I involves measuring the absorbance of different concentrations of the larotrectinib at 264 nm in concentrations ranging from 2 to 15 μg/mL in ethanol while first derivative peak amplitude (Method II) was derived and measured at 278 nm in concentration ranges from 2 to 15 μg/mL. A spectrofluorimetric technique was carried out by creating an ion pair complex through the interaction of larotrectinib with eosin Y in the presence of a Britton–Robinson buffer at pH 3.5. The fluorescence quenching of the resulting complex was then detected at 535 nm as the emission peak following excitation at 265 nm. The spectrofluorimetric technique exhibited high sensitivity and linearity across concentration ranging between 0.5 and 10 μg/mL. These three methods were effectively utilized to quantify larotrectinib in both its raw form and its pharmaceutical formulation. Greenness of the developed methodologies was concerned and evaluated via three different tools including analytical ecoscale, green analytical procedure index (GAPI), and analytical greenness metric approach (AGREE).</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoquinoline-Fused Benzimidazoles Based Highly Selective Fluorogenic Receptors for Detection of Cu2+, Fe3+, and Cl− Ions: Cytotoxicity and HepG2 Cancer Cell Imaging 基于异喹啉融合苯并咪唑的高选择性荧光受体检测Cu2+， Fe3+和Cl−离子：细胞毒性和HepG2癌细胞成像

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-07 DOI: 10.1002/bio.70137

Parvathavarthini Murugaperumal, Venkatramani Sriram, Sengottuvelan Nallathambi, Siva Ayyanar, Ashokkumar Balasubramaniem

{"title":"Isoquinoline-Fused Benzimidazoles Based Highly Selective Fluorogenic Receptors for Detection of Cu2+, Fe3+, and Cl− Ions: Cytotoxicity and HepG2 Cancer Cell Imaging","authors":"Parvathavarthini Murugaperumal, Venkatramani Sriram, Sengottuvelan Nallathambi, Siva Ayyanar, Ashokkumar Balasubramaniem","doi":"10.1002/bio.70137","DOIUrl":"https://doi.org/10.1002/bio.70137","url":null,"abstract":"<div>\u0000 \u0000 <p>An efficient isoquinoline-fused benzimidazole–based “turn-on” fluorescence receptor 9,10-bis(2-phenylhydrazineyl)-7H-benzo[de]imidazo[2,1-a]isoquinolin-7-one <b>OXPH(ANQ)</b> and “turn-off” fluorescence receptor 9,10-bis((3-(1H-imidazol-1-yl)propyl)amino)-7H-benzo[de]imidazo[2,1-a]isoquinolin-7-one <b>OXPID(ANQ)</b> were prepared and characterized by various spectral techniques. The sensing behavior of receptors was demonstrated by UV–vis and fluorescence experiments, and naked-eye detection exhibited prominent visual emission color change toward Cu<sup>2+</sup>/Cl<sup>−</sup> and Fe<sup>3+</sup> over other testing cations/anions in DMSO:water (9:1, ν/v) solution. The 1:1 binding stoichiometry was confirmed by Job's plot, FT-IR, mass spectral titration, and also DFT studies with target ions as evidence for the binding nature of <b>OXPH(ANQ)</b>/<b>OXPID(ANQ)</b> with Cu<sup>2+</sup>/Cl<sup>−</sup> and Fe<sup>3+</sup> ions, respectively. Limits of detection for <b>OXPH(ANQ)</b> with Cu<sup>2+</sup>/Cl<sup>−</sup> ions were of 4.50 and 4.91 μM, and <b>OXPID(ANQ)</b> with Fe<sup>3+</sup> ions were of 5.06 μM. Interestingly, chemosensors <b>OXPH(ANQ)</b>/<b>OXPID(ANQ)</b> applied to intracellular image of Cu<sup>2+</sup>/Cl<sup>−</sup> and Fe<sup>3+</sup> ions in living cells of HepG2 (Liver cancer cells) via confocal fluorescence microscopy technique at physiological environmental and also utilized for antimicrobial activity.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Simple Methoxyquinoline-Based Ratiometric Fluorescent Probe for Specific Detection of Hydrogen Peroxide in Living Cells and Zebrafish 一种简单的基于甲氧基喹啉的比例荧光探针用于活细胞和斑马鱼中过氧化氢的特异性检测

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-05 DOI: 10.1002/bio.70105

Xinyu Cai, Xinke Li, Wenzhai Li, Tingyi Yan, Caiyun Liu, Xiaodi Rong, Wenlong Sheng, Baocun Zhu

引用次数: 0

Label-Free Spectrofluorometric Method for Simultaneous Estimation of Methocarbamol and Aspirin in Biological and Pharmaceutical Matrices: Whiteness and Greenness Evaluation 同时测定生物和药物基质中甲氨基酚和阿司匹林的无标记荧光光谱法：白度和绿度评价

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-05 DOI: 10.1002/bio.70139

Heba Abd El-Aziz, Abdallah M. Zeid

{"title":"Label-Free Spectrofluorometric Method for Simultaneous Estimation of Methocarbamol and Aspirin in Biological and Pharmaceutical Matrices: Whiteness and Greenness Evaluation","authors":"Heba Abd El-Aziz, Abdallah M. Zeid","doi":"10.1002/bio.70139","DOIUrl":"https://doi.org/10.1002/bio.70139","url":null,"abstract":"<div>\u0000 \u0000 <p>A combination of methocarbamol and aspirin is commonly used for the treatment of acute musculoskeletal pain, such as low back and neck pain. Simultaneous analysis of these analytes in dosage forms and biofluids using rapid, sensitive, and selective methods would be highly beneficial. Herein, we report the first direct, label-free spectrofluorometric method for simultaneously quantifying methocarbamol (MET) and aspirin (ASP) in coformulated tablets and spiked human urine. The method utilizes excitation at 274 nm with independent emission detection at 300 nm for MET and 402 nm for ASP, using methanol as the diluting solvent. The assay was rectilinear over ranges of 0.10–0.80 μg/mL for MET and 0.05–0.50 μg/mL for ASP with detection limits of 14.9 and 10.6 ng/mL for MET and ASP, respectively. The method was validated in compliance with ICH regulations. The approach was applied efficiently to assay both analytes in their tablets and spiked human urine with high % recoveries (98%–103%) and low RSD (1.7%–3.3%). In addition, the sustainability and practicality of the developed method were assessed using the RGB-12 whiteness algorithm, indicating the whiteness of the developed method. The method's greenness was also confirmed using three greenness metrics that showed excellent eco-friendliness of the developed method.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic-Induced Toxicity in the HCT-116 Cell Model: A Luminesce-Based Study 在HCT-116细胞模型中探讨香薷和豆蔻对砷毒性的细胞保护作用：基于发光的研究

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-05 DOI: 10.1002/bio.70119

Vinod Kumar Nelson, Selva Kumar Radha Krishnan, Ayed A. Dera, Syed Parween Ali, M Yasmin Begum, Gowri Sankara Rao Burle, Punna Rao Suryadevara, Geetha Birudala

{"title":"Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic-Induced Toxicity in the HCT-116 Cell Model: A Luminesce-Based Study","authors":"Vinod Kumar Nelson, Selva Kumar Radha Krishnan, Ayed A. Dera, Syed Parween Ali, M Yasmin Begum, Gowri Sankara Rao Burle, Punna Rao Suryadevara, Geetha Birudala","doi":"10.1002/bio.70119","DOIUrl":"https://doi.org/10.1002/bio.70119","url":null,"abstract":"<div>\u0000 \u0000 <p>Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS that interacts with vital organs. Chelation therapy is currently recommended for arsenic toxicity. However, these treatment options are not specific and only target symptoms. Besides, they also show toxic effects and irreversibly damage crucial organs. Hence, there is an urgent need for a potential and safer therapeutic strategy that can prevent arsenic toxicity. Therefore, in this study, we have investigated SA and EC individually and in combination against arsenic toxicity in HCT-116 cells. The results obtained from various experiments revealed that both plant materials comparably inhibited arsenic-induced cellular damage by increasing the antioxidant function. Conversely, combining both plants showed even better cytoprotection against arsenic toxicity. The FT-IR and HPLC analysis of the active fractions revealed the presence of polyphenol compounds (ferulic acid and gallic acid) responsible for the pharmacological effect. This finding is unique because no cytoprotective impact has been reported yet on this combination.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Characterization of CaYSi2Al2O2N5:Eu2+ CaYSi2Al2O2N5:Eu2+ 的合成与表征

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70140

S. A. Fartode, Anoop P. Fartode, Tushar R. Shelke, S. J. Dhoble

引用次数: 0

Trio-Colored Appraisal of Microwave-Assisted Synthesis of Carbon Quantum Dots as a Fluorescence Turn Off Nanoprobe for Analyzing Ledipasvir in Tablets and Rat Feces: Study of Silymarin Impact on Excretion Recovery 微波辅助合成碳量子点荧光关闭纳米探针用于分析雷地帕韦片剂和大鼠粪便中的三色评价：水飞蓟素对排泄恢复的影响研究

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70138

Aya R. Ahmed, Haydi S. Elbordiny, Mai M. Elnaggar, Mahmoud A. Ragab, Tarek S. Belal, Sara I. Aboras

{"title":"Trio-Colored Appraisal of Microwave-Assisted Synthesis of Carbon Quantum Dots as a Fluorescence Turn Off Nanoprobe for Analyzing Ledipasvir in Tablets and Rat Feces: Study of Silymarin Impact on Excretion Recovery","authors":"Aya R. Ahmed, Haydi S. Elbordiny, Mai M. Elnaggar, Mahmoud A. Ragab, Tarek S. Belal, Sara I. Aboras","doi":"10.1002/bio.70138","DOIUrl":"https://doi.org/10.1002/bio.70138","url":null,"abstract":"<div>\u0000 \u0000 <p>The current work offers a rigorous way for the microwave-assisted synthesis of N and S doped carbon quantum dots (QDs). The latter are deemed highly sensitive and selective fluorescence sensors that were widely investigated in pharmaceutical analysis. Quenching of luminescence of the prepared QDs in lab fabricated sensor at λ emission = 418 nm after excitation at 370 nm was implemented to quantify the anti-HCV drug Ledipasvir (LDP). LDP showed a linear response within the dynamic range of 1–40 μM. The calculated LDP detection and quantification limits were 313.06 and 948.67 nM, respectively. Besides the analysis of LDP in bulk and commercial dosage form, the scope of application extended to evaluate the effect of the nutraceutical silymarin (liver support) on the excretion of LDP in rat feces. The compliance with the green and white analytical chemistry fundamentals is comprehensively investigated and compared with selected versatile reported procedures. Numerous prevalent metrics, namely, analytical eco-scale, AGREE, RGB12, RGB fast, BAGI, and complex GAPI, were employed. Our developed fluorometric procedure demonstrated great sensitivity, selectivity, and functionality that outperformed other sophisticated platforms. Thus, the utility of the depicted procedure in pharmaceutical analysis and studying pharmacokinetics aspects is profoundly proven.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dual-Channel Fluorescent Probe for Detection of Biothiols in Green and Further Differentiation of Cys/Hcy in Near-Infrared Regions 绿色生物硫醇双通道荧光探针检测及近红外区域Cys/Hcy的进一步分化

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70142

Yuyuan Sun, Hui Wang, Xulong He, Fan Liu, Yu Yuan, Xiaodong Jia, Gang Chen, Shuwei Zhang

引用次数: 0