Luminescence最新文献_第4页

Analytical-Quality-by-Design Fluoroprobes for Quantitation of Entecavir and Penciclovir in Spiked Human Plasma and Content Uniformity Testing: Insights of DNA Mismatching, Three-Colors Assessment and Sustainability Profiling

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-03 DOI: 10.1002/bio.70128

Sarah S. Saleh, Ahmed Samir, Omnia A. El-Naem

{"title":"Analytical-Quality-by-Design Fluoroprobes for Quantitation of Entecavir and Penciclovir in Spiked Human Plasma and Content Uniformity Testing: Insights of DNA Mismatching, Three-Colors Assessment and Sustainability Profiling","authors":"Sarah S. Saleh, Ahmed Samir, Omnia A. El-Naem","doi":"10.1002/bio.70128","DOIUrl":"https://doi.org/10.1002/bio.70128","url":null,"abstract":"<div>\u0000 \u0000 Entecavir and penciclovir are nucleoside-analog antiviral drugs structurally related to guanine that act by inhibiting the active viral replication process. Through this study, the quantitation of both drugs was carried out using two fluorescent probes, referred to as fluoroprobes. The first type was prepared by the addition of surfactants such as Tween 80 and sodium dodecyl sulfate (micelle-enhanced fluoroprobes), while the second type includes the formation of a tertiary complex of drug-terbium-DNA (Tb-DNA fluoroprobes). The preparation of the fluoroprobes was optimized using analytical quality by design (AQbD) via I-optimal design. A positive effect of the selected antiviral drugs on DNA mismatching was observed. The analytical procedures were validated according to ICH guidelines with a linearity range of 2.0–40.0 μM and 25.0–300.0 nM for micelle-enhanced and Tb-DNA fluoroprobes, respectively. The analytical procedures were evaluated in compliance with the three-color (GBW) assessments: greenness (using AGREE and ComplexGAPI metrics), blueness (using the BAGI tool), and whiteness (using the RGB algorithm). The sustainability profiles were established using the efficient-valid-green (EVG) framework. Both types of fluoroprobes were successfully applied to quantify entecavir and penciclovir in content uniformity testing and spiked human plasma as a simpler and cheaper alternative to hyphenated analytical techniques.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Hydrogen Peroxide Fluorescent Probe Monitored Butyric Acid Inhibition of Ferroptosis Process”

IF 3.2 4区化学

Luminescence Pub Date : 2025-03-02 DOI: 10.1002/bio.70144

引用次数: 0

Sensitive Assessment of Ketotifen Levels in Tablets and Plasma Using a Photoinduced Electron Transfer (PET) Inhibition Spectrofluorimetric Approach

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70134

Islam M. Mostafa, Abobakr A. Mohamed, Yaser Alahmadi, Ahmed K. B. Aljohani, Raed Alghamdi, Mahmoud A. Omar

{"title":"Sensitive Assessment of Ketotifen Levels in Tablets and Plasma Using a Photoinduced Electron Transfer (PET) Inhibition Spectrofluorimetric Approach","authors":"Islam M. Mostafa, Abobakr A. Mohamed, Yaser Alahmadi, Ahmed K. B. Aljohani, Raed Alghamdi, Mahmoud A. Omar","doi":"10.1002/bio.70134","DOIUrl":"https://doi.org/10.1002/bio.70134","url":null,"abstract":"<div>\u0000 \u0000 Ketotifen (KTF) is a type of asthma medication that is taken along with other antiasthma medications and may reduce the frequency, severity, and duration of asthma symptoms or attacks in children. This research introduces a novel spectrofluorimetric method for detecting KTF in its tablets and human blood plasma samples (spiked with KTF). The detection mechanism is based on a photoinduced electron transfer (PET) inhibition spectrofluorimetric approach for the sensitive detection of KTF different samples. By protonating KTF with 2.0 M acetic acid, the PET process is effectively inhibited, leading to a significant enhancement in the fluorescence intensity of KTF at 392 nm. This method detects KTF at values from 50 to 500 ng mL−1. The technique offers excellent detection and quantification limits of 13.41 and 40.65 ng mL−1, respectively. The range of the obtained percentage recoveries of KTF for spiked plasma samples was found to be 98.40% ± 1.30%–99.82% ± 1.20%, demonstrating the method's precision and reliability in diverse biological matrices. Also, the approach successfully evaluated KTF content uniformity in tablets without interference.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of 5,5′-Bi(1,10-Phenanthroline)-Based PVC Membrane Potentiometric Sensor for Silver Determination

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70136

Derya Güngördü Solğun, Nurcan Kaya, Gülşah Saydan Kanberoğlu, Mehmet Salih Ağirtaş

{"title":"Development of 5,5′-Bi(1,10-Phenanthroline)-Based PVC Membrane Potentiometric Sensor for Silver Determination","authors":"Derya Güngördü Solğun, Nurcan Kaya, Gülşah Saydan Kanberoğlu, Mehmet Salih Ağirtaş","doi":"10.1002/bio.70136","DOIUrl":"https://doi.org/10.1002/bio.70136","url":null,"abstract":"<div>\u0000 \u0000 In this study, the selectivity of the 5.5′-bi(1,10-phenanthroline) Compound (1) against Ag+ ions as a chemical sensor was investigated by both absorption and potentiometric methods. First, a 1 × 10−5 M solution of Compound (1) in acetonitrile was prepared. For the selectivity test, 1 × 10−2 M solutions of metal ions in acetonitrile were prepared. UV–visible absorption measurements were performed by adding metal ions to a 5.5′-bi(1,10-phenanthroline) compound at certain concentrations. Among the studied metal ions, it was found to be selective only against silver ions. In addition, solid-state contact polyvinylchloride (PVC) membrane electrodes prepared using 5.5′-bi(1,10-phenanthroline) as an ionophore were found to be selective against Ag+ ions among other ions. The optimum membrane composition of the measurement was determined as 3% 5.5′-bi(1,10-phenanthroline) + 32% PVC + 64% o-nitrophenyl octyl ether (o-NPOE) + 1% potassium tetrakis(4-chlorophenyl) borate (KTpClPB). The potentiometric properties of the silver selective electrode were determined as linear working range 1.0 × 10−7–1.0 × 10−3 M, detection limit 1.0 × 10−7 M, pH working range 3.23–9.08, and response time 3 s. Absorption and potentiometric methods confirm the selectivity towards silver ions. The IRC analysis of the silver-containing complex, performed using the DFT/B3LYP method with the LanL2DZ basis set, reveals an activation energy of approximately 0.002 Eh, with the transition state energy at −1.433173 Eh.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence Assisted Investigation of ERK1/2 Signaling in the Regulation of ATG3 and ATG5 Under Glutamine and Glucose Deprivation in Breast Cancer Cells

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70132

G. Gokulapriya, B. S. Lakshmi

{"title":"Fluorescence Assisted Investigation of ERK1/2 Signaling in the Regulation of ATG3 and ATG5 Under Glutamine and Glucose Deprivation in Breast Cancer Cells","authors":"G. Gokulapriya, B. S. Lakshmi","doi":"10.1002/bio.70132","DOIUrl":"https://doi.org/10.1002/bio.70132","url":null,"abstract":"<div>\u0000 \u0000 Extracellular signal–regulated kinases (ERKs) belong to the family of mitogen-activated protein kinases and transmit extracellular signals. The present study investigates ERK-mediated control of ATG3 and ATG5 as an adaptive response to glutamine and glucose deprivation, with the ERK–CREB axis implicated in this regulatory mechanism. Hyperactivation of ERKs plays a major role in tumor progression and differentiation. Phosphorylation of ERK1/2 at Thr202/Tyr204 residues was higher during glutamine and glucose starvation. Inhibition of ERK1/2 reduced cell viability, increased the presence of acidic vesicular organelle as observed by acridine orange fluorescence staining, and enhanced the expression levels of ATG3 and ATG5 proteins, signifying the protective role of ERK1/2 through control of ATG3 and ATG5 during starvation. The transcription factor CREB is activated by various kinases, including ERKs. Phosphorylation at Serine133 enables CREB to carry out transcriptional activation. Inhibition of ERK1/2 decreased CREB expression, suggesting that ERK1/2-dependent activation of CREB contributes to a reduction in cell viability and upregulation of ATG3 and ATG5 during glutamine and glucose starvation. Our findings collectively suggest that the ERK-mediated control of ATG3 and ATG5, in association with CREB, is essential for maintaining cell viability, serving as a stress adaptive strategy during glutamine and glucose starvation.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Sensing of Fe3+ in Acidic Environment by Carbon Dots Derived From Empty Fruit Bunch Biochar: Central Composite Design Optimization

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70127

Mohammed Abdullah Issa, Zaid H. Jabbar, Hamid Zentou, Reham Basim Khalaf

{"title":"Fluorescent Sensing of Fe3+ in Acidic Environment by Carbon Dots Derived From Empty Fruit Bunch Biochar: Central Composite Design Optimization","authors":"Mohammed Abdullah Issa, Zaid H. Jabbar, Hamid Zentou, Reham Basim Khalaf","doi":"10.1002/bio.70127","DOIUrl":"https://doi.org/10.1002/bio.70127","url":null,"abstract":"<div>\u0000 \u0000 A rapid, eco-friendly, and selective monitoring of Fe(III) in real media utilizing carbon dots (CDs) as a luminescence detector has been reported. CDs were fabricated by a hydrothermal route from empty fruit bunch biochar. The as-synthesized CDs were analyzed using various analytical tools. The results reveal that CDs have spherical shapes with a narrow particle size distribution and are enriched with multiple active sites, which impart excellent hydrophilicity and photostability. The CDs displayed bright blue emission under UV light with emission/excitation maxima at 452/350 nm, respectively, and a QY of 7.54%. The CDs exhibited high resistance to photobleaching and high salt conditions and pose a long lifetime of up to 6 months with no agglomeration. The detection variables, including pH, temperature, and CDs concentration, were optimized via response surface methodology. The statistical data verified the precision of the quadratic model for predicting the sensing performance of the nanoprobe. Under optimal environments, a linear range from 0 to 50 μM and a detection limit of 0.17 μM was obtained. The turn-off process includes the strong coordination between Fe(III) and electron-donating oxygen species on the edge of CDs. The rapid luminescence recognition using acid-free materials renders CDs a promising option for water treatment.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Eosin Y as a Probe for Spectroscopic Determination of Aripiprazole in Human Plasma

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70131

Mohamed A. Saeed, Noha S. Mostafa, Amr M. Mahmoud, Mohamed Ahmed Elsayed

{"title":"Application of Eosin Y as a Probe for Spectroscopic Determination of Aripiprazole in Human Plasma","authors":"Mohamed A. Saeed, Noha S. Mostafa, Amr M. Mahmoud, Mohamed Ahmed Elsayed","doi":"10.1002/bio.70131","DOIUrl":"https://doi.org/10.1002/bio.70131","url":null,"abstract":"<div>\u0000 \u0000 This work presents the development of new, rapid, and sensitive spectrophotometric and spectrofluorimetric methods for the determination of Aripiprazole in different dosage forms and human plasma. Both methods are based on the formation of an ion-pair complex between Eosin Y and the studied drug in an acidic medium. In the spectrophotometric method, the absorbance of the formed complex was estimated at 551 nm, showing a linear range from 1.0 to 13.0 μg mL−1 with detection and quantification limits of 0.20 and 0.60 μg mL−1, respectively. The spectrofluorimetric method measured the fluorescence emission of the formed complex at 545 nm upon excitation at 255 nm. This method exhibited a good linear range from 0.1 to 2.0 μg mL−1 with detection and quantification limits of 0.03 and 0.09 μg mL−1, respectively. The developed techniques offer several benefits, such as simplicity, cost-effectiveness, and high sensitivity. The proposed methods were validated in accordance with ICH guidelines, permitting precise analysis of the studied drug in its tablets and spiked human plasma samples with a high percent recovery. Moreover, the eco-friendly characteristics of the proposed methods were evaluated using two greenness assessment tools: AGREE and GAPI.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and Computational Optoelectrochemical Investigation of Quinoxaline Based Charge Transfer Derivatives: Green-Orange Emissive, AIEE Active Materials

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-27 DOI: 10.1002/bio.70130

Pooja S. Singh, Sandeep E. Jadhav, Balaji R. Madje, Sajeev Chacko, Rajesh M. Kamble

{"title":"Experimental and Computational Optoelectrochemical Investigation of Quinoxaline Based Charge Transfer Derivatives: Green-Orange Emissive, AIEE Active Materials","authors":"Pooja S. Singh, Sandeep E. Jadhav, Balaji R. Madje, Sajeev Chacko, Rajesh M. Kamble","doi":"10.1002/bio.70130","DOIUrl":"https://doi.org/10.1002/bio.70130","url":null,"abstract":"<div>\u0000 \u0000 2,3-Diphenylquinoxalin-6-yl based dyes were synthesized and characterized using 1H, 13C, HRMS and NOSEY spectroscopic technique. The comprehensive photophysical, aggregation-induced emission enhancement (AIEE) activity, electrochemical and theoretical studies of dyes explored. The intramolecular charge transfer transition (ICT) at 380–386 nm in absorption spectra suggest weak push-pull feature of dyes. Dyes show emission in green to orange region (λmax: 561–588 nm) in solvent as well as solid state. The Stokes shift of dyes is 7979–9167 cm−1. The minimal positive solvatochromism (slight variation in λemi) own by dyes, suggest environment stability of dyes in various solvent polarity. AIEE activity with good emission at solid-state make the dyes suitable candidature for solid state OLED's application. Further Dynamic Light Scattering (DLS) studies of dye 1 validate reverse correlation of emission behavior of nanoaggregate formed at high water fraction of THF–H2O mixture with its particle size. The good thermal stability of dyes reflected by decomposition temperature i.e., 221°C–357°C (292°C–372°C) for 5(10)% weight loss. The LUMO (−3.68 to −3.83 eV) of derivatives are lower than LUMO of reported n-type materials (−3.0 to −3.30 eV). Thus, photophysical with AIEE activity and electrochemical properties obtained for dyes signify suitability of it in organic electronics.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Photoluminescence Properties of Eu3+-Activated Ba2Cd(BO3)2 Red-Emitting Phosphors for Near-Ultraviolet Excited White Light-Emitting Diodes

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-26 DOI: 10.1002/bio.70135

S. B. Töreli, V. E. Kafadar, F. M. Emen, E. Öztürk, R. Altınkaya

{"title":"Synthesis and Photoluminescence Properties of Eu3+-Activated Ba2Cd(BO3)2 Red-Emitting Phosphors for Near-Ultraviolet Excited White Light-Emitting Diodes","authors":"S. B. Töreli, V. E. Kafadar, F. M. Emen, E. Öztürk, R. Altınkaya","doi":"10.1002/bio.70135","DOIUrl":"https://doi.org/10.1002/bio.70135","url":null,"abstract":"A new class of rare-earth doped borate phosphors, Ba2Cd(BO3)2: xEu3+ (x = 2, 3, 4, 5, and 6 mol%), was synthesized using the high-temperature solid-state reaction technique in air. X-ray diffraction (XRD) confirmed the phase formation of Ba2Cd(BO3)2, while Fourier transform infrared spectroscopy (FT-IR) revealed the presence of trigonal [BO3] units. The surface morphology was studied using field emission scanning electron microscopy (FE-SEM), and energy dispersive spectroscopy (EDS) identified the elements. Photoluminescence (PL) analysis showed that the phosphors emitted at 592, 613, 652, and 701 nm, corresponding to the 5D0 → 7F1, 5D0 → 7F2, 5D0 → 7F3, and 5D0 → 7F4 transition of Eu3+ ions, respectively. The 613 nm red emission, from the 5D0 → 7F2 transition, was strongest for the 6 mol% Eu3+ sample. The emission intensity increased with Eu3+ concentration, peaking at 6 mol%. CIE chromaticity, correlated color temperature (CCT), and color purity calculations showed acceptable color coordinates (0.6426 and 0.3548), a low CCT value (2355 K), and high purity (91.34%), making the 6 mol% Eu3+-doped phosphor ideal for red light in white light-emitting diodes (WLEDs).","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bio.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Novel Donor-π-Acceptor Benzothiazole-Thiazolidinone Fluorescent Chromophores With Enhanced Biological Activity

IF 3.2 4区化学

Luminescence Pub Date : 2025-02-24 DOI: 10.1002/bio.70125

Haifa Alharbi, Hatun H. Alsharief, Abdulmajeed F. Alrefaei, Abdulrhman M. Alsharari, S. A. Al-Ghamdi, F. M. Aldosari, Ibrahim S. S. Alatawi, Nashwa M. El-Metwaly

{"title":"Synthesis of Novel Donor-π-Acceptor Benzothiazole-Thiazolidinone Fluorescent Chromophores With Enhanced Biological Activity","authors":"Haifa Alharbi, Hatun H. Alsharief, Abdulmajeed F. Alrefaei, Abdulrhman M. Alsharari, S. A. Al-Ghamdi, F. M. Aldosari, Ibrahim S. S. Alatawi, Nashwa M. El-Metwaly","doi":"10.1002/bio.70125","DOIUrl":"https://doi.org/10.1002/bio.70125","url":null,"abstract":"<div>\u0000 \u0000 Four benzothiazole-thiazolidine-4-one derivatives 6 and 7a–c were prepared, and their chemical constructions were proved by IR, NMR, UV–Vis absorption, and emission spectra. The absorption spectra of the synthesized derivatives showed that extending the conjugated system through the insertion of a substituted benzylidene group led to a red shift of λmax, where the nitro derivative 7c displayed the longer wavelength. Likewise, the emission spectra presented the same effect, where the Stock shift displayed a reversed order in which the parent 6 has the highest value. The synthesized derivatives exhibited cytotoxic effectiveness against several tumor cell lines, where compound 7b displayed significant cytotoxicity towards MCF-7 cells (IC50 = 8.73 ± 0.41 μM). The in vitro VEGFR-2 kinase inhibitory activity of synthetic benzothiazole-thiazolidin-4-one derivatives has been assessed, where derivative 7c had the strongest inhibition (IC50 = 0.20 ± 0.10 μM), followed by derivatives 7b and 7a, respectively. However, the molecular docking showed that derivatives 7b and 7c have higher binding affinity than Sorafenib due to unique molecular interactions with target residues. Moreover, the pharmacokinetic parameters of the newly synthesized derivatives showed that derivative 7b revealed moderate lipophilicity and a lack of Lipinski violations, making it a viable lead contender.\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0