Luminescence最新文献

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Sustainable Fluorescent Carbon Dots From Apple Snail Eggs for Enhanced Visualization of Shed Skin Cells in Latent Fingerprints 从苹果蜗牛卵中提取可持续荧光碳点,增强潜在指纹中脱皮细胞的可视化
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-25 DOI: 10.1002/bio.70246
Ratima Janthima, Oratai Weeranantanapan, Sirapanat Injinda, Sineenat Siri
{"title":"Sustainable Fluorescent Carbon Dots From Apple Snail Eggs for Enhanced Visualization of Shed Skin Cells in Latent Fingerprints","authors":"Ratima Janthima,&nbsp;Oratai Weeranantanapan,&nbsp;Sirapanat Injinda,&nbsp;Sineenat Siri","doi":"10.1002/bio.70246","DOIUrl":"https://doi.org/10.1002/bio.70246","url":null,"abstract":"<div>\u0000 \u0000 <p>Latent fingerprints contain shed skin cells that serve as critical DNA sources for forensic analysis; however, the efficiency of touch DNA analysis is often limited by insufficient cell quantities. This study presents a novel fluorescent carbon dot (CD) synthesized from a sustainable biomass source—apple snail eggs (ASE)—to enhance cell visualization in latent fingerprints. The ASE-derived CDs (ASE-CDs) were synthesized via a microwave-assisted hydrothermal method, optimized with 0.1-g/mL ASE extract at 1200 W, 200°C, for 60 min. The resulting ASE-CDs exhibited strong fluorescence, with excitation and emission peaks at 351 and 416 nm, respectively. Transmission electron microscopy (TEM) revealed a uniform morphology with an average particle size of 5.4 nm, while X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy confirmed their crystallinity, graphitization, and surface functional groups. ASE-CDs enabled the effective visualization of shed skin cells in latent fingerprints, displaying higher fluorescence intensity than commonly used dyes—Diamond Nucleic Acid Dye (DD) and SYBR Green I Nucleic Acid Gel Stain (SGI)—while demonstrating lower photobleaching than DD. These findings highlight ASE-CDs as a sustainable, eco-friendly fluorescent probe with potential forensic applications.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 7","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Synchronous Spectrofluorometric Method for Assessing a Novel Drug Combination in Amyotrophic Lateral Sclerosis: In Vivo Human Application With Greenness and Sustainability Evaluation 创新同步荧光光谱法评估肌萎缩性侧索硬化症新药物组合:绿色和可持续性评价的人体体内应用
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-24 DOI: 10.1002/bio.70222
Amal B. Ahmed, Mohammed E. Draz, Haydy Asad, Ibrahim A. Naguib, Fadwa H. Edrees
{"title":"Innovative Synchronous Spectrofluorometric Method for Assessing a Novel Drug Combination in Amyotrophic Lateral Sclerosis: In Vivo Human Application With Greenness and Sustainability Evaluation","authors":"Amal B. Ahmed,&nbsp;Mohammed E. Draz,&nbsp;Haydy Asad,&nbsp;Ibrahim A. Naguib,&nbsp;Fadwa H. Edrees","doi":"10.1002/bio.70222","DOIUrl":"https://doi.org/10.1002/bio.70222","url":null,"abstract":"<div>\u0000 \u0000 <p>Amyotrophic lateral sclerosis (ALS) is a severe neurological disorder that causes damage to sensory neurons, then paralysis and death. A novel combination of celecoxib (CXP) and ciprofloxacin (CIP) has recently been used to enhance both motor performance and CNS cell morphology, alterations in the rate of disease progression, quality of life, and survival, which passed phase IIb RCT study. Celecoxib is classified as a non-steroidal anti-inflammatory drug; ciprofloxacin is a fluoroquinolone antibiotic that has a synergistic effect for the treatment of ALS, which is a severe neurological disorder. A new sustainable, simple, sensitive, and environmentally friendly synchronous spectrofluorimetric approach (SSF) was established to simultaneously estimate celecoxib and ciprofloxacin in pure form and biological fluids. The approach depends on synchronous fluorescence spectroscopy, where CXP and CIP were detected at 364 and 438 nm, correspondingly, using Δ<i>λ</i> of 80-nm utilizing sodium dodecyl sulphate (SDS) micellar system, which considerably improved synchronous fluorescence intensity. The approach was validated and revealed excellent linearity with concentrations varying from 10 to 10,000 and 5 to 20,000 ng/mL for CXP and CIP; correspondingly, CXP and CIP showed extremely low limits of detection (LODs) 0.58–0.24 ng/mL, which guarantee the sensitivity of the proposed approach. The suggested approach was successfully implemented to analyze the co-administered pharmaceuticals in their pure form and actual human plasma after concurrent oral administration of both drugs, which may be employed in an inquiry on the pharmacokinetics and bioavailability of human plasma to the new coming PrimeC pharmaceutical formulation. Ultimately, the method's remarkable greenness was proved by evaluating its greenness profile using various assessment strategies. The findings revealed that the SSF approach is a sustainable and environmentally friendly analytical approach.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Signal-Switching” Fluorescence Sensing of Fe3+ and Ascorbic Acid by Songaria Cynomorium Polysaccharide-Doped Carbon Dots of the Tibetan Medicinal Herb 藏药锁阳多糖掺杂碳点对Fe3+和抗坏血酸的“信号开关”荧光传感
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-24 DOI: 10.1002/bio.70233
Huan Wang, Tianfeng Ma, Wencheng Mu, Cailin Wang, Siqi Sheng, Yanyan Jia, Yongchang Lu
{"title":"“Signal-Switching” Fluorescence Sensing of Fe3+ and Ascorbic Acid by Songaria Cynomorium Polysaccharide-Doped Carbon Dots of the Tibetan Medicinal Herb","authors":"Huan Wang,&nbsp;Tianfeng Ma,&nbsp;Wencheng Mu,&nbsp;Cailin Wang,&nbsp;Siqi Sheng,&nbsp;Yanyan Jia,&nbsp;Yongchang Lu","doi":"10.1002/bio.70233","DOIUrl":"https://doi.org/10.1002/bio.70233","url":null,"abstract":"<div>\u0000 \u0000 <p>The Songaria Cynomorium polysaccharide-doped carbon dots (SP-CDs) were synthesized by carbonization-heating method. Songaria Cynomorium polysaccharide (PS) was the carbon source. Ethylenediamine (EDA), phosphoric acid (H<sub>3</sub>PO<sub>4</sub>), and concentrated hydrochloric acid (HCl) were dopants, respectively. The SP-CDs exhibited the maximum fluorescence emission wavelength of 540 nm under the excitation wavelength of 485 nm (“ON” state). After the introduction of Fe<sup>3+</sup> with an intermediate bridging effect, the fluorescence intensity of SP-CDs was quenched due to the formation of the complex (SP-CDs/Fe<sup>3+</sup>) between SP-CDs and Fe<sup>3+</sup> (“OFF” state). Subsequently, the fluorescence signal returned to “ON” due to the redox reaction between AA and Fe<sup>3+</sup> when ascorbic acid was introduced into SP-CDs/Fe<sup>3+</sup> solution. Therefore, the synthesized SP-CDs could be used as a “switch type” fluorescence sensor for detecting Fe<sup>3+</sup> and AA. The analysis revealed that the linear range of Fe<sup>3+</sup> extended from 0.05 to 500.00 μM, with the limit of detection (LOD) of 0.02 μM (S/<i>N</i> = 3). The scope of analysis for AA was determined to be within the range of 0.65–400.00 μM, with the limit of detection (LOD) of 0.09 μM (<i>S/N</i> = 3). Furthermore, the recommended fluorescence sensor was successfully employed for quantitatively detecting Fe<sup>3+</sup> and AA in serum samples.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the Binding Mechanism of Oclacitinib With Bovine Serum Albumin: A Multidisciplinary Approach Combining Spectroscopy, Thermodynamics, and Molecular Docking 奥克拉替尼与牛血清白蛋白结合机制的研究:光谱学、热力学和分子对接的多学科方法
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-24 DOI: 10.1002/bio.70244
Dong Chen, Hui Gu, Jia-Ping Huang, Yu-Ting Wu, Rong-Juan Zhang, Shao-Liang Jiang, Jie-Hua Shi
{"title":"Elucidating the Binding Mechanism of Oclacitinib With Bovine Serum Albumin: A Multidisciplinary Approach Combining Spectroscopy, Thermodynamics, and Molecular Docking","authors":"Dong Chen,&nbsp;Hui Gu,&nbsp;Jia-Ping Huang,&nbsp;Yu-Ting Wu,&nbsp;Rong-Juan Zhang,&nbsp;Shao-Liang Jiang,&nbsp;Jie-Hua Shi","doi":"10.1002/bio.70244","DOIUrl":"https://doi.org/10.1002/bio.70244","url":null,"abstract":"<div>\u0000 \u0000 <p>This paper elucidates the in vitro binding of oclacitinib (OLTN) with BSA through a multifaceted approach that combines experimental methodologies and theoretical computations. Spectroscopic analyses reveal that OLTN significantly attenuates the intrinsical fluorescence of BSA through the formation of an OLTN–BSA complex, indicating a static quenching mechanism. Experimental data further confirmed the formation of a nonfluorescent OLTN–BSA complex. These findings provide valuable insights into the molecular interactions governing the OLTN–BSA system, enhancing our understanding of drug–protein binding dynamics. The binding constant and stoichiometric ratio of the complex were determined to be approximately 10<sup>4</sup> M<sup>−1</sup> and 1:1, respectively, suggesting moderate binding affinity of OLTN for BSA. Molecular docking assays verified that OLTN primarily associated with the Sudlow's Site II, inducing conformational alterations in both the secondary structure and quaternary structure of BSA. Thermodynamic and molecular docking analyses established that hydrophobicity interactions and hydrogen bonding (including conventional hydrogen bonding and the carbon hydrogen bonding) serve as the dominant driving forces for stabilizing the complex. This investigation provides critical guidance for understanding the pharmacodynamics and pharmacokinetics of OLTN in human, particularly regarding its plasma protein binding behavior and potential drug–drug interactions.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fluorescent Probe Derived From Methoxy-Modified Imidazo-Pyridin for Monitoring Sulfite in Chinese Medicinal Materials 甲氧基修饰咪唑吡啶荧光探针监测中药材中亚硫酸盐
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-19 DOI: 10.1002/bio.70240
Panpan Yang, Chaoyue Wang, Ke Ying, Fengping Wang, Xiuping Wu, Xiaohong Zhu, Xionggao Han, Lisi Mao
{"title":"A Fluorescent Probe Derived From Methoxy-Modified Imidazo-Pyridin for Monitoring Sulfite in Chinese Medicinal Materials","authors":"Panpan Yang,&nbsp;Chaoyue Wang,&nbsp;Ke Ying,&nbsp;Fengping Wang,&nbsp;Xiuping Wu,&nbsp;Xiaohong Zhu,&nbsp;Xionggao Han,&nbsp;Lisi Mao","doi":"10.1002/bio.70240","DOIUrl":"https://doi.org/10.1002/bio.70240","url":null,"abstract":"<div>\u0000 \u0000 <p>In this work, a methoxy-modified imidazo-pyridin–derived fluorescent probe <b>IPOMe-SF</b> was developed for monitoring sulfite in Chinese medicinal materials, and the imaging in living colorectal cells was conducted. Under the excitation of 355 nm, the response system with <b>IPOMe-SF</b> exhibited the concentration-dependent fluorescence enhancement at 490 nm along with the increase of the sulfite level. The response system suggested advantages including a relatively high sensitivity, high stability, rapid response, high selectivity, and low cytotoxicity. The particular privileges associated with the Chinese medicinal materials included the long linear response range and reliable anti-interference. <b>IPOMe-SF</b> inferred reliable steadiness for monitoring the sulfite level in the water decoction samples covered the “Zhebawei” herbal series. Further, the imaging system with <b>IPOMe-SF</b> realized the monitoring of both the exogenous and endogenous sulfite level, as well as the water decoction-treated status in colorectal cells. This work was meaningful for studying Chinese medicinal materials.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation on the Photodegradation Performance of S-Rich g-C3N4/MnO2 Composites for Efficient Removal of Hazardous Dyes From Aqueous Phase 富s g-C3N4/MnO2复合材料光降解水中有害染料性能的研究
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-18 DOI: 10.1002/bio.70239
P. Varun Prasath, S. M. Muba Shera, K. Suganandam, G. Kalaiarasi, S. Sudhakar, K. Ravichandran, A. Kosiha
{"title":"Investigation on the Photodegradation Performance of S-Rich g-C3N4/MnO2 Composites for Efficient Removal of Hazardous Dyes From Aqueous Phase","authors":"P. Varun Prasath,&nbsp;S. M. Muba Shera,&nbsp;K. Suganandam,&nbsp;G. Kalaiarasi,&nbsp;S. Sudhakar,&nbsp;K. Ravichandran,&nbsp;A. Kosiha","doi":"10.1002/bio.70239","DOIUrl":"https://doi.org/10.1002/bio.70239","url":null,"abstract":"<div>\u0000 \u0000 <p>Sulfur (S)-rich g-C<sub>3</sub>N<sub>4</sub>/α-MnO<sub>2</sub> (α-MnO<sub>2</sub>/GCN-S) heterojunction was synthesized using a simple hydrothermal technique, which was effectively utilized for the photodegradation of methylene blue and congo red dyes under visible light illumination. The results of the characterization analysis suggest that the α-MnO<sub>2</sub>/GCN-S composite exhibits a high crystalline nature and the heterojunction successfully formed between g-C<sub>3</sub>N<sub>4</sub> and α-MnO<sub>2</sub> demonstrates an effective photocatalytic agent for selected hazardous dyes. According to the obtained findings, α-MnO<sub>2</sub>/GCN-S composite exhibited outstanding visible light absorption when compared with pure g-C<sub>3</sub>N<sub>4</sub> and α-MnO<sub>2</sub> under visible light irradiation. The enhanced photocatalytic performance of the α-MnO<sub>2</sub>/GCN-S can be attributed to the effective separation of electron–hole pairs facilitated by g-C<sub>3</sub>N<sub>4</sub>, along with the improved visible light absorption properties of the S-doped α-MnO<sub>2</sub>. The findings indicate that the α-MnO<sub>2</sub>/GCN-S composite demonstrates exceptional photocatalytic performance, achieving degradation efficiencies of 91% and 92% for congo red and methylene blue in 30 and 60 min, respectively. On the other hand, the pristine form of GCN-S and α-MnO<sub>2</sub> exhibited lower degradation rates of 51% and 55% for congo red, and 67%, 69% for methylene blue, respectively. These results highlight the capability of α-MnO<sub>2</sub>/GCN-S composites to efficiently eliminate harmful dyes from aqueous solutions.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining 莫那可林X对人肝癌细胞株的抗凋亡作用:AO/EB和DCFHDA荧光染色研究
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-17 DOI: 10.1002/bio.70229
Vennila Jayaraman, Madan Kumar Arumugam, Shana Balachandran, Lokeshkumar Boopathy, Sasikumar Arumugam, Jamunarani Srirangaramasamy, Sandhanasamy Devanesan, Arumugam Suresh, Shobana Sampath
{"title":"Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining","authors":"Vennila Jayaraman,&nbsp;Madan Kumar Arumugam,&nbsp;Shana Balachandran,&nbsp;Lokeshkumar Boopathy,&nbsp;Sasikumar Arumugam,&nbsp;Jamunarani Srirangaramasamy,&nbsp;Sandhanasamy Devanesan,&nbsp;Arumugam Suresh,&nbsp;Shobana Sampath","doi":"10.1002/bio.70229","DOIUrl":"https://doi.org/10.1002/bio.70229","url":null,"abstract":"<div>\u0000 \u0000 <p>Hepatocellular carcinoma (HCC) most prevalent form of liver cancer and poses a few available treatments and is a major worldwide health burden. Monacolin X, a natural compound derived from the marine sponge-associated symbiont <i>Monascus ruber</i>, has garnered attention for its potential anticancer and anti-angiogenesis properties. This current study aimed to investigate the anticancer and apoptosis-inducing effects of Monacolin X against the human liver cancer (HepG2) cell line in vitro. This present study utilized various assays to assess cytotoxicity by MTT assay, apoptosis induction, DCFH-DA staining to measure the intracellular ROS levels, and apoptosis-and inflammation-related gene expression changes induced by the Monacolin X. The MTT results discovered dose-dependent cytotoxicity in HepG2 cells with an IC<sub>50</sub> value of 72.4 μM. The apoptosis-inducing effect of Monacolin X was evident through propidium iodide (PI) and acridine orange/ethidium bromide (AO/EB) staining, accompanied by increased intracellular ROS levels and downregulated expression of pro-inflammatory cytokines (<i>IL-6, IL-1β, TNF-α</i>) and modulation of key apoptosis regulators (<i>Bax</i> and <i>Bcl-2</i>) as determined by qPCR analysis. In conclusion, these observations suggest a mechanism whereby Monacolin X has potent anticancer activity against the HepG2 cell line, and further investigation will be required to determine the molecular pathways responsible for the potential therapeutic effects for the clinical implications in liver cancer.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and Thermoluminescence Characteristics of Ytterbium Borosilicate Glasses for Radiation Dosimetry Applications 辐射剂量测定用硼硅酸镱玻璃的制备及其热释光特性
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-16 DOI: 10.1002/bio.70237
Mohamed Ehab, E. Salama, Lina Sayed El-Ahll, H. A. Saudi, H. A. Abdel Ghany, Huda A. Alazab
{"title":"Preparation and Thermoluminescence Characteristics of Ytterbium Borosilicate Glasses for Radiation Dosimetry Applications","authors":"Mohamed Ehab,&nbsp;E. Salama,&nbsp;Lina Sayed El-Ahll,&nbsp;H. A. Saudi,&nbsp;H. A. Abdel Ghany,&nbsp;Huda A. Alazab","doi":"10.1002/bio.70237","DOIUrl":"https://doi.org/10.1002/bio.70237","url":null,"abstract":"<div>\u0000 \u0000 <p>A borosilicate glass composite (SiO<sub>2</sub>—Na<sub>2</sub>CO<sub>3</sub>—ZnO—H<sub>3</sub>BO<sub>3</sub>) doped with varying concentrations of Yb<sub>2</sub>O<sub>3</sub> (0–0.1 mol%) was fabricated using the melt-quenching technique. The thermoluminescence (TL) properties of the prepared composite were investigated, revealing that the highest TL response (the total area under the curve) was achieved with 0.06 mol% Yb<sub>2</sub>O<sub>3</sub>. Subsequently, a comprehensive dosimetric analysis, considering annealing conditions, dose–response relationship, minimum detectable dose, reproducibility of the TL response, and thermal and optical fading of the prepared glass, was determined. The obtained results demonstrated that this glass composite exhibited a linear dose–response across a wide gamma dose range of 0.5–2 kGy and about 28% TL fading after 24 h of irradiation, followed by 16% after 7 days without any further deterioration during around 1 month of examination. These advantageous properties suggest that radiation detection applications can use this examined glass composite.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144299787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Polysaccharide-Based Fluorescent Polymer Carrier for Natural Product Delivery and Gastric Cancer Inhibition 天然产物传递和胃癌抑制的多糖基荧光聚合物载体
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-13 DOI: 10.1002/bio.70235
Minghan Bai, Yupeng Yang, Yuan Wen
{"title":"A Polysaccharide-Based Fluorescent Polymer Carrier for Natural Product Delivery and Gastric Cancer Inhibition","authors":"Minghan Bai,&nbsp;Yupeng Yang,&nbsp;Yuan Wen","doi":"10.1002/bio.70235","DOIUrl":"https://doi.org/10.1002/bio.70235","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we designed and synthesized a novel polysaccharide-based fluorescent nanocarrier system, HPMC-AuNPs@1, for the delivery of plant extract compound 1. The HPMC-AuNPs@1 system was synthesized by functionalizing gold nanoparticles (AuNPs) with hydroxypropyl methylcellulose (HPMC) and loading Compound 1 into the system. The resulting nanocarrier exhibited a typical aggregation-induced emission (AIE) effect in aqueous media, showing strong green fluorescence in a DMSO-H<sub>2</sub>O (5:95) solution. Host-guest sensing experiments revealed that HPMC-AuNPs@1 demonstrated high selectivity for detecting carcinoembryonic antigen (CEA) among 14 different metallic ions and antigen molecules. A noticeable fluorescence shift occurred upon binding with CEA, and the detection limit for CEA was as low as 2.56 × 10<sup>−6</sup> M. Additionally, we explored the potential therapeutic applications of HPMC-AuNPs@1 in cancer treatment, particularly in inducing pyroptosis, a form of programmed cell death. In vitro experiments with SNU-16 cells showed that HPMC-AuNPs@1 nanoparticles inhibited cancer cell proliferation by inducing pyroptosis. These findings suggest that HPMC-AuNPs@1 holds great promise as a therapeutic platform for cancer treatment, particularly in targeting cell proliferation pathways via pyroptosis induction.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blue-Emissive Nitrogen-Doped Carbon Quantum Dots as Highly Effective Fluorescent Nanosensor for Congo Red Sensing 蓝发射氮掺杂碳量子点作为高效刚果红荧光纳米传感器
IF 3.2 4区 化学
Luminescence Pub Date : 2025-06-12 DOI: 10.1002/bio.70236
Shen Zhang, Zhuo Wang, Yanan Li, Yuyu Guo
{"title":"Blue-Emissive Nitrogen-Doped Carbon Quantum Dots as Highly Effective Fluorescent Nanosensor for Congo Red Sensing","authors":"Shen Zhang,&nbsp;Zhuo Wang,&nbsp;Yanan Li,&nbsp;Yuyu Guo","doi":"10.1002/bio.70236","DOIUrl":"https://doi.org/10.1002/bio.70236","url":null,"abstract":"<div>\u0000 \u0000 <p>Based on the necessity of Congo red detection and excellent performance of the fluorescence method, nitrogen-doped carbon quantum dots (N-CQDs) were established through a facile and green hydrothermal method. N-CQDs were synthesized from hawthorn leaves and N-isopropylacrylamide and were firstly used for Congo red detection. Through the inner filter effect and static quenching principle, this as-prepared probe was successfully applied in the sensitive and selective detection of Congo red. Combining various characterization results, well-dispersed N-CQDs possessed superior fluorescent property, water solubility, and stability. The blue fluorescence emitted at 438 nm when the maximum excitation wavelength was located at 365 nm. Under the optimal detecting condition, the linear range achieved 0.5–300 μM with a detection limit of 0.089 μM. More importantly, the outstanding performance of recovery experiments in real samples and temperature sensing displayed great promise for Congo red detection through N-CQDs.</p>\u0000 </div>","PeriodicalId":49902,"journal":{"name":"Luminescence","volume":"40 6","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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