Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique最新文献

{"title":"Lettre à l’éditeur au sujet de l’article « Innovation thérapeutique et enjeux capacitaires en médecine nucléaire : la situation de la RIV en Occitanie » par Guignard et al. (1)","authors":"F. Courbon , P.O. Kotzki , V. Boudousq , C. Fersing , P.-Y. Salaun , E. Deshayes","doi":"10.1016/j.mednuc.2025.06.008","DOIUrl":"10.1016/j.mednuc.2025.06.008","url":null,"abstract":"","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 257-259"},"PeriodicalIF":0.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lettre à l’éditeur au sujet de l’article « Innovation thérapeutique et enjeux capacitaires en médecine nucléaire : la situation de la RIV en Occitanie » par Guignard et al. (1)","authors":"F. Courbon , P.O. Kotzki , V. Boudousq , C. Fersing , P.-Y. Salaun , E. Deshayes","doi":"10.1016/j.mednuc.2025.06.008","DOIUrl":"10.1016/j.mednuc.2025.06.008","url":null,"abstract":"","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 257-259"},"PeriodicalIF":0.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of 18F-FDG PET/CT in neoadjuvant therapy response in breast cancer with axillary metastasis","authors":"S. Saraçoğlu ,&nbsp;F. Özülker ,&nbsp;O. Güven ,&nbsp;T. Özülker","doi":"10.1016/j.mednuc.2025.07.002","DOIUrl":"10.1016/j.mednuc.2025.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to investigate whether it is possible to predict the response to neoadjuvant therapy (NAT) in axillary lymph node metastasis of breast cancer patients using parameters from ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) scans, and to evaluate the correlation of post-NAT PET/CT findings with axillary histopathology results.</div></div><div><h3>Materials and methods</h3><div>Breast cancer patients with axillary lymph node involvement, who underwent staging and post-NAT PET/CT, followed by surgery or histopathological evaluation, were included. Metabolic and volumetric ¹⁸F-FDG PET/CT parameters were analyzed to determine their predictive value for NAT response. Receiver operating characteristic (ROC) curves and Chi-square tests were used for statistical evaluation.</div></div><div><h3>Results</h3><div>Forty-three breast cancer patients were included in the study. Statistically significant differences were observed between the axillary pathology-negative and positive patient groups for the following variables: post-NAT SUVmax (primary and axilla), ΔSUVmax% (primary and axilla), the largest lymph node diameter on staging PET/CT, and the change in diameter of the same lymph node post-NAT. In the post-NAT axillary lymph node visual evaluation, the sensitivity, specificity, the positive predictive value (PPV), and the negative predictive value (NPV) for detecting metastatic axillary lymph nodes on PET/CT, based on pathology results, were calculated as 81.8%, 66.7%, 72%, and 77.7%, respectively. When a 92.38% threshold value was determined for ΔSUVmax% (axilla), they were 90.9%, 42.9%, 62.5%, and 81.8%, respectively.</div></div><div><h3>Conclusion</h3><div>Metabolic parameters obtained from ¹⁸F-FDG PET/CT can contribute to predicting the treatment response for axillary metastases. ¹⁸F-FDG PET/CT provides insights into the necessity of sentinel lymph node biopsy (SLNB) and axillary dissection. However, due to ¹⁸F-FDG PET/CT's inability to achieve sufficient sensitivity and specificity, it is unlikely to replace SLNB.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 284-291"},"PeriodicalIF":0.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of 18F-FDG PET/CT in neoadjuvant therapy response in breast cancer with axillary metastasis","authors":"S. Saraçoğlu ,&nbsp;F. Özülker ,&nbsp;O. Güven ,&nbsp;T. Özülker","doi":"10.1016/j.mednuc.2025.07.002","DOIUrl":"10.1016/j.mednuc.2025.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to investigate whether it is possible to predict the response to neoadjuvant therapy (NAT) in axillary lymph node metastasis of breast cancer patients using parameters from ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) scans, and to evaluate the correlation of post-NAT PET/CT findings with axillary histopathology results.</div></div><div><h3>Materials and methods</h3><div>Breast cancer patients with axillary lymph node involvement, who underwent staging and post-NAT PET/CT, followed by surgery or histopathological evaluation, were included. Metabolic and volumetric ¹⁸F-FDG PET/CT parameters were analyzed to determine their predictive value for NAT response. Receiver operating characteristic (ROC) curves and Chi-square tests were used for statistical evaluation.</div></div><div><h3>Results</h3><div>Forty-three breast cancer patients were included in the study. Statistically significant differences were observed between the axillary pathology-negative and positive patient groups for the following variables: post-NAT SUVmax (primary and axilla), ΔSUVmax% (primary and axilla), the largest lymph node diameter on staging PET/CT, and the change in diameter of the same lymph node post-NAT. In the post-NAT axillary lymph node visual evaluation, the sensitivity, specificity, the positive predictive value (PPV), and the negative predictive value (NPV) for detecting metastatic axillary lymph nodes on PET/CT, based on pathology results, were calculated as 81.8%, 66.7%, 72%, and 77.7%, respectively. When a 92.38% threshold value was determined for ΔSUVmax% (axilla), they were 90.9%, 42.9%, 62.5%, and 81.8%, respectively.</div></div><div><h3>Conclusion</h3><div>Metabolic parameters obtained from ¹⁸F-FDG PET/CT can contribute to predicting the treatment response for axillary metastases. ¹⁸F-FDG PET/CT provides insights into the necessity of sentinel lymph node biopsy (SLNB) and axillary dissection. However, due to ¹⁸F-FDG PET/CT's inability to achieve sufficient sensitivity and specificity, it is unlikely to replace SLNB.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 284-291"},"PeriodicalIF":0.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging brain metastases of prostate cancer with 68Ga-PSMA PET/MRI: Two case reports","authors":"S. Gülbahar Ateş,&nbsp;U. Aydos,&nbsp;Ü.Ö. Akdemir,&nbsp;L.Ö. Atay","doi":"10.1016/j.mednuc.2025.06.009","DOIUrl":"10.1016/j.mednuc.2025.06.009","url":null,"abstract":"<div><div>Brain metastasis in prostate cancer is a rare entity with a poor prognosis. Early detection of brain metastasis might improve patient management and prognosis. 68-Gallium prostate-specific membrane antigen (68Ga-PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) is a unique imaging modality for prostate cancer patients with higher accuracy and soft tissue resolution, which provides excellent identification of soft tissue metastases. We have presented two prostate adenocarcinoma patients with unexpected brain metastases demonstrated by 68Ga-PSMA PET/MRI.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 292-295"},"PeriodicalIF":0.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging brain metastases of prostate cancer with 68Ga-PSMA PET/MRI: Two case reports","authors":"S. Gülbahar Ateş,&nbsp;U. Aydos,&nbsp;Ü.Ö. Akdemir,&nbsp;L.Ö. Atay","doi":"10.1016/j.mednuc.2025.06.009","DOIUrl":"10.1016/j.mednuc.2025.06.009","url":null,"abstract":"<div><div>Brain metastasis in prostate cancer is a rare entity with a poor prognosis. Early detection of brain metastasis might improve patient management and prognosis. 68-Gallium prostate-specific membrane antigen (68Ga-PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) is a unique imaging modality for prostate cancer patients with higher accuracy and soft tissue resolution, which provides excellent identification of soft tissue metastases. We have presented two prostate adenocarcinoma patients with unexpected brain metastases demonstrated by 68Ga-PSMA PET/MRI.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 292-295"},"PeriodicalIF":0.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic de l’amylose cardiaque à TTR par une approche quantitative","authors":"A. Iep ,&nbsp;R. Chequer ,&nbsp;V. Algalarrondo ,&nbsp;B. Mahida ,&nbsp;T. Cabilic ,&nbsp;K. Doyeux ,&nbsp;F. Rouzet","doi":"10.1016/j.mednuc.2025.04.003","DOIUrl":"10.1016/j.mednuc.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>International recommendations for the non-invasive diagnosis of transthyretin cardiac amyloidosis (TTR-CA) rely on visual analysis according to the Perugini 4-point-grading described with planar scintigraphy.</div></div><div><h3>Objective</h3><div>To evaluate the diagnostic performance of quantitative metrics with ^99mTc-DPD whole-body SPECT/CT for TTR-CA.</div></div><div><h3>Methods</h3><div>Consecutive patients imaged on the Veriton-CT with whole-body ^99mTc-DPD SPECT/CT were retrospectively analyzed and compared with the TTR-CA diagnosis established by the reference center.</div></div><div><h3>Results</h3><div>One hundred and ninety-four patients were included (47 with TTR-CA) and diagnostic performance of quantitative measure of cardiac amyloid burden normalized to the whole body, was high with an area under the curve (AUC) of 0.956 (95% CI<!--> <!-->=<!--> <!-->[0.916; 0.995]), a sensitivity of 87.2%, and a specificity of 93.2%; comparable to Perugini grading with an AUC of 0.936 (95% CI<!--> <!-->=<!--> <!-->[0.088; 0.984]), a sensitivity of 87.2%, and a specificity of 100%.</div></div><div><h3>Conclusion</h3><div>Semi-automated quantitative analysis with whole-body ^99mTc-DPD SPECT/CT is not inferior to Perugini visual analysis for the diagnosis of ATTR-CA.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 267-277"},"PeriodicalIF":0.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic de l’amylose cardiaque à TTR par une approche quantitative","authors":"A. Iep ,&nbsp;R. Chequer ,&nbsp;V. Algalarrondo ,&nbsp;B. Mahida ,&nbsp;T. Cabilic ,&nbsp;K. Doyeux ,&nbsp;F. Rouzet","doi":"10.1016/j.mednuc.2025.04.003","DOIUrl":"10.1016/j.mednuc.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>International recommendations for the non-invasive diagnosis of transthyretin cardiac amyloidosis (TTR-CA) rely on visual analysis according to the Perugini 4-point-grading described with planar scintigraphy.</div></div><div><h3>Objective</h3><div>To evaluate the diagnostic performance of quantitative metrics with ^99mTc-DPD whole-body SPECT/CT for TTR-CA.</div></div><div><h3>Methods</h3><div>Consecutive patients imaged on the Veriton-CT with whole-body ^99mTc-DPD SPECT/CT were retrospectively analyzed and compared with the TTR-CA diagnosis established by the reference center.</div></div><div><h3>Results</h3><div>One hundred and ninety-four patients were included (47 with TTR-CA) and diagnostic performance of quantitative measure of cardiac amyloid burden normalized to the whole body, was high with an area under the curve (AUC) of 0.956 (95% CI<!--> <!-->=<!--> <!-->[0.916; 0.995]), a sensitivity of 87.2%, and a specificity of 93.2%; comparable to Perugini grading with an AUC of 0.936 (95% CI<!--> <!-->=<!--> <!-->[0.088; 0.984]), a sensitivity of 87.2%, and a specificity of 100%.</div></div><div><h3>Conclusion</h3><div>Semi-automated quantitative analysis with whole-body ^99mTc-DPD SPECT/CT is not inferior to Perugini visual analysis for the diagnosis of ATTR-CA.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 5","pages":"Pages 267-277"},"PeriodicalIF":0.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boiteries : diagnostic différentiel en scintigraphie osseuse","authors":"T. Paunet,&nbsp;A. Bourdon","doi":"10.1016/j.mednuc.2025.07.001","DOIUrl":"10.1016/j.mednuc.2025.07.001","url":null,"abstract":"<div><div>Limping in children is a common and polymorphic symptom that can reveal a wide spectrum of underlying conditions, from benign mechanical disorders to severe infectious, inflammatory, or tumoral diseases. Bone scintigraphy plays a key role in the diagnostic workup, especially when a systemic or infectious cause is suspected. Through a series of illustrative clinical cases, this article highlights unusual causes of limping identified by bone scintigraphy, including oncological (metastatic neuroblastoma, acute leukemia), infectious (appendicitis, spondylodiscitis, sacroiliitis), inflammatory (osteochondrosis, SAPHO syndrome), and traumatic (tendinopathies) conditions. We emphasize the importance of systematically evaluating both soft tissue and delayed phases of scintigraphy, as certain extra-skeletal abnormalities may be the first signs of serious underlying diseases.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 4","pages":"Pages 237-243"},"PeriodicalIF":0.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prise en charge d’une suspicion de maltraitance infantile : le cadre médico-judiciaire","authors":"M. Jonca","doi":"10.1016/j.mednuc.2025.06.002","DOIUrl":"10.1016/j.mednuc.2025.06.002","url":null,"abstract":"<div><div>Child abuse is a major public health and justice issue in France. This article explains the practices involved in the medico-judicial process, from reporting to judicial investigation. The main difficulties encountered by healthcare practitioners faced with a situation likely to give rise to a report are discussed. For example, medical confidentiality, often perceived as an obstacle, does not prevent a report from being made in cases of suspected abuse, in accordance with the provisions of article 226-14 of the French Penal Code. The placement of a child remains an exceptional measure, decided to guarantee the child's safety, while preserving family ties if possible. The hearing of the child victim follows strict protocols to ensure that the child's voice is heard without influencing him or her, while minimizing the trauma. Finally, forensic and psychological expertise plays a crucial role in assessing the extent of physical injury and psychological impact. Professional coordination and training are essential to optimize the management of these complex situations.</div></div>","PeriodicalId":49841,"journal":{"name":"Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique","volume":"49 4","pages":"Pages 222-224"},"PeriodicalIF":0.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}