Diagnostic de l’amylose cardiaque à TTR par une approche quantitative

IF 0.2 4区医学 Q4 PATHOLOGY

Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique Pub Date : 2025-09-03 DOI:10.1016/j.mednuc.2025.04.003

A. Iep , R. Chequer , V. Algalarrondo , B. Mahida , T. Cabilic , K. Doyeux , F. Rouzet

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引用次数: 0

Abstract

Background

International recommendations for the non-invasive diagnosis of transthyretin cardiac amyloidosis (TTR-CA) rely on visual analysis according to the Perugini 4-point-grading described with planar scintigraphy.

Objective

To evaluate the diagnostic performance of quantitative metrics with ^99mTc-DPD whole-body SPECT/CT for TTR-CA.

Methods

Consecutive patients imaged on the Veriton-CT with whole-body ^99mTc-DPD SPECT/CT were retrospectively analyzed and compared with the TTR-CA diagnosis established by the reference center.

Results

One hundred and ninety-four patients were included (47 with TTR-CA) and diagnostic performance of quantitative measure of cardiac amyloid burden normalized to the whole body, was high with an area under the curve (AUC) of 0.956 (95% CI = [0.916; 0.995]), a sensitivity of 87.2%, and a specificity of 93.2%; comparable to Perugini grading with an AUC of 0.936 (95% CI = [0.088; 0.984]), a sensitivity of 87.2%, and a specificity of 100%.

Conclusion

Semi-automated quantitative analysis with whole-body ^99mTc-DPD SPECT/CT is not inferior to Perugini visual analysis for the diagnosis of ATTR-CA.

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心脏淀粉样蛋白TTR定量诊断

国际推荐的经甲状腺素型心脏淀粉样变性（TTR-CA）的无创诊断依赖于平面闪烁显像描述的Perugini 4点分级的视觉分析。目的评价99mTc-DPD全身SPECT/CT定量指标对TTR-CA的诊断价值。方法回顾性分析连续患者在verton -CT和全身99mTc-DPD SPECT/CT上的影像，并与参考中心建立的TTR-CA诊断进行比较。结果纳入194例患者（47例为TTR-CA），曲线下面积（AUC）为0.956 (95% CI =[0.916; 0.995])，灵敏度为87.2%，特异性为93.2%；与Perugini分级相当，AUC为0.936 (95% CI =[0.088; 0.984])，敏感性为87.2%，特异性为100%。结论全身99mTc-DPD SPECT/CT半自动化定量分析对atr - ca的诊断不低于Perugini目视分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique PATHOLOGY-

CiteScore

0.30

自引率

0.00%

发文量

160

审稿时长

19.8 weeks

期刊介绍： Le but de Médecine nucléaire - Imagerie fonctionnelle et métabolique est de fournir une plate-forme d''échange d''informations cliniques et scientifiques pour la communauté francophone de médecine nucléaire, et de constituer une expérience pédagogique de la rédaction médicale en conformité avec les normes internationales.