Medicina-Lithuania最新文献

{"title":"Malignant Lacrimal Sac Tumours-Review of the Literature and Report of Own Experience.","authors":"Olga Karłowska-Bijak, Grażyna Stryjewska-Makuch, Marta Michalak-Kolarz, Magdalena Marków, Grażyna Lisowska","doi":"10.3390/medicina61030533","DOIUrl":"10.3390/medicina61030533","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Tumours of the lacrimal drainage system are rare and most located in the lacrimal sac. The authors of this study aimed to conduct a literature review to find out which malignant tumours most often occurred in the lacrimal sac and what symptoms patients reported in the early stages of the disease. <i>Materials and Methods</i>: The PubMed database was searched for papers published between 2019 and 2024. The inclusion criteria were presence of an abstract, malignant lacrimal sac tumours, papers written in English, studies on humans, and case reports. The exclusion criteria were lack of an abstract, pathologies other than malignant tumours, including benign tumours of the lacrimal drainage system, malignant tumours of a part of the drainage system other than the lacrimal sac, papers in languages other than English, studies not involving humans, and no case report. No gender criterion was used. <i>Results</i>: Based on the data available in the literature, 31 studies were included in the article, describing 34 cases of malignant lacrimal sac tumours. Moreover, a case of a 58-year-old patient diagnosed with non-Hodgkin lymphoma was presented. <i>Conclusions</i>: As a result of the literature analysis, it was impossible to find any symptoms reported by patients with lacrimal sac tumours that would clearly suggest their diagnosis.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Endothelial Differentiation of Mesenchymal Stem Cells Derived from Human Turbinates Using Lab-on-a-Chip Technology.","authors":"Do Hyun Kim, Sang Hi Park, Mi-Yeon Kwon, Chae-Yoon Lim, Sun Hwa Park, David W Jang, Se Hwan Hwang, Sung Won Kim","doi":"10.3390/medicina61030528","DOIUrl":"10.3390/medicina61030528","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Endothelial cells are essential to various therapeutic strategies for cardiovascular diseases. Developing efficient methods to generate large quantities of well-defined endothelial cells could improve cardiovascular treatment. This study explored the impact of lab-on-a-chip technology on the endothelial differentiation potential of mesenchymal stem cells derived from the human inferior nasal turbinate (hNTSCs). <i>Materials and Methods</i>: hNTSCs were isolated from five patients and divided into two groups: an experimental group subjected to lab-on-a-chip technology and a control group following two-dimensional differentiation protocols. The endothelial differentiation capacity of hNTSCs was assessed through histological examination and gene expression analysis. <i>Results</i>: Comparative evaluation of traditional differentiation methods and lab-on-a-chip technology indicated that hNTSCs expressed endothelial cell-specific markers, including CD34, KDR, CDH5, and CD31. Notably, CD31, CD34, and CDH5 exhibited significantly elevated expression levels in the lab-on-a-chip system. Additionally, cytokine analysis showed marked increases in IL-1a and IL-8 expression under lab-on-a-chip conditions compared to standard differentiation techniques. <i>Conclusions</i>: Lab-on-a-chip technology may enhance the differentiation of hNTSCs into endothelial cells with angiogenic potential, highlighting its promise for future cardiovascular regenerative applications.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of OCTA in Studying Vessel Density and Retinal Thickness in Individuals with Myopia.","authors":"Marija Veselinović, Marija Trenkić, Vladimir Čanadanović, Predrag Jovanović, Aleksandar Veselinović, Maja Petrović, Aida Kasumović Bećirović","doi":"10.3390/medicina61030532","DOIUrl":"10.3390/medicina61030532","url":null,"abstract":"<p><p><i>Background and Objectives</i>: This study explores the relationship between retinal structure, vascular densities (VD), and the progression of myopia, aiming to identify novel biomarkers for assessing myopia severity. <i>Materials and Methods</i>: A total of 260 eyes were divided into four groups: Emmetropia (EM) (<i>n</i> = 74), Low Myopia (LM) (<i>n</i> = 68), Moderate Myopia (MM) (<i>n</i> = 64), and High Myopia (HM) (<i>n</i> = 54). VD and retinal thickness (RT) in the macular and peripheral quadrants were measured using optical coherence tomography-angiography (OCTA). SVD and DVD were analyzed across the paranasal, peritemporal, perisuperior, and peri-inferior quadrants. <i>Results</i>: Significant differences in superficial vessel density (SVD) were found in the paranasal (EM vs. MM, <i>p</i> = 0.017; EM vs. HM, <i>p</i> = 0.001), peritemporal (EM vs. MM, <i>p</i> = 0.006; EM vs. HM, <i>p</i> = 0.001; LM vs. HM, <i>p</i> = 0.004; MM vs. HM, <i>p</i> = 0.032), perisuperior (EM vs. MM, <i>p</i> = 0.005; EM vs. HM, <i>p</i> = 0.001; LM vs. HM, <i>p</i> = 0.027), and perifoveal quadrants (EM vs. MM, <i>p</i> = 0.003; EM vs. HM, <i>p</i> = 0.008; LM vs. HM, <i>p</i> = 0.004; MM vs. HM, <i>p</i> = 0.012). Deep vessel density (DVD) showed significant differences in the paranasal (<i>p</i> = 0.012-0.022), peritemporal (<i>p</i> = 0.002-0.026), perisuperior (<i>p</i> = 0.003-0.034), perifoveal (<i>p</i> = 0.002-0.017), and peri-inferior (<i>p</i> = 0.002-0.022) quadrants. Retinal thickness was significantly reduced in HM eyes, with the most pronounced reduction in the peritemporal quadrant (mean difference: 16.7 ± 3.2 µm; <i>p</i> < 0.001). <i>Conclusions</i>: Structural and vascular changes in the retina become more pronounced as myopia progresses from moderate to high. The strong correlation between DVD, RT, and myopia severity highlights their potential as reliable biomarkers for monitoring myopia progression through OCTA imaging. These findings provide new insights into the vascular and structural changes underlying myopia and their diagnostic significance.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Nasal Nitric Oxide in Allergic Rhinitis: A Controversial Biomarker.","authors":"Natalia Louca, Despina Damianou, Nektaria Kostea, Panayiotis Kouis, Panayiotis Yiallouros, Constantinos Pitsios","doi":"10.3390/medicina61030516","DOIUrl":"10.3390/medicina61030516","url":null,"abstract":"<p><p><i>Background and objectives:</i> Increased levels of nitric oxide (NO) are produced in various inflammatory diseases like allergic asthma. Fractional exhaled NO has been studied as a biomarker of type 2 inflammation in asthma, while the use of nasal NO (nNO) as a diagnostic tool for allergic rhinitis (AR) is less established. In the present study, we investigated nNO as a potential biomarker for differentiating AR from nonallergic rhinitis (NAR). <i>Materials and methods:</i> Medical students were invited to complete a questionnaire on rhinitis symptoms. Individuals who reported nasal symptoms were invited to participate in the clinical phase of the study, which included considering the patient's medical history, clinical examination, skin-prick tests (SPTs) for the 14 most relevant allergens in the region, and nNO measurement using the NIOX VERO portable nitric oxide analyzer. Informed consent was obtained at each stage of recruitment and clinical assessment. <i>Results:</i> Overall, 62 out of 122 volunteers recruited reported rhinitis symptoms and were investigated further with nNO measurements and SPTs. In total, 39 had SPT-confirmed AR, while 23 were classified as NAR subjects. Both nNO measurements and SPTs were performed on the same day, during the pollen season. The comparison of mean nNO concentrations (830 ± 247 ppb and 851 ± 373 in AR and NAR groups, respectively) showed no statistically significant difference. <i>Conclusions:</i> we concluded that nNO is not a reliable independent biomarker in the diagnosis of AR.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Biomarkers in Ischemic Stroke Diagnostics and Treatment-Future Perspectives.","authors":"Anja Babić, David Bonifačić, Vita Komen, Slavica Kovačić, Melani Mamić, Vladimira Vuletić","doi":"10.3390/medicina61030514","DOIUrl":"10.3390/medicina61030514","url":null,"abstract":"<p><p>Stroke is a leading cause of disability and the second most common cause of death worldwide, with its incidence increasing due to an aging population. Early diagnosis is crucial for timely medical intervention. Biomarkers serve as objective indicators to predict outcomes, monitor treatment responses, and assess prognosis. This review examines the evolving landscape of stroke biomarkers, highlighting their potential clinical applications and the challenges hindering their widespread use. Blood biomarkers are readily accessible and provide insight into the pathophysiological processes underlying stroke. This review focuses on neuronal and glial biomarkers, as well as those associated with inflammation, thrombosis, excitotoxicity, and neuroprotection. Also, it focuses on genetic biomarkers. The timing of biomarker measurement is particularly critical in the early stages of stroke, when rapid decision-making is essential, and it requires systematic investigation. Although numerous molecules have been proposed as stroke biomarkers in recent years, none have yet been integrated into routine clinical practice. Stroke biomarkers hold great promise for enhancing diagnosis, risk stratification, and personalized treatment strategies. However, well-designed studies and rigorous validation are necessary to bridge the gap between research findings and clinical implementation. Integrating biomarkers with existing diagnostic tools could revolutionize stroke management and improve patient outcomes. Continued research into blood biomarkers and their clinical utility remains imperative for advancing stroke care.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Heart Rate Variability as a Biomarker for Autonomic Function in Parkinson's Disease Rehabilitation: A Clustering-Based Analysis of Exercise-Induced Changes.","authors":"Ahmed M Basri, Ahmad F Turki","doi":"10.3390/medicina61030527","DOIUrl":"10.3390/medicina61030527","url":null,"abstract":"<p><p><i>Background</i>: Heart rate variability (HRV) is a key biomarker reflecting autonomic nervous system (ANS) function and neurocardiac regulation. Reduced HRV has been associated with cardiovascular risk, neurodegenerative disorders, and autonomic dysfunction. In Parkinson's disease (PD), HRV impairments indicate altered autonomic balance, which may be modifiable through structured exercise interventions. This study investigates the effects of aerobic exercise on HRV in patients with PD and evaluates autonomic adaptations to rehabilitation. <i>Methods</i>: A total of 110 patients with PD (55 male, 55 female) participated in a supervised three-month aerobic exercise program. HRV was assessed pre- and post-intervention using electrocardiogram (ECG) recordings. Time-domain and frequency-domain HRV metrics, including standard deviation of RR intervals (SDRR), very-low-frequency (VLF), low-frequency (LF), high-frequency (HF) power, and LF/HF ratio, were analyzed. Principal Component Analysis (PCA) and clustering techniques were applied to identify subgroups of HRV responders based on autonomic adaptation. <i>Results</i>: Significant improvements in HRV were observed post-intervention, with a reduction in LF/HF ratio (<i>p</i> < 0.05), indicating improved autonomic balance. Cluster analysis identified four distinct HRV response subgroups: Strong Responders, Moderate Responders, Mixed/Irregular Responders, and Low Responders. These findings highlight individual variability in autonomic adaptations to exercise. PCA revealed that key HRV parameters contribute differently to autonomic regulation, emphasizing the complexity of HRV changes in PD rehabilitation. <i>Conclusions</i>: This study demonstrates that aerobic exercise induces beneficial autonomic adaptations in PD patients, as reflected by HRV changes. The identification of response subgroups suggests the need for personalized rehabilitation strategies to optimize autonomic function. Further research is warranted to explore the long-term impact of HRV-guided rehabilitation interventions in PD management.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Individual Components of E-Cigarettes on Ion Transport and Airway Surface Liquid Height in Human Bronchial Epithelial Cells.","authors":"Ozge Beyazcicek, Robert Tarran, Recep Ozmerdivenli, Ersin Beyazcicek","doi":"10.3390/medicina61030526","DOIUrl":"10.3390/medicina61030526","url":null,"abstract":"<p><strong>Background and objectives: </strong>The rising popularity of new-generation electronic cigarettes (e-cig) like JUUL necessitates a better understanding of their impact on respiratory and other body systems, as the effects of JUUL's components remain unclear. This study aimed to investigate the effects of JUUL components on ion channels and airway surface liquid (ASL) height in human bronchial epithelial cells (HBECs). Furthermore, the cytotoxic effects of these components were investigated in human embryonic kidney 293T (HEK293T) cells.</p><p><strong>Materials and methods: </strong>The components tested included nicotine salt (NicSalt), benzoic acid (BA), sodium hydrogen tartrate (NaTar), propylene glycol/vegetable glycerin (PG/VG), freebase nicotine (FBNic) and nicotine salt+benzoic acid (NicSalt+BA). Each component was prepared at 100 µM, and HBECs were exposed for 24 h to measure ASL height, short-circuit current (<i>I_sc</i>), and transepithelial electrical resistance (TEER).</p><p><strong>Results: </strong>Initial exposure (0 h) to these substances did not significantly alter ASL height. However, after 2 h, FBNic-treated HBECs exhibited a significant reduction in ASL height compared to NicSalt and other tested substances, with the most pronounced decrease observed at the 6th hour. This effect persisted over prolonged exposure, suggesting a cumulative impact on airway hydration and epithelial function. Additionally, adenosine administration did not induce a significant increase in ASL height. NicSalt, BA, and FBNic were found to disrupt ion balance in HBECs, affecting ion channels and ASL homeostasis while significantly decreasing TEER. In terms of cytotoxicity, NicSalt, and benzoic acid demonstrated minimal cytotoxicity at low concentrations, whereas FBNic showed significantly higher cytotoxicity at moderate levels.</p><p><strong>Conclusions: </strong>In conclusion, this study highlights that e-cigarette components can disrupt airway surface liquid homeostasis by affecting ion channel activity, compromise epithelial barrier integrity by reducing transepithelial electrical resistance, and emphasize the importance of their cytotoxic effects.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Symptomatic Extracranial Carotid Artery Stenting in Octogenarians: A Single-Center Retrospective Study on Restenosis, Risk Factors, and Complications.","authors":"Özgür Zülfükar Ertuğrul, Fırat Karaaslan, Reşit Yılmaz, Mehmet Cudi Tuncer","doi":"10.3390/medicina61030519","DOIUrl":"10.3390/medicina61030519","url":null,"abstract":"<p><p><i>Objectives:</i> This study aimed to evaluate the 6-month restenosis rate, risk factors, and complications following carotid artery stenting (CAS) in patients aged 80 years and older, assessing the efficacy and safety of CAS in this population. <i>Materials and Methods:</i> Fifty-six patients aged ≥80 years with symptomatic extracranial carotid stenosis who underwent CAS between May 2023 and August 2024 were retrospectively analyzed. Follow-up at 6 months included Doppler ultrasonography to assess restenosis. Demographic, clinical, and procedure-related complications were recorded, and risk factors for in-stent restenosis were evaluated. <i>Results:</i> Among the patients, 42.9% were female (n = 24) and 57.1% were male (n = 32), with a mean age of 85.3 ± 4.40 years. The restenosis rate was 12.5%. Restenosis was significantly associated with smoking (<i>p</i> = 0.002), severe stenosis (<i>p</i> = 0.016), and advanced age (<i>p</i> = 0.045). The minor complication rate was 5.3%, and no major complications were observed. Smoking and advanced age were identified as independent risk factors for restenosis. <i>Conclusions:</i> CAS is a safe and effective treatment option for elderly patients. However, those with a history of smoking, advanced age, or severe stenosis are at an increased risk of restenosis. These findings provide valuable insights into the outcomes and safety of CAS in patients aged 80 and older.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Remimazolam and Propofol on Blood Glucose and Serum Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial with Prospective Randomized Control.","authors":"Sang Hun Kim, Sang Min Yoon, Ji Hye Ahn, Yoon Ji Choi","doi":"10.3390/medicina61030523","DOIUrl":"10.3390/medicina61030523","url":null,"abstract":"<p><p><i>Background and Objectives:</i> Patients with type 2 diabetes are at a higher risk of postoperative complications, such as infections, delayed wound healing, and increased mortality compared to non-diabetic patients. <i>Materials and Methods:</i> This prospective randomized study aims to compare the effects of two anesthetics, remimazolam and propofol, on blood glucose levels and immune function in diabetic patients undergoing surgery. Seventy-four diabetic patients undergoing general anesthesia were randomly assigned to receive either remimazolam or propofol. Plasma blood glucose levels, anti-inflammatory markers, and insulin levels were measured during the perioperative period. <i>Results:</i> No statistically significant differences were observed between the remimazolam and propofol groups in terms of neutrophil-to-lymphocyte ratio, anti-inflammatory markers, or glucose levels during the perioperative period (<i>p</i> value > 0.05). <i>Conclusions:</i> These results suggest that there is no difference between propofol and remimazolam in immune function deterioration that occurs due to surgical stress. This study is limited by its small sample size, and in future, larger trials could be conducted to find differences in the effects of blood sugar levels and serum inflammatory markers between the two groups.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Hybrid Approach to Manage Mycotic Pseudoaneurysm Post-Renal Transplantation: Successful Graft Preservation.","authors":"Ho Li, Yi-Chang Lin, Chien-Chang Kao, Pei-Jhang Chiang, Meng-Han Chou, Hui-Kung Ting, Yu-Cing Jhuo, Ming-Hsin Yang, Chih-Wei Tsao, En Meng, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Chin-Li Chen, Sheng-Tang Wu","doi":"10.3390/medicina61030521","DOIUrl":"10.3390/medicina61030521","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Post-transplant anastomotic pseudoaneurysms are a rare but serious complication of renal transplantation, typically requiring graft sacrifice. This case report demonstrates a novel hybrid approach for managing a mycotic pseudoaneurysm while preserving graft function. <i>Case report:</i> A 56-year-old male developed a pseudoaneurysm at the anastomotic site after cadaveric kidney transplantation, presenting with recurrent infections and declining renal function. Imaging confirmed the pseudoaneurysm. A hybrid strategy combining femoral-femoral bypass with a polytetrafluoroethylene graft, percutaneous transluminal angioplasty with stenting, and coil embolization was performed. <i>Results</i>: The intervention successfully isolated the pseudoaneurysm and preserved graft function. Post-procedure, serum creatinine levels improved, stabilizing at 2.3 mg/dL during follow-up. Imaging confirmed no residual flow in the aneurysm, and vascular complications were absent. <i>Conclusions</i>: This report highlights a successful combined surgical and endovascular approach for treating mycotic pseudoaneurysms, preserving graft function and restoring limb blood flow. This strategy offers a promising alternative for managing complex post-transplant complications, though long-term outcomes require further evaluation.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}