Medicina-Lithuania最新文献

{"title":"Editorial Board Members' Collection Series: Gastrointestinal and Hepatic Diseases.","authors":"Ludovico Abenavoli, Marcello Candelli","doi":"10.3390/medicina61040758","DOIUrl":"https://doi.org/10.3390/medicina61040758","url":null,"abstract":"<p><p>The Special Issue titled \"Editorial Board Members' Collection Series: Gastrointestinal and Hepatic Diseases\" is a collection of papers from our Editorial Board Members and researchers invited by them [...].</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Survival Outcomes Among Asian Ethnic Groups with Stage IV NSCLC.","authors":"Aria Bassiri, Yue-Lin Hu, Christina Boutros, Boxiang Jiang, Jillian Sinopoli, Leonidas Tapias Vargas, Philip A Linden, Christopher W Towe","doi":"10.3390/medicina61040753","DOIUrl":"https://doi.org/10.3390/medicina61040753","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Patients of Asian descent are often grouped together despite their diverse ethnicities and genetic backgrounds. Cancer outcomes result from a complex interplay of genetics, environment, and socioeconomic factors. This study aims to describe lung cancer survival outcome variations in Asian ethnic subgroups, hypothesizing that significant outcome differences exist between subgroups. <i>Materials and Methods</i>: A retrospective analysis of the 2020 National Cancer Database identified patients with stage IV non-small-cell lung cancer (NSCLC). Asian patients were subcategorized into nine groups: Chinese, Japanese, Korean, Asian Indian/Pakistani, Vietnamese, Pacific Islander, Filipino, Laotian/Hmong/Kampuchean/Thai, and Other Asian/Asian not otherwise specified (NOS). The primary outcome was overall survival, and the secondary outcome was utilization of palliative care. Kaplan-Meier analysis and multivariate Cox and logistic modeling were used to assess outcomes of interest. <i>Results</i>: A total of 23,747 Asian patients with stage IV NSCLC were identified. Demographic characteristics of the subgroups varied by age, sex, Charlson-Deyo Comorbidity Index, and utilization of palliative care. Relative to Chinese Asians, multivariate Cox analysis showed worse survival outcomes among patients categorized as Japanese, Korean, Pacific Islanders, Filipino, and Laotian/Hmong/Kampuchean/Thai. The rate of palliative care utilization also varied among Asian subgroups. Compared to Chinese patients, palliative care was more likely to be utilized by patients categorized as Japanese and Pacific Islander. <i>Conclusions</i>: Amongst Asian subgroups, variations in survival outcomes and palliative care utilization in stage IV NSCLC patients were observed. Surgeons should acknowledge these disparities and consider disaggregating Asian races in prognosis analysis to enhance understanding of race's impact on outcomes. Recognizing these differences is crucial for guiding personalized treatment strategies, optimizing resource allocation, and informing health policy to ensure equitable cancer care for all Asian populations.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and Neuropsychiatric Effects of 40 Hz tACS Simultaneously with Cognitive Exercises for Dementia: A Randomized, Crossover, Double-Blind, Sham-Controlled Study.","authors":"Maria Anabel Uehara, Sumeet Kalia, Mari Garcia Campuzano, Mohammad Jafari-Jozani, Brian Lithgow, Zahra Moussavi","doi":"10.3390/medicina61040757","DOIUrl":"https://doi.org/10.3390/medicina61040757","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Transcranial alternating current stimulation (tACS) at 40 Hz has shown potential to enhance cognitive function. However, research on its combination with cognitive exercises, particularly its long-term effects in a dementia population, remains limited. This study investigated the effects of 40 Hz tACS paired with simultaneous cognitive exercises on cognition, neuropsychiatric symptoms, and the depression status of individuals with dementia in a sham-controlled, double-blind crossover design. <i>Materials and Methods</i>: A total of 42 participants with dementia were randomized into two groups: (1) the R1S2 group received 40 Hz real tACS with cognitive exercises, followed by a ≥8-week washout period, and then sham tACS with cognitive exercises; (2) the S1R2 group received the reversed sequence. tACS was applied at 1.5 mA peak-to-peak with electrodes over the left dorsolateral prefrontal cortex and contralateral supraorbital area. Participants received two 30 min stimulation sessions per day, 5 days per week, for 4 consecutive weeks, paired with cognitive exercises using the MindTriggers app (2.9.1). The primary outcome was the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) and the secondary outcomes included the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Neuropsychiatric Inventory Questionnaire (NPI-Q). All outcome measures were assessed before and after each treatment block. <i>Results</i>: Real tACS paired with cognitive exercises significantly improved ADAS-Cog scores post-treatment compared to pre-treatment (<i>p</i>-value = 0.019), whereas sham tACS did not. Furthermore, real tACS produced significant long-term improvements approximately 2-3 months post-treatment in ADAS-Cog scores compared to sham (<i>p</i>-value = 0.048). Both real (<i>p</i>-value = 0.003) and sham (<i>p</i>-value = 0.015) tACS significantly reduced NPI-Q scores post-treatment. MADRS scores significantly improved (<i>p</i>-value = 0.007) post-treatment for real tACS but not sham. <i>Conclusions</i>: The 40 Hz tACS paired with cognitive exercises improves cognition, neuropsychiatric symptoms, and depression post-treatment in dementia, with sustained cognitive effects. The findings highlight its potential as a non-invasive therapeutic intervention for dementia.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta and Theta Band Power Alterations During Face and Face Pareidolia Perception in Children with Autism Spectrum Disorder: An Electroencephalographic Analysis.","authors":"Gülsüm Akdeniz","doi":"10.3390/medicina61040754","DOIUrl":"https://doi.org/10.3390/medicina61040754","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Autism Spectrum Disorder (ASD) is characterized by a range of deficits across cognitive, sensory, motor, emotional, language, and social domains, which can significantly hinder daily functioning and social interactions. This study explores the differences in brain activity between children with ASD and typically developing peers, focusing on their responses to face and face pareidolia stimuli. <i>Materials and Methods</i>: A group comprising ten typically developing children (four males, six females), aged between 6 and 16 years, alongside eleven children diagnosed with ASD (three males, eight females), whose ages ranged from 6 to 15 years, were engaged in the pilot study. We recorded brain electrical activity using electroencephalography (EEG) while participants viewed images of face and face pareidolia images. Following face and pareidolia stimulus presentation, delta and theta powers in the 0.5-4 Hz and 4-6 Hz frequency ranges and within the 140-190 ms time window were analyzed for both typically developing children and children with ASD. <i>Results</i>: The research result reveals that children with ASD show lower amplitude and delayed latency in their EEG responses, particularly in the theta and delta frequency bands, when processing images that evoke face pareidolia. <i>Conclusions</i>: The findings suggest that while children with ASD face challenges in recognizing faces, they may still possess some perceptual abilities that could be harnessed for therapeutic interventions. Moreover, this research highlights the potential of the face pareidolia paradigm to provide insights that could inform future strategies aimed at enhancing social attention and interaction skills in children with ASD. Despite the limitations of the current sample size, this study provides a valuable foundation for future investigations. Expanding the participant pool will be crucial for confirming and generalizing these findings.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of NT-proBNP on Serum Calcium: A Longitudinal Analysis.","authors":"Maria Rita Stancanelli, Giuseppe Restivo, Thea Corriere, Carmela Cannarozzo, Maria Gabriella Ferrara, Rosario Salemi, Maria Eva Sberna, Angelo Iraci, Ada Restivo, Valeria Furia, Elisa Longhitano, Domenico Santoro, Vincenzo Calabrese","doi":"10.3390/medicina61040755","DOIUrl":"https://doi.org/10.3390/medicina61040755","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Brain natriuretic peptide (NT-proBNP) is a biomarker widely used in diagnosing and monitoring heart failure. Its impact on electrolyte homeostasis is known, particularly for sodium. However, its relationship with serum calcium remains unclear. This retrospective observational study aimed to investigate the longitudinal association between NT-proBNP and serum calcium levels in a cohort of hospitalized patients with the goal of determining whether NT-proBNP could have a direct or indirect impact on calcium metabolism. <i>Materials and Methods</i>: We included 688 patients with 1022 repeated measurements of NT-proBNP and serum calcium collected during hospitalization from March 2022 to February 2025. Linear mixed models (LMMs) were employed to analyze longitudinal associations, adjusting for age, eGFR, estimated plasma volume status (ePVs), CRP, potassium, and albumin. <i>Results</i>: Baseline analysis revealed a negative correlation between NT-proBNP and serum calcium (r = -0.23, <i>p</i> < 0.001). Univariate LMM demonstrated a significant negative association (β = -1.3 × 10^-5, <i>p</i> < 0.001), which remained significant in multivariate analysis (β = -6.9 × 10^-6, <i>p</i> = 0.01), accounting for intrasubject variability. This suggests that as NT-proBNP increases, serum calcium levels decrease within individual patients, independent of confounders. This study's findings indicate that NT-proBNP may influence calcium excretion, possibly through mechanisms involving the sodium-calcium exchanger (NCX) in renal tubules, similar to its effects on sodium homeostasis. <i>Conclusions</i>: This is the first study to evaluate the longitudinal impact of NT-proBNP on serum calcium, highlighting a potential clinical relevance in patients with cardiac dysfunction. Limitations include a retrospective design and a lack of urine calcium data. Further research is warranted to validate these findings and elucidate the underlying mechanisms.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Early Epidural Analgesia on the Course of Labor and Delivery.","authors":"Atene Simanauskaite, Gabriele Kavaliauskaite, Justina Kacerauskiene, Vilda Vilimiene","doi":"10.3390/medicina61040750","DOIUrl":"https://doi.org/10.3390/medicina61040750","url":null,"abstract":"<p><p><i>Background and Objectives</i>: This study aimed to assess the impact of early epidural analgesia (EA) on the progression of labor and delivery outcomes among nulliparous women. <i>Materials and Methods</i>: A retrospective analysis was conducted utilizing data from the Birth Registry of the Department of Obstetrics and Gynecology at LUHS. The dataset encompassed women who underwent childbirth between 1 January 2021 and 31 December 2021 and who received EA for labor pain management. A total of 89 women with low-risk deliveries and EA were included in the study. The cohort was divided into two groups: Group I-parturients who underwent early EA with cervical dilatation ≤3 cm-and Group II-parturients who underwent EA with cervical dilatation >3 cm but <7 cm. The results were processed using IBM SPSS. <i>Results</i>: Group I consisted of 25 (28.1%) women and Group II consisted of 64 (71.9%). The prevalence of obesity was higher in Group II (<i>p</i> = 0.021). Bishop score was statistically elevated in Group II (<i>p</i> = 0.018). Upon hospital admission, Group II exhibited greater cervical dilation (<i>p</i> = 0.001). The rate of cervical dilation was higher in Group II at 1.54 cm/h (<i>p</i> = 0.033). Episiotomy was more frequently performed in Group II (<i>p</i> = 0.014). The average durations of the first stage of labor (<i>p</i> = 0.045), the second stage of labor (<i>p</i> = 0.033), and the overall labor (<i>p</i> = 0.023) were prolonged in Group I. <i>Conclusions</i>: The cervical dilation up to 10 cm occurs at a swifter pace when EA is administered following cervical dilation exceeding 3 cm. Notable associations were observed between EA and the incidence of episiotomy as well as the duration of labor stages. Early EA exhibited no impact on neonatal outcomes.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Important Biomarker in Patients with Bell's Palsy: Serum Calprotectin.","authors":"Cihan Türker, Elif Emre, Süleyman Aydın, Mustafa Dalgıç, Deniz Baklacı","doi":"10.3390/medicina61040747","DOIUrl":"https://doi.org/10.3390/medicina61040747","url":null,"abstract":"<p><p><i>Background and Objectives</i>: This study aimed to examine the relationship between serum calprotectin levels and facial paralysis in patients with Bell's palsy and to determine its prognostic significance. <i>Materials and Methods</i>: This study included 40 patients diagnosed with Bell's palsy and 20 healthy individuals as controls. The patients were categorized into three groups based on their response to treatment: complete response, partial response, and no response. Blood samples were taken before treatment and in the third month after treatment to measure C-reactive protein, white blood cell count, lymphocyte count, neutrophil count, neutrophil-to-lymphocyte ratio, and calprotectin levels. <i>Results</i>: Serum calprotectin levels were found to be elevated in patients with BP compared to the healthy controls; however, no significant correlation was observed between calprotectin levels and disease prognosis. <i>Conclusions</i>: The findings suggest that Bell's palsy patients have elevated serum calprotectin levels compared to healthy individuals, indicating the potential use of calprotectin as a biomarker in Bell's palsy. However, no significant difference in calprotectin levels was observed between patients with varying degrees of treatment response, suggesting that calprotectin may be limited in predicting disease prognosis.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folic Acid Mitigates Sertraline-Induced Liver Damage in Adult Female Albino Rats During Pregnancy and Postpartum: A Biochemical and Histological Study.","authors":"Ayman A Refai, Mohammad I Jumaa, Einas M Yousef, Ala M Aljehani, Rana Ahmed Alduraywish, Mohamed R Elkabary, Safaa M Hanafy, Hanan S Seleem, Eman S El-Roghy","doi":"10.3390/medicina61040751","DOIUrl":"https://doi.org/10.3390/medicina61040751","url":null,"abstract":"<p><p><i>Background and Objectives:</i> Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is frequently prescribed during pregnancy to treat mood disorders. Studies indicate that chronic use of sertraline is associated with elevated liver enzymes, oxidative stress, and histological alterations in the liver. Folic acid, a recommended supplement currently used during the first trimester of pregnancy, has antioxidant and anti-inflammatory effects. Hence, folic acid might be a potential protective agent against sertraline-induced liver injury. The current study aimed to investigate the possible hepatotoxic effects of sertraline administration during pregnancy and early postpartum. In addition, we sought to evaluate the potential protective effects of folic acid supplementation in alleviating any sertraline-induced liver damage. <i>Materials and Methods:</i> Eighty pregnant albino rats were randomly divided into four groups: control, folic acid-treated, sertraline-treated, and folic acid-sertraline-treated. Each group was divided into rats euthanized immediately after giving birth (0 h) or 14 days postpartum. Biochemical, histological, and immunohistochemical evaluations of liver function and structure were conducted. <i>Results:</i> Administration of sertraline was associated with a significant increase in hepatic enzymes (ALT and AST) and disrupted lipid profile (elevated cholesterol, triglycerides, and LDL-c) compared to the control group. Increased apoptosis was evidenced by increased caspase 3 expression and histological alterations, including vacuolation and inflammatory infiltrates, in sertraline-treated rats. Folic acid supplementation effectively mitigated these effects by preserving liver architecture, normalizing biochemical markers (ALT, AST, and lipid profile changes), and reducing apoptotic activity (lower caspase 3 expression). <i>Conclusions:</i> Folic acid mitigated sertraline-induced hepatic damage in pregnant rats. This suggests the potential benefits of using folic acid during the whole duration of pregnancy in patients treated with sertraline.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Longitudinal Study Analyzing Vaginal Microbiota Differences Between Term and Preterm Pregnancies in Korean Women.","authors":"Gina Nam, Kyung A Lee, Soo Jung Kim, Kwan Young Oh, Sunghee Lee, Hyun Chul Lee, So Yoon Kim, Mi Hye Park","doi":"10.3390/medicina61040752","DOIUrl":"https://doi.org/10.3390/medicina61040752","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Preterm birth (PTB), defined as delivery before 37 weeks of gestation, remains a significant public health concern due to its association with neonatal morbidity and mortality. Although studies have suggested that microbial factors in vaginal microbiota (VMB) influence PTB, longitudinal research on Korean women is limited. This study aimed to analyze VMB differences between term and preterm pregnancies in Korean women and their correlation with the cervical length (CL). <i>Materials and Methods</i>: A cohort of 60 pregnant Korean women (40 who had a term birth (TB) and 20 who had a PTB) was recruited. Vaginal samples were collected at five time points (first, second, and third trimester; 1-2 weeks postpartum; 1-2 months postpartum). Microbial DNA was extracted and analyzed using quantitative PCR targeting 12 bacterial species. The CL was measured in the second and third trimesters. <i>Results</i>: <i>Lactobacillus crispatus</i> was consistently dominant in the TB group, whereas PTB cases exhibited greater microbial diversity with elevated levels of <i>Prevotella salivae</i> and <i>Ureaplasma</i> species. The CL was significantly shorter in PTB cases, correlating with shifts in the VMB composition. <i>Conclusions</i>: A stable, <i>Lactobacillus</i>-dominant microbiome is protective in pregnancy, while increased diversity in PTB cases suggests microbial biomarkers for early risk prediction. Combining VMB profiling with CL measurement may enhance early, non-invasive PTB risk assessments.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D CT-Based Preoperative Planning and Intraoperative Navigation in Reverse Shoulder Arthroplasty: Early Clinical Outcomes.","authors":"Elisa Troiano, Azzurra Masini, Giovanni Battista Colasanti, Caterina Drago, Stefano Giannotti, Nicola Mondanelli","doi":"10.3390/medicina61040749","DOIUrl":"https://doi.org/10.3390/medicina61040749","url":null,"abstract":"<p><p><i>Background and Objectives</i>: Reverse shoulder arthroplasty (RSA) is an effective surgical procedure for treating end-stage rotator cuff arthropathy, but it is burdened by a relatively high complication rate, mainly due to glenoid component failure. Preoperative planning and intraoperative navigation based on three-dimensional computed tomography (3D CT) scans have proven to be efficient tools for improving the accuracy and stability of the glenoid component. However, this technology is still developing, and there is currently little available research on the subject, especially where clinical outcomes are concerned. The purpose of this retrospective observational study is to report the radiographic and clinical outcomes of a consecutive series of patients that underwent RSA with the use of these new technologies, compared to a standard procedure. <i>Materials and Methods</i>: A consecutive series of 80 patients underwent RSA for shoulder osteoarthritis by a single surgeon at a single institution with a mean follow-up of 41.9 ± 23.6 months (range 24-108) and were divided into two groups according to the surgical technique employed (conventional or navigated surgery), and they were clinically and radiographically assessed at 1, 3, 6, and 12 months after surgery, and then annually. <i>Results</i>: No statistically significant differences were highlighted among the two groups according to complication rate, radiographical glenoid notching, and clinical outcomes. However, a statistically significant difference was observed in screw number and length and surgical time. In the navigated group, fewer screws with longer lengths had been implanted, with a longer surgical time. <i>Conclusions</i>: The use of 3D CT-based preoperative planning and intraoperative navigation is a safe procedure and produces comparable results with respect to standard instrumentation, without an increased risk of complications. It allowed to achieve higher stability of the implant, saving bone stock due to the use of fewer and longer screws than in a conventional procedure. This could also eventually result in a higher longevity of the implant itself.</p>","PeriodicalId":49830,"journal":{"name":"Medicina-Lithuania","volume":"61 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}