Nervenarzt最新文献

{"title":"[Psychiatric challenges in Prader-Willi syndrome].","authors":"Christian Karl Eberlein, Maximilian Jakob, Angelina Jechalke, Gesa Ordon","doi":"10.1007/s00115-026-01971-6","DOIUrl":"10.1007/s00115-026-01971-6","url":null,"abstract":"<p><strong>Background: </strong>Prader-Willi syndrome (PWS) is highly associated with psychiatric comorbidity.</p><p><strong>Objectives: </strong>This article investigates the prevalence of mental disorders in PWS, explores their association with neurobiological foundations, and outlines the resulting clinical recommendations.</p><p><strong>Methods: </strong>An evaluation of the scientific literature in the context of clinical experience from the special outpatient clinic for mental health in rare syndromic disorders at Hannover Medical School.</p><p><strong>Results: </strong>Psychiatric manifestations are present in 44-89% of PWS patients, with disruptive behavior, skin picking, psychosis, compulsive symptoms, and affective disorders being the most common. PWS psychosis differs from schizophrenic psychosis and can be difficult to treat in some cases. Treatment approaches exist for disruptive behavior, affective symptoms, and compulsive symptoms.</p><p><strong>Conclusions: </strong>Knowledge of the neurobiological basis of PWS is necessary for the adequate treatment of psychiatric disorders. In addition to pharmacological therapies, behavioral interventions and environmental control should also be included.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"339-344"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[New interdisciplinary S3 guidelines on deletion syndrome 22q11.2, a genetic disease predisposing to neuropsychiatric morbidity].","authors":"Franziska Radtke, Carina Sauter","doi":"10.1007/s00115-026-01979-y","DOIUrl":"10.1007/s00115-026-01979-y","url":null,"abstract":"<p><p>The deletion syndrome 22q11.2 is one of the most frequent genetic syndromes in humans, with a prevalence of 1:2500 [1]. The syndrome is particularly relevant for neurology, psychiatry and child and adolescent psychiatry due to a massive genetic predisposition to neuropsychiatric disorders that has been proven in recent years. Somatic symptoms are highly variable and can be diverse. Congenital heart defects, otorhinolaryngologic (ENT) abnormalities, parathyroid dysfunction and orthopedic abnormalities are particularly frequent and typical. In addition, many affected individuals suffer from susceptibility to infections. Almost all affected children show developmental disorders.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"357-362"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Late-onset manifestation of Tay-Sachs disease-A disease of the cerebellum and motor neurons with psychiatric sequelae].","authors":"Karl Eugen Mengel, Grecia Mendoza, Latha Mani, Jürgen Deckert, Laila Arash-Kaps","doi":"10.1007/s00115-026-01985-0","DOIUrl":"10.1007/s00115-026-01985-0","url":null,"abstract":"<p><p>Data on the manifestation and progression of neurological and psychiatric symptoms in adult patients with late-onset Tay-Sachs (LOTS) disease after the age of 2 years are scarce and not available for Germany. In this cross-sectional study data from the \"8 in 1\" register study for gangliosidoses of 16 adult patients with LOTS were retrospectively evaluated with respect to the manifestation and the occurrence of neurological and psychiatric symptoms. The LOTS can be manifested in preschool age with a neurodevelopmental disorder, in school age and adolescence with cerebellar symptoms or in adolescence and adulthood with leg dominant muscle weakness and muscle atrophy in the sense of a motor neuron disease (MND). The initial symptoms of LOTS begin insidiously, are variable and often go unrecognized. Severe psychiatric disorders regularly occur in the course of the disease, particularly in those patients who have neurological developmental disorders and manifestation of cerebellar symptoms. The prevalence of psychiatric disorders is 62.5%. In 10 of the 16 adult patients, psychoses occurred that were diagnosed as severe depression, bipolar affective disorder, as polymorphic psychotic disorder or as schizoaffective disorder. The patients were treated in particular with atypical antipsychotic drugs, benzodiazepines and mood stabilizers. Neuropsychiatric symptoms in LOTS were explained with the concept of a cerebellar cognitive affective syndrome (CCAS) as an organic brain disease of the cerebellum; however, symptoms such as massive psychomotor agitation, anxiety, rapid mood swings, confusion, formal and content-related thought disorder as well as hallucinations cannot be completely explained by CCAS and are consistent with concepts that describe a role of cerebellar network dysfunctions in psychoses. Our data can help to include LOTS as a differential diagnosis in patients with psychiatric and neurological symptoms.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"351-356"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathological hoarding-A review of the disorder].","authors":"Mark Mühlbacher, Rebecca Schennach, Robert Birk, Ulrich Voderholzer","doi":"10.1007/s00115-026-01983-2","DOIUrl":"10.1007/s00115-026-01983-2","url":null,"abstract":"<p><p>Pathological hoarding is an independent psychological disorder characterized by persistent difficulties in discarding possessions, excessive accumulation and a functionally relevant impairment of living conditions and daily functioning. The prevalence is estimated at approximately 2-3%, with symptom onset often already occurring in childhood or adolescence. This article provides a structured overview of the epidemiology, etiopathogenesis, typical comorbidities and relevant differential diagnoses of pathological hoarding. A further focus is on evidence-based treatment approaches, in particular disorder-specific cognitive behavioral therapy and the relevance of pharmacotherapy for comorbid conditions. Finally, the substantial psychosocial of pathological hoarding as well as social law are discussed.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"415-423"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitteilungen der DGPPN 04/2026.","authors":"","doi":"10.1007/s00115-026-01988-x","DOIUrl":"https://doi.org/10.1007/s00115-026-01988-x","url":null,"abstract":"","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":"97 4","pages":"424-428"},"PeriodicalIF":1.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Digital health applications and adherence in depression: a qualitative study from the perspective of healthcare providers].","authors":"Francesca Denby, Sophie Brenner, Brit S Schneider","doi":"10.1007/s00115-026-01994-z","DOIUrl":"10.1007/s00115-026-01994-z","url":null,"abstract":"<p><strong>Background: </strong>Shortages of healthcare professionals and the rising prevalence of depressive disorders are creating gaps in care. When used correctly and consistently, digital health applications (DiGA) can help bridge these gaps. This study examines, from the perspective of healthcare providers, criteria for DiGA selection, their integration into therapy and the promotion of patient adherence.</p><p><strong>Methods: </strong>For this qualitative study eight semi-structured expert interviews were conducted with psychiatrists, psychotherapists and general practitioners in and around Osnabrück, Germany. The interviews were analyzed using Mayring's qualitative content analysis.</p><p><strong>Results: </strong>Respondents primarily use DiGA as adjunctive therapy or to bridge waiting periods. They seem particularly suitable for patients with mild symptoms, technical skills and good self-organization. Monitoring progress and integrating DiGA into therapeutic routines support continued use. Providers are only partially aware of their influence on adherence. Most respondents reported limited knowledge of the app content and a lack of confidence in the technology.</p><p><strong>Conclusion: </strong>Although the effectiveness of DiGA is proven and the role of medical or therapeutic support in promoting adherence is recognized, insufficient information, a lack of transparency regarding app content and the absence of best practices are hindrances to practical implementation. To realize the full potential of DiGA providers should be supported with product-neutral, quality-assured information and practical guidance for integration into therapy.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wissenschaftliche Bewertung von Methoden für den Nachweis von „Post-/Long-COVID-Syndromen“ und ihrer Überlappung mit „ME/CFS“ : Kurzfassung der Stellungnahme der Deutschen Gesellschaft für Neurowissenschaftliche Begutachtung (DGNB).","authors":"F Erbguth, M Tegenthoff, C Böwering-Möllenkamp, H Schain, H-C Hansen, B Widder","doi":"10.1007/s00115-026-01996-x","DOIUrl":"https://doi.org/10.1007/s00115-026-01996-x","url":null,"abstract":"","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[High on stage? Substance use and performance anxiety among professional musicians].","authors":"Antonia Bendau, Jens Plag, Andreas Ströhle, Felix Betzler, Lukas Roediger, Moritz Bruno Petzold, Alexander Schmidt, Isabel Fernholz","doi":"10.1007/s00115-026-01980-5","DOIUrl":"https://doi.org/10.1007/s00115-026-01980-5","url":null,"abstract":"<p><strong>Background: </strong>Substance use is commonly assumed to be widespread among musicians; however, empirical data on consumption patterns and the associations with anxiety are limited and heterogeneous. In particular, differentiated longitudinal findings across substances and musical genres are lacking.</p><p><strong>Objective: </strong>Therefore, the aim of this study was to investigate the use of various psychoactive substances among professional musicians from different genres, including the examination of changes over time and associations with (performance) anxiety.</p><p><strong>Material and methods: </strong>An anonymous online study with two assessment waves (T1: January-June 2024, T2: June 2025) was conducted; 1392 musicians (including music students) participated in T1, of whom 327 also took part in T2. The frequency of use for 16 substances, indicators of problematic substance use (Cut down, Annoyed, Guilty, Eye-opener-adapted to include drugs, CAGE-AID), performance anxiety (stage anxiety questionnaire, BAF), and general anxiety symptoms (GAD-7) were assessed.</p><p><strong>Results: </strong>Overall, a generally elevated prevalence of substance use was not observed. Alcohol was the most frequently used substance and 21% of participants showed a positive screening for problematic substance use. Musicians in popular/jazz genres tended to report higher levels of substance use than classical musicians. Cross-sectionally, weak associations between some substances and performance anxiety were observed. Longitudinally, cross-lagged panel models indicated minimal changes over time and no significant longitudinal effects between substance use and anxiety.</p><p><strong>Discussion: </strong>The findings do not provide evidence for generally increased levels of substance use among musicians but point to individual risk profiles that should be considered when providing care for this population.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nutritional psychiatry and psychosomatics in the DACH region : Clinical treatment concepts and research at the university hospitals of Graz, Berlin and Zurich].","authors":"Sabrina Mörkl, Anna Ramirez-Obermayer, Sonja Mötteli, Florian Hotzy, Nazli Esfahani-Bayerl, Sonja Lackner, Jolana Wagner-Skacel","doi":"10.1007/s00115-026-01976-1","DOIUrl":"https://doi.org/10.1007/s00115-026-01976-1","url":null,"abstract":"<p><strong>Background: </strong>Individuals with mental disorders have an increased risk for metabolic disturbances, inflammation and nutrient deficiencies. Nevertheless, nutritional aspects have so far received little attention in psychiatric care. Nutritional psychiatry and nutritional psychosomatics (NP) combine psychiatry with nutritional and lifestyle medicine to systematically integrate the interaction of these domains into the diagnostics and therapy.</p><p><strong>Objective: </strong>Illustration of specialized structures and description of three outpatient clinics in the DACH region (Germany, Austria and Switzerland).</p><p><strong>Methods: </strong>Overview of scientific foundations, international trends and guidelines, along with a description of the clinics based on the locations.</p><p><strong>Results: </strong>The outpatient clinics represent complementary approaches: Graz focuses on nutrition and mental health, the gut-brain axis and integrative therapy; Berlin emphasizes micronutrient diagnostics and functional medicine; Zurich adopts an interdisciplinary, behaviorally and pharmacologically oriented approach. Together, they highlight the need for specialized, multiprofessional structures and scientific evaluation.</p><p><strong>Discussion: </strong>The discipline of NP opens up new avenues for prevention and personalized therapy. To meet the high demand and address existing challenges, greater capacity, interdisciplinary networks, health services research and integration into regional healthcare systems are needed. Close alignment of research and clinical practice is essential to sustainably establish evidence-based care concepts and teaching approaches in psychiatry.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of ChatGPT as a digital advisor in acute psychiatric crises: a feasibility study.","authors":"Lubomir Barabas, Michal Novotny, Dennis Jung, Thomas Müller, Nicolas Nagysomkuti Mertse","doi":"10.1007/s00115-025-01837-3","DOIUrl":"10.1007/s00115-025-01837-3","url":null,"abstract":"<p><strong>Background: </strong>This exploratory study tested ChatGPT as a digital advisor chatbot for German-speaking individuals in acute psychiatric crises. Additionally, the attitudes of young physicians and psychologists towards the use of large language models (LLMs) in healthcare were investigated.</p><p><strong>Methods: </strong>In total, 20 resident physicians and psychologists simulated patients in three clinical scenarios (depression, psychosis, adjustment disorder) and interacted with ChatGPT. They evaluated the chatbot's performance regarding overall experience, pleasantness, appropriateness of the responses, realism, and helpfulness. Before and after the intervention, their attitudes towards such a chatbot were assessed. Finally, they assessed 12 statements about the future of LLMs in healthcare and provided open feedback on the chat experience.</p><p><strong>Results: </strong>ChatGPT received predominantly positive ratings (over 8/10 points) for overall experience, helpfulness, pleasantness, and appropriateness, while realism was rated slightly lower at 7/10 points. The appropriateness of the responses varied significantly between the scenarios, with lower ratings for the psychosis scenario. Open feedback confirmed the limited suitability of ChatGPT for psychosis patients. Overall, 70% or more of the participants agreed that LLMs will become increasingly important in everyday life and healthcare, and that an LLM-based chatbot would be a modern tool for low-threshold access to initial psychiatric aid. However, the high number of neutral responses across all 12 items (20-45%) indicates uncertainty regarding the actual benefits and risks.</p><p><strong>Conclusion: </strong>The performance of ChatGPT was rated positively overall by the participants. Significant practical and methodological limitations remain, however, highlighting the need for further research including real patients for a gradual, carefully monitored integration of LLMs into mental healthcare.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"265-271"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}