IF 0.9 4区医学

Nervenarzt Pub Date : 2025-01-22 DOI: 10.1007/s00115-025-01803-z

V Sondermann, J C Gerber, W H Polanski, M Brandt, J Schäfer, E Dinter, R Haußmann

引用次数: 0

[Compatibility of care work and specialist training in psychiatry : Position paper of the generation PSY-Next generation initiative of the German Association for Psychiatry and Psychotherapy]. [精神病学护理工作和专家培训的兼容性：德国精神病学和心理治疗协会新一代精神病学-下一代倡议的立场文件]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2025-01-20 DOI: 10.1007/s00115-024-01793-4

Nina Schubotz, Linda Meyer, Katrin Radenbach

引用次数: 0

[Utilization of healthcare services by young adults with first psychotic episodes at the FRITZ am Urban in Berlin considering the migration background]. [考虑到移民背景，在柏林城市FRITZ首次精神病发作的年轻成年人的医疗保健服务的利用]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2025-01-16 DOI: 10.1007/s00115-024-01777-4

Miriam Bernhardt, Stefan Siebert, Johanna Baumgardt, Olga Maria Domanska, Karolina Leopold, Andreas Bechdolf

{"title":"[Utilization of healthcare services by young adults with first psychotic episodes at the FRITZ am Urban in Berlin considering the migration background].","authors":"Miriam Bernhardt, Stefan Siebert, Johanna Baumgardt, Olga Maria Domanska, Karolina Leopold, Andreas Bechdolf","doi":"10.1007/s00115-024-01777-4","DOIUrl":"https://doi.org/10.1007/s00115-024-01777-4","url":null,"abstract":"Background: In Germany, there are hardly any studies that investigated the care pathways in the early course of psychosis and the duration of untreated psychosis (DUP) and took the migration background into account.Objective: The study examined whether young adults with (PwM) and without a migration background (PoM) who had a first psychotic episode or first contact with the psychiatric care system within the last 5 years differ in their utilization of care services and DUP.Material and methods: The data collection and post hoc analyses were carried out as a part of a cohort study (84 inpatients) at the Early Intervention and Therapy Center (FRITZ) in Berlin.Results: The number of PwM (n = 38) who experienced a first psychotic episode did not significantly differ from the comparison group (PoM, n = 46) in the utilization of healthcare services (p = 0.22). Neither the time until seeking help from the first service nor the number of contacts with healthcare services and DUP significantly differed between PwM and Pom. The PwM were predominantly young adults with a good education background who grew up in Germany.Discussion: Users sought help at FRITZ relatively quickly, independent of their migration background, which supports further implementation of specialized early detection and intervention services in Germany. The results could be attributed to the selection of the study population.Conclusion: Further studies are needed that address people with lower education and low language skills. The early detection programs and awareness campaigns should be adapted to this target group.","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Mechanisms of action of antidepressive pharmacotherapy: brain and mind-body and environment]. [抗抑郁药物治疗的作用机制：脑、心身和环境]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2025-01-16 DOI: 10.1007/s00115-024-01786-3

Moritz Spangemacher, Jonathan Reinwald, Hana Adolphi, Laura Kärtner, Lea J Mertens, Christian N Schmitz, Gerhard Gründer

{"title":"[Mechanisms of action of antidepressive pharmacotherapy: brain and mind-body and environment].","authors":"Moritz Spangemacher, Jonathan Reinwald, Hana Adolphi, Laura Kärtner, Lea J Mertens, Christian N Schmitz, Gerhard Gründer","doi":"10.1007/s00115-024-01786-3","DOIUrl":"https://doi.org/10.1007/s00115-024-01786-3","url":null,"abstract":"Background: Novel antidepressive substances are challenging the explanations for the mechanisms of action of traditional psychopharmacology.Objective: What could be the shared effects of various antidepressants and in this context what role do extrapharmacological factors, such as the body and environment, play?Material and method: The available literature on clinical and preclinical data for assumed combined active factors of serotonergic psychedelic drugs, (es)ketamine, monoaminergic antidepressants and zuranolone are presented and the influence of context factors on the individual mechanisms of action is discussed.Results: There are many indications that classical and novel pharmacological approaches could share similar mechanisms of action in the treatment of depression. These mechanisms favor long-term neuroplasticity, which can trigger subsequent molecular cascades and vice versa. Furthermore, an improvement in the negative bias in emotional processing could be detected for most antidepressive substances. The influence of extrapharmacological factors appears to be necessary so that the biopsychological alterations can have an antidepressive effect.Conclusion: Instead of attributing factors such as environment, body and social interaction to placebo effects, they should be tested as essential components of the antidepressive effect and considered in the clinical practice.","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Psychotropic drug-related weight gain-Are incretins/twincretins an option?] 精神药物相关体重增加——肠促胰岛素/双肠促胰岛素是一种选择吗？］

IF 0.9 4区医学

Nervenarzt Pub Date : 2025-01-08 DOI: 10.1007/s00115-024-01788-1

Michael Paulzen

引用次数: 0

[Long-term courses of bipolar disorders]. [双相情感障碍的长期病程]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2024-12-21 DOI: 10.1007/s00115-024-01791-6

Tabea Czempiel, Pavol Mikolas, Michael Bauer, Sabrina Vogel, Philipp Ritter

{"title":"[Long-term courses of bipolar disorders].","authors":"Tabea Czempiel, Pavol Mikolas, Michael Bauer, Sabrina Vogel, Philipp Ritter","doi":"10.1007/s00115-024-01791-6","DOIUrl":"https://doi.org/10.1007/s00115-024-01791-6","url":null,"abstract":"Background: Bipolar disorder (short: BD) is a severe illness with very heterogeneous trajectories. While some of the patients show no or hardly any long-term impairments, other affected individuals show substantial neurocognitive deficits with a clear decline in psychosocial functioning. Which factors influence the course of the disease is the subject of current research efforts.Objective: This review presents the long-term course of bipolar disease and the factors influencing it. In particular, differential trajectory types are discussed. The cognitive and psychosocial functional level as well as the psychopathological characteristics of the disease are elucidated. In addition, biological factors and treatment approaches influencing the course and prognosis are identified.Material and methods: Literature search using PubMed focusing on longitudinal studies over several years (see online supplement).Results: To date, there are only a few predictors and biomarkers that allow prediction of long-term progression. None have been sufficiently studied to enable clinical use. Appropriate pharmacological and psychotherapeutic treatment of those affected is essential to avoid renewed episodes of the disease.Discussion: The long-term course of bipolar disorder is highly heterogeneous and multifaceted. Despite intensive research efforts, no predictors have yet been identified that reliably predict the clinical course. This makes further research all the more important in order to offer individualized therapy options, develop new therapies and positively influence the course of the disease at an early stage.","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Temporobasal meningioma as possible cause of a cognitive disturbance with depression in old age]. [颞基底脑膜瘤可能导致老年认知障碍伴抑郁]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2024-12-20 DOI: 10.1007/s00115-024-01787-2

Meret Heibel, Horst Urbach, Katharina Domschke, Sabine Hellwig

引用次数: 0

[Long-term courses of anxiety disorders]. [焦虑症的长期病程]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2024-12-20 DOI: 10.1007/s00115-024-01789-0

Jens Plag, Selina Heuer, Antonia Bendau, Andreas Ströhle

{"title":"[Long-term courses of anxiety disorders].","authors":"Jens Plag, Selina Heuer, Antonia Bendau, Andreas Ströhle","doi":"10.1007/s00115-024-01789-0","DOIUrl":"https://doi.org/10.1007/s00115-024-01789-0","url":null,"abstract":"Background: At present there is no comprehensive overview of the long-term development of the clinical picture, disease-associated impairments and neurobiological correlates of anxiety disorders as well as what influence certain risk factors and treatment have on the prognosis.Objective: This article presents findings regarding disorder-specific symptoms and disorder-associated changes in the areas of functional level, quality of life, neurocognitive performance and structural brain anatomy over the lifespan. It also reports on how patient-related and environment-related aspects as well as guideline-oriented therapy influence the course of the disorder.Material and methods: A literature search was conducted in PubMed on the aspects of individual components. Meta-analyses, longitudinal and cohort studies were included. To illustrate changes over time, the findings were predominantly presented separately for children and adolescents as well as for early and late adulthood.Results: Anxiety disorders primarily exhibit age-associated differences in the symptom profile but also in the areas of functional level and quality of life. Risk factors for an unfavorable course of the disorder were identified particularly for young and middle-aged people; however, the findings indicate that evidence-based psychotherapy or pharmacotherapy also has a lasting effect even after termination.Conclusion: For long-term therapeutic success, age-dependent characteristics and limitations as well as prognostically relevant aspects in the diagnostics and treatment of anxiety disorders should be taken into consideration and treatment should be started as soon as possible.","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Long-term courses in schizophrenia : A review of current results and developments]. [精神分裂症的长期疗程：对当前结果和发展的回顾]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2024-12-19 DOI: 10.1007/s00115-024-01790-7

Igor Nenadić, Irina Falkenberg, Stephanie Mehl, Tilo Kircher

引用次数: 0

[Assessment of cognition: dementia and delirium : In consideration of the AWMF guidelines 038-013 and 084-002LG]. [认知评估：痴呆和谵妄：考虑到AWMF指南038-013和084-002LG]。

IF 0.9 4区医学

Nervenarzt Pub Date : 2024-12-17 DOI: 10.1007/s00115-024-01795-2

Sonja Krupp, Bernhard Iglseder

引用次数: 0

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