NervenarztPub Date : 2024-07-18DOI: 10.1007/s00115-024-01708-3
Maria Ilyas-Feldmann, Luise Graf, Thea Hüsing, Jakob Dörrfuß, Martin Holtkamp
{"title":"[Discontinuation of antiseizure medication in patients with epilepsy].","authors":"Maria Ilyas-Feldmann, Luise Graf, Thea Hüsing, Jakob Dörrfuß, Martin Holtkamp","doi":"10.1007/s00115-024-01708-3","DOIUrl":"https://doi.org/10.1007/s00115-024-01708-3","url":null,"abstract":"<p><strong>Background: </strong>Approximately two thirds of patients with epilepsy become seizure-free with antiseizure medication (ASM). A central question is whether and when ASM can be discontinued.</p><p><strong>Objective: </strong>To present an overview of the current knowledge about risks and benefits of discontinuation of ASM.</p><p><strong>Material and methods: </strong>Review of the current literature, discussion of data on and recommendations for discontinuation of ASM.</p><p><strong>Results: </strong>The risk of seizure recurrence after discontinuation of ASM is approximately 40-50% and thus twice as high as continuing with ASM. Guidelines recommend considering discontinuation of ASM at earliest after a seizure-free period of 2 years. Predictive variables for seizure recurrence after stopping ASM include longer duration of epilepsy and higher number of seizures until remission, a shorter seizure-free interval until stopping ASM, older age at epilepsy onset, developmental delay or IQ < 70, febrile seizures in childhood, absence of a self-limiting epilepsy syndrome, and evidence of epileptiform activity in the electroencephalograph (EEG). The individual risk of seizure recurrence after stopping ASM can be estimated using an online prediction tool.</p><p><strong>Conclusion: </strong>Discontinuation of ASM should be discussed with patients at the earliest after 2 years of seizure freedom in a shared decision-making process weighing up the risks and benefits. The risk of a seizure recurrence depends on a number of clinical variables. Psychosocial aspects, such as impact on driving and occupational issues must be taken into consideration as well as individual fears and concerns of patients about seizure recurrence or the long-term use of ASM.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-06-17DOI: 10.1007/s00115-024-01678-6
Denise Linsmayer, Gunter P Eckert, Julia Reiff, Dieter F Braus
{"title":"[Nutrition, metabolism, brain and mental health].","authors":"Denise Linsmayer, Gunter P Eckert, Julia Reiff, Dieter F Braus","doi":"10.1007/s00115-024-01678-6","DOIUrl":"10.1007/s00115-024-01678-6","url":null,"abstract":"<p><p>This review article explores the intricate relationship between nutrition, metabolism, brain function and mental health. It highlights two key complementary models: the energy balance model and the more comprehensive carbohydrate-insulin model, to understand the development of obesity and metabolic dysfunctions. It particularly focuses on the role of dopamine in dietary regulation and insulin in the brain, both of which are crucial in the pathogenesis of neurodegenerative and stress-associated mental disorders. Additionally, the significance of sleep and dietary habits, such as medically assisted calorie restriction for mental health and the concept of \"brain food\" are described. These findings emphasize the importance of nutritional medicine in psychiatry and psychotherapy and the consideration of metabolic states for the prevention and treatment of mental and neurodegenerative diseases.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"667-680"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-06-21DOI: 10.1007/s00115-024-01694-6
Regina Steil, Andreas Maercker, Lena Jaworski, Rahel Bachem, David Eberle
{"title":"[Evidence-based psychotherapy of posttraumatic stress syndrome-An update].","authors":"Regina Steil, Andreas Maercker, Lena Jaworski, Rahel Bachem, David Eberle","doi":"10.1007/s00115-024-01694-6","DOIUrl":"10.1007/s00115-024-01694-6","url":null,"abstract":"<p><strong>Background: </strong>The aim of this article is to summarize the current state of research on the effectiveness of psychotherapeutic treatment of posttraumatic stress disorder (PTSD).</p><p><strong>Methods: </strong>The results of current meta-analyses and trend-setting individual studies are summarized and the most important forms of intervention are explained.</p><p><strong>Results: </strong>The psychotherapeutic treatment methods for PTSD are very effective, the effect sizes are large and superior to those of pharmacotherapy. Trauma exposure and cognitive restructuring are most effective. Trauma-focused procedures are generally superior to other forms of psychotherapy. A range of different cognitive behavioral procedures as well as eye movement desensitization and reprocessing are recommended. The most recent initial findings confirm a very good effectiveness for imagery rescripting methods as protective interventions without a formal confrontation with trauma. Individual therapy works better than group psychotherapy. In the group setting cognitive processing therapy has proven to be the best intervention. Trauma-focused treatment should also be used when comorbid conditions such as schizophrenia, bipolar disorder or addiction are present.</p><p><strong>Discussion: </strong>Trauma-focused psychotherapy in an individual setting is the treatment of choice for PTSD. A large selection of effective methods and well-reviewed manuals are available. The German language S3 guidelines are currently being updated.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"616-621"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-07-03DOI: 10.1007/s00115-024-01677-7
Ingo Schäfer, Ulrich Voderholzer
{"title":"[Treatment of sequelae of trauma].","authors":"Ingo Schäfer, Ulrich Voderholzer","doi":"10.1007/s00115-024-01677-7","DOIUrl":"10.1007/s00115-024-01677-7","url":null,"abstract":"","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":"95 7","pages":"595-596"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-05-16DOI: 10.1007/s00115-024-01672-y
Christopher Baethge
{"title":"[Changes in the perception of benefits and risks of antidepressive pharmacotherapy].","authors":"Christopher Baethge","doi":"10.1007/s00115-024-01672-y","DOIUrl":"10.1007/s00115-024-01672-y","url":null,"abstract":"<p><p>Antidepressive pharmacotherapy has undergone various phases in its history. The euphoria of the early years on the relief of depressive symptoms was followed by a long period of clinical experience and intensive scientific work resulting in a more balanced perspective. Current debates circle around the actual effectiveness, especially with respect to long-term treatment, the prevention of suicide and the sequelae of discontinuation of an antidepressant. The evaluation of antidepressants as a group and often also the risk-benefit ratio of an individual treatment change over time. Antidepressants are typical for many forms of psychiatric treatment which, in a term from Hanfried Helmchen, are just as Janus-faced as psychiatry in a general sense is as a science and as a clinical discipline.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"651-655"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-07-03DOI: 10.1007/s00115-024-01656-y
Andreas Heinz
{"title":"[Introduction to the topic: psychiatry in the course of time].","authors":"Andreas Heinz","doi":"10.1007/s00115-024-01656-y","DOIUrl":"10.1007/s00115-024-01656-y","url":null,"abstract":"","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":"95 7","pages":"639-640"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01Epub Date: 2024-06-04DOI: 10.1007/s00115-024-01676-8
Marc Giesmann, Isabella Flatten-Whitehead, Lina Specht, Jörg M Fegert, Julia Schellong, Miriam Rassenhofer, Ingo Schäfer
{"title":"[Rapid assistance for victims of acute violence-Current treatment in outpatient trauma clinics in Germany].","authors":"Marc Giesmann, Isabella Flatten-Whitehead, Lina Specht, Jörg M Fegert, Julia Schellong, Miriam Rassenhofer, Ingo Schäfer","doi":"10.1007/s00115-024-01676-8","DOIUrl":"10.1007/s00115-024-01676-8","url":null,"abstract":"<p><strong>Background: </strong>Assistance following acute violence was previously regulated by the Victim Compensation Act (OEG). At the beginning of the current year it was replaced by the Social Code XIV (SGB XIV). The SGB XIV defines new groups of beneficiaries, outpatient trauma clinics must be provided nationwide and binding criteria for the quality of care were established. The aim of this study was to map the current status of care in outpatient trauma clinics in accordance with the requirements of the new SGB XIV. With respect to new beneficiaries, the status of services for victims of human trafficking was recorded as an example.</p><p><strong>Methods: </strong>Outpatient clinics that provide rapid assistance under the OEG or SGB XIV were surveyed on structural and content-related aspects of their work. An online survey consisting of 10 thematic modules was used. Data were obtained from a total of N = 110 outpatient clinics (response rate 50%).</p><p><strong>Results: </strong>The participating outpatient clinics reported a wide range in terms of the number of staff and the number of people seeking counselling. Some of the outpatient clinics reported deficits with respect to structural aspects, such as the waiting time for the initial consultation and specific training in trauma treatment for staff. The majority of outpatient clinics were uncertain about how to deal with victims of human trafficking.</p><p><strong>Discussion: </strong>Outpatient trauma clinics appear to reach their target population and provide appropriate services for their care; however, a significant number of outpatient clinics need to make improvements in order to fulfil the quality criteria of SGB XIV and provide adequate care to new groups of beneficiaries.</p>","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":"597-606"},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NervenarztPub Date : 2024-07-01DOI: 10.1007/s00115-024-01697-3
Andreas Schuld, Thomas Pollmächer, Knut Schnell, Bettina Wilms, Sylvia Claus
{"title":"[Education of psychotherapists in hospitals for psychiatry and psychotherapy : Survey on the implementation of different aspects of the old and new education pathways].","authors":"Andreas Schuld, Thomas Pollmächer, Knut Schnell, Bettina Wilms, Sylvia Claus","doi":"10.1007/s00115-024-01697-3","DOIUrl":"https://doi.org/10.1007/s00115-024-01697-3","url":null,"abstract":"","PeriodicalId":49770,"journal":{"name":"Nervenarzt","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}