NeurocasePub Date : 2023-02-01Epub Date: 2023-12-16DOI: 10.1080/13554794.2023.2280276
Yan-Jun Ma, Lei Zhao, Jie-Qiong Li, Liu Yang, Yue-Ming Yan, Jiang-Bo Li, Li-Hong Gao
{"title":"Epstein-Barr virus infection with non-tumor-associated Anti-N-Methyl-D-Aspartate receptor encephalitis: a case report and review of literature.","authors":"Yan-Jun Ma, Lei Zhao, Jie-Qiong Li, Liu Yang, Yue-Ming Yan, Jiang-Bo Li, Li-Hong Gao","doi":"10.1080/13554794.2023.2280276","DOIUrl":"10.1080/13554794.2023.2280276","url":null,"abstract":"<p><p>To study a case of a middle-aged male with a non-tumor-associated Epstein-Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of EBV in the pathogenesis of anti-NMDARE. The patient was diagnosed with \"Anti-NMDARE, EBV infection\" by using Cerebrospinal fluid (CSF) autoimmune encephalitis profile, and Metagenomics Next-Generation Sequencing (mNGS) pathogenic microbial assays, we discuss the relationship between EBV and NMDARE by reviewed literature. EBV infection may trigger and enhance anti-NMDARE, and the higher the titer of NMDAR antibody, the more severe the clinical presentation.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"1-5"},"PeriodicalIF":0.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2023-02-01Epub Date: 2023-03-30DOI: 10.1080/13554794.2023.2191858
Tania C Ghazarian, Matthew G H Hall, Leslie A Horton, Bruce L Miller, Robert T Rubin
{"title":"Behavioral variant frontotemporal dementia in a 23-year-old man.","authors":"Tania C Ghazarian, Matthew G H Hall, Leslie A Horton, Bruce L Miller, Robert T Rubin","doi":"10.1080/13554794.2023.2191858","DOIUrl":"10.1080/13554794.2023.2191858","url":null,"abstract":"<p><p>A 23-year-old man presented with behavioral disinhibition, stereotypies, motor apathy, flattened affect, and inappropriate laughter. CT demonstrated generalized cerebral atrophy. He was admitted with a diagnosis of unspecified psychosis and discharged on antipsychotic medication. He was readmitted 3 months later, was diagnosed with schizophrenia, and antipsychotic medication was continued. Owing to symptom progression and aggressive behavior, he was readmitted 2 months later. CT again demonstrated moderate central and cortical cerebral atrophy. MRI showed severe, stable atrophy with frontotemporal predominance, and he was diagnosed with probable behavioral variant frontotemporal dementia (bvFTD). Over the next year he rapidly deteriorated, with loss of cognitive abilities. Genetic testing revealed several variants, none of which are clearly disease-causing.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"6-13"},"PeriodicalIF":0.6,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9214305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2023-02-01Epub Date: 2023-05-07DOI: 10.1080/13554794.2023.2208271
Rima Abou-Khalil, Lealani Mae Y Acosta
{"title":"A case report of acquired synesthesia and heightened creativity in a musician after traumatic brain injury.","authors":"Rima Abou-Khalil, Lealani Mae Y Acosta","doi":"10.1080/13554794.2023.2208271","DOIUrl":"10.1080/13554794.2023.2208271","url":null,"abstract":"<p><strong>Introduction: </strong>We report on a musician who acquired synesthesia, enhanced sensory experience, and improved creativity following traumatic brain injury (TBI).</p><p><strong>Background: </strong>Creativity and synesthesia can be acquired from an injury, though both simultaneously has not been frequently documented.</p><p><strong>Narrative: </strong>This case report details heightened creativity and developing synesthesia in a 66-year-old right-handed man following TBI. He developed a \"compulsion\" to write music. Synesthesia included \"seeing\" the notation and being able to name chord structures of music he heard, both of which were novel experiences. The Synesthesia Battery revealed a vision-sound synesthesia with higher than average level of Vividness of Visual Imagery (VVIQ-2), and \"Absolute Pitch/Perfect Pitch.\"</p><p><strong>Patient experience: </strong>The patient experienced an approximate four-month history of these changes, including musical compositions, developing perfect pitch, and enhanced sensory experience of typical phenomena.</p><p><strong>Discussion: </strong>Both creativity and synesthesia depend on novel connections in the brain, and both have been reported following insults to the brain, including in degenerative conditions. However, the development of both simultaneously is not frequently reported. Evidence for the etiology of one prompting the other has not been described. Brain injury may result in increased creativity and synesthesia. Our fields would benefit from increased awareness of this possible relationship.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"18-21"},"PeriodicalIF":0.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2023-02-01Epub Date: 2023-12-16DOI: 10.1080/13554794.2023.2280278
Dilara Mermi Dibek, Pınar Tamer Çoban, Sevgi Ferik, I Brahim Öztura, Barış Baklan
{"title":"Ictal religious speech in non-dominant temporal lobe epilepsy: three cases.","authors":"Dilara Mermi Dibek, Pınar Tamer Çoban, Sevgi Ferik, I Brahim Öztura, Barış Baklan","doi":"10.1080/13554794.2023.2280278","DOIUrl":"10.1080/13554794.2023.2280278","url":null,"abstract":"<p><p>Ictal religious speech and gestures, rare ictal semiological findings, sign the epileptic focus at the non-dominant temporal lobe in the literature. Therefore, we aim to present non-dominant temporal lobe semiological findings, including ictal praying and religious gestures in three cases.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"25-27"},"PeriodicalIF":0.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electroconvulsive therapy for obsessive compulsive symptoms in a patient with schizophrenia: a brief report.","authors":"Chih-Yuan Lin, Hsin-Ya Kuo, Cheng-Ho Chang, Chih-Chuan Pan, Che-Sheng Chu, Jeremy Couper, Yung-Chih Chiang","doi":"10.1080/13554794.2023.2280274","DOIUrl":"10.1080/13554794.2023.2280274","url":null,"abstract":"<p><p>Comorbid obsessive-compulsive disorder (OCD) is common among patients with schizophrenia. The role of electroconvulsive therapy (ECT) in the treatment of OCD in schizophrenia is unclear. Herein, we present a 45-year-old man who was diagnosed with schizophrenia along with OCD and received ECT due to relapse of psychosis owing to refractive schizophrenia. Together with psychotic symptoms, obvious symptoms of OCD were observed prior to treatment, including obsessive thoughts, difficulty in starting activities, and repetitive and ritualistic behavior. After 12 sessions of ECT, symptoms of schizophrenia and OCD both improved significantly (Positive and Negative Syndrome Scale [PANSS] score decreased from 95 points to 58 points, and Yale - Brown Obsessive-Compulsive Scale [Y-BOCS] score decreased from 29 points to 11 points). Mild aggravation of OCD symptoms was noted 3 months after ECT treatment (Y-BOCS score increased from 11 points to 17 points) without obvious relapse of psychotic symptoms (PANSS score changed from 58 points to 62 points). In conclusion, ECT could be considered as an alternative therapy for patients with schizophrenia and OCD with limited response to pharmacological treatment.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":" ","pages":"22-24"},"PeriodicalIF":0.8,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2022-12-01DOI: 10.1080/13554794.2022.2159444
Maya Troyanskaya, Nicholas J Pastorek, Fariha Jamal, George R Jackson, Aliya I Sarwar, Elisabeth A Wilde, Randall S Scheibel
{"title":"A pilot study of olfactory function in veterans with a history of deployment-related mild traumatic brain injury.","authors":"Maya Troyanskaya, Nicholas J Pastorek, Fariha Jamal, George R Jackson, Aliya I Sarwar, Elisabeth A Wilde, Randall S Scheibel","doi":"10.1080/13554794.2022.2159444","DOIUrl":"https://doi.org/10.1080/13554794.2022.2159444","url":null,"abstract":"<p><p>Olfactory impairment in military populations is highly prevalent and often attributed to the long-term effects of mild traumatic brain injury (mTBI) and chronic psychiatric disorders. The main goal of this investigation was to examine olfactory function in a cohort of combat veterans using a quantitative smell test.Participants underwent a neurological examination, completed performance validity testing (PVT), provided deployment history, and their medical records were reviewed.Participants were 38 veterans with a deployment-related mTBI who passed the PVT and did not have ongoing substance misuse issues. Olfactory examination revealed normosmia in 20 participants and various degrees of deficit in 18. The groups did not differ in demographics, post-injury interval, or current clinical (non-psychiatric) conditions. Participants with hyposmia frequently reported being exposed to a higher number of blasts and being positioned closer to the nearest primary blast, and more often endorsed a period of loss of consciousness after the most serious mTBI. In addition, they more often reported tympanic membrane perforation, extracranial injuries, and histories of both blast and blunt force mTBI. Comorbid diagnoses of posttraumatic stress disorder, depression, chronic headaches, and pain were more common among them as well.Several blast exposure and injury-related characteristics increase the likelihood of long-term olfactory impartments, comorbid psychiatric conditions, and chronic pain among veterans with history of deployment-related mTBI. Notably, none of the participants with hyposmia had a clinical diagnosis of olfactory dysfunction or were receiving service-connected disability for loss of sense of smell at the time of their assessment.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":"28 6","pages":"459-466"},"PeriodicalIF":0.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9332969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2022-12-01DOI: 10.1080/13554794.2023.2176779
Dovlat Khalilov, Garen Haryanyan, Baris Salman, Emrah Yucesan, Sibel Ugur Iseri, Nerses Bebek
{"title":"Epilepsy or neurodevelopmental disorders are associated with homozygous and pathogenic <i>ELP2</i> variation in three siblings.","authors":"Dovlat Khalilov, Garen Haryanyan, Baris Salman, Emrah Yucesan, Sibel Ugur Iseri, Nerses Bebek","doi":"10.1080/13554794.2023.2176779","DOIUrl":"https://doi.org/10.1080/13554794.2023.2176779","url":null,"abstract":"<p><p>Developmental and Epileptic Encephalopathies (DEEs) are a group of early-onset syndromic disorders characterized by varying degree of intellectual disability, autism spectrum, seizures, and developmental delay. Herein, we have clinically and genetically dissected three siblings from Turkey with DEE born to first cousin unaffected parents. We identified a homozygous pathogenic variant in <i>ELP2</i> (ENST00000358232.11:c.1385G>A; p.(Arg462Gln)). Our results, together with in depth literature review, underlie the importance of codon encoding the arginine at position 462 as a hotspot for <i>ELP2</i> related neurological phenotypes.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":"28 6","pages":"488-492"},"PeriodicalIF":0.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9649065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2022-12-01DOI: 10.1080/13554794.2023.2168558
Greta Demichelis, Dunja Duran, Giuseppe Ciullo, Lorenzo Lorusso, Stefano Zago, Sara Palermo, Anna Nigri, Matilde Leonardi, Maria Grazia Bruzzone, Davide Fedeli
{"title":"A multimodal imaging approach to foreign accent syndrome. A case report.","authors":"Greta Demichelis, Dunja Duran, Giuseppe Ciullo, Lorenzo Lorusso, Stefano Zago, Sara Palermo, Anna Nigri, Matilde Leonardi, Maria Grazia Bruzzone, Davide Fedeli","doi":"10.1080/13554794.2023.2168558","DOIUrl":"https://doi.org/10.1080/13554794.2023.2168558","url":null,"abstract":"ABSTRACT This article describes a case of Foreign accent syndrome (FAS) in an Italian woman who developed a Canadian-like foreign accent without brain damage (functional FAS). The patient underwent an in-depth neuroimaging and (neuro)psychological evaluation. Language networks in the frontotemporal-parietal areas were typically activated bilaterally through fMRI and MEG assessments based on task-based data. Resting-state fMRI showed preserved connectivity between language areas. An obsessive-compulsive personality profile and mild anxiety were found, suggesting psychological and psychiatric factors may be relevant. Accordingly with our findings, multimodal imaging is beneficial to understand FAS neurological and functional etiologies.","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":"28 6","pages":"467-476"},"PeriodicalIF":0.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9279291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2022-12-01DOI: 10.1080/13554794.2023.2176778
Petra Aboulhosn, Andrew Ryu, Azadeh Shafieesabet, Anusha Lekshminarayanan, Sohni Husain, Kathryn O'Connor, Saarah D'Souza, Shannon O'Neill, Eric L Altschuler
{"title":"Partial Balint's syndrome and left homonymous hemianopsia presenting after resection of a right occipito-parietal glioblastoma.","authors":"Petra Aboulhosn, Andrew Ryu, Azadeh Shafieesabet, Anusha Lekshminarayanan, Sohni Husain, Kathryn O'Connor, Saarah D'Souza, Shannon O'Neill, Eric L Altschuler","doi":"10.1080/13554794.2023.2176778","DOIUrl":"https://doi.org/10.1080/13554794.2023.2176778","url":null,"abstract":"<p><p>A 66-year-old left-handed male was admitted to our acute inpatient rehabilitation (AIR) unit following a resection of the right occipito-parietal glioblastoma. He presented with symptoms of horizontal oculomotor apraxia, contralateral optic ataxia and left homonymous hemianopsia. We diagnosed this patient with partial Bálint's syndrome (BS)- oculomotor apraxia, optic ataxia but not simultanagnosia. BS is typically caused by bilateral posterior parietal lesions, but we here describe a unique case due toresection of a right intracranial tumor. A short AIR stay allowed our patient to learn how to compensate for visuomotor and visuospatial deficits, and improved his quality of life significantly.</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":"28 6","pages":"483-487"},"PeriodicalIF":0.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9285651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeurocasePub Date : 2022-12-01DOI: 10.1080/13554794.2023.2176777
Sunyoung Kim, Jin-Sung Park, Jae-Hyeok Lee, Ha-Young Shin, Hui-Jun Yang, Jin-Hong Shin
{"title":"Clinical, electrophysiological, and genetic characteristics of cerebrotendinous xanthomatosis in South Korea.","authors":"Sunyoung Kim, Jin-Sung Park, Jae-Hyeok Lee, Ha-Young Shin, Hui-Jun Yang, Jin-Hong Shin","doi":"10.1080/13554794.2023.2176777","DOIUrl":"https://doi.org/10.1080/13554794.2023.2176777","url":null,"abstract":"<p><p>Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disorder caused by 27-hydroxylase deficiency. We report the clinical characteristics of six Korean CTX patients. The median age of onset was 22.5 years, the median age at diagnosis was 42 years, and the diagnostic delay was 18.1 years. The most common clinical symptoms were tendon xanthoma and spastic paraplegia. Four of five patients exhibited latent central conduction dysfunction. All patients carried the same mutation in <i>CYP27A1</i> (c.1214 G>A [p.R405Q]). CTX is a treatable neurodegenerative disorder; however, our results revealed that patients with CTX in Korea might receive the diagnosis after a prolonged delay. .</p>","PeriodicalId":49762,"journal":{"name":"Neurocase","volume":"28 6","pages":"477-482"},"PeriodicalIF":0.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9285655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}