eb病毒感染合并非肿瘤相关性抗n-甲基- d -天冬氨酸受体脑炎1例报告及文献复习

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2023-02-01 Epub Date: 2023-12-16 DOI:10.1080/13554794.2023.2280276

Yan-Jun Ma, Lei Zhao, Jie-Qiong Li, Liu Yang, Yue-Ming Yan, Jiang-Bo Li, Li-Hong Gao

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引用次数: 0

摘要

研究1例非肿瘤相关性eb病毒(EBV)感染合并抗n-甲基- d -天冬氨酸受体脑炎(NMDARE)的中年男性患者，探讨EBV在抗NMDARE发病机制中的作用。通过脑脊液(CSF)自身免疫性脑炎谱和宏基因组学下一代测序(mNGS)致病微生物检测，诊断为“抗NMDARE, EBV感染”，我们通过文献复习讨论EBV与NMDARE的关系。EBV感染可触发并增强抗NMDAR抗体，且NMDAR抗体滴度越高，临床表现越严重。

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Epstein-Barr virus infection with non-tumor-associated Anti-N-Methyl-D-Aspartate receptor encephalitis: a case report and review of literature.

To study a case of a middle-aged male with a non-tumor-associated Epstein-Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of EBV in the pathogenesis of anti-NMDARE. The patient was diagnosed with "Anti-NMDARE, EBV infection" by using Cerebrospinal fluid (CSF) autoimmune encephalitis profile, and Metagenomics Next-Generation Sequencing (mNGS) pathogenic microbial assays, we discuss the relationship between EBV and NMDARE by reviewed literature. EBV infection may trigger and enhance anti-NMDARE, and the higher the titer of NMDAR antibody, the more severe the clinical presentation.

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.