Polish Journal of Pathology最新文献_第5页

LncRNA-PVT1 enhances glucose metabolism of pediatric low-grade glioma cells through sponging miR-187-3p. LncRNA-PVT1通过海绵化miR-187-3p增强小儿低级别胶质瘤细胞的糖代谢。

IF 0.7 4区医学

Polish Journal of Pathology Pub Date : 2024-01-01 DOI: 10.5114/pjp.2024.146455

Beibei Li, Zijian Feng, Yanyan Zheng

{"title":"LncRNA-PVT1 enhances glucose metabolism of pediatric low-grade glioma cells through sponging miR-187-3p.","authors":"Beibei Li, Zijian Feng, Yanyan Zheng","doi":"10.5114/pjp.2024.146455","DOIUrl":"10.5114/pjp.2024.146455","url":null,"abstract":"Pediatric low-grade glioma (PLGG) is a heterogeneous group of primary central nervous system malignancies which represent the most frequent brain tumors in children. Although diagnosis and treatment of PLGG have been improved recently, the molecular mechanisms underlying the oncogenesis and progression of PLGG remain elusive. Studies have revealed critical roles of long non-coding RNAs (lncRNAs) in brain tumor progressions. Here, we aimed to investigate the clinical roles and molecular mechanisms of lncRNA PVT1 in PLGG. Expression of PVT1 was significantly upregulated in PLGG tissues compared with normal brain tissues. Blocking PVT1 effectively suppressed the glucose metabolism of PLGG-derived cells. MicroRNA-187-3p was detected to be remarkedly downregulated in PLGG tissues. Moreover, miR-187-3p is negatively correlated with PVT1 in PLGG tissues. We identified PVT1 sponged miR-187-3p to block its expression in PLGG cells. This association was further verified by RNA pull-down and luciferase assay. Subsequently, rescue experiments validated that inhibition of miR-187-3p in PVT1-silenced PLGG cells successfully overcame the low-PVT1-induced miR-187-3p upregulation and glucose metabolism. In summary, this study reports critical roles and molecular mechanisms of the lncRNA PVT1-accelarated glucose metabolism of PLGG cells.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"75 4","pages":"324-332"},"PeriodicalIF":0.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In search of an appropriate clinical diagnostic term with indefinite etiology. A case series on lobular capillary hemangioma. 在寻找一个适当的临床诊断术语与不确定的病因。小叶毛细血管瘤病例分析。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.127012

Biswadip Shyam, Mandavi Shailesh Waghmare, Vasavi Santosh, Bhavika Sachin Vhatkar

{"title":"In search of an appropriate clinical diagnostic term with indefinite etiology. A case series on lobular capillary hemangioma.","authors":"Biswadip Shyam, Mandavi Shailesh Waghmare, Vasavi Santosh, Bhavika Sachin Vhatkar","doi":"10.5114/pjp.2023.127012","DOIUrl":"https://doi.org/10.5114/pjp.2023.127012","url":null,"abstract":"Lobular capillary hemangioma, a benign vascular tumor of the skin or mucous membranes characterized by rapid growth and a friable surface, is widely but inappropriately termed pyogenic granuloma (now considered a misnomer by some theories) due to lack of evidence for infectious etiopathogenesis. Some studies promote the theory of a hyperplastic, neovascular response to an angiogenic stimulus with imbalance of promoters and inhibitors. Here we present a series of 4 cases of patients who visited the Oral Medicine OPD with a complaint of similar painless malformations showing granulomatous and/or fibrous tissue proliferation andwhich, after thorough history taking, clinical examination and excisional biopsy, were revealed to be lobular capillary hemangioma under histopathologic diagnosis. The following discussion revolves around the fact that, even though such exophytic lesions may present with variable features, a proper, accurate and logical diagnostic entity may be used to help in better coordination among the oral physician, oral pathologist and oral surgeon in framing the desired treatment plan.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 1","pages":"51-55"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9620508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour budding - an additional prognostic factor in colorectal cancer survival. 肿瘤萌芽-结直肠癌生存的另一个预后因素。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.127040

Gülçİn Harman Kamall, Cemal Ulusoy, Andrej Nikolovski, Sedat Kamall

{"title":"Tumour budding - an additional prognostic factor in colorectal cancer survival.","authors":"Gülçİn Harman Kamall, Cemal Ulusoy, Andrej Nikolovski, Sedat Kamall","doi":"10.5114/pjp.2023.127040","DOIUrl":"https://doi.org/10.5114/pjp.2023.127040","url":null,"abstract":"Tumour budding (TB) in cancer is a phenomenon of tumour cells forming clusters, and it is associated with an epithelial-mesenchymal transition into the extracellular matrix of the tumour. It has been shown that the presence of TB in colorectal cancer (CRC) is associated with worse overall survival, higher possibility for vessel invasion, lymph node involvement, and distant metastases appearance. In this retrospective study TB presence in operated patients for CRC is analysed. In the data from 81 patients, 26 presented with TB. Analysis revealed high statistical significance of the effect of TB presence on the number of metastatic lymph nodes, and the lymphovascular and perineural invasion. A statistically meaningful correlation was found between the presence of TB and CRC survival ( p = 0.016). Patients with right-sided colon cancer presented with worse overall survival ( p = 0.011). The patients who presented lymph node metastases and TB presence had worse overall survival ( p = 0.026 and p = 0.021, respectively). Tumour budding, tumour location, and age over 64 years are found to be the independent prognostic factors in CRC patients. Tumour budding is an important prognostic factor in CRC patients that will contribute to treatment. Pathological examination must consider TB in detail.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 1","pages":"36-41"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9612864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ectopic breast tissue of the vulva. 外阴异位乳房组织。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.128787

Lanzhi Zhang, Xiao Ling Yao, Xiujuan Zhu, Ying Fu, Shaojun Li

引用次数: 0

The role of antral histopathology in diagnosing paediatric celiac disease. 前胃组织病理学在诊断小儿乳糜泻中的作用。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.134290

Zahra Heidari, Manijeh Khalili, Hamidreza Mahmoudzadeh Sagheb, Mahdi Afshari, Fateme Parooie, Iraj Shahramian, Fateme Sargazi, Alireza Aminisefat, Mahdi Shirdel Kahkha Zhale, Ali Mansuri

{"title":"The role of antral histopathology in diagnosing paediatric celiac disease.","authors":"Zahra Heidari, Manijeh Khalili, Hamidreza Mahmoudzadeh Sagheb, Mahdi Afshari, Fateme Parooie, Iraj Shahramian, Fateme Sargazi, Alireza Aminisefat, Mahdi Shirdel Kahkha Zhale, Ali Mansuri","doi":"10.5114/pjp.2023.134290","DOIUrl":"10.5114/pjp.2023.134290","url":null,"abstract":"The aim of this study was to evaluate the diagnostic potential of gastric antrum histology in children suspected of having celiac disease (CD). The present retrospective study was performed on 224 patients who were suspected of having CD and had several duodenal and one gastric antrum biopsies. They were divided into 2 groups based on the definite diagnosis of CD. The statistical analysis was performed using SPSS version 22 software. Receiver operating characteristic (ROC) curves were drown and the area under the curves (AUCs) was calculated. Article authorized by the Editor-in-Chief. Based on MARSH criteria, out of 224 patients, 124 were diagnosed as definite CD and 100 patients comprised the non-celiac group. The AUC for the mean of all pathological tests was estimated to be 0.90 (p < 0.001). The pooled AUC for the combination of 3 pathologic findings with the highest AUCs (cell, crypt, and gland size) was estimated to be 0.89 (p < 0.001). We observed that the histological changes we found in the gastric antrum were identical to those found in the duodenum of paediatric CD patients. Because providing a biopsy from the gastric antrum is easier than getting multiple biopsies from the duodenum, we suggest using the criteria mentioned in this study in other studies with larger sample sizes.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 4","pages":"256-264"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion. 伴有 PAX3/FOXO1 融合的双型鼻窦肉瘤

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.134321

Ilkay Tosun, Murat H Karabulut, Ismail Yilmaz, Ahmet A Cırık, Onur Sahin

引用次数: 0

Primary amelanotic melanoma of anorectum - a rare case report with diagnostic challenge. 肛门直肠原发性黑色素瘤--一例罕见病例报告及诊断难题。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.133846

Gyanendra Singh, Anurag Singh

{"title":"Primary amelanotic melanoma of anorectum - a rare case report with diagnostic challenge.","authors":"Gyanendra Singh, Anurag Singh","doi":"10.5114/pjp.2023.133846","DOIUrl":"10.5114/pjp.2023.133846","url":null,"abstract":"Anorectal melanoma is an exceptionally rare and aggressive form of cancer. One per cent of anorectal malignant tumours are anorectal malignant melanomas, which are exceedingly uncommon. We report a case of a 47-year-old woman who experienced painless rectal bleeding. On examination, an irregular lump was seen in the posterior rectal wall, measuring 4 × 3.7 cm. Biopsies were obtained under endoscopic guidance for histomorphology and immunohistochemistry. The biopsy examination showed nests of tumour mass in the lamina and muscularis mucosae. The tumour mass was composed of round to oval cells having enlarged nuclei, conspicuous nucleoli, and a scant amount of cytoplasm. No melanin pigmentation was noted in the tumour cells. HMB-45, S-100, and vimentin were all detected by immunohistochemistry. A definitive diagnosis of amelanotic malignant melanoma was rendered. The patient underwent abdominoperineal resection with a hysterectomy and bilateral salpingo-oophorectomy. Anorectal melanoma presents with bleeding per rectum and is often misdiagnosed as internal haemorrhoids or adenocarcinoma clinically. Amelanotic melanoma, which lacks melanin pigment, is difficult to diagnose. Patients who appear with rectal bleeding should have a malignant melanoma evaluation as a possible differential diagnosis, and suitable diagnostic procedures, such as a colonoscopy and a biopsy with immunohistochemistry, should be carried out to arrive at a conclusive diagnosis.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 4","pages":"293-296"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast carcinoma grading on core needle biopsy - to grade or not to grade? 乳腺癌芯针活检分级-分级还是不分级?

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.132225

Joanna Szpor, Karolina Witczak, Monika Storman, Anna Streb-Smoleń, Agnieszka Krzemień, Krzysztof Okoń, Diana Hodorowicz-Zaniewska, Joanna Streb

{"title":"Breast carcinoma grading on core needle biopsy - to grade or not to grade?","authors":"Joanna Szpor, Karolina Witczak, Monika Storman, Anna Streb-Smoleń, Agnieszka Krzemień, Krzysztof Okoń, Diana Hodorowicz-Zaniewska, Joanna Streb","doi":"10.5114/pjp.2023.132225","DOIUrl":"10.5114/pjp.2023.132225","url":null,"abstract":"Core needle biopsy (CNB) is well established as an important diagnostic tool in diagnosing breast cancer and it is now considered the initial method of choice for diagnosing breast disease and the basis for the treatment planning. The concordance rate between CNB and surgical excision specimen in determination of histological grade (HG) varies widely across literature, ranging from 59-91%. The aim of our study was to investigate the level of concordance between CNB and surgical excision specimen for the determination of HG for breast cancer patients. The study population included 157 women with a breast tumor who underwent a core needle biopsy for breast carcinoma and a subsequent surgical excision of the tumor. The concordance level between core needle biopsy and surgical resection specimen for overall histologic grading was 73%: for tubule formation - 71%, for nuclear pleomorphism - 91%, for the mitotic index - 59%. Our study shows that our institution's histologic grading of CNBs and surgical excisions shows a fairly good correlation and is useful for the planning of treatment.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 3","pages":"203-210"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency. PD-1和PD-L1在错配修复蛋白缺乏的侵袭性膀胱尿路上皮癌中的表达状况

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.132221

Nuran Sungu, Merve M Kıran

{"title":"Status of PD-1 and PD-L1 expression in invasive urothelial carcinoma of the bladder with mismatch repair protein deficiency.","authors":"Nuran Sungu, Merve M Kıran","doi":"10.5114/pjp.2023.132221","DOIUrl":"10.5114/pjp.2023.132221","url":null,"abstract":"It has been reported that mismatch repair deficient (d-MMR) tumors show sensitivity to immune checkpoint inhibitors. We aimed to evaluate the correlation of d-MMR and PD-1/PD-L1 expression in invasive urothelial carcinoma of the bladder. Tissue microarray (TMA) tissues were stained PD-1/PD-L1 and MMR proteins. The expression ratio of these markers has been compared with histopathologic parameters. d-MMR tumors were more superficial muscle invasive (p = 0.012). When the d-MMR, and PD-1/PD-L1 expression ratios were examined, a significant correlation was obtained between the d-MMR and PD-L1 expression ratio of > 5% in both the tumor and immune cells (p = 0.02 and p = 0.004, respectively). The expression ratio was higher in the patients without MMR loss. PD-1 and PD-L1expression in those with MSH6 loss was one or none. When PD1/PDL1 expression was compared with histopathological parameters, a significant relationship was observed between tumor grade and depth of muscle invasion. PD-L1 expression was not observed in the superficial muscle invasive tumors. This study was shown the status of d-MMR and PD-1/PD-L1 in invasive urothelial cancers and their correlation with prognostic markers. PD-1/PD-L1 expression may contribute to the progression and poor prognosis of bladder cancer. However, further studies are required to research the clinical utility.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 3","pages":"161-170"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin-converting enzyme insertion/deletion gene polymorphism and Henoch-Schonlein purpura nephritis risk in children: a meta-analysis. 血管紧张素转换酶插入/缺失基因多态性与儿童紫癜性肾炎风险:一项荟萃分析

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.127014

Pan Yan, Song Xu

{"title":"Angiotensin-converting enzyme insertion/deletion gene polymorphism and Henoch-Schonlein purpura nephritis risk in children: a meta-analysis.","authors":"Pan Yan, Song Xu","doi":"10.5114/pjp.2023.127014","DOIUrl":"https://doi.org/10.5114/pjp.2023.127014","url":null,"abstract":"It has been demonstrated in many studies that angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is related to Henoch-Schonlein purpura nephritis (HSPN) risk in children. However, this conclusion remains controversial. In this study, we systemically retrieved relevant studies in electronic databases such as PUBMED, CNKI, and EMBASE followed by calculation of odds ratios (OR) with 95% confidence intervals (CI). In addition, meta-package in STATA version 12.0 was used. Angiotensin-converting enzyme I/D polymorphism was related to HSPN susceptibility in children (D vs. I: OR 1.47, 95% CI: 1.13-1.93; DD vs. II: OR 2.29, 95% CI: 1.29-4.07; DI vs. II: OR 1.10, 95% CI: 0.82-1.48; dominant model: OR 1.44, 95% CI: 1.09-1.89; recessive model: OR 2.26, 95% CI: 1.67-3.06). In addition, subgroup analysis stratified according to ethnicity indicated a significant relationship between this polymorphism and HSPN susceptibility among Asians and Caucasians. The data extracted from HaploReg indicated that ACE I/D polymorphism was not in linkage disequilibrium with other variants in the ACE gene. The research shows that ACE I/D polymorphism is related to HSPN susceptibility in children.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 1","pages":"29-35"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9612865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0