Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine最新文献_第7页

Impact of exercise stress testing on plasma active factor VII-antithrombin levels in asymptomatic patients with aortic stenosis. 运动应激试验对无症状主动脉瓣狭窄患者血浆活性因子7 -抗凝血酶水平的影响

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-27 Epub Date: 2025-02-24 DOI: 10.20452/pamw.16962

Magdalena Kopytek, Renata Kolasa-Trela, Michał Ząbczyk, Joanna Natorska, Anetta Undas

引用次数: 0

Successful two-stage percutaneous coronary intervention strategy with delayed stent optimization in late-presenting ST-segment elevation myocardial infarction. 延迟支架优化的两期经皮冠状动脉介入治疗晚期st段抬高型心肌梗死的成功策略。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-26 DOI: 10.20452/pamw.16957

Artur Dziewierz, Bogdan Januś, Krzysztof Bielamowicz, Jarosław Blicharz, Stanisław Bartuś, Tomasz Rakowski

引用次数: 0

Blunt cardiac injury followed by an unusual late course of intramyocardial dissecting hematoma. 钝性心脏损伤后出现不寻常的晚期心内解剖性血肿。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-26 DOI: 10.20452/pamw.16958

Justyna M Sokolska, Julia Honisz, Wojciech Kosmala, Mateusz Sokolski

引用次数: 0

How to improve cardiovascular risk assessment in type 1 diabetes? The role of vascular age and arterial stiffness. 如何改进1型糖尿病心血管风险评估？血管年龄和动脉硬度的作用。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-24 DOI: 10.20452/pamw.16956

Dariusz Naskret, Michal Kulecki, Mikolaj Kaminski, Dominika Kasprzak, Pawel Lachowski, Justyna Flotynska, Iwona Anderko, Bartosz Lasowski, Dorota Zozulinska-Ziolkiewicz, Aleksandra Uruska

{"title":"How to improve cardiovascular risk assessment in type 1 diabetes? The role of vascular age and arterial stiffness.","authors":"Dariusz Naskret, Michal Kulecki, Mikolaj Kaminski, Dominika Kasprzak, Pawel Lachowski, Justyna Flotynska, Iwona Anderko, Bartosz Lasowski, Dorota Zozulinska-Ziolkiewicz, Aleksandra Uruska","doi":"10.20452/pamw.16956","DOIUrl":"https://doi.org/10.20452/pamw.16956","url":null,"abstract":"Introduction: Cardiovascular disease is the leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM). Traditional cardiovascular risk (CVR) models may underestimate risk in this population, especially in high-risk countries. Vascular age (VA) and arterial stiffness (AS) are emerging as potential markers for improving CVR assessment.Objectives: This study investigated the association between VA, AS, and the modified Steno Type 1 Risk Engine (ST1RE) score in adults with T1DM.Patients and methods: We included 109 T1DM adults, aged 18-50 years, with at least five years of disease duration. None had been diagnosed with cardiovascular disease or hypertension. VA was calculated using carotid intima-media thickness (cIMT), while AS was assessed by 24-hour measurement of aortic pulse wave velocity (PWV). We compared the standard ST1RE score, based on chronological age, with a modified ST1RE score based on VA.Results: Study participants had a median age of 32.4 (25.5-38.6) years and a diabetes duration of 14.0 (10.0-20.0) years. Using VA in the modified ST1RE score reclassified 32.1% of participants into a higher CVR category. The median CVR for the modified ST1RE was 9.68 (4.61-20.08)%, compared to 4.74 (3.24-8.12)% using the standard score. The modified ST1RE score was positively associated with PWV, OR 2.37 (95% CI: 1.46-3.84) p = 0.004, adjusting for sex, BMI, and at least one diabetic complication.Conclusions: Implementing VA and AS in clinical practice could enhance risk assessment in T1DM individuals, especially in high-risk populations. Further validation in larger cohorts is necessary.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased turnover of non-malignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression. 慢性淋巴细胞白血病患者非恶性T淋巴细胞周转增加可能影响临床进展。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-14 DOI: 10.20452/pamw.16955

Agata Kosmaczewska, Lidia Ciszak, Irena Frydecka, Edyta Pawlak, Aleksandra Szteblich, Tomasz Wróbel, Dariusz Wołowiec

{"title":"Increased turnover of non-malignant T lymphocytes in patients with chronic lymphocytic leukemia may affect clinical progression.","authors":"Agata Kosmaczewska, Lidia Ciszak, Irena Frydecka, Edyta Pawlak, Aleksandra Szteblich, Tomasz Wróbel, Dariusz Wołowiec","doi":"10.20452/pamw.16955","DOIUrl":"https://doi.org/10.20452/pamw.16955","url":null,"abstract":"Introduction: A unique feature of chronic lymphocytic leukemia (CLL) is the increased number of circulating T cells preventing malignant B cells from undergoing apoptosis. Dysregulated expression of p27Kip1 and cyclin D2 (G1 phase regulators controlling lymphocyte survival) was examined in leukemic B cells but not non-malignant T cells.Objectives: Assessment of anti-apoptotic p27Kip1 and cyclin D2 in peripheral blood (PB) leukemic B and T cells in relation to ex vivo apoptosis in CLL patients with different clinical courses.Patients and methods: Using flow cytometry, we determined G1 regulators' expression and apoptosis of B and T cells in 47 previously untreated CLL patients (median age 60.0; 26 men) with stable disease (SD), progressive disease (PD), and 39 controls, matched for age and sex.Results: We noted increased apoptosis within T cells in CLL patients compared to controls (P <0.001), whereas B cells exhibited failed apoptosis. All patients exerted higher p27Kip1 and cyclin D2 expression in leukemic B and T cells compared to controls (P <0.001). Comparative analysis between B and T cells showed pronounced T cell apoptosis in only PD patients (P <0.001). In SD patients, G1 regulators' expression was higher in T cells than in B cells (P ≤0.02). Increased p27Kip1 expression and low apoptosis within B cells, and lower cyclin D2 expression and high apoptosis within T cells were predictive of earlier disease progression.Conclusions: CLL progression is associated with increased T-cell turnover triggered by dysregulated expression of G1 regulators, suggesting the involvement of the non-malignant T-cell compartment in disease pathogenesis and clinical outcomes.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune thrombocytopenic purpura in a patient with the presence of a left atrial thrombus who underwent mitral valve replacement. 免疫血小板减少性紫癜患者的存在左房血栓接受二尖瓣置换术。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16950

Natalia Maruszak, Joanna Zdziarska, Barbara Zawiślak, Renata Rajtar-Salwa, Stanisław Bartuś, Danuta Sorysz

引用次数: 0

Oral manifestations of systemic sclerosis: a grave challenge or a great opportunity for early and adequate diagnosis? 系统性硬化症的口腔表现：早期充分诊断的严峻挑战还是巨大机遇？

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16952

Jakub Bukowski, Agnieszka Cabała, Małgorzata Płatek-Kopeć, Joanna Śręba

引用次数: 0

A supervised telemedical monitoring in the heart failure population in regions of social exclusion is associated with an improvement in functional capacity and quality of life. 在社会排斥地区的心力衰竭人群中进行监督远程医疗监测与功能能力和生活质量的改善有关。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16954

Piotr Wańczura, David Aebisher, Wojciech Stecko, Hubert Bukowski, Marek Kos, Andrzej Przybylski, Jarosław Zalewski

{"title":"A supervised telemedical monitoring in the heart failure population in regions of social exclusion is associated with an improvement in functional capacity and quality of life.","authors":"Piotr Wańczura, David Aebisher, Wojciech Stecko, Hubert Bukowski, Marek Kos, Andrzej Przybylski, Jarosław Zalewski","doi":"10.20452/pamw.16954","DOIUrl":"https://doi.org/10.20452/pamw.16954","url":null,"abstract":"Introduction: Telemedicine is intended to provide medical care to patients in remote areas.Objectives: This study sought to investigate whether the application of e-health solutions for patients with heart failure (HF) who live in regions of social exclusion would improve their functional performance and quality of life (QoL).Patients and methods: In this prospective, non-controlled study carried out between June and December 2023, HF patients were enrolled in 14 primary care units located in 5 rural voivodeships in eastern Poland. All patients were evaluated at baseline and after 3 months using the New York Heart Association (NYHA) scale, Chronic Heart Failure Questionnaire (CHFQ), and EuroQol Visual Analogue Scale (EQVAS), and monitored by a general practitioner under the supervision of a cardiologist.Results: In 429 patients with HF, more than 100 000 telemedical examinations/consultations were performed resulting in 575 treatment modifications. During the 3-month program, one patient died. Simultaneously, an improvement in NYHA scale by median of 1 class (interquartile range 0-1, P <0.001) was identified. A 6% improvement in QoL was found in emotional function measured by CHFQ (P <0.001) while a 7.7% improvement in subjective health status measured by EQVAS (P <0.001). A history of atrial fibrillation (odds ratio [OR] 1.539, 95% confidence interval [CI] 1.021-2.353) and no history of cancer (OR 2.793, 95% CI 1.224-6.369) were associated with the NYHA class improvement.Conclusions: The applied telemedical model of care under the specialist's supervision was associated with an improvement in NYHA class and QoL in the HF population from regions of social exclusion.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medium-bore lightning flash catheter aspiration thrombectomy in acute pulmonary embolism: first experience in Poland. 急性肺栓塞中径闪电导管抽吸取栓：波兰的首次经验。

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-13 DOI: 10.20452/pamw.16951

Sylwia Sławek-Szmyt, Aneta Klotzka, Sonia Nartowicz, Stanisław Jankiewicz, Maciej Lesiak, Aleksander Araszkiewicz

引用次数: 0

Long-term microvascular alterations in kidney transplant recipients after SARS-CoV-2 infection. SARS-CoV-2感染后肾移植受者的长期微血管改变

IF 3.8 4区医学

Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine Pub Date : 2025-02-11 DOI: 10.20452/pamw.16948

Edyta Dąbrowska, Jacek Wolf, Maksym Jopek, Marcin Hellmann, Paulina Sulecka, Mateusz Ślizień, Katarzyna Michalska-Małecka, Joanna Konopa, Bogdan Biedunkiewicz, Leszek Tylicki, Krzysztof Narkiewicz, Alicja Dębska-Ślizień

{"title":"Long-term microvascular alterations in kidney transplant recipients after SARS-CoV-2 infection.","authors":"Edyta Dąbrowska, Jacek Wolf, Maksym Jopek, Marcin Hellmann, Paulina Sulecka, Mateusz Ślizień, Katarzyna Michalska-Małecka, Joanna Konopa, Bogdan Biedunkiewicz, Leszek Tylicki, Krzysztof Narkiewicz, Alicja Dębska-Ślizień","doi":"10.20452/pamw.16948","DOIUrl":"https://doi.org/10.20452/pamw.16948","url":null,"abstract":"Introduction: The long-term cardiovascular consequences of COVID-19 in organ recipients have been insufficiently studied.Objective: The aim of our study was to evaluate the association between COVID-19 and microvascular abnormalities in kidney transplant recipients 8 weeks after SARS-CoV-2 infection. Patients and methods: The study population consisted of 54 kidney transplant recipients, and was divided into two subgroups: patients with a history of COVID-19 (n = 35) and patients without a history of COVID-19 (n = 21). We assessed both the structure and function of microcirculation.Results: The study group was aged 47.6 (12.7) years and included 54% of women. Patients with and without a history of COVID-19 did not differ in baseline characteristics. Compared to patients without a history of COVID-19, subjects after SARS-CoV-2 infection had substantially lower values of ischemic response: IRmax; 7.0 (5.0-8.7) vs. 9.6 (8.8-11.5), P = 0.04; IR index 3.1 (2.3-4.2) vs 7.2 (5.2-8.2), P = 0.01), with the IR index further confirmed in a multivariable analysis. Logistic regression analysis showed that estimated glomerular filtration rate was linked to microvascular functional decline, expressed by a poorer normoxia oscillatory index (odds ratio 0.95, CI 0.90-0.99, P = 0.047). C-reactive protein was associated with arterioles' wall thickness (R = 0.42, P = 0.02) and wall-to-lumen ratio (R = 0.48, P = 0.01).Conclusion: We documented that microvascular dysfunction was associated with SARS-CoV-2 infection and is detectable 8 weeks after the acute phase in kidney transplant recipients.","PeriodicalId":49680,"journal":{"name":"Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0