Public Health最新文献

{"title":"Effect of aspirin use on cancer incidence and mortality: An updated systematic review and meta-analysis","authors":"Fausto Petrelli ,&nbsp;Antonio Ghidini ,&nbsp;Maria Antista ,&nbsp;Nicole Meli ,&nbsp;Lorenzo Dottorini ,&nbsp;Mauro Rossitto ,&nbsp;Angeli Irene ,&nbsp;Giovanna Moleri ,&nbsp;Ornella Garrone ,&nbsp;Gianluca Tomasello ,&nbsp;Michele Ghidini","doi":"10.1016/j.puhe.2025.105924","DOIUrl":"10.1016/j.puhe.2025.105924","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the association between aspirin use and cancer incidence and mortality, and to clarify aspirin's potential role in cancer prevention.</div></div><div><h3>Study design</h3><div>Meta-analysis of observational studies and randomized controlled trials comparing cancer outcomes in aspirin users versus non-users.</div></div><div><h3>Methods</h3><div>A systematic literature search was performed in PubMed, Embase, and the Cochrane Library up to April 2024. Studies reporting hazard ratios (HRs) for cancer incidence or mortality in relation to aspirin use were included. Data were extracted and pooled using a random-effects model to account for study heterogeneity, and results were expressed as hazard ratios (HRs) with 95 % confidence intervals (CIs).</div></div><div><h3>Conclusions</h3><div>This meta-analysis supports the growing body of evidence suggesting aspirin's potential role in reducing cancer incidence and mortality, particularly for colorectal and liver cancers. Future studies should focus on identifying the optimal dosage and duration of aspirin use and elucidating the mechanisms behind its protective effects to guide clinical recommendations.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105924"},"PeriodicalIF":3.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDEAHL comprehensive protocol for obtaining qualitative information from European citizens on digital health literacy","authors":"I. Rey Hidalgo ,&nbsp;A. Fernández-Feito ,&nbsp;L. Pruneda González ,&nbsp;M. Perello ,&nbsp;B. Avagnina ,&nbsp;M.M. Pisano-González ,&nbsp;IDEAHL consortium","doi":"10.1016/j.puhe.2025.105918","DOIUrl":"10.1016/j.puhe.2025.105918","url":null,"abstract":"<div><h3>Objective</h3><div>To design a comprehensive protocol for obtaining qualitative information from a wide range of population groups on digital health literacy (dHL). This protocol was used for the development of a European dHL Strategy.</div></div><div><h3>Study design</h3><div>protocol design.</div></div><div><h3>Methods</h3><div>An extensive review of existing literature and a collaborative design of the protocol was carried out involving dHL experts and strategic stakeholders in the definition of the different sections adapted to the specific characteristics of different population groups, including vulnerable groups.</div></div><div><h3>Results</h3><div>A description of all the sections of the protocol is provided, recruitment strategies with recommendations for each population group were included, general and specific-group questions for interviews were designed and participatory techniques for each group were identified. The protocol was successfully implemented in 10 European countries engaging a total of 1434 European citizens from 19 population groups.</div></div><div><h3>Conclusions</h3><div>This methodology is a novel protocol to be used by policy makers in the future development of national and regional dHL action plans. The protocol will facilitate the acquisition of qualitative information and new insights into barriers and suggestions for improvement in dHL, thereby advancing diversity, equity, and inclusion when capturing the nuanced lived experiences of diverse groups.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105918"},"PeriodicalIF":3.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood environmental burden and chronic kidney disease in the US: A cross-sectional study","authors":"Liwen Wang ,&nbsp;Weiye Liu ,&nbsp;Junhui Yang ,&nbsp;Yu Zhao ,&nbsp;Xiuquan Hu ,&nbsp;Xuewei Huang ,&nbsp;Hui Liu","doi":"10.1016/j.puhe.2025.105927","DOIUrl":"10.1016/j.puhe.2025.105927","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to analyze the association between overall environmental burden and chronic kidney disease prevalence in communities across the United States.</div></div><div><h3>Study design</h3><div>A cross-sectional study based on national neighborhood-level environmental burden and health data.</div></div><div><h3>Methods</h3><div>The study used data from 71,688 U S. census tracts from the Centers for Disease Control. We performed a mixed-effects linear regression model to analyze the association between the combined environmental burden and the prevalence of CKD. We analyzed whether there are differences or potential interactions in the association between environmental burden and CKD under different social vulnerability. We used the Boruta algorithm to analyze the association of different environmental indicators with the prevalence of chronic kidney disease.</div></div><div><h3>Results</h3><div>Neighborhoods with the highest environmental burden had a 0.377 % increase in the prevalence of CKD compared to neighborhoods with the lowest environmental burden ([95 %CI: 0.359, 0.395]; <em>P</em> &lt; 0.001). This association remains significant after adjusted. The association between environmental burden and the prevalence of CKD is notably stronger in neighborhoods with the highest social vulnerability (β = 1.047 [1.028,1.065]; <em>P</em> &lt; 0.001). A significant interaction (<em>P</em> &lt; 0.001) between social vulnerability and environmental burdens was observed in this study. We found that air pollution was the most important variable for predicting CKD prevalence.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the higher cumulative environmental burden is associated with a higher prevalence of CKD in a dose-dependent manner. The strongest associations were observed in socially vulnerable neighborhoods.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105927"},"PeriodicalIF":3.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of co-created lifestyle interventions in improving health behaviour, physical and mental health in adults with non-communicable diseases: A systematic review with meta-analysis","authors":"Ebuka Miracle Anieto ,&nbsp;Philippa Margaret Dall ,&nbsp;Ukachukwu Abaraogu ,&nbsp;Sebastien Chastin ,&nbsp;Ijeoma Blessing Anieto ,&nbsp;Giuliana Raffaella Longworth ,&nbsp;Israel Ikechukwu Adandom ,&nbsp;Ogochukwu Kelechi Onyeso ,&nbsp;Anthony Obinna Iwuagwu ,&nbsp;Niamh Smith ,&nbsp;Kolawole Francis ,&nbsp;Miracle Ndubuaku ,&nbsp;Mark Chigozie Odom ,&nbsp;Chris Seenan","doi":"10.1016/j.puhe.2025.105929","DOIUrl":"10.1016/j.puhe.2025.105929","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aimed to evaluate the effectiveness of co-created lifestyle interventions in modifying health behaviour, and mental/physical health outcomes in individuals with non-communicable diseases (NCDs).</div></div><div><h3>Study design</h3><div>A systematic review of Randomized Control Trials (RCTs).</div></div><div><h3>Methods</h3><div>A systematic search of nine databases from inception until March 2023 was performed, plus weekly email alerts of new literature until March 2025. Studies comparing co-created lifestyle interventions with any control were included. Meta-analysis using the random effects model was conducted. Risk of bias was assessed using the Cochrane-RoB-2, and quality of evidence was assessed using GRADE system.</div></div><div><h3>Results</h3><div>Sixteen RCTs (2201 participants; 74.2 % female; mean 53.8 years) were included. Meta-analysis showed that at &lt;6 months, there is moderate quality evidence that co-created lifestyle interventions significantly improve health behaviour (moderate effect; SMD = 0.49, 95 %CI: 0.33–0.65) and physical health (small effect; SMD = 0.21, 95 %CI: 0.09–0.34), and mental health (small effect; SMD = 0.29, 95 %CI: 0.14–0.43), in individuals with NCDs. At ≥6 months, there is moderate quality evidence that co-created interventions improve health behaviour (small effect; SMD = 0.21, 95 %CI: 0.07–0.35), and mental health (small effect; SMD = 0.19, 95 %CI: 0.12–0.26). A small effect with low quality evidence (SMD = 0.11, 95 %CI: 0.09-0.32) was also observed for physical health, however, it was not statistically significant.</div></div><div><h3>Conclusions</h3><div>There is moderate quality evidence that co-created lifestyle interventions for secondary prevention of NCDs have a significant positive impact on the target health behaviour, and on mental health, and physical health outcomes.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105929"},"PeriodicalIF":3.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From material hardship to harsh parenting: Testing the Family Stress Model in dyadic family context","authors":"Yiran Zhang ,&nbsp;Michelle Johnson-Motoyama ,&nbsp;Susan Yoon ,&nbsp;Gia Barboza-Salerno","doi":"10.1016/j.puhe.2025.105917","DOIUrl":"10.1016/j.puhe.2025.105917","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the association between material hardship and harsh parenting behaviors within the framework of the Family Stress Model (FSM) using a dyadic family systems perspective.</div></div><div><h3>Study design</h3><div>This is a longitudinal study.</div></div><div><h3>Methods</h3><div>Utilizing data from the Future of Families and Child Wellbeing Study, the analysis examines both maternal and paternal pathways, focusing on the mediating role of parental depression. The sample consists of 2597 families, with data collected when the child was aged five, and at age nine. Structural equation modeling with the Actor-Partner Interdependence Mediation Model was employed to explore the interdependent relationships between maternal and paternal material hardship, depression, and harsh parenting, including physical and psychological aggression.</div></div><div><h3>Results</h3><div>Results revealed that both maternal and paternal material hardship significantly predicted their own depression but did not exhibit partner effects. Maternal depression partially mediated the relationship between maternal material hardship and both maternal and paternal harsh parenting, highlighting its central role in shaping family dynamics. These findings extend the FSM by demonstrating the interconnected influences of material hardship, depression and harsh parenting within a dyadic family context.</div></div><div><h3>Conclusion</h3><div>The study underscores the need for family-centered interventions addressing both parents to mitigate the impacts of economic stress and improve parenting practices. Additionally, policies aimed at reducing material hardship and enhancing access to mental health resources are critical for fostering healthier family dynamics and preventing harsh parenting behaviors.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105917"},"PeriodicalIF":3.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National trends in depressive symptoms, antidepressant use, and mental health consultations among US adults, 2005–2020","authors":"Shuai Zhao ,&nbsp;Haoxue Wang ,&nbsp;Qi Jiang ,&nbsp;Yanan Feng ,&nbsp;Kaiheng Zhu ,&nbsp;Rundong Liu ,&nbsp;Zhen Xiang ,&nbsp;Jun Tang ,&nbsp;Ranran Song","doi":"10.1016/j.puhe.2025.105916","DOIUrl":"10.1016/j.puhe.2025.105916","url":null,"abstract":"<div><h3>Objectives</h3><div>Depression significantly contributes to the global disease burden. This study aims to monitor national trends in depressive symptoms, antidepressant use and mental health consultations among American adults and identify key subgroups that require attention.</div></div><div><h3>Study design</h3><div>Serial cross-sectional analysis.</div></div><div><h3>Methods</h3><div>This study utilized data from the National Health and Nutrition Examination Survey during 2005–2020. Adults over 18 were included, using the PHQ-9 to screen for depressive symptoms. Excluding 4461 participants with missing PHQ-9 values, 39,467 adults were analyzed. Temporal trends were evaluated using the Joinpoint regression program.</div></div><div><h3>Results</h3><div>The prevalence of depressive symptoms increased from 21.6 % to 25.1 % (<em>P</em> for trend = 0.009) between 2005 and 2020, particularly among females and non-Hispanic whites. In pharmacotherapy, 26.7 % of depressed individuals reported taking any antidepressants, with usage rates of 21.7 % for mild and 36.7 % for clinically relevant symptoms. After adjusting for covariates, overall antidepressant use increased from 25.4 % to 30.8 % (<em>P</em> for trend = 0.044). Compared with 2005–2008, antidepressant use among individuals with PHQ-9 ≥5 and ≥ 10 increased by 5.2 % and 8.8 %, respectively, while mental health professional consultation rates rose by 8.0 % and 12.2 %, respectively.</div></div><div><h3>Conclusions</h3><div>The estimated prevalence of depressive symptoms significantly increased. Antidepressant use remained relatively stable, but it may relatively higher among those with mild depressive symptoms. After adjusting for covariates, antidepressant use increased significantly among those with depressive symptoms. Compared with 2005–2008, rates of antidepressant use and mental health consultations among individuals with depressive symptoms increased significantly. Urgent implementation of intervention strategies across multiple domains is warranted.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"247 ","pages":"Article 105916"},"PeriodicalIF":3.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare reimagined: Carebots from hospital to home","authors":"A.K. Kaliya-Perumal,&nbsp;A. Sidarta","doi":"10.1016/j.puhe.2025.105920","DOIUrl":"10.1016/j.puhe.2025.105920","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore how healthcare robots (carebots) are transforming care delivery across the continuum, from hospital to home, particularly in response to ageing populations, chronic disease burdens and healthcare workforce shortages.</div></div><div><h3>Study design</h3><div>A brief narrative grounded in the authors’ observations, professional experiences and selected literature.</div></div><div><h3>Methods</h3><div>This short communication draws on real-world insights and current trends to explore how carebots are used in hospitals and communities. It highlights their roles in nursing, rehabilitation, mobility and remote care, and examines key barriers, such as acceptance, cost, capability, safety and reliability.</div></div><div><h3>Results</h3><div>In hospitals, carebots improve efficiency, reduce staff workload and enhance patient outcomes. In homes and communities, they support ageing-in-place by improving mobility, offering cognitive support and enabling remote care. Although carebots have the potential to bridge the urban-rural healthcare divide, adoption remains low in resource-limited settings due to stigma, high costs, inadequate infrastructure and policy gaps.</div></div><div><h3>Conclusions</h3><div>To unlock the full potential of carebots in addressing global care gaps, focus should be on inclusive design, equitable investment, and supportive policies and training. Carebots can pave the way for more person-centred, tech-enabled healthcare across the entire care continuum, from hospital to home.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105920"},"PeriodicalIF":3.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decriminalization of drug possession in British Columbia and hospitalizations for opioid poisoning","authors":"Jürgen Rehm ,&nbsp;Sami Aftab Abdul ,&nbsp;Farihah Ali ,&nbsp;Cayley Russell ,&nbsp;Jean-François Crépault ,&nbsp;Tara Elton-Marshall ,&nbsp;Bernard Le Foll ,&nbsp;Brooke Kinniburgh ,&nbsp;Heather Palis ,&nbsp;Sameer Imtiaz","doi":"10.1016/j.puhe.2025.105915","DOIUrl":"10.1016/j.puhe.2025.105915","url":null,"abstract":"<div><h3>Objectives</h3><div>In January of 2023, the provincial government of British Columbia, Canada, received federal approval to decriminalize the personal possession of certain illegal drugs. The policy had multiple aims, including a long-term goal of reducing drug-related overdoses by decreasing stigma associated with drug use and promoting health service and treatment engagement. In May of 2024, the policy was amended to recriminalize drug possession in public spaces. We evaluated the association between the implementation of British Columbia's drug decriminalization policy, including both the initial enactment and the May 2024 amendment, and opioid-related poisoning hospitalizations.</div></div><div><h3>Study design</h3><div>We conducted interrupted time series analyses using quarterly data on opioid-related poisonings leading to hospitalization.</div></div><div><h3>Methods</h3><div>The study period spanned from the first quarter of 2016 to the third quarter of 2024, inclusively. Data were sourced from British Columbia and other Canadian provinces without decriminalization (excluding Quebec, Newfoundland and Labrador, and Prince Edward Island). Two intervention time points were assessed: January 31, 2023, marking the implementation of the initial decriminalization exemption, and May 7, 2024, when a substantial amendment to the exemption was enacted. Data were analyzed using generalized additive models.</div></div><div><h3>Results</h3><div>We found no association between the slope of opioid-related poisoning hospitalization rates associated with the original enactment of the decriminalization legislation, and also no associations with this indicator after the May 7th amendment either in level or slope.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that decriminalization was not associated with increases in opioid-related poisoning hospitalizations.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"248 ","pages":"Article 105915"},"PeriodicalIF":3.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between walking speeds and osteoarthritis risk based on the National Health and Nutrition Examination Survey and Mendelian randomization study","authors":"Yuntao Wang ,&nbsp;Ying Ge ,&nbsp;Wei Yan ,&nbsp;Lina Wang ,&nbsp;Zhenzhen Zhuang ,&nbsp;Daikun He","doi":"10.1016/j.puhe.2025.105867","DOIUrl":"10.1016/j.puhe.2025.105867","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the association between walking speed and osteoarthritis (OA) risk using nationally representative data and Mendelian randomization analysis to infer potential causality.</div></div><div><h3>Study design</h3><div>A cross-sectional study combined with a two-sample Mendelian randomization analysis.</div></div><div><h3>Methods</h3><div>Data were obtained from the National Health and Nutrition Examination Survey (NHANES), including information on walking speed, OA status, and covariates. Logistic regression models were used to assess the association between walking speed and OA. A two-sample Mendelian randomization (MR) approach was performed using genome-wide association study (GWAS) summary statistics to explore the potential causal relationship. Sensitivity analyses including heterogeneity and pleiotropy tests were conducted to ensure robustness.</div></div><div><h3>Results</h3><div>A total of 2027 participants were included. OA patients demonstrated a slower average walking speed (0.9 m/s) compared to non-OA individuals (1.0 m/s). Obesity was significantly associated with OA (OR 1.85, 95 % CI: 1.46–2.33, p &lt; 0.001), and reduced walking speed also showed a strong association (OR 0.23, 95 % CI: 0.16–0.33, p &lt; 0.001). MR analysis supported a causal protective effect of higher walking speed on OA risk.</div></div><div><h3>Conclusions</h3><div>Faster walking speed is associated with a reduced risk of osteoarthritis, and MR results suggest a potential causal relationship. Walking speed may serve as a modifiable behavioral marker for OA prevention and could inform future public health and clinical strategies.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"247 ","pages":"Article 105867"},"PeriodicalIF":3.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes driven effects on incidence and mortality of breast cancer: A meta-analysis","authors":"Rashmi Rashmi ,&nbsp;Richa Singhal ,&nbsp;Gauri Misra","doi":"10.1016/j.puhe.2025.105914","DOIUrl":"10.1016/j.puhe.2025.105914","url":null,"abstract":"<div><h3>Objective</h3><div>This meta-analysis is aimed at investigating the impact of metabolic disorders like diabetes on breast cancer.</div></div><div><h3>Study design</h3><div>This study is a meta-analysis.</div></div><div><h3>Methods</h3><div>We searched Scopus, PubMed, and Google Scholar from January 2012 to January 2024 and identified case-control and cohort studies that assessed the incidence of breast cancer or mortality due to it. The analysis included 48 studies using a random effects model to obtain a pooled risk ratio (RR) and 95 % confidence interval (CI). The methodological aspects of selected studies were estimated using the Newcastle-Ottawa Scale (NOS).</div></div><div><h3>Results</h3><div>Data analysis revealed that diabetes was statistically related to breast cancer with a 20 % increase in breast cancer incidence (RR = 1.203, 95 % CI = 1.135–1.276). This also enhanced the breast cancer mortality (RR = 1.201, 95 % CI = 1.094–1.318). Interestingly, sub-group analysis revealed that breast cancer incidence in Asia was larger as compared to America and Europe (RR = 1.291 in Asia; RR = 1.131 in America; RR = 1.083 in Europe).</div></div><div><h3>Conclusion</h3><div>This association indicates potential shared pathways and modifiable risk factors connecting these two major non-communicable diseases. Understanding this association is important for prevention and personalized treatment strategies for individuals suffering from these diseases.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"247 ","pages":"Article 105914"},"PeriodicalIF":3.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}