Public Health最新文献

{"title":"The burden of rheumatoid arthritis in China from 1990 to 2019 and projections to 2030","authors":"Yue Zhou ,&nbsp;Xiaomei Luo ,&nbsp;Peng Li ,&nbsp;Xiaohui Liu ,&nbsp;Jie Li ,&nbsp;Li Su ,&nbsp;Xueyan Gu ,&nbsp;Jianhua Ma","doi":"10.1016/j.puhe.2025.02.033","DOIUrl":"10.1016/j.puhe.2025.02.033","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the independent effects of age, period, and cohort on RA in China from 1990 to 2019, with a comparative analysis by gender, and projects the future burden of RA over the next decade.</div></div><div><h3>Study design</h3><div>A comprehensive analysis was performed using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.</div></div><div><h3>Methods</h3><div>Data were obtained from the Global Burden of Disease (GBD) study in 2019. The Joinpoint regression model was employed to calculate the annual percentage change in RA, while the Age-Period-Cohort analysis was utilized to estimate the effects of age, period, and cohort. The Bayesian APC model was used to predict the trend of RA incidence in China from 2020 to 2030.</div></div><div><h3>Results</h3><div>From 1990 to 2019, the incidence, prevalence and DALY associated with RA in China exhibited an upward trend, with varying rates of increase across different periods. The peak incidence occurred between the ages of 60–65 years for men and 55–60 years for women, with DALYs increasing with age in both genders. Incidence was negatively associated with vegetable consumption, while the consumption of other food items and alcohol showed positive associations. The Bayesian APC model predicts a decrease in RA incidence among both genders over the next decade, with women consistently exhibiting higher incidence rates than men.</div></div><div><h3>Conclusions</h3><div>The burden of RA remains substantial in China. Therefore, it is crucial to implement targeted health education and screening programs to prevent RA, especially among menopausal women.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 71-78"},"PeriodicalIF":3.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The trend in incidence of non-alcoholic fatty liver disease and its impact on cirrhosis and liver cancer: An analysis from Global Burden of Disease 2021","authors":"Yu Gu ,&nbsp;Chengnan Guo ,&nbsp;Zhenqiu Liu ,&nbsp;Yujiao Zhang ,&nbsp;Xinyu Han ,&nbsp;Xin Zhang ,&nbsp;Shuzhen Zhao ,&nbsp;Haili Wang ,&nbsp;Tiejun Zhang","doi":"10.1016/j.puhe.2025.02.028","DOIUrl":"10.1016/j.puhe.2025.02.028","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to recognize the burden of NAFLD and support public health policy development for its prevention and management.</div></div><div><h3>Study design</h3><div>A cross-sectional analysis of GBD 2021 results was conducted.</div></div><div><h3>Methods</h3><div>We collected incidence data on NAFLD from 1990 to 2021 using Global Burden of Disease Study in 2021. Estimated annual percentage changes (EAPCs) in NAFLD age standardized incidence rate (ASR) were calculated to quantify the temporal trends in NAFLD ASR. Bayesian age-period-cohort models were constructed to project NAFLD incidence rates and cases up to 2050. Additionally, we assessed the percentage of cirrhosis and liver cancer attributable to NAFLD.</div></div><div><h3>Results</h3><div>Globally, the newly-occurred cases of NAFLD increased by 94.49 % from 24, 856, 159 in 1990 to 48, 353, 272 in 2021. The case number will further increase to 78,602,984 in 2050, and ASR will increase from 5.93 per 1000 in 2021 to 7.26 per 1000 in 2050. The most pronounced increases were observed in young people and men. In 2021, NAFLD accounted for 82.7 % of cirrhosis and other chronic liver diseases and 8.0 % of liver cancer cases.</div></div><div><h3>Conclusions</h3><div>From 1990 to 2021, the incidence of NAFLD has been continuously increasing and is expected to continue rising until 2050. The increases in young people and men highlight their priority in future schedules. The rising proportions of cirrhosis and liver cancer caused by NAFLD further underscore the serious health risks.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 79-86"},"PeriodicalIF":3.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of tobacco use among healthcare workers in Italy: A systematic review and meta-analysis","authors":"Corrado Colaprico,&nbsp;Federica Colaiuda,&nbsp;Alberto Picerno,&nbsp;Ilaria Rocchi,&nbsp;Giuseppe La Torre","doi":"10.1016/j.puhe.2025.02.034","DOIUrl":"10.1016/j.puhe.2025.02.034","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this work is to be able to assess the prevalence of tobacco use among health care workers, particularly among physicians and nurses, and whether there has been a decrease over time in the scope of work.</div></div><div><h3>Study design</h3><div>Systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>Observational studies and systematic reviews that examined smoking prevalence in healthcare workers were included and classified. Data extraction and analysis was performed on all included studies that consider only hospital and healthcare services workers. The search strategy included three electronic databases (PubMed, Scopus and Web of Science) between March 01, 2023, and April 30, 2024.</div></div><div><h3>Results</h3><div>700 articles were found and once duplicates and studies not fulfilling the inclusion criteria were removed, 23 articles were examined. The average pooled prevalence calculated on the basis of tobacco use among physicians was 21.4 % in the period 1998–2021; if we break down the population by gender, the prevalence is 17.4 % for females and 21.8 % for males. If we consider high quality studies (NOS &gt;7) the prevalence among physicians rises to 22.9 %, an increase from 2010 where the prevalence was 19.1 %. About nurses, we have an overall prevalence of 37.6 %, while considering only high-quality articles the prevalence was 37.2 %; the time frame (before and after 2010) did not impact smoking prevalence.</div></div><div><h3>Conclusion</h3><div>Smoking prevalence in healthcare workers is high, particularly among nurses. Companies should raise awareness and strengthen strategies to reduce the prevalence of this phenomenon among employees; moreover, workers should not only be aware of the risks, but also promote prevention in the population in order to prevent major tobacco-related diseases.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 65-70"},"PeriodicalIF":3.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Playing for understanding: The impact of interactive gaming on young adults’ sexual health education","authors":"Gloria Aidoo-Frimpong ,&nbsp;Toluwani Adekunle ,&nbsp;Sabena Thomas ,&nbsp;Seleshi Asfaw ,&nbsp;Adonis Durado ,&nbsp;Eric R. Williams ,&nbsp;Omar Martinez ,&nbsp;Peter Memiah ,&nbsp;Caroline Kingori","doi":"10.1016/j.puhe.2025.02.022","DOIUrl":"10.1016/j.puhe.2025.02.022","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examines the impact of a “choose your own adventure” (CYOA) game on improving understanding and facilitating discussions about dating, sex, and sexual health among immigrant and refugee youth who often face cultural and language barriers.</div></div><div><h3>Study design</h3><div>A qualitative exploratory design was used to capture participants’ experiences with the game.</div></div><div><h3>Methods</h3><div>Thirty-two immigrant and refugee youth aged 18–25 participated in semi-structured interviews. Inductive thematic analysis was conducted to explore the perceived effectiveness of the CYOA game, which was accessible via smartphones and desktop devices.</div></div><div><h3>Results</h3><div>Participants described the CYOA game as an accessible and engaging way to explore sensitive topics, providing a discreet and safe environment for learning and discussion. Cultural and religious backgrounds influenced comfort levels, and culturally sensitive content and non-judgmental delivery were particularly valued. Participants reported that while school-based sexual health education was often insufficient, community programs provided more relevant support.</div></div><div><h3>Conclusions</h3><div>CYOA games are perceived to be effective educational tools for sexual health, especially when they incorporate culturally appropriate content. These games foster open discussions and understanding among immigrant and refugee youths, highlighting the need for culturally relevant resources to support traditional approaches to promoting sexual health.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 58-64"},"PeriodicalIF":3.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysocial risk score, lifestyle, genetic factors and risk of incident lung cancer","authors":"Qida He ,&nbsp;Mengtong Sun ,&nbsp;Na Sun ,&nbsp;Qiang Han ,&nbsp;Yueping Shen ,&nbsp;Linyan Li","doi":"10.1016/j.puhe.2025.02.024","DOIUrl":"10.1016/j.puhe.2025.02.024","url":null,"abstract":"<div><h3>Objectives</h3><div>Lung cancer (LC) is the most frequently diagnosed cancer globally; however, the role of social risk factors in its development is not well understood. While previous studies have identified various lifestyle and genetic factors contributing to LC, the interplay between these elements and broader social determinants of health is still unclear. In this study, we aimed to construct a polysocial risk score (PsRS) that captures the multifaceted nature of social environment risk exposure and its relationship with incident LC, and to explore whether the effect of PsRS is influenced by lifestyle behaviours and heritable risk.</div></div><div><h3>Study design</h3><div>Cohort study.</div></div><div><h3>Methods</h3><div>In the UK Biobank cohort, 349,553 participants without previous a cancer diagnosis were recruited. For PsRS construction, 12 social determinants of health were calculated across three domains consistently associated with incident LC. Cox models were used to estimate the association between PsRS and incident LC. Healthy lifestyle and LC genetic risk scores were constructed to evaluate whether lifestyle behaviours and genetic susceptibility modified the effect of PsRS on LC incidence. Mediation analysis was used to estimate whether a healthy lifestyle mediates the effect of PsRS' on LC incidence.</div></div><div><h3>Results</h3><div>Compared with participants with low PsRS (≤3), the fully adjusted hazard ratio (HR) (95 % CI) for high PsRS (≥7) in developing LC was 2.75 (2.43–3.12). We observed an additive interaction between PsRS and lifestyle. The proportion of mediation effect of lifestyle in the association between PsRS and LC was 6.41 % (95 % CI: 5.74–7.08 %). Individuals with high PsRS and genetic risk had a 4.63-fold higher risk of incident LC.</div></div><div><h3>Conclusion</h3><div>A high PsRS is associated with a higher risk of LC, and lifestyle influences this association. High heritable susceptibility and unfavourable social vulnerability may synergistically contribute to higher LC incidence.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 50-57"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke incidence, trends, and geographic disparities in Ghana: An analysis of nationwide health facility records","authors":"E.W. Kanmiki ,&nbsp;V.M. Oguoma ,&nbsp;S. Mayeden ,&nbsp;S.K. Kofitse ,&nbsp;E.A. Nonterah ,&nbsp;J. Akazili ,&nbsp;A.A. Mamun","doi":"10.1016/j.puhe.2025.02.023","DOIUrl":"10.1016/j.puhe.2025.02.023","url":null,"abstract":"<div><h3>Objectives</h3><div>Despite the increasing burden of stroke and its effects in sub-Saharan Africa, there is a paucity of empirical studies on the burden of stroke and its risk factors to help guide targeted interventions in the region. This study examines the incidence, trends and some factors associated with stroke cases in Ghana.</div></div><div><h3>Study design</h3><div>Retrospective analysis of observational routinely collected data.</div></div><div><h3>Methods</h3><div>Empirical data of confirmed stroke cases from all government-affiliated healthcare facilities were extracted from the District Health Information Management Systems of the Ghana Health Service spanning 2016–2021. Variables include stroke case counts by sex, age group and location. Cartographic geospatial mapping of stroke case density and negative binomial regressions were employed to assess trends and factors associated with stroke.</div></div><div><h3>Results</h3><div>Stroke cases increased by more than two-fold in just six years (from 10,732 to 23,009). The rates for people 35–59years (IRR = 5.06, 95% CI: 4.04–6.63) and those above 60 years (IRR = 6.29, 95% CI: 5.01–7.88) were 5 and 6 times higher compared with 0–35year old. The rate of stroke in the year 2021 was 61 % higher than in 2016 (IRR = 1.61, 95% CI: 1.18–2.21). People in the northern savannah ecological zone had 77 % lower rate of stroke compared with those in the coastal zone of Ghana (IRR = 0.23, 95% CI: 0.18–0.30).</div></div><div><h3>Conclusions</h3><div>The incidence of stroke in Ghana is rising across all age groups, sexes and locations with a trajectory of early onset within the life course. There is an urgent need for the implementation of public health interventions for early detection, prevention and management of stroke cases in the country.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 44-49"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease prevalence and working ability among socio-medically assessed unemployed people in Germany between 2016 and 2021: A secondary data analysis of the Federal Employment Agency","authors":"Andreas G. Franke ,&nbsp;Patrik Roser ,&nbsp;Norbert Scherbaum ,&nbsp;Claudia Pieper ,&nbsp;Kirsi Manz ,&nbsp;Gabriele Lotz-Metz","doi":"10.1016/j.puhe.2025.02.021","DOIUrl":"10.1016/j.puhe.2025.02.021","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess socio-medical status of unemployed persons registered in Germany between 2016 and 2021 regarding medical diagnoses and work ability.</div></div><div><h3>Study design</h3><div>We conducted a secondary data analysis.</div></div><div><h3>Methods</h3><div>We used <em>t</em>-test to compare means of groups and odds ratio to calculate the probability for work ability.</div></div><div><h3>Results</h3><div>4.3 million clients were assessed (43.3 ± 13.2 years; 52.4 % male). Nearly all clients (96.5 %) received at least one diagnosis. Regarding first and secondary diagnosis, 52.1 % suffered from mental disorders, followed by diseases of the musculoskeletal system and connective tissue (31.4 %), and the circulatory system (10.7 %). Of those with at least one diagnosis 41.7 % were unable to return to work. Clients with mental disorders (first diagnosis) were more likely to be unable to work (68.2 %, n = 958,144) than those with diseases of the musculoskeletal system and connective tissue (16.9 %, n = 237,459) and diseases of the circulatory system (9.4 %, n = 131,513).</div></div><div><h3>Conclusions</h3><div>Our study provides disease prevalence and work ability based on secondary data of all socio-medical assessments of the German Federal Employment Agency between 2016 and 2021. Further studies should be enhanced by both individual and external factors to provide a broader perspective.</div><div>Labor market policy instruments should address both, the improvement of re-employment rates and the targeted prevention of diseases among unemployed. It is mandatory to define target populations who suffer from an increased risk for (mental) health problems and to design future labor market instruments.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 37-43"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between adverse childhood experiences and self-reported physician-diagnosed depression: The moderating effect of race/ethnicity","authors":"Philip Baiden ,&nbsp;Catherine A. LaBrenz ,&nbsp;Christina M. Sellers","doi":"10.1016/j.puhe.2025.02.013","DOIUrl":"10.1016/j.puhe.2025.02.013","url":null,"abstract":"<div><h3>Objectives</h3><div>Although research indicates that individuals with a history of adverse childhood experiences (ACEs) are at greater risk of experiencing chronic conditions, including depression, less is known about the association between ACEs and depression and how this association is dependent on race/ethnicity. This study examined the moderating effects of race/ethnicity on the association between ACEs and self-reported physician-diagnosed depression among adults.</div></div><div><h3>Study design</h3><div>Cross-sectional study.</div></div><div><h3>Methods</h3><div>Data for this study came from the 2021 Behavioral Risk Factor Surveillance System. An analytic sample of 26,877 adults 18–64 years old (50.4% female) was analyzed using binary logistic regression. The outcome variable investigated in this study was self-reported physician-diagnosed depression, the main explanatory variable was ACE score, and the moderating variable was race/ethnicity.</div></div><div><h3>Results</h3><div>Of the 26,877 respondents, 28.1% had no ACEs, 47.2% had one to three ACEs, and 24.7% had four or more ACEs. About one in four respondents had physician-diagnosed depression. In the multivariable logistic regression, we found that the effect of ACEs on self-reported physician-diagnosed depression depends on race/ethnicity. Specifically, the effect of four or more ACEs is significantly stronger when the respondent identifies as Hispanic compared to those who identify as non-Hispanic Black or another race (AOR = 2.80, 95% CI = 1.42, 5.53).</div></div><div><h3>Conclusion</h3><div>The findings of this study demonstrate that experiencing four or more ACEs is associated with self-reported physician-diagnosed depression during adulthood, and this association is moderated by race/ethnicity.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"241 ","pages":"Pages 171-178"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of video-assisted educational intervention on improving knowledge, attitude and practice among mothers of children below five years on malnutrition: A systematic review","authors":"Sowmya Pujari ,&nbsp;Muhammed Rashid ,&nbsp;Girish Thunga ,&nbsp;Ranjitha S. Shetty ,&nbsp;Suneel C. Mundkur ,&nbsp;Elsa Sanatombi Devi ,&nbsp;Unnikrishnan B ,&nbsp;Sreedharan Nair","doi":"10.1016/j.puhe.2025.02.031","DOIUrl":"10.1016/j.puhe.2025.02.031","url":null,"abstract":"<div><h3>Objectives</h3><div>This review aimed to assess the effect of video-assisted educational interventions in enhancing knowledge, attitudes, and practices (KAP) among mothers of malnourished children aged &lt;5 years.</div></div><div><h3>Study design</h3><div>This was a systematic review.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Scopus, and EMBASE databases from inception until November 2022. The selection criteria adhered to the PICOS framework, targeting randomized controlled trials (RCTs) involving mothers who received video-assisted educational interventions alongside comparison groups to evaluate malnutrition-associated KAP outcomes. Risk of bias was assessed using the Cochrane risk of bias assessment tool. Two independent reviewers performed study selection, data extraction, and quality assessment, resolving any disagreements through discussion or consultation with a third reviewer.</div></div><div><h3>Results</h3><div>Among 11,434 screened articles, seven RCTs met the inclusion criteria, focusing on mothers of children aged &lt;5 years. Statistically significant improvements were observed in maternal knowledge (n = 2), attitude (n = 1), and practice (n = 6) with respect to the feeding practices following video-assisted educational interventions. However, the effect of the educational intervention on children's z-scores remained inconclusive.</div></div><div><h3>Conclusions</h3><div>Video-assisted educational interventions were effective in KAP concerning feeding practices among mothers of children aged &lt;5 years. However, their impact on children's z-scores remain inconclusive, emphasising the need for further research to explore factors influencing these outcomes. Further research is needed to determine the long-term effect on children's nutritional status.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 28-36"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between main ambient air pollutants and ischaemic heart disease risk in the UK biobank: A prospective cohort study","authors":"Mingxing Ni ,&nbsp;Ziying Chen ,&nbsp;Junyu Zhang ,&nbsp;Yilin Niu ,&nbsp;Huixian Li ,&nbsp;Yu Ning ,&nbsp;Miao Lin ,&nbsp;Huiying Liang","doi":"10.1016/j.puhe.2024.12.039","DOIUrl":"10.1016/j.puhe.2024.12.039","url":null,"abstract":"<div><h3>Objectives</h3><div>Air pollutants have been associated with multiple cardiovascular diseases, but evidence on the long-term and combined effects of air pollutants on the incidence of ischaemic heart disease (IHD) remains limited.</div></div><div><h3>Study design</h3><div>Prospective cohort study.</div></div><div><h3>Methods</h3><div>A total of 398,547 participants from the UK Biobank were included in this prospective cohort study. Concentrations of air pollutants were calculated using the Land Use Regression (LUR) model, including particulate matter (PM) [PM_2.5, PM_10-2.5, PM₁₀] and nitrogen oxides (NO_x and NO₂). Cox proportional hazards models and restricted cubic spline models were utilised to detect associations between air pollutants and IHD incidence. A novel air pollution score was proposed to indicate the synergistic effect of five air pollutants by combining variance contribution and eigenvalue of each pollutant in principal components analysis (PCA).</div></div><div><h3>Results</h3><div>In a median follow-up of 12.5 years, 23,721 of 398,547 participants were diagnosed with IHD. For every 1-μg/m³ increase, the risk of IHD was 1.026 (95 % confidence interval [CI]: 1.012–1.040) and 1.002 (95 % CI: 1.001–1.003) for PM_2.5 and NO_x, respectively. This study found that for every increase in quartile of PM_2.5 level, the hazard ratios (HRs) for IHD were 1.035 (95 % CI: 0.998–1.073), 1.043 (95 % CI: 1.005–1.082) and 1. 063 (95 % CI: 1.022–1.106) compared with the lowest quartile. Long-term estimated exposure to multiple air pollutants showed a significant association with elevated risk of IHD (HRs = 1.029, 95 % CI: 1.007–1.051) and the exposure-response curve was linear.</div></div><div><h3>Conclusions</h3><div>Among UK adults, long-term and synchronous exposure to multiple air contaminants was associated with an increased risk of IHD.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 14-20"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}