Reviews in the Neurosciences最新文献_第7页

In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs. 体内C6胶质瘤模型：更新并指导对潜在抗胶质母细胞瘤药物进行更有效的临床前评估。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-09-01 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0067

Safura Pournajaf, Nastaran Afsordeh, Mohammad Hossein Pourgholami

引用次数: 0

An update to pain management after spinal cord injury: from pharmacology to circRNAs. 脊髓损伤后疼痛管理的最新进展:从药理学到环状rna。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0089

Graciela L Mazzone, María F Coronel, Miranda Mladinic, Cynthia Sámano

{"title":"An update to pain management after spinal cord injury: from pharmacology to circRNAs.","authors":"Graciela L Mazzone, María F Coronel, Miranda Mladinic, Cynthia Sámano","doi":"10.1515/revneuro-2022-0089","DOIUrl":"https://doi.org/10.1515/revneuro-2022-0089","url":null,"abstract":"Neuropathic pain (NP) following a spinal cord injury (SCI) is often hard to control and therapies should be focused on the physical, psychological, behavioral, social, and environmental factors that may contribute to chronic sensory symptoms. Novel therapeutic treatments for NP management should be based on the combination of pharmacological and nonpharmacological options. Some of them are addressed in this review with a focus on mechanisms and novel treatments. Several reports demonstrated an aberrant expression of non-coding RNAs (ncRNAs) that may represent key regulatory factors with a crucial role in the pathophysiology of NP and as potential diagnostic biomarkers. This review analyses the latest evidence for cellular and molecular mechanisms associated with the role of circular RNAs (circRNAs) in the management of pain after SCI. Advantages in the use of circRNA are their stability (up to 48 h), and specificity as sponges of different miRNAs related to SCI and nerve injury. The present review discusses novel data about deregulated circRNAs (up or downregulated) that sponge miRNAs, and promote cellular and molecular interactions with mRNAs and proteins. This data support the concept that circRNAs could be considered as novel potential therapeutic targets for NP management especially after spinal cord injuries.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"599-611"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer's disease using neuroimaging. 三维卷积神经网络在阿尔茨海默病神经影像学诊断中的应用综述。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0122

Xinze Xu, Lan Lin, Shen Sun, Shuicai Wu

{"title":"A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer's disease using neuroimaging.","authors":"Xinze Xu, Lan Lin, Shen Sun, Shuicai Wu","doi":"10.1515/revneuro-2022-0122","DOIUrl":"https://doi.org/10.1515/revneuro-2022-0122","url":null,"abstract":"Alzheimer's disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. To obtain an accurate and timely diagnosis and detect AD at an early stage, numerous approaches based on convolutional neural networks (CNNs) using neuroimaging data have been proposed. Because 3D CNNs can extract more spatial discrimination information than 2D CNNs, they have emerged as a promising research direction in the diagnosis of AD. The aim of this article is to present the current state of the art in the diagnosis of AD using 3D CNN models and neuroimaging modalities, focusing on the 3D CNN architectures and classification methods used, and to highlight potential future research topics. To give the reader a better overview of the content mentioned in this review, we briefly introduce the commonly used imaging datasets and the fundamentals of CNN architectures. Then we carefully analyzed the existing studies on AD diagnosis, which are divided into two levels according to their inputs: 3D subject-level CNNs and 3D patch-level CNNs, highlighting their contributions and significance in the field. In addition, this review discusses the key findings and challenges from the studies and highlights the lessons learned as a roadmap for future research. Finally, we summarize the paper by presenting some major findings, identifying open research challenges, and pointing out future research directions.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"649-670"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control. 阿尔茨海默病的微生物-肠-脑轴和相关治疗:综合治疗和炎症控制的前景。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2023-0006

Jiahao Li, Feng Zhang, Li Zhao, Chunbo Dong

{"title":"Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control.","authors":"Jiahao Li, Feng Zhang, Li Zhao, Chunbo Dong","doi":"10.1515/revneuro-2023-0006","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0006","url":null,"abstract":"Alzheimer's disease (AD) is the most common type of dementia in the elderly and causes neurodegeneration, leading to memory loss, behavioral disorder, and psychiatric impairment. One potential mechanism contributing to the pathogenesis of AD may be the imbalance in gut microbiota, local and systemic inflammation, and dysregulation of the microbiota-gut-brain axis (MGBA). Most of the AD drugs approved for clinical use today are symptomatic treatments that do not improve AD pathologic changes. As a result, researchers are exploring novel therapeutic modalities. Treatments involving the MGBA include antibiotics, probiotics, transplantation of fecal microbiota, botanical products, and others. However, single-treatment modalities are not as effective as expected, and a combination therapy is gaining momentum. The purpose of this review is to summarize recent advances in MGBA-related pathological mechanisms and treatment modalities in AD and to propose a new concept of combination therapy. \"MGBA-based multitherapy\" is an emerging view of treatment in which classic symptomatic treatments and MGBA-based therapeutic modalities are used in combination. Donepezil and memantine are two commonly used drugs in AD treatment. On the basis of the single/combined use of these two drugs, two/more additional drugs and treatment modalities that target the MGBA are chosen based on the characteristics of the patient's condition as an adjuvant treatment, as well as the maintenance of good lifestyle habits. \"MGBA-based multitherapy\" offers new insights for the treatment of cognitive impairment in AD patients and is expected to show good therapeutic results.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"695-718"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9984548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances in stem cell therapy in the treatment of multiple sclerosis. 干细胞治疗多发性硬化的最新进展。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0102

Parnian Zolfaghari Baghbadorani, Amirmasoud Rayati Damavandi, Samira Moradi, Meysam Ahmadi, Peyman Bemani, Hamid Aria, Hossein Mottedayyen, Amirhossein Rayati Damavandi, Nahid Eskandari, Farshid Fathi

{"title":"Current advances in stem cell therapy in the treatment of multiple sclerosis.","authors":"Parnian Zolfaghari Baghbadorani, Amirmasoud Rayati Damavandi, Samira Moradi, Meysam Ahmadi, Peyman Bemani, Hamid Aria, Hossein Mottedayyen, Amirhossein Rayati Damavandi, Nahid Eskandari, Farshid Fathi","doi":"10.1515/revneuro-2022-0102","DOIUrl":"https://doi.org/10.1515/revneuro-2022-0102","url":null,"abstract":"Multiple sclerosis (MS) is an inflammatory disease related to the central nervous system (CNS) with a significant global burden. In this illness, the immune system plays an essential role in its pathophysiology and progression. The currently available treatments are not recognized as curable options and, at best, might slow the progression of MS injuries to the CNS. However, stem cell treatment has provided a new avenue for treating MS. Stem cells may enhance CNS healing and regulate immunological responses. Likewise, stem cells can come from various sources, including adipose, neuronal, bone marrow, and embryonic tissues. Choosing the optimal cell source for stem cell therapy is still a difficult verdict. A type of stem cell known as mesenchymal stem cells (MSCs) is obtainable from different sources and has a strong immunomodulatory impact on the immune system. According to mounting data, the umbilical cord and adipose tissue may serve as appropriate sources for the isolation of MSCs. Human amniotic epithelial cells (hAECs), as novel stem cell sources with immune-regulatory effects, regenerative properties, and decreased antigenicity, can also be thought of as a new upcoming contender for MS treatment. Overall, the administration of stem cells in different sets of animal and clinical trials has shown immunomodulatory and neuroprotective results. Therefore, this review aims to discuss the different types of stem cells by focusing on MSCs and their mechanisms, which can be used to treat and improve the outcomes of MS disease.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"613-633"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9926122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of the effects of transcranial photobiomodulation on brain activity in humans. 经颅光生物调节对人类大脑活动影响的系统综述。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2023-0003

Marjorie Dole, Vincent Auboiroux, Lilia Langar, John Mitrofanis

{"title":"A systematic review of the effects of transcranial photobiomodulation on brain activity in humans.","authors":"Marjorie Dole, Vincent Auboiroux, Lilia Langar, John Mitrofanis","doi":"10.1515/revneuro-2023-0003","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0003","url":null,"abstract":"In recent years, transcranial photobiomodulation (tPBM) has been developing as a promising method to protect and repair brain tissues against damages. The aim of our systematic review is to examine the results available in the literature concerning the efficacy of tPBM in changing brain activity in humans, either in healthy individuals, or in patients with neurological diseases. Four databases were screened for references containing terms encompassing photobiomodulation, brain activity, brain imaging, and human. We also analysed the quality of the included studies using validated tools. Results in healthy subjects showed that even after a single session, tPBM can be effective in influencing brain activity. In particular, the different transcranial approaches - using a focal stimulation or helmet for global brain stimulation - seemed to act at both the vascular level by increasing regional cerebral blood flow (rCBF) and at the neural level by changing the activity of the neurons. In addition, studies also showed that even a focal stimulation was sufficient to induce a global change in functional connectivity across brain networks. Results in patients with neurological disease were sparser; nevertheless, they indicated that tPBM could improve rCBF and functional connectivity in several regions. Our systematic review also highlighted the heterogeneity in the methods and results generated, together with the need for more randomised controlled trials in patients with neurological diseases. In summary, tPBM could be a promising method to act on brain function, but more consistency is needed in order appreciate fully the underlying mechanisms and the precise outcomes.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"671-693"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Targeting NMDA receptor signaling for therapeutic intervention in brain disorders. 靶向NMDA受体信号对脑部疾病的治疗干预。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0096

He Chen, Yuanping Dong, Yun Wu, Feng Yi

引用次数: 1

Fine-tuning the circadian system with light treatment for Parkinson's disease: an in-depth, critical review. 用光治疗微调帕金森病的昼夜节律系统：一篇深入的评论文章。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-23 Print Date: 2024-01-29 DOI: 10.1515/revneuro-2023-0026

Gregory L Willis, Stuart M Armstrong

{"title":"Fine-tuning the circadian system with light treatment for Parkinson's disease: an in-depth, critical review.","authors":"Gregory L Willis, Stuart M Armstrong","doi":"10.1515/revneuro-2023-0026","DOIUrl":"10.1515/revneuro-2023-0026","url":null,"abstract":"Late in the twentieth century, interest intensified regarding the involvement of the circadian system in the aetiology and treatment of Parkinson's disease (PD). It has been envisaged that this approach might provide relief beyond the limited benefits and severe side effects achieved by dopamine (DA) replacement. In the first clinical article, published in 1996, polychromatic light was used to shift the circadian clock as it is considered to be the most powerful zeitgeber (time keeper) that can be implemented to realign circadian phase. Since that time, 11 additional articles have implemented light treatment (LT) in various forms as an adjuvant to DA replacement. In spite of the growing interest in this area, the systematic exploration of LT in PD has been stymied by several methodological factors. Such factors include time of LT presentation, duration of studies undertaken, frequency of light employed, dose of light prescribed and relevance of experimental design to the prolonged course of the illness. On this basis, it is the purpose of this review to provide an in-depth examination of these papers, and the underlying preclinical work, to provide critique, thereby giving direction for future studies in therapeutic applications of LT for PD. Consideration of this collective work may serve to carve a path for future research and thereby improve the lives of those suffering from this debilitating disorder.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"57-84"},"PeriodicalIF":3.4,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral inflammation is a potential etiological factor in Alzheimer's disease. 外周炎症是阿尔茨海默病的潜在致病因素。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-21 Print Date: 2024-01-29 DOI: 10.1515/revneuro-2023-0049

Ziyuan Li, Hui Wang, Yafu Yin

{"title":"Peripheral inflammation is a potential etiological factor in Alzheimer's disease.","authors":"Ziyuan Li, Hui Wang, Yafu Yin","doi":"10.1515/revneuro-2023-0049","DOIUrl":"10.1515/revneuro-2023-0049","url":null,"abstract":"Peripheral inflammation could constitute a risk factor for AD. This review summarizes the research related to peripheral inflammation that appears to have a relationship with Alzheimer's disease. We find there are significant associations between AD and peripheral infection induced by various pathogens, including herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Porphyromonas gingivalis, Helicobacter pylori, and Toxoplasma gondii. Chronic inflammatory diseases are also reported to contribute to the pathophysiology of AD. The mechanisms by which peripheral inflammation affects the pathophysiology of AD are complex. Pathogen-derived neurotoxic molecule composition, disrupted BBB, and dysfunctional neurogenesis may all play a role in peripheral inflammation, promoting the development of AD. Anti-pathogenic medications and anti-inflammatory treatments are reported to decrease the risk of AD. Studies that could improve understanding the associations between AD and peripheral inflammation are needed. If our assumption is correct, early intervention against inflammation may be a potential method of preventing and treating AD.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"99-120"},"PeriodicalIF":3.4,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis underlying hexanucleotide repeat expansions in C9orf72 gene in amyotrophic lateral sclerosis. 肌萎缩性脊髓侧索硬化症中 C9orf72 基因六核苷酸重复扩增的发病机制。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-02 Print Date: 2024-01-29 DOI: 10.1515/revneuro-2023-0060

Zhao Zhong Chong, Daniel L Menkes, Nizar Souayah

{"title":"Pathogenesis underlying hexanucleotide repeat expansions in C9orf72 gene in amyotrophic lateral sclerosis.","authors":"Zhao Zhong Chong, Daniel L Menkes, Nizar Souayah","doi":"10.1515/revneuro-2023-0060","DOIUrl":"10.1515/revneuro-2023-0060","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Mutations in C9orf72 and the resulting hexanucleotide repeat (GGGGCC) expansion (HRE) has been identified as a major cause of familial ALS, accounting for about 40 % of familial and 6 % of sporadic cases of ALS in Western patients. The pathological outcomes of HRE expansion in ALS have been recognized as the results of two mechanisms that include both the toxic gain-of-function and loss-of-function of C9ORF72. The gain of toxicity results from RNA and dipeptide repeats (DPRs). The HRE can be bidirectionally transcribed into RNA foci, which can bind to and disrupt RNA splicing, transport, and translation. The DPRs that include poly-glycine-alanine, poly-glycine-proline, poly-glycine- arginine, poly-proline-alanine, and poly-proline-arginine can induce toxicity by direct binding and sequestrating other proteins to interfere rRNA synthesis, ribosome biogenesis, translation, and nucleocytoplasmic transport. The C9ORF72 functions through binding to its partners-Smith-Magenis chromosome regions 8 (SMCR8) and WD repeat-containing protein (WDR41). Loss of C9ORF72 function results in impairment of autophagy, deregulation of autoimmunity, increased stress, and disruption of nucleocytoplasmic transport. Further insight into the mechanism in C9ORF72 HRE pathogenesis will facilitate identifying novel and effective therapeutic targets for ALS.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"85-97"},"PeriodicalIF":3.4,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0