Reviews in the Neurosciences最新文献_第6页

Exploring the latest findings on endovascular treatments for giant aneurysms: a review 探索巨型动脉瘤血管内治疗的最新发现：综述

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-30 DOI: 10.1515/revneuro-2023-0082

David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Anargyros Chlorogiannis, Nefeli Kosta, Jonathan Andreas Sänger, Achilles Chatziioannou, Panagiotis Papanagiotou

引用次数: 0

An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets. 用于老年性黄斑变性临床前研究的视网膜光损伤模型概述：确定分子标志和治疗目标。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0130

Giulia Carozza, Darin Zerti, Annamaria Tisi, Marco Ciancaglini, Mauro Maccarrone, Rita Maccarone

{"title":"An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets.","authors":"Giulia Carozza, Darin Zerti, Annamaria Tisi, Marco Ciancaglini, Mauro Maccarrone, Rita Maccarone","doi":"10.1515/revneuro-2023-0130","DOIUrl":"10.1515/revneuro-2023-0130","url":null,"abstract":"Age-related macular degeneration (AMD) is a complex, multifactorial disease leading to progressive and irreversible retinal degeneration, whose pathogenesis has not been fully elucidated yet. Due to the complexity and to the multiple features of the disease, many efforts have been made to develop animal models which faithfully reproduce the overall AMD hallmarks or that are able to mimic the different AMD stages. In this context, light damage (LD) rodent models of AMD represent a suitable and reliable approach to mimic the different AMD forms (dry, wet and geographic atrophy) while maintaining the time-dependent progression of the disease. In this review, we comprehensively reported how the LD paradigms reproduce the main features of human AMD. We discuss the capability of these models to broaden the knowledge in AMD research, with a focus on the mechanisms and the molecular hallmarks underlying the pathogenesis of the disease. We also critically revise the remaining challenges and future directions for the use of LD models.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"303-330"},"PeriodicalIF":3.4,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying the Alzheimer’s disease continuum using EEG and fMRI in single-modality and multi-modality settings 在单模态和多模态环境下使用脑电图和 fMRI 研究阿尔茨海默病的连续性

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 DOI: 10.1515/revneuro-2023-0098

Jing Li, Xin Li, Futao Chen, Weiping Li, Jiu Chen, Bing Zhang

{"title":"Studying the Alzheimer’s disease continuum using EEG and fMRI in single-modality and multi-modality settings","authors":"Jing Li, Xin Li, Futao Chen, Weiping Li, Jiu Chen, Bing Zhang","doi":"10.1515/revneuro-2023-0098","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0098","url":null,"abstract":"Alzheimer’s disease (AD) is a biological, clinical continuum that covers the preclinical, prodromal, and clinical phases of the disease. Early diagnosis and identification of the stages of Alzheimer’s disease (AD) are crucial in clinical practice. Ideally, biomarkers should reflect the underlying process (pathological or otherwise), be reproducible and non-invasive, and allow repeated measurements over time. However, the currently known biomarkers for AD are not suitable for differentiating the stages and predicting the trajectory of disease progression. Some objective parameters extracted using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are widely applied to diagnose the stages of the AD continuum. While electroencephalography (EEG) has a high temporal resolution, fMRI has a high spatial resolution. Combined EEG and fMRI (EEG–fMRI) can overcome single-modality drawbacks and obtain multi-dimensional information simultaneously, and it can help explore the hemodynamic changes associated with the neural oscillations that occur during information processing. This technique has been used in the cognitive field in recent years. This review focuses on the different techniques available for studying the AD continuum, including EEG and fMRI in single-modality and multi-modality settings, and the possible future directions of AD diagnosis using EEG–fMRI.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"51 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic ischemic brain injury: animal models reveal new mechanisms of melatonin-mediated neuroprotection. 缺氧缺血性脑损伤：动物模型揭示了褪黑激素介导的神经保护新机制。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0126

Serafina Perrone, Silvia Carloni, Valentina Giovanna Dell'Orto, Laura Filonzi, Virginia Beretta, Chiara Petrolini, Chiara Lembo, Giuseppe Buonocore, Susanna Esposito, Francesco Nonnis Marzano

{"title":"Hypoxic ischemic brain injury: animal models reveal new mechanisms of melatonin-mediated neuroprotection.","authors":"Serafina Perrone, Silvia Carloni, Valentina Giovanna Dell'Orto, Laura Filonzi, Virginia Beretta, Chiara Petrolini, Chiara Lembo, Giuseppe Buonocore, Susanna Esposito, Francesco Nonnis Marzano","doi":"10.1515/revneuro-2023-0126","DOIUrl":"10.1515/revneuro-2023-0126","url":null,"abstract":"Oxidative stress (OS) and inflammation play a key role in the development of hypoxic-ischemic (H-I) induced brain damage. Following H-I, rapid neuronal death occurs during the acute phase of inflammation, and activation of the oxidant-antioxidant system contributes to the brain damage by activated microglia. So far, in an animal model of perinatal H-I, it was showed that neuroprostanes are present in all brain damaged areas, including the cerebral cortex, hippocampus and striatum. Based on the interplay between inflammation and OS, it was demonstrated in the same model that inflammation reduced brain sirtuin-1 expression and affected the expression of specific miRNAs. Moreover, through proteomic approach, an increased expression of genes and proteins in cerebral cortex synaptosomes has been revealed after induction of neonatal H-I. Administration of melatonin in the experimental treatment of brain damage and neurodegenerative diseases has produced promising therapeutic results. Melatonin protects against OS, contributes to reduce the generation of pro-inflammatory factors and promotes tissue regeneration and repair. Starting from the above cited aspects, this educational review aims to discuss the inflammatory and OS main pathways in H-I brain injury, focusing on the role of melatonin as neuroprotectant and providing current and emerging evidence.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"331-339"},"PeriodicalIF":3.4,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease 摆脱 X 染色体失活与阿尔茨海默病的性别差异

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-12-29 DOI: 10.1515/revneuro-2023-0108

Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He

{"title":"Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease","authors":"Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He","doi":"10.1515/revneuro-2023-0108","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0108","url":null,"abstract":"Sex differences exist in the onset and progression of Alzheimer’s disease. Globally, women have a higher prevalence, while men with Alzheimer’s disease experience earlier mortality and more pronounced cognitive decline than women. The cause of sex differences in Alzheimer’s disease remains unclear. Accumulating evidence suggests the potential role of X-linked genetic factors in the sex difference of Alzheimer’s disease (AD). During embryogenesis, a remarkable process known as X-chromosome inactivation (XCI) occurs in females, leading to one of the X chromosomes undergoing transcriptional inactivation, which balances the effects of two X chromosomes in females. Nevertheless, certain genes exceptionally escape from XCI, which provides a basis for dual expression dosage of specific genes in females. Based on recent research findings, we explore key escape genes and their potential therapeutic use associated with Alzheimer’s disease. Also, we discuss their possible role in driving the sex differences in Alzheimer’s disease. This will provide new perspectives for precision medicine and gender-specific treatment of AD.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"194 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies. 髓磷脂在神经退行性变中的作用:对药物靶点和神经保护策略的影响。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-11-22 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0081

Gabriella E Parrilla, Vivek Gupta, Roshana Vander Wall, Akanksha Salkar, Devaraj Basavarajappa, Mehdi Mirzaei, Nitin Chitranshi, Stuart L Graham, Yuyi You

{"title":"The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies.","authors":"Gabriella E Parrilla, Vivek Gupta, Roshana Vander Wall, Akanksha Salkar, Devaraj Basavarajappa, Mehdi Mirzaei, Nitin Chitranshi, Stuart L Graham, Yuyi You","doi":"10.1515/revneuro-2023-0081","DOIUrl":"10.1515/revneuro-2023-0081","url":null,"abstract":"Myelination of axons in the central nervous system offers numerous advantages, including decreased energy expenditure for signal transmission and enhanced signal speed. The myelin sheaths surrounding an axon consist of a multi-layered membrane that is formed by oligodendrocytes, while specific glycoproteins and lipids play various roles in this formation process. As beneficial as myelin can be, its dysregulation and degeneration can prove detrimental. Inflammation, oxidative stress, and changes in cellular metabolism and the extracellular matrix can lead to demyelination of these axons. These factors are hallmark characteristics of certain demyelinating diseases including multiple sclerosis. The effects of demyelination are also implicated in primary degeneration in diseases such as glaucoma and Alzheimer's disease, as well as in processes of secondary degeneration. This reveals a relationship between myelin and secondary processes of neurodegeneration, including resultant degeneration following traumatic injury and transsynaptic degeneration. The role of myelin in primary and secondary degeneration is also of interest in the exploration of strategies and targets for remyelination, including the use of anti-inflammatory molecules or nanoparticles to deliver drugs. Although the use of these methods in animal models of diseases have shown to be effective in promoting remyelination, very few clinical trials in patients have met primary end points. This may be due to shortcomings or considerations that are not met while designing a clinical trial that targets remyelination. Potential solutions include diversifying disease targets and requiring concomitant interventions to promote rehabilitation.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"271-292"},"PeriodicalIF":3.4,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia. 脊髓损伤诱导免疫缺陷综合征（SCI-IDS）的主要机制：交感神经反射亢进。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-30 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0090

Ping Yang, Zhi-Qun Bian, Zhen-Bo Song, Cheng-Ying Yang, Li Wang, Zhong-Xiang Yao

{"title":"Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia.","authors":"Ping Yang, Zhi-Qun Bian, Zhen-Bo Song, Cheng-Ying Yang, Li Wang, Zhong-Xiang Yao","doi":"10.1515/revneuro-2023-0090","DOIUrl":"10.1515/revneuro-2023-0090","url":null,"abstract":"Clinical studies have shown that individuals with spinal cord injury (SCI) are particularly susceptible to infectious diseases, resulting in a syndrome called SCI-induced immunodeficiency syndrome (SCI-IDS), which is the leading cause of death after SCI. It is believed that SCI-IDS is associated with exaggerated activation of sympathetic preganglionic neurons (SPNs). After SCI, disruption of bulbospinal projections from the medulla oblongata C1 neurons to the SPNs results in the loss of sympathetic inhibitory modulation from the brain and brainstem and the occurrence of abnormally high levels of spinal sympathetic reflexes (SSR), named sympathetic hyperreflexia. As the post-injury survival time lengthens, mass recruitment and anomalous sprouting of excitatory interneurons within the spinal cord result in increased SSR excitability, resulting in an excess sympathetic output that disrupts the immune response. Therefore, we first analyze the structural underpinnings of the spinal cord-sympathetic nervous system-immune system after SCI, then demonstrate the progress in highlighting mechanisms of SCI-IDS focusing on norepinephrine (NE)/Beta 2-adrenergic receptor (β2-AR) signal pathways, and summarize recent preclinical studies examining potential means such as regulating SSR and inhibiting β2-AR signal pathways to improve immune function after SCI. Finally, we present research perspectives such as to promote the effective regeneration of C1 neurons to rebuild the connection of C1 neurons with SPNs, to regulate excitable or inhibitory interneurons, and specifically to target β2-AR signal pathways to re-establish neuroimmune balance. These will help us design effective strategies to reverse post-SCI sympathetic hyperreflexia and improve the overall quality of life for individuals with SCI.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"259-269"},"PeriodicalIF":3.4,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61565806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracortical brain-computer interfaces for improved motor function: a systematic review. 改善运动功能的皮质内脑机接口：一项系统综述。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-17 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0077

Matthew W Holt, Eric C Robinson, Nathan A Shlobin, Jacob T Hanson, Ismail Bozkurt

{"title":"Intracortical brain-computer interfaces for improved motor function: a systematic review.","authors":"Matthew W Holt, Eric C Robinson, Nathan A Shlobin, Jacob T Hanson, Ismail Bozkurt","doi":"10.1515/revneuro-2023-0077","DOIUrl":"10.1515/revneuro-2023-0077","url":null,"abstract":"In this systematic review, we address the status of intracortical brain-computer interfaces (iBCIs) applied to the motor cortex to improve function in patients with impaired motor ability. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Guidelines for Systematic Reviews. Risk Of Bias In Non-randomized Studies - of Interventions (ROBINS-I) and the Effective Public Health Practice Project (EPHPP) were used to assess bias and quality. Advances in iBCIs in the last two decades demonstrated the use of iBCI to activate limbs for functional tasks, achieve neural typing for communication, and other applications. However, the inconsistency of performance metrics employed by these studies suggests the need for standardization. Each study was a pilot clinical trial consisting of 1-4, majority male (64.28 %) participants, with most trials featuring participants treated for more than 12 months (55.55 %). The systems treated patients with various conditions: amyotrophic lateral sclerosis, stroke, spinocerebellar degeneration without cerebellar involvement, and spinal cord injury. All participants presented with tetraplegia at implantation and were implanted with microelectrode arrays via pneumatic insertion, with nearly all electrode locations solely at the precentral gyrus of the motor cortex (88.88 %). The development of iBCI devices using neural signals from the motor cortex to improve motor-impaired patients has enhanced the ability of these systems to return ability to their users. However, many milestones remain before these devices can prove their feasibility for recovery. This review summarizes the achievements and shortfalls of these systems and their respective trials.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"213-223"},"PeriodicalIF":3.4,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult ADHD: it is old and new at the same time - what is it? 成人多动症：它是旧的，也是新的——它是什么？

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-11 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0071

Raly James Perez Custodio, Jan G Hengstler, Jae Hoon Cheong, Hee Jin Kim, Edmund Wascher, Stephan Getzmann

{"title":"Adult ADHD: it is old and new at the same time - what is it?","authors":"Raly James Perez Custodio, Jan G Hengstler, Jae Hoon Cheong, Hee Jin Kim, Edmund Wascher, Stephan Getzmann","doi":"10.1515/revneuro-2023-0071","DOIUrl":"10.1515/revneuro-2023-0071","url":null,"abstract":"Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understanding adult ADHD, both at preclinical and clinical levels, due to the increasing evidence that adult ADHD is highly distinct and a different entity from childhood ADHD. This review paper outlines the symptoms, diagnostics, and neurobiological mechanisms of ADHD, with emphasis on how adult ADHD could be different from childhood-onset. Data show a difference in the environmental, genetic, epigenetic, and brain structural changes, when combined, could greatly impact the behavioral presentations and the severity of ADHD in adults. Furthermore, a crucial aspect in the quest to fully understand this disorder could be through longitudinal analysis. In this way, we will determine if and how the pathology and pharmacology of ADHD change with age. This goal could revolutionize our understanding of the disorder and address the weaknesses in the current clinical classification systems, improving the characterization and validity of ADHD diagnosis, specifically those in adults.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"225-241"},"PeriodicalIF":3.4,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety. 大麻和大麻素对社交焦虑的主观、行为和神经生物学影响。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-11 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0078

Bárbara Dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula de Lima, Daniel Araki Ribeiro, Milena de Barros Viana

{"title":"Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety.","authors":"Bárbara Dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula de Lima, Daniel Araki Ribeiro, Milena de Barros Viana","doi":"10.1515/revneuro-2023-0078","DOIUrl":"10.1515/revneuro-2023-0078","url":null,"abstract":"Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to these therapeutic options. During the last years, Cannabis and cannabinoid-containing products have been investigated for the treatment of different neuropsychiatric disorders. Nevertheless, their efficacy for the treatment of anxiety disorders is still a matter of debate. The purpose of this review was to investigate subjective, behavioral, and neurobiological effects of Cannabis and cannabinoids in social anxiety and SAD. A search in the PubMed database for articles published between the years of 2003-2023 was conducted. One hundred and seventeen (117) original studies were identified. After the exclusion criteria, eighteen (18) studies were selected. The studies investigated the effects of the cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in patients or healthy volunteers submitted to tasks that assessed social anxiety. Results showed that CBD decreases social anxiety, producing an inverted U-shaped curve, with anxiety measurements being reduced at intermediate doses administered orally (300-600 mg), but not at lower or higher doses. THC either reduces (lower doses, 6-7.5 mg) or increases (higher doses) social anxiety measurements. CBD attenuates the anxiogenic effects of THC. The effects of THC and CBD in anxiety are associated to the modulation of fronto-limbic regions. Further clinical trials, conducted with male and female patients and larger cohorts are still necessary to consolidate these results.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"197-211"},"PeriodicalIF":3.4,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0