Reviews in the Neurosciences最新文献_第6页

Adult ADHD: it is old and new at the same time - what is it? 成人多动症：它是旧的，也是新的——它是什么？

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-11 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0071

Raly James Perez Custodio, Jan G Hengstler, Jae Hoon Cheong, Hee Jin Kim, Edmund Wascher, Stephan Getzmann

{"title":"Adult ADHD: it is old and new at the same time - what is it?","authors":"Raly James Perez Custodio, Jan G Hengstler, Jae Hoon Cheong, Hee Jin Kim, Edmund Wascher, Stephan Getzmann","doi":"10.1515/revneuro-2023-0071","DOIUrl":"10.1515/revneuro-2023-0071","url":null,"abstract":"Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understanding adult ADHD, both at preclinical and clinical levels, due to the increasing evidence that adult ADHD is highly distinct and a different entity from childhood ADHD. This review paper outlines the symptoms, diagnostics, and neurobiological mechanisms of ADHD, with emphasis on how adult ADHD could be different from childhood-onset. Data show a difference in the environmental, genetic, epigenetic, and brain structural changes, when combined, could greatly impact the behavioral presentations and the severity of ADHD in adults. Furthermore, a crucial aspect in the quest to fully understand this disorder could be through longitudinal analysis. In this way, we will determine if and how the pathology and pharmacology of ADHD change with age. This goal could revolutionize our understanding of the disorder and address the weaknesses in the current clinical classification systems, improving the characterization and validity of ADHD diagnosis, specifically those in adults.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"225-241"},"PeriodicalIF":3.4,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety. 大麻和大麻素对社交焦虑的主观、行为和神经生物学影响。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-10-11 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0078

Bárbara Dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula de Lima, Daniel Araki Ribeiro, Milena de Barros Viana

{"title":"Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety.","authors":"Bárbara Dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula de Lima, Daniel Araki Ribeiro, Milena de Barros Viana","doi":"10.1515/revneuro-2023-0078","DOIUrl":"10.1515/revneuro-2023-0078","url":null,"abstract":"Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to these therapeutic options. During the last years, Cannabis and cannabinoid-containing products have been investigated for the treatment of different neuropsychiatric disorders. Nevertheless, their efficacy for the treatment of anxiety disorders is still a matter of debate. The purpose of this review was to investigate subjective, behavioral, and neurobiological effects of Cannabis and cannabinoids in social anxiety and SAD. A search in the PubMed database for articles published between the years of 2003-2023 was conducted. One hundred and seventeen (117) original studies were identified. After the exclusion criteria, eighteen (18) studies were selected. The studies investigated the effects of the cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in patients or healthy volunteers submitted to tasks that assessed social anxiety. Results showed that CBD decreases social anxiety, producing an inverted U-shaped curve, with anxiety measurements being reduced at intermediate doses administered orally (300-600 mg), but not at lower or higher doses. THC either reduces (lower doses, 6-7.5 mg) or increases (higher doses) social anxiety measurements. CBD attenuates the anxiogenic effects of THC. The effects of THC and CBD in anxiety are associated to the modulation of fronto-limbic regions. Further clinical trials, conducted with male and female patients and larger cohorts are still necessary to consolidate these results.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"197-211"},"PeriodicalIF":3.4,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41184020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontmatter 头版头条

3区医学

Reviews in the Neurosciences Pub Date : 2023-10-01 DOI: 10.1515/revneuro-2023-frontmatter7

引用次数: 0

Understanding visual processing of motion: completing the picture using experimentally driven computational models of MT. 理解运动的视觉处理：使用实验驱动的MT计算模型完成图片。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-09-20 Print Date: 2024-04-25 DOI: 10.1515/revneuro-2023-0052

Parvin Zarei Eskikand, David B Grayden, Tatiana Kameneva, Anthony N Burkitt, Michael R Ibbotson

引用次数: 0

Automated diagnosis of autism with artificial intelligence: State of the art. 人工智能自动诊断自闭症：最新技术。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-09-08 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0050

Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Soheil Heidari Some'eh, Hossein Hosseini-Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani, Iman Menbari-Oskouie, Faezeh Aghajani, Alireza Mirzamohamadi, Mohammad Ghafouri, Shahriar Faghani, Amir Hossein Memari

{"title":"Automated diagnosis of autism with artificial intelligence: State of the art.","authors":"Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Soheil Heidari Some'eh, Hossein Hosseini-Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani, Iman Menbari-Oskouie, Faezeh Aghajani, Alireza Mirzamohamadi, Mohammad Ghafouri, Shahriar Faghani, Amir Hossein Memari","doi":"10.1515/revneuro-2023-0050","DOIUrl":"10.1515/revneuro-2023-0050","url":null,"abstract":"Autism spectrum disorder (ASD) represents a panel of conditions that begin during the developmental period and result in impairments of personal, social, academic, or occupational functioning. Early diagnosis is directly related to a better prognosis. Unfortunately, the diagnosis of ASD requires a long and exhausting subjective process. We aimed to review the state of the art for automated autism diagnosis and recognition in this research. In February 2022, we searched multiple databases and sources of gray literature for eligible studies. We used an adapted version of the QUADAS-2 tool to assess the risk of bias in the studies. A brief report of the methods and results of each study is presented. Data were synthesized for each modality separately using the Split Component Synthesis (SCS) method. We assessed heterogeneity using the I 2 statistics and evaluated publication bias using trim and fill tests combined with ln DOR. Confidence in cumulative evidence was assessed using the GRADE approach for diagnostic studies. We included 344 studies from 186,020 participants (51,129 are estimated to be unique) for nine different modalities in this review, from which 232 reported sufficient data for meta-analysis. The area under the curve was in the range of 0.71-0.90 for all the modalities. The studies on EEG data provided the best accuracy, with the area under the curve ranging between 0.85 and 0.93. We found that the literature is rife with bias and methodological/reporting flaws. Recommendations are provided for future research to provide better studies and fill in the current knowledge gaps.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"141-163"},"PeriodicalIF":3.4,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10552799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Brain-breath" interactions: respiration-timing-dependent impact on functional brain networks and beyond. "大脑与呼吸 "之间的相互作用：呼吸计时对大脑功能网络及其他方面的影响。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-09-01 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0062

Nozomu H Nakamura, Yoshitaka Oku, Masaki Fukunaga

{"title":"\"Brain-breath\" interactions: respiration-timing-dependent impact on functional brain networks and beyond.","authors":"Nozomu H Nakamura, Yoshitaka Oku, Masaki Fukunaga","doi":"10.1515/revneuro-2023-0062","DOIUrl":"10.1515/revneuro-2023-0062","url":null,"abstract":"Breathing is a natural daily action that one cannot do without, and it sensitively and intensely changes under various situations. What if this essential act of breathing can impact our overall well-being? Recent studies have demonstrated that breathing oscillations couple with higher brain functions, i.e., perception, motor actions, and cognition. Moreover, the timing of breathing, a phase transition from exhalation to inhalation, modulates specific cortical activity and accuracy in cognitive tasks. To determine possible respiratory roles in attentional and memory processes and functional neural networks, we discussed how breathing interacts with the brain that are measured by electrophysiology and functional neuroimaging: (i) respiration-dependent modulation of mental health and cognition; (ii) respiratory rhythm generation and respiratory pontomedullary networks in the brainstem; (iii) respiration-dependent effects on specific brainstem regions and functional neural networks (e.g., glutamatergic PreBötzinger complex neurons, GABAergic parafacial neurons, adrenergic C1 neurons, parabrachial nucleus, locus coeruleus, temporoparietal junction, default-mode network, ventral attention network, and cingulo-opercular salience network); and (iv) a potential application of breathing manipulation in mental health care. These outlines and considerations of \"brain-breath\" interactions lead to a better understanding of the interoceptive and cognitive mechanisms that underlie brain-body interactions in health conditions and in stress-related and neuropsychiatric disorders.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":" ","pages":"165-182"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10184701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs. 体内C6胶质瘤模型：更新并指导对潜在抗胶质母细胞瘤药物进行更有效的临床前评估。

IF 3.4 3区医学

Reviews in the Neurosciences Pub Date : 2023-09-01 Print Date: 2024-02-26 DOI: 10.1515/revneuro-2023-0067

Safura Pournajaf, Nastaran Afsordeh, Mohammad Hossein Pourgholami

引用次数: 0

An update to pain management after spinal cord injury: from pharmacology to circRNAs. 脊髓损伤后疼痛管理的最新进展:从药理学到环状rna。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0089

Graciela L Mazzone, María F Coronel, Miranda Mladinic, Cynthia Sámano

{"title":"An update to pain management after spinal cord injury: from pharmacology to circRNAs.","authors":"Graciela L Mazzone, María F Coronel, Miranda Mladinic, Cynthia Sámano","doi":"10.1515/revneuro-2022-0089","DOIUrl":"https://doi.org/10.1515/revneuro-2022-0089","url":null,"abstract":"Neuropathic pain (NP) following a spinal cord injury (SCI) is often hard to control and therapies should be focused on the physical, psychological, behavioral, social, and environmental factors that may contribute to chronic sensory symptoms. Novel therapeutic treatments for NP management should be based on the combination of pharmacological and nonpharmacological options. Some of them are addressed in this review with a focus on mechanisms and novel treatments. Several reports demonstrated an aberrant expression of non-coding RNAs (ncRNAs) that may represent key regulatory factors with a crucial role in the pathophysiology of NP and as potential diagnostic biomarkers. This review analyses the latest evidence for cellular and molecular mechanisms associated with the role of circular RNAs (circRNAs) in the management of pain after SCI. Advantages in the use of circRNA are their stability (up to 48 h), and specificity as sponges of different miRNAs related to SCI and nerve injury. The present review discusses novel data about deregulated circRNAs (up or downregulated) that sponge miRNAs, and promote cellular and molecular interactions with mRNAs and proteins. This data support the concept that circRNAs could be considered as novel potential therapeutic targets for NP management especially after spinal cord injuries.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"599-611"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer's disease using neuroimaging. 三维卷积神经网络在阿尔茨海默病神经影像学诊断中的应用综述。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2022-0122

Xinze Xu, Lan Lin, Shen Sun, Shuicai Wu

{"title":"A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer's disease using neuroimaging.","authors":"Xinze Xu, Lan Lin, Shen Sun, Shuicai Wu","doi":"10.1515/revneuro-2022-0122","DOIUrl":"https://doi.org/10.1515/revneuro-2022-0122","url":null,"abstract":"Alzheimer's disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. To obtain an accurate and timely diagnosis and detect AD at an early stage, numerous approaches based on convolutional neural networks (CNNs) using neuroimaging data have been proposed. Because 3D CNNs can extract more spatial discrimination information than 2D CNNs, they have emerged as a promising research direction in the diagnosis of AD. The aim of this article is to present the current state of the art in the diagnosis of AD using 3D CNN models and neuroimaging modalities, focusing on the 3D CNN architectures and classification methods used, and to highlight potential future research topics. To give the reader a better overview of the content mentioned in this review, we briefly introduce the commonly used imaging datasets and the fundamentals of CNN architectures. Then we carefully analyzed the existing studies on AD diagnosis, which are divided into two levels according to their inputs: 3D subject-level CNNs and 3D patch-level CNNs, highlighting their contributions and significance in the field. In addition, this review discusses the key findings and challenges from the studies and highlights the lessons learned as a roadmap for future research. Finally, we summarize the paper by presenting some major findings, identifying open research challenges, and pointing out future research directions.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"649-670"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control. 阿尔茨海默病的微生物-肠-脑轴和相关治疗:综合治疗和炎症控制的前景。

IF 4.1 3区医学

Reviews in the Neurosciences Pub Date : 2023-08-28 DOI: 10.1515/revneuro-2023-0006

Jiahao Li, Feng Zhang, Li Zhao, Chunbo Dong

{"title":"Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control.","authors":"Jiahao Li, Feng Zhang, Li Zhao, Chunbo Dong","doi":"10.1515/revneuro-2023-0006","DOIUrl":"https://doi.org/10.1515/revneuro-2023-0006","url":null,"abstract":"Alzheimer's disease (AD) is the most common type of dementia in the elderly and causes neurodegeneration, leading to memory loss, behavioral disorder, and psychiatric impairment. One potential mechanism contributing to the pathogenesis of AD may be the imbalance in gut microbiota, local and systemic inflammation, and dysregulation of the microbiota-gut-brain axis (MGBA). Most of the AD drugs approved for clinical use today are symptomatic treatments that do not improve AD pathologic changes. As a result, researchers are exploring novel therapeutic modalities. Treatments involving the MGBA include antibiotics, probiotics, transplantation of fecal microbiota, botanical products, and others. However, single-treatment modalities are not as effective as expected, and a combination therapy is gaining momentum. The purpose of this review is to summarize recent advances in MGBA-related pathological mechanisms and treatment modalities in AD and to propose a new concept of combination therapy. \"MGBA-based multitherapy\" is an emerging view of treatment in which classic symptomatic treatments and MGBA-based therapeutic modalities are used in combination. Donepezil and memantine are two commonly used drugs in AD treatment. On the basis of the single/combined use of these two drugs, two/more additional drugs and treatment modalities that target the MGBA are chosen based on the characteristics of the patient's condition as an adjuvant treatment, as well as the maintenance of good lifestyle habits. \"MGBA-based multitherapy\" offers new insights for the treatment of cognitive impairment in AD patients and is expected to show good therapeutic results.","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"695-718"},"PeriodicalIF":4.1,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9984548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0