Revista Romana De Medicina De Laborator最新文献_第3页

Evaluation of muscle elasticity in patients with end-stage renal disease complicated with sarcopenia by real-time shear wave elastography multipoint measurement 实时剪切波弹性成像多点测量评价终末期肾脏疾病合并肌肉减少患者的肌肉弹性

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-04-01 DOI: 10.2478/rrlm-2023-0008

Li Guo, L. Ran, Yapu Zhang, XiaoHong Guo, Jing Li, Youlan Gong, Xuan Zhou, XiaoXi Wu

{"title":"Evaluation of muscle elasticity in patients with end-stage renal disease complicated with sarcopenia by real-time shear wave elastography multipoint measurement","authors":"Li Guo, L. Ran, Yapu Zhang, XiaoHong Guo, Jing Li, Youlan Gong, Xuan Zhou, XiaoXi Wu","doi":"10.2478/rrlm-2023-0008","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0008","url":null,"abstract":"Abstract Background To analyze the value of real-time shear wave elastography (SWE) multi-point measurement in the evaluation of muscle elasticity in patients with end-stage renal disease (ESRD) complicated with sarcopenia. Methods We enrolled 169 ESRD patients treated as the research objects from January 2019 to February 2022. According to whether they were complicated with sarcopenia, the patients were divided into sarcopenia group (n=63) and non-sarcopenia group (n=106). The Young’s modulus and shear wave velocity (SWV) of muscles in relaxed and contracted states were measured by SWE technology in the two groups. Results Logistic regression analysis showed that age and hs-CRP were independent risk factors for sarcopenia in ESRD patients (P<0.05), while BMI, muscle thickness, Young’s modulus in stretched state and SWV in stretched state were protective factors for sarcopenia in ESRD patients (P<0.05). BMI, muscle thickness, Young’s modulus in extended state, SWV in extended state and Young’s modulus in rest state were all negatively correlated with age and hs-CRP (P<0.05), while there was a significant positive correlation between age and hs-CRP (P<0.05). Independent influencing factors were used to construct the prediction model of nomogram. The consistency index (C-index) was 0.845 (95% CI: 0.830~0.857), and the AUC of ROC curve was 0.852 (95% CI: 0.836~0.871), which had good discrimination. Conclusion SWE could accurately evaluate the muscle elasticity of ESRD patients, so as to reflect the changes of muscle mass and stiffness of patients, and could provide the important imaging indicator for the prediction of sarcopenia.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"10 1","pages":"135 - 144"},"PeriodicalIF":0.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85276142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the key differences between ISO 15189:2022 and ISO 15189:2012 for an improved medical laboratory quality of service 了解ISO 15189:2022和ISO 15189:2012在提高医疗实验室服务质量方面的主要区别

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-04-01 DOI: 10.2478/rrlm-2023-0011

Radu Ilinca, I. Chiriac, D. Luțescu, Ionela Ganea, Smaranda Hristodorescu-Grigore, R. Dǎnciulescu-Miulescu

引用次数: 1

Decision tree analysis as predictor tool for in-hospital mortality in critical SARS-CoV-2 infected patients 决策树分析作为SARS-CoV-2危重患者住院死亡率的预测工具

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-04-01 DOI: 10.2478/rrlm-2023-0015

A. Huțanu, A. A. Molnar, Krisztina Pál, M. Gabor, J. Szederjesi, M. Dobreanu

{"title":"Decision tree analysis as predictor tool for in-hospital mortality in critical SARS-CoV-2 infected patients","authors":"A. Huțanu, A. A. Molnar, Krisztina Pál, M. Gabor, J. Szederjesi, M. Dobreanu","doi":"10.2478/rrlm-2023-0015","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0015","url":null,"abstract":"Abstract Identification of predictive biomarkers for the evolution of critically ill COVID-19 patients would represent a milestone in the management of patients and in human and financial resources prioritization and allocation. This retrospective analysis performed for 396 critically ill COVID-19 patients admitted to the intensive care unit aims to find the best predictors for fatal outcomes in this category of patients. The inflammatory and metabolic parameters were analyzed and Machine Learning methods were performed with the following results: (1) decision tree with Chi-Square Automatic Interaction Detector (CHAID) algorithm, based on the cut-off values using ROC Curve analysis, indicated NLR, IL-6, comorbidities, and AST as the main in-hospital mortality predictors; (2) decision tree with Classification and Regression Tree (CRT) algorithm confirmed NLR alongside CRP, ferritin, IL-6, and SII (Systemic Inflammatory Index) as mortality predictors; (3) neural networks with Multilayer Perceptron (MLP) found NLR, age, and CRP to be the best mortality predictors. Structural Equation Modeling (SEM) analysis was complementarily applied to statistically validate the resulting predictors and to emphasize the inferred causal relationship among factors. Our findings highlight that for a deeper understanding of the results, the combination of Machine Learning and statistical methods ensures identifying the most accurate predictors of in-hospital mortality to determine classification rules for future events.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"11228 1","pages":"91 - 106"},"PeriodicalIF":0.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75416024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change of routine coagulation parameters in plasma samples with different hematocrit values 不同红细胞压积值血浆样品常规凝血参数的变化

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-04-01 DOI: 10.2478/rrlm-2023-0014

I. Kucukcetin, Cahit Nacitarhan, S. Ozdem

{"title":"Change of routine coagulation parameters in plasma samples with different hematocrit values","authors":"I. Kucukcetin, Cahit Nacitarhan, S. Ozdem","doi":"10.2478/rrlm-2023-0014","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0014","url":null,"abstract":"Abstract Aim There are many preanalytical variables affecting routine coagulation tests. Increased hematocrit (Htc) levels are one of these variables. However, no study has been conducted to determine the effect of low Htc values on coagulation tests. Therefore, in this study, we aimed to evaluate whether low Htc values affect coagulation tests besides high Htc values. Methods Standard human plasma was injected into coagulation tubes containing 3.2% sodium citrate to reflect hematocrit rates of 5% to 75% and prothrombin time (PT), active partial thromboplastin time (aPTT), thrombin time (TT) and fibrinogen measurements were performed. Results Three groups were formed according to Htc levels: A (5-25%), B (30-50%) and C (55-75%). PT (s) were found 13.7±0.30 in group A, 14.88±0.57 s in group B, 20.16 ±4.66 s in group C respectively. aPTT (s) results were 35.79±1.39 s in group A, 42.48 ± 3.51 s in group B and 76.47 ± 31.55 in group C. TT (s) results were found to be 26.42 ± 0.77 s (group A), 28.24±1.17 s (group B) and 32.02±2.60 (group C). Fibrinogen levels (g/L) were measured as 2.30 ± 0,05, 2.21 ± 0,07 and 1.90 ± 0.20 in groups A, B, C, respectively. For all measured parameters, group A reflecting low Htc was significantly (P < 0 ,0001) different from the other groups. Conclusion Previous studies have reported that high Htc (> 55%) levels affected routine coagulation tests. In our study, low Htc (5-25%) values were also shown to cause errors in the test results.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"25 1","pages":"83 - 90"},"PeriodicalIF":0.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82596531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis 前胶原1型氨基末端特性(P1NP)、细胞色素P450 (CYPs)和骨保护素(OPG)作为潜在骨功能标志物在前列腺癌骨转移中的作用

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0006

P. A. Yousif, P. Ismail

{"title":"The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis","authors":"P. A. Yousif, P. Ismail","doi":"10.2478/rrlm-2023-0006","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0006","url":null,"abstract":"Abstract Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis. Cytochrome P450 enzymes help tumor development and treatment (CYPs). Cytochrome P450 activates and deactivates anticancer drugs and procarcinogens. Objective: The study examined the amounts of a diagnostic marker of bone formation, the amino terminal propeptide of type I procollagen (PINP), Osteoprotegerin (OPG), and P450, in prostate cancer patients at different stages and its ability to detect osteoblastic metastases. Methods: ELISA was used to measure PINP, OPG, and P450 levels in 30 prostate cancer patients. (n = 32) and healthy men’s serum (n = 36). Results: Prostate cancer patients had higher blood levels of PINP, OPG, and P450 than healthy persons (301.3±134.9, 980±467.2, and 84.2±28.4 pg/mL, respectively). Compared to I+II prostate cancer patients, III+IV patients showed higher serum PINP, OPG, and P450 levels (P 0.001). OPG, P450, and PINP had statistically significant Area under the ROC curve (0.9467, P= 0.0001, 0.91, P= 0.0001, and 0.6977, P= 0.4035) in prostate cancer patients. Conclusions: Metastatic prostate cancer patients had greater PINP, OPG, and P450 levels, according to our findings. PINP, OPG, and P450 levels may affect prostate cancer progression. These findings imply that serum PINP, OPG, and P450 levels may predict and diagnose prostate cancer.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"3 1","pages":"25 - 34"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88761314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making the most out of proficiency testing participation for a medical laboratory from the standardization point of view 从标准化的角度充分利用医学实验室的能力测试参与

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0003

Radu Ilinca, Ionela Ganea

引用次数: 1

On the relationship between CT measured abdominal fat parameters and three metabolic risk biomarkers CT测量腹部脂肪参数与三种代谢风险生物标志物的关系

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0005

M. Pop, R. Pop

{"title":"On the relationship between CT measured abdominal fat parameters and three metabolic risk biomarkers","authors":"M. Pop, R. Pop","doi":"10.2478/rrlm-2023-0005","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0005","url":null,"abstract":"Abstract Introduction: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, and there is a need for the development of adjacent markers to assess cardiovascular risk. In this study, we examined the relationship between the areas of abdominal fat compartments, as measured by computed tomography (CT)-based planar measurements, and laboratory-validated cardiovascular risk markers. Methods: Fat distribution was measured on CT scans in 252 patients (M: F = 1.13) who underwent routine abdominal CT, using in-house and commercially available software. The included laboratory parameters were glucose, triglycerides, and the triglycerideglucose index. Results: The visceral abdominal fat (VAF) area and VAF percentage were lower in females compared to the VAF area and VAF percentage in males, (p=0.001, and p<0.001 respectively). However, the total abdominal fat (TAF) area was not significantly different between genders. Visceral fat and triglyceride levels showed a weakly positive connection for females (r=0.447, p=0.002) but not for males (r=0.229, p=0.09). The glucose levels had a weak correlation with CT calculated abdominal fat parameters, with the strongest statistically significant correlation value being with TAF for females (r=0.331, p=0.003). Conclusions: Areas of abdominal fat compartments correlate with metabolic parameters in the blood, and in the future, their assessment might be considered when constructing risk scores. Visceral fat content assessment for every abdominal computed tomography procedure might become a surrogate marker for cardio-vascular risk estimation after defining clear cut-off values and image analysis parameters.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"106 1","pages":"51 - 58"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81196762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of HLA class II alleles with suicidal behavior in a Transylvanian population 特兰西瓦尼亚人群HLA II类等位基因与自杀行为的关系

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0001

Mihaela Elvira Vușcan, M. Vică, Ștefana Bâlici, G. Z. Nicula, Sergiu Ionica Rusu, C. Siserman, H. Coman, H. Matei

{"title":"Association of HLA class II alleles with suicidal behavior in a Transylvanian population","authors":"Mihaela Elvira Vușcan, M. Vică, Ștefana Bâlici, G. Z. Nicula, Sergiu Ionica Rusu, C. Siserman, H. Coman, H. Matei","doi":"10.2478/rrlm-2023-0001","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0001","url":null,"abstract":"Abstract Background: Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex is the most polymorphic gene cluster of the entire human genome, being linked to both the regulation of the immune system and various psychiatric diseases. The aim of this study was to identify HLA-DQB1 and DRB1 alleles and genotypes susceptible to influence suicidal behavior. Methods: We explored the association of HLA-DQB1 alleles with the suicidal behavior on a sample of 427 individuals (including 110 suicide attempters) from Transylvania, as well as the association of HLA-DRB1 alleles with the suicidal behavior on a sample of 271 individuals (including 50 suicide attempters), using the single specific primer-PCR (SSP-PCR) technique. Results: We found that the HLA-DQB1*02, *03 and *06 alleles, the DQB1*02/*03, DQB1*02/*06, DRB1*12/*15 and DRB1*07/*13 genotypes, as well as the DQB1*06~DRB1*07 and DQB1*02~DRB1*13 haplotypes, were more frequent in suicide attempters. In contrast, the HLA-DQB1*04 and DQB1*13 alleles, the DQB1*02/*05 and DQB1*03/*05 genotypes and the DQB1*03~DRB1*13 haplotype were less frequent in the case group. Conclusion: HLA-DQB1*02, *03 and *06 alleles and the DQB1*02/*03 and *02/*06 genotypes are susceptible to favor a suicide behavior, while the HLA-DQB1*04 and *13 alleles and the DQB1*02/*05 and *03/*05 genotypes were protective against such behavior. A similar analysis regarding the HLA-DRB1 alleles detected a possible risk for suicidal behavior among individuals possessing either the DRB1*12/*15 or the DRB1*07/*13 genotypes. DQB1*06~DRB1*07 and DQB1*02~DRB1*13 haplotypes were found susceptible to favor a suicidal behavior, while DQB1*03~DRB1*13 exhibited a protective influence.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"332 1","pages":"15 - 24"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86785251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferritin and procalcitonin in COVID-19 associated acute kidney injury – gender disparities, but similar outcomes 铁蛋白和降钙素原在COVID-19相关急性肾损伤中的作用——性别差异，但结果相似

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0004

D. Radulescu, C. David, E. Cuiban, F. Turcu, L. F. Feier, S. Onofrei, I. A. Vacaroiu

{"title":"Ferritin and procalcitonin in COVID-19 associated acute kidney injury – gender disparities, but similar outcomes","authors":"D. Radulescu, C. David, E. Cuiban, F. Turcu, L. F. Feier, S. Onofrei, I. A. Vacaroiu","doi":"10.2478/rrlm-2023-0004","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0004","url":null,"abstract":"Abstract Background: Acute kidney injury is a severe complication of COVID-19. Both COVID-19 and related acute kidney injury are reported in the literature to be more prevalent and more severe in males. Methods: We performed a retrospective analysis of the COVID-19 associated acute kidney injury cases in order to search for differences between genders regarding patients’ and renal outcome. Results: 250 patients with acute kidney injury were included in the study: 93 women (37.20%), 157 men (62.80%). There were no differences between sexes regarding age. Diabetes mellitus was significantly more present in women. Peak ferritin and procalcitonin levels were significantly higher in men, but other severity markers for COVID-19 did not differ between genders. There were no differences between sexes regarding history of chronic kidney disease, timing of acute kidney injury, need for dialysis or recovery of renal function. ICU admission and in-hospital mortality were similar between men and women. Conclusions: In our study, COVID-19 related-AKI was more prevalent in men than in women, but the patients’ and renal outcome were similar. Significantly higher ferritin and procalcitonin serum levels registered in male patients when compared to women may have additional explanations beside more severe SARS-CoV-2 infection in males.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"65 1","pages":"35 - 42"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85768260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of a case of Castleman’s disease coexisting with or occurring after transplanted Hodgkin’s lymphoma 一例Castleman病与移植霍奇金淋巴瘤共存或发生后的治疗

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2023-01-01 DOI: 10.2478/rrlm-2023-0007

M. Andreescu, S. Zurac, Andreea Lacatusu, Andrei T. Tudor, N. Ilie, Laura G. Tirlea, Rozeta Ionescu, V. Popov, A. Tanase

{"title":"Management of a case of Castleman’s disease coexisting with or occurring after transplanted Hodgkin’s lymphoma","authors":"M. Andreescu, S. Zurac, Andreea Lacatusu, Andrei T. Tudor, N. Ilie, Laura G. Tirlea, Rozeta Ionescu, V. Popov, A. Tanase","doi":"10.2478/rrlm-2023-0007","DOIUrl":"https://doi.org/10.2478/rrlm-2023-0007","url":null,"abstract":"Abstract Castleman’s disease is a benign lymphoproliferative disorder. The coexistence of Hodgkin’s lymphoma and multicentric Castle-man’s disease is a rare phenomenon. We discuss a case of a 48-year-old female patient who had been in the records of the Colentina Hematology Clinic since 2019, with the diagnosis of classic Hodgkin’s Lymphoma, nodular sclerosis type I BNLI, stage IIXB. For this, she underwent 3 courses of ABVD and 2 courses of BEACOPP, without showing complete remission on PET/CT evaluation at the end of treatment. After that, we initiated rescue therapy and performed 4 IGEV courses, followed by autologous stem cell transplantation. For maintenance treatment, we opted for Brentuximab, but it was discontinued after the first administration due to the appearance of adverse reactions. Subsequently, we decided to perform radiotherapy with 20 fractions cumulating a total dose of 36 Gy. Shortly after the radiotherapy, symptoms reappeared which were suspected to be in the context of a relapse of the disease. For confirmatory diagnosis, we performed a new PET-CT which highlighted metabolically active ganglion images. Further, were carried out lymph node biopsy for histopathological and immunohistochemical examinations were carried out. The underlying disease was diagnosed as plasmacytic subtype, HHV8 negative, multicentric Castleman’s disease. For treatment, we relied on administrations of Siltuximab treatment therapy that showed complete remission. Castleman’s disease presents a unique diagnostic challenge, but a confirmatory diagnosis can be based on a biopsy examination, advisable after each relapse.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"28 1","pages":"59 - 64"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75746173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0