Revista Romana De Medicina De Laborator最新文献_第10页

Pseudohyponatremia and falsely increased serum osmolal gap caused by paraprotein in a patient with severe metabolic acidosis – a case study 严重代谢性酸中毒患者假低钠血症和副蛋白引起的假血清渗透压间隙增高一例

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0017

T. Šálek

{"title":"Pseudohyponatremia and falsely increased serum osmolal gap caused by paraprotein in a patient with severe metabolic acidosis – a case study","authors":"T. Šálek","doi":"10.2478/rrlm-2021-0017","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0017","url":null,"abstract":"Abstract Introduction: The aim of the study is to present a case study of a 63-year-old male with pseudohyponatremia, falsely increased serum osmolal gap and severe metabolic acidosis. Material and Methods: Venous whole blood (direct sodium selective electrode measurement) and serum (indirect sodium selective electrode measurement) were used to measure sodium concentration. Serum cholesterol, triacylglycerides and total protein were measured to confirm pseudohyponatremia. Base excess in extracellular fluid and serum bicarbonate concentrations were employed as markers of metabolic acidosis. Serum protein electrophoresis and free light chain analysis were used for the detection of paraproteins. Results: Venous whole blood acid base analysis showed a pH of 7.171, negative base excess in extracellular fluid of – 18.6 mmol/L and sodium concentration of 140 mmol/L. Serum test measurement revealed serum sodium concentration of 130 mmol/L, osmolal gap of 24 mmol/kg, creatinine concentration of 702 µmol/L, HCO3- concentration of 6.1 mmol/L and total protein concentration of 134.9 g/L. Serum paraprotein IgG kappa with a concentration of 86 g/L and a serum free light chains kappa/lambda ratio of 223.5, along with the final diagnosis of multiple myeloma were detected. Toxic alcohol ingestion was considered, both methanol and ethylene glycol tests were negative. Conclusions: High paraprotein concentrations in serum may lead to pseudohyponatremia when measured by indirect ion selective electrodes. Multiple myeloma frequently leads to renal failure with metabolic acidosis.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"36 1","pages":"229 - 233"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89341065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possibility of clinical use for the oxidative stress marker in correlation with blood flow parameters in pregnancy-induced hypertension 妊娠高血压中氧化应激标志物与血流参数相关性的临床应用可能性

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0014

D. Draganović, Branka Cancarevic-Djajic, Dragica Jojić, Vesna Ljubojević, Jelena Todorović

{"title":"The possibility of clinical use for the oxidative stress marker in correlation with blood flow parameters in pregnancy-induced hypertension","authors":"D. Draganović, Branka Cancarevic-Djajic, Dragica Jojić, Vesna Ljubojević, Jelena Todorović","doi":"10.2478/rrlm-2021-0014","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0014","url":null,"abstract":"Abstract Introduction: In pregnancy-induced hypertension (PIH) there is a disorder in placental blood flow which causes intrauterine fetal hypoxia, and oxidative stress has a significant role in this condition. The aims of this research were to analyze the relation of thiobarbituric acid reactive substance (TBARS), as a marker of oxidative stress and absent end-diastolic flow (AEDF), as well as the relation of TBARS and cerebroplacental ratio (CPR). Methods: The research included 200 pregnant women in the gestation period from 28th to 40th, 100 were in a control group and 100 were with PIH. The CPR and TBARS were analyzed in all examined pregnant women. The CPR was calculated by dividing the Doppler indices of the middle cerebral artery by the umbilical artery. Results: Mean value of TBARS in the group with the PIH who had AEDF was in the interval of high values - 43.22 μmol/l. The result shows that through the application of Spearman’s coefficient, the correlation results in a statistically significant correlation between CPR and TBARS values: ρ = - 0.249, p = 0.0001. Conclusion: PIH has a very high level of oxidative stress, especially in pregnant women with absent end-diastolic flow in the umbilical artery and pathologic CPR. The Spearman’s test results in statistical significance and negative correlation, which means that in higher TBARS values, values of CPR are lower and vice versa, which indicates a possibility of clinical application of TBARS.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"51 1","pages":"143 - 151"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75226034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation 2型糖尿病患者Friedewald方的可靠性及其与糖尿病调节中血脂的关系

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0007

Didem Barlak Keti, S. Muhtaroğlu

{"title":"Reliability of Friedewald formula in patients with type 2 diabetes mellitus and its relation to lipid profile in diabetes regulation","authors":"Didem Barlak Keti, S. Muhtaroğlu","doi":"10.2478/rrlm-2021-0007","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0007","url":null,"abstract":"Abstract Introduction: Many laboratories utilize Friedewald formula (FF) to analyze LDL cholesterol levels of patients including diabetes mellitus (DM). Therefore, it is essential to consider the coherence of results acquired by FF and direct measurement. The number of studies that investigated the effect of lipid parameters, especially TG/HDL cholesterol ratio, on the difference between the two methods is limited. The study was designed to compare LDL cholesterol values obtained by using FF with direct measurement, and to evaluate the relationship between diabetes regulation and lipid profile. Material and Methods: In the cross-sectional study, 529 type 2 DM patients and 1703 non-DM subjects were divided into four groups regarding TG concentrations. Unlike other studies, the study focuses on direct LDL (DLDL) cholesterol levels obtained with the help of different DLDL cholesterol kits (n=20). The correlations were implemented between HbA1c and lipid profiles. Results: It was determined that the bias% was over 10% in 24% of patients with 100-199 mg/dL TG levels. The parameter revealed that the most significant difference and the strongest correlation with HbA1c was TG/HDL cholesterol ratio in patients with type 2 DM. Conclusions: In patients with type 2 DM, even if it was TG <200 mg/dL, LDL calculated with FF should be evaluated together with the TG/HDL cholesterol ratio. Otherwise, direct measurement can be recommended. This ratio is related to diabetes regulation and may be used to monitor patients..","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"5 1 1","pages":"179 - 187"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82667445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic value of serum lactate dehydrogenase in hospitalized patients with Covid-19 血清乳酸脱氢酶在Covid-19住院患者中的预后价值

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0016

V. Aguadero, Elisa Nuez, Carlos García-Miralles, Gemma Solé-Enrech, Ruth Cano-Corres

引用次数: 1

Vaginal candidiasis in Konya area: Etiology, risk factors, virulence patterns, and antifungal susceptibility 阴道念珠菌病在科尼亚地区:病因学，危险因素，毒力模式，和抗真菌敏感性

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0012

Semih Tokak, İ. Kiliç, J. Horasanlı, E. G. Mutlu, F. E. Taşbent, I. D. Karagöz

{"title":"Vaginal candidiasis in Konya area: Etiology, risk factors, virulence patterns, and antifungal susceptibility","authors":"Semih Tokak, İ. Kiliç, J. Horasanlı, E. G. Mutlu, F. E. Taşbent, I. D. Karagöz","doi":"10.2478/rrlm-2021-0012","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0012","url":null,"abstract":"Abstract Vulvovaginal candidiasis (VVC), a common genital tract infection, is known to affect millions of women worldwide. In this study, it was aimed to determine the prevalence, virulence, possible risk factors and antifungal susceptibility model of Candida species. Vaginal swab samples were taken from patients aged 18 years and older who presented to the gynecology outpatient clinic with signs and symptoms suggestive of vulvovaginitis. Demographic data were recorded using a questionnaire. Standard microbiological methods were used for the identification of the isolates. Broth microdilution method was used to determine the antifungal susceptibility of Candida isolates. Virulence factors of Candida strains were determined by performing proteinase, phospholipase, hemolytic and biofilm activity tests. Sequencing of the isolates identified as Candida were performed using ITS 1-4 primers. Vaginal discharge (OR: 3.365; 95% CI: 1.595-7.101), burning complaint (OR: 9.098; 95% CI: 2.284-36.232) and history of allergy (OR: 3.396; 95% CI: 0.968) were risk factors. The results showed that the most common isolated strain was Candida albicans (57%). It was found that the prevalence of C. glabrata remained at 26%, 44 of the C. albicans isolates presented proteinase, 35 had phospholipase, 47 had biofilm, and 47 had hemolytic activity. In this study, susceptible dose-dependent and resistant rates of all Candida strains were found for fluconazole as 9% and 16%, respectively. Host and organism-related factors should be considered in the clinical treatment of VVC, and continuous monitoring of changes in the prevalence of Candida species and susceptibility rates is required for effective antifungal therapy.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"36 1","pages":"201 - 215"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82529665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Predictors associated with increased troponin in acute decompensated and chronic heart failure patients 急性失代偿和慢性心力衰竭患者肌钙蛋白升高的相关预测因素

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0015

A. Draghici, C. A. Buzea, C. Delcea, A. Vîjan, G. Dan

{"title":"Predictors associated with increased troponin in acute decompensated and chronic heart failure patients","authors":"A. Draghici, C. A. Buzea, C. Delcea, A. Vîjan, G. Dan","doi":"10.2478/rrlm-2021-0015","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0015","url":null,"abstract":"Abstract Background: Myocardial injury (INJ) expressed by elevated high-sensitivity troponin (hs-Tn) is common in heart failure (HF), due to cardiovascular and non-cardiac conditions. The mechanisms of INJ in acute decompensated HF (ADHF) versus chronic HF (CHF) are still debated. This study’s purpose was to evaluate the determinants of elevated hs-TnT in ADHF and CHF. Methods: We retrospectively analyzed consecutive HF patients with hs-TnT measured on admission, hospitalized in a tertiary-care hospital. Rehospitalizations, acute coronary syndromes, embolisms, infections, autoimmunity and malignancy were excluded. Cut-off point for hs-TnT was 14 ng/L. Results: Our study included 488 HF patients, 56.55% with ADHF. Mean age was 72.52±10.09 years. 53.89% were females. 67.75% ADHF and 45.75% CHF patients had elevated hs-TnT. Median hs-TnT was higher in ADHF versus CHF (21.05[IQR 12.74-33.81] vs 13.20[IQR 7.93-23.25], p<0.0001). In multivariable analysis in ADHF and CHF, log10NT-proBNP (HR=5.30, 95%CI 2.71–10.38, p<0.001, respectively HR=5.49, 95%CI 1.71–17.57, p=0.004) and eGFR (HR=0.72, 95%CI 0.62–0.85, p<0.001, respectively HR=0.71, 95%CI 0.55–0.93, p=0.014) were independent predictors for increased hs-TnT. Independent factors associated with elevated hs-TnT in ADHF were male sex (HR=2.52, 95%CI 1.31-4.87, p=0.006) and chronic pulmonary obstructive disease (COPD) (HR=10.57, 95%CI 1.26-88.40, p=0.029), while in CHF were age (HR=2.68, 95%CI 1.42-5.07, p=0.002) and previous stroke (HR=5.35, 95%CI 0.98-29.20, p=0.053). Conclusion: HF severity, expressed by NT-proBNP levels, and kidney disease progression, expressed by eGFR, were independent predictors associated with increased hs-TnT in both ADHF and CHF. Specific independent predictors were also indentified in ADHF (male sex, COPD) and CHF (age, history of stroke).","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"34 1","pages":"153 - 164"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85815966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Plasma AA/DHA+EPA Ratio in Obese Romanian Children 罗马尼亚肥胖儿童血浆AA/DHA+EPA比值的评价

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0002

A. Huțanu, M. Zaharia, L. Farczádi, I. Pașcanu, R. Pop, M. Dobreanu

{"title":"Evaluation of Plasma AA/DHA+EPA Ratio in Obese Romanian Children","authors":"A. Huțanu, M. Zaharia, L. Farczádi, I. Pașcanu, R. Pop, M. Dobreanu","doi":"10.2478/rrlm-2021-0002","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0002","url":null,"abstract":"Abstract The aim of the study was to evaluate the plasma profile of arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), as well to analyze the relationship of Omega 6/Omega 3 ratio with anthropo-metric parameters and insulin resistance markers. Material and methods: Plasma levels of free fatty acids (FFAs) were measured using a high-throughput LC-MS AB Sciex4600 in 202 children (127 obese and 75 non-obese), age and sex-matched. Lipid and glucose profiles were assessed with current laboratory methods, while insulin resistance and beta-cell function were evaluated using HOMA-IR and HOMA-β respectively. Results: In obese children, AA and AA/(DHA+EPA) ratio were significantly higher regardless of age and gender. In the lowest quartile of DHA, there was a clear trend for insulin resistance, with plasma insulin level, HOMA-IR, and HOMA-β significantly higher compared to the highest quartile of DHA. After adjustment for age and gender DHA remains a negative predictive factor for insulin resistance. Waist-to-height ratio (WHtR), a marker of visceral obesity was higher in children with a higher AA/(DHA+EPA) ratio. Conclusions: In obese children, the AA is higher in concordance with insulin resistance. Additionally, children with a higher AA/(DHA+EPA) ratio have greater BMI, fat mass, waist circumference, and WHtR, important indicators of central adiposity, and cardio-metabolic disorders. LC/MS is a versatile tool for Omega ratio assessment, especially in children where the sample size is a limiting factor for metabolic and nutrition evaluation.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"47 1","pages":"165 - 178"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78701004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Apoptotic and Inflammatory Activity in Liver Tissue of Rats Fed with Clam (Pecten maximus, Linnaeus 1758) 蛤蜊(Pecten maximus, Linnaeus 1758)对大鼠肝组织凋亡和炎症活性的影响

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI: 10.2478/rrlm-2021-0013

L. C. Irkin

{"title":"Investigation of Apoptotic and Inflammatory Activity in Liver Tissue of Rats Fed with Clam (Pecten maximus, Linnaeus 1758)","authors":"L. C. Irkin","doi":"10.2478/rrlm-2021-0013","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0013","url":null,"abstract":"Abstract One of the most important threats for living things in aquatic ecosystems is environmental pollution. The changes in water quality caused by environmental pollution also reduce the quality of life for organisms in the environment. Among these, the crustaceans which are most affected by the negative changes of environment, fed by the filtration method, are seen as pollution indicator. The consumption of these creatures reaches all steps of the pyramid, especially humans, through the food chain. People who frequently use seafood in their diets may be affected by these negative changes. Heavy metal contents of the clams obtained from Dardanelles were determined by the ICPOES. Twenty-four female Wistar albino rats were fed for 30 days with the experimental diet using clams (Pecten maximus), which was dried and formed into pellets and added to the food in certain proportions. At the end of the study, the subjects were sacrificed under anesthesia, liver tissues were taken, and histochemical examination was performed. TUNEL method was performed to detect apoptotic activity, and immunohistochemical staining with TNF-α and NF-κB antibodies to determine inflammation. Concluding from the results, it was observed that the degeneration of vital digestive system tissues such as liver was inevitable in living creatures that frequently consume seafood obtained from unhealthy environment in their daily diets. The high analysis values of the heavy metal (P. maximus) in food additive can be considered as a reason for histopathological results.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"30 1","pages":"189 - 200"},"PeriodicalIF":0.5,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83397432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment on the influence of TLR4 and DNA repair genes in laryngeal cancer susceptibility: a selective examination in a Romanian case control study 评估TLR4和DNA修复基因对喉癌易感性的影响:罗马尼亚病例对照研究中的选择性检查

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-01-01 DOI: 10.2478/rrlm-2021-0005

Corina Iulia Cornean, V. Necula, M. Cosgarea, A. Maniu, A. Catana

{"title":"Assessment on the influence of TLR4 and DNA repair genes in laryngeal cancer susceptibility: a selective examination in a Romanian case control study","authors":"Corina Iulia Cornean, V. Necula, M. Cosgarea, A. Maniu, A. Catana","doi":"10.2478/rrlm-2021-0005","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0005","url":null,"abstract":"Abstract Background: Tumor characterization through the study of molecular biology has become an invaluable tool in understanding cancer development and evolution due to its relationship with chromosomal mutations, alterations or aberrations. The purpose of this study was to investigate the involvement of genes such as TLR-4 and DNA repair pathways (XRCC1 and XPD) in laryngeal cancer susceptibility in a Romanian population. Method: We performed a case-control study on 157 laryngeal cancer patients and 101 healthy controls. Genetic testing was carried out using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. Results: We identified the Gln allele of the XPDLys751Gln polymorphism as an individual risk factor in laryngeal cancer development (Gln vs Lys, adjusted OR=1.65, 95%CI=1.13–2.40, P=0.008). Subjects with the mutant homozygote variant (Gln/Gln) had a two fold increase in cancer risk (adjusted OR=2.18, 95%CI=1.06–4.47, p=0.028) when compared to the reference wild type genotype (Lys/Lys). Stratification by sex and age, identified males under 62 years as the most susceptible group with an almost three fold risk (adjusted OR=2.94, 95%CI=1.31–6.59, p=0.007) for the dominant model (Lys/Gln+Gln/Gln). No associations were found for TLR-4Thr399Ile, XRCC1Arg194Trp and XRCC1Arg399Gln. Conclusion: The results of the study show that the XPDLys751Gln polymorphism may be among other independent risk factors for developing laryngeal cancer where as TLR-4Thr399Ile, XRCC1Arg194Trp and XRCC1 Arg399Gln show no such association. However, we consider the relative small number of the subjects selected for this analyses a possible limitation towards the real influence the obtain results may pertain in laryngeal cancer evolution.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"36 1","pages":"19 - 31"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81316800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The positive rate of IgM and IgG antibodies against SARS-CoV-2 is similar in severe and non-severe COVID-19 patients 重症和非重症患者抗SARS-CoV-2的IgM和IgG抗体阳性率相似

IF 0.5 4区医学

Revista Romana De Medicina De Laborator Pub Date : 2021-01-01 DOI: 10.2478/rrlm-2021-0010

N. Jiang, Yaoyao Sun, Hongyan Sun, Bo Yang, Juan Tan, Huan-ying Sun, Shuai Wang, Qiong Yu

{"title":"The positive rate of IgM and IgG antibodies against SARS-CoV-2 is similar in severe and non-severe COVID-19 patients","authors":"N. Jiang, Yaoyao Sun, Hongyan Sun, Bo Yang, Juan Tan, Huan-ying Sun, Shuai Wang, Qiong Yu","doi":"10.2478/rrlm-2021-0010","DOIUrl":"https://doi.org/10.2478/rrlm-2021-0010","url":null,"abstract":"Abstract Background: Coronavirus disease 2019 (COVID-19) has spread rapidly in China and globally. In order to control the spread of the epidemic, it is important to find an efficient diagnostic method. Objectives: The aim of this study was to assess the responses of antibodies during SARS-CoV-2 infection in relation to disease severity and to evaluate the association between the positive rate of antibody detection and nucleic acid test. Methods: Ninety patients with SARS-CoV-2 infection were recruited in this retrospective observational study. Demographic, clinical data, and SARS-CoV-2 IgM and IgG antibodies in serum specimens were detected at 4 and 6 weeks after diagnosis. Results: IgM and IgG antibody levels showed a decreased tendency, the titers at week 4 were higher than the titers at week 6: The positive rates of IgM at week 4 and 6 were 92.9% and 67.9%, respectively. The positive rates of IgG at week 4 and week 6 were 100%. No association was found between the positive rate of antibody detection at week 4 or 6 and that of nucleic acid test (P>0.05). No difference between the positive rate of antibodies against SARS-CoV-2 in severe and non-severe COVID-19 patients was observed. Conclusions: Antibody detection is an effective means in the diagnosis of COVID-19. The titer and positive rate of IgM are lower than those of IgG in the first six weeks after infection. Positive rate of antibodies was not different between severe and non-severe patients.","PeriodicalId":49599,"journal":{"name":"Revista Romana De Medicina De Laborator","volume":"450 1","pages":"85 - 91"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82967558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0