Prognostic value of serum lactate dehydrogenase in hospitalized patients with Covid-19

IF 0.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Revista Romana De Medicina De Laborator Pub Date : 2021-04-01 DOI:10.2478/rrlm-2021-0016

V. Aguadero, Elisa Nuez, Carlos García-Miralles, Gemma Solé-Enrech, Ruth Cano-Corres

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引用次数: 1

Abstract

Abstract Background: Biochemical markers in COVID-19 remain to be defined. We analyzed the usefulness of LDH and ferritin in predicting outcome. Methods: This retrospective study analyzed ferritin and LDH concentrations obtained during the first 11 days of hospitalization in COVID-19 patients. We compared the change in ferritin and LDH concentrations obtained on each day of hospital admission with respect to baseline values between patients with favorable and unfavorable outcomes. We used receiver operating curve analysis to determine cutoffs for predicting outcomes. Results: We analyzed 387 patients. For determinations done on the 9th day, increases in LDH concentrations > 14.6% over the baseline yielded 80% positive predictive value, and a lack of increase yielded 96% negative predictive value for unfavorable outcomes. The change in ferritin concentration yielded lower predictive values. Conclusion: The percentage of change in LDH with respect to the baseline on the 9th day of hospitalization can predict outcome..

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血清乳酸脱氢酶在Covid-19住院患者中的预后价值

背景:2019冠状病毒病的生化指标尚未明确。我们分析了LDH和铁蛋白在预测预后方面的有效性。方法:回顾性分析COVID-19患者住院前11天的铁蛋白和LDH浓度。我们比较了有利和不利结果患者入院后每天铁蛋白和LDH浓度的变化与基线值。我们使用受试者工作曲线分析来确定预测结果的截止点。结果:我们分析了387例患者。对于第9天进行的检测，LDH浓度比基线增加> 14.6%产生80%的阳性预测值，缺乏增加产生96%的阴性预测值。铁蛋白浓度的变化产生了较低的预测值。结论:住院第9天LDH相对于基线的变化百分比可以预测预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Romana De Medicina De Laborator MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

0.31

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of the journal is to publish new information that would lead to a better understanding of biological mechanisms of production of human diseases, their prevention and diagnosis as early as possible and to monitor therapy and the development of the health of patients