Sao Paulo Medical Journal最新文献

{"title":"Isotemporal substitution of sleep or sedentary behavior with physical activity in the context of frailty among older adults: a cross-sectional study.","authors":"Giovana Silva Martins,&nbsp;Lucas Lima Galvão,&nbsp;Sheilla Tribess,&nbsp;Joilson Meneguci,&nbsp;Jair Sindra Virtuoso Júnior","doi":"10.1590/1516-3180.2021.0420.R3.03032022","DOIUrl":"https://doi.org/10.1590/1516-3180.2021.0420.R3.03032022","url":null,"abstract":"<p><strong>Background: </strong>Frailty syndrome is associated with various physical, cognitive, social, economic, and environmental factors. Although frailty syndrome occurs progressively with age, prevention and treatment are possible. Reducing or eliminating risks and increasing protective factors may be potential strategies for reducing the prevalence of injuries related to frailty. One of the most effective actions is to decrease the time spent in sedentary behavior (SB) by increasing regular physical activity (PA).</p><p><strong>Objective: </strong>To examine the hypothetical effect of substitution of the time spent in sleep or SB with an equivalent time spent performing moderate or vigorous PA on frailty syndrome in the older population.</p><p><strong>Design and setting: </strong>An analytical cross-sectional study conducted using exploratory methods of survey, carried out in Alcobaça city, Bahia, Brazil.</p><p><strong>Methods: </strong>A total of 456 older adults of both sexes, aged ≥ 60 years, participated in this study. Frailty syndrome was identified according to the criteria of the Study of Osteoporotic Fractures. PA and SB were assessed using the International Physical Activity Questionnaire, and sleep was assessed using the Pittsburgh Sleep Quality Index. The effects of time substitution on these behaviors were verified using Poisson regression.</p><p><strong>Results: </strong>The replacement of 60 min/day of SB (prevalence ratio, PR = 0.52; 95% confidence interval, CI: 0.28-0.96) or sleep (PR = 0.52; 95% CI: 0.27-0.98) with 60 min/day of moderate PA (MPA) was associated with a 48% reduction in the prevalence of frailty syndrome.</p><p><strong>Conclusions: </strong>Replacing the time spent sitting or sleeping with the same amount of MPA time may reduce frailty; the longer the duration of time spent in the substitution of sleep or SB with MPA, the greater the benefits.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10835973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the university use of anxiolytics: a review","authors":"Ana Carolina Correia Cruz, Lara Dorighetto Gomes, Ana Paula dos Reis Castro, Luana Carla Dos Santos, André Dias Almeida Mucci de Aguiar, Carlos Alexandre Gomes Passarinho Menezes, Luiza Goulart Bacha Bustamante, Maria Eduarda Andrade Luciano, Sarah Araújo do Rosário, Isabeli Gomes de Oliveira, Letícia Silveira Arut, André Luis Andriolo","doi":"10.5327/1516-3180.141s1.506","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.506","url":null,"abstract":"Introduction: The use of anxiolytics is becoming increasingly popular in today’s society, especially among academics. However, improper use can cause adverse effects and become a health problem. Objectives: This is an integrative literature review whose objective is to evaluate the neurological side effect of anxiolytics among students. Methods: This is a systematic review, consulted the Databases PubMed, SciELO and Google Scholar. Chosen as descriptors (DeCS): “Anti-Anxiety Agents”, “Nervous System Diseases” and “Students” separated by Boolean connectors, and articles in English and Portuguese. Results: These evidenced the exacerbated and unknown use of anxiolytics as a problem in the school environment, including cognitive ones. Moreover, it was also exposed that neurological effects, in addition to cognition, can range from changes in social relationships, such as behavioral (mood destabilization, convulsion, psychosis). In addition, given its potential for dependence, it was also evidenced that medical prescription is essential for both initiation and cessation of treatment. Conclusion: The exacerbated and unknowing use of anxiolytics as a problem in the school environment, having the potential to negatively affect mental and physical health. It is possible to infer those problems such as the failure of communication between the health professional and the patient, abandonment of treatment and disobedience to medical guidance are still recurrent.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70951529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Wake-up” onset of pharyngocervicobrachial variant of Guillain-Barré syndrome: a case report","authors":"Evelliny Gomes da Silva, A. Holanda, V. Arca, Daniel Alves de Oliveira, Anna Paula Paranhos Miranda Covaleski, Letícia Klabinske Marques Monteiro, Eduardo Sousa de Melo","doi":"10.5327/1516-3180.141s1.565","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.565","url":null,"abstract":"Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in the world. There are variants. Of the cranial forms, the following stand out: the classic form, facial diplegia with distal paresthesias, pharyngo-cervico-brachial form, polyneuritis cranialis, Miller-Fisher syndrome and Bickerstaff encephalitis. This study aimed to report the case of a 73-year-old male patient, diabetic, former smoker and alcoholic, who presented at the Neurology outpatient clinic of a tertiary hospital in Pernambuco, after emergency care and 19 days of symptoms, reported as sudden cervical weakness, dysarthrophonia, dysphagia and weakness in the right hemiface, three weeks after vaccination (influenza and triple viral) and flu syndrome. He had dyspnea since the onset of the condition, with no progression or fluctuating complaints. The neurological examination showed multiple cranial nerve syndrome (right peripheral pattern facial palsy, reduced elevation of the soft palate and cervical extension paresis) associated with global hypo/arreflexia. Complementary exams showed, in addition to leukocytosis and signs of bronchopathy on chest tomography, cerebrospinal fluid with 00 cells and 48 proteins and electroneuromyography with predominantly sensitive axonal polyneuropathy, decrease in bilateral facial motor amplitude, needle with myopathic pattern. Brain magnetic resonance imaging without alterations. With the possibility of cranial polyradiculoneuritis and a history of dyspnea raised, he was admitted to the intensive care unit to monitor his breathing pattern and dysautonomia. He received antibiotic therapy for seven days due to pneumonia and pulse therapy with IVIG (2 g/kg for five days). He maintained progressive improvement of symptoms. He was discharged with a multidisciplinary outpatient follow-up scheduled. It is concluded, therefore, that the recognition of GBS and variant forms is necessary.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70953322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo assessment of striatal compartments in patients with idiopathic upper limb dystonia","authors":"A. M. Paulo, J. Waugh, Joselisa Queirzos de Paiva, J. Sato, Danilo Donizete de Faria, V. Borges, S. M. Silva, H. Ferraz, P. Aguiar","doi":"10.5327/1516-3180.141s1.331","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.331","url":null,"abstract":"Introduction: The striatum is an essential hub in the motor system associated with dystonia and other movement disorders. The function of the striosomes and matrix in motor control is not clear. A recently developed method using diffusion tensor imaging (DTI) enables us to distinguish compartments of the striatum, namely matrixes-like and striosomes-like voxels. Objectives: To access striatal matrix and striosome compartments in patients with idiopathic upper limb dystonia using diffusion tensor imaging. Methods: We analyzed 3T magnetic resonance imaging (MRI) images from 26 patients with idiopathic upper limb dystonia aged 43.88 ± 11.32 years (standard deviation, SD; range 19–60) with a mean disease duration of 12.55 ± 10.25 years (SD; range 1–25) and healthy controls aged 39.42 ±1 1.42 years (SD; range 19–58). The striatum was parcellated by targeting cortical regions that favored striosomes and matrix-favoring areas. The bilateral striatum was assessed for changes in volume and mean fractional anisotropy value. Results: Patients show significant reductions of left Matrix-like voxels volume relative to controls (P = 0.022), with a moderate effect size (Cohen’s d = 0.640). No difference was observed in the right striatum compartments. Conclusion: By parcellating the striatum into striosome and matrix-like voxels, we showed that patients with idiopathic dystonia have a reduced volume in matrix-like voxels in agreement with anatomopathological findings of some genetic types of dystonia. Even in non-degenerative dystonias, volume differences may reflect an imbalance between matrix and striosome signaling, ultimately favoring the direct pathway.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70947853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenge in a middle-aged woman with recurrent ischemic strokes: a case of primary central nervous system vasculitis","authors":"Y. S. Raposo, Hiago Antunis Silva, Patrícia Marques Mendes, Igor Pereira Matos de Oliveira, Eduardo Mendonça Werneck da Silva, Ilana Werneck Augsten, Maycon Melo Lopes","doi":"10.5327/1516-3180.141s1.378","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.378","url":null,"abstract":"Introduction: Primary vasculitides of the central nervous system (CNS) are rare vascular disorders whose pathophysiology involves inflammatory infiltration exclusively in the vessels of the CNS and clinically without constitutional symptoms. The aim is to report a case of primary vasculitis of the CNS. Case report and brief bibliographic review with Health Sciences Descriptors. Case report: This case portrays a 46-year-old woman with a history of multiple ischemic strokes. She previously had systemic arterial hypertension, prediabetes, obesity, and smoking. During follow-up after the second ischemic event, a small patent foramen ovale was detected with a positive microbubble test and the use of edoxaban was chosen. Transthoracic echocardiogram and magnetic resonance angiography of the cerebral arteries were without relevant changes. However, she recurred with new neurological deficits three more times. Edoxaban was replaced by dabigatran. Cerebrospinal fluid analysis was done twice and both were normal. Cerebral angiography was performed at the time of the last stroke and revealed suggestive signs of vasculitis. The characteristics of this case that corroborate the hypothesis of angiitis, to the detriment of reversible cerebral vasoconstriction syndrome, are the patient’s age, chronic headache, and focal symptoms not temporally associated with the headache. Secondary causes of vasculitis have been extensively investigated with negative results. Intravenous methylprednisolone pulse therapy was performed for five days. She evolved with progressive improvement of the motor deficit. On hospital discharge was prescribed prednisone and azathioprine. Conclusion: This report reinforces the importance of investigating CNS vasculitis in patients with recurrent ischemic strokes.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70948855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) secondary to demyelinating brainstem lesion","authors":"Mateus Gustavo Favaro, Bárbara Loiola Santos, Gabriela Lopes de Morais, Vanessa Lauanna Lima Silva, Gustavo Maximiano Alves, Katharina Vieira Messias, Nathália Rossoni Ronchi, V. D. Marques","doi":"10.5327/1516-3180.141s1.431","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.431","url":null,"abstract":"We report the case of a healthy 25-year-old man presenting with sudden onset dizziness, strabismus, and cloudy vision that improved when he closed one of his eyes. He denied pain with eye movement or color desaturation, as well as history of recent immunization or febrile illness. He did not present any other neurologic symptom, but he affirmed having had a limited episode of a discrete strabismus four months before. In his first assessment at the emergency room his neurologic examination revealed a 30° exotropia of the right eye on the primary gaze position along with adduction deficit and abduction nystagmus bilaterally on conjugated horizontal eye movement, characterizing an internuclear ophthalmoplegia on both eyes. He also presented with asymmetrical convergence deficit, with inability on completing adduction on his right eye. On the vertical upward gaze there was also a vertical nystagmus. Eye fundus examination did not show retinal and optic nerve alterations. Visual acuity was normal. This set of findings qualified a WEBINO (wall-eyed bilateral internuclear ophthalmoplegia). During investigation, lumbar puncture showed mild hyperproteinrachia, with absence of oligoclonal bands and normal CSF (cerebrospinal fluid GigG (immunoglobulin G) index. He was submitted to a course of pulse therapy with methylprednisolone. Neuroaxis magnetic resonance imaging evidenced a demyelinating periaqueductal lesion, involving medium longitudinal fasciculus, ponto-mesencephalic junction and mesencephalic tegmentum, without gadolinium enhancement. As he remained symptomatic, plasmapheresis was indicated, with complete remission of symptoms afterwards. Following his investigation the tests for both anti-aquaporin-4 and anti-MOG antibodies were negative, and until the conclusion of this report, a diagnosis of clinical isolated syndrome remained as the main hypothesis.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70949795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic basal ganglia calcification and Hoarding disorder","authors":"Marcos Venâncio Araújo Ferreira, Rafael Henrique Neves Gomes, F. Correia, Mariana Beber Chamon, Sérgio Roberto Pereira da Silva Júnior, Isadora Chain Lima, Marcus Vinicius de Sousa, Murilo Justino de Almeida, Daniel Sabino de Oliveira, T. Vale","doi":"10.5327/1516-3180.141s1.499","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.499","url":null,"abstract":"Introduction: Basal ganglia calcifications are associated with many neurological and metabolic disorders, being present also on asymptomatic patients. It may present in its primary form, including familial and sporadic cases. Its secondary form is associated especially to hypoparathyroidism but also associated to infections, toxic exposure, rheumatologic diseases, mitochondrial disorders. It has an heterogenous clinical presentation with movement disorders and neuropsychiatric symptoms. Case presentation: A 66-year-old patient presented with a progressive hoarding disorder for the last six years. In the last 2 years started an aggressive behavior, loss of acquired skills, urinary incontinence, sleep-wake cicle disorder and one episode of focal seizure. Physical examination revealed bilateral asymmetrical tremor, bradykinesia and cogwheel rigidity. MoCA test was 23/30 for 12 years of schooling. Brain Computed Tomography showed calcifications in basal ganglia affecting predominantly pallidum e thalamus and cerebellar hemispheres. Brain Magnetic Resonance Imaging revealed hypointensites in the same regions and in nucleus caudate suggestive of calcification. Laboratory testing for endocrine and calcium metabolism was normal. No clinical signs of other disorders. Discussion: We presented a case of probable Idiopathic Basal Ganglia Calcification initially treated as a hoarding disorder. The normal laboratory results, lack of other clinical signs and familial history suggests a primary sporadic form that might be due to de novo mutations or transmitted by asymptomatic parent. The most commonly mutations in SLC20A2, PDGFB and PDGFRB but genetic testing is commonly unavailable. Parkinsonism is the most common movement disorder and the neuropsychiatric features include cognitive impairment, psychotic and obsessive compulsive disorders. Conclusion: This case demonstrates that attention is needed to the progression of psychiatric disorders suggesting some rare neurological disorders.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70951265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiculopathy C8-T1 atypical initial presentation: a case report","authors":"Rafael de Almeida, Sayuri Aparecida Hirayama, Francine de Paula Roberto Domingos, Lucas Silva Dias, Lorena Dias de Araújo, Paulo Henrique Martinelli Oliveira, Raderi Luiz Cardoso dos Santos, Larissa Miyashiro, Rushansky Vilela de Azevedo, Gustavo Carvalho Costa","doi":"10.5327/1516-3180.141s1.487","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.487","url":null,"abstract":"Introduction: Radiculopathy is a common condition whose symptoms can include pain, sensory change, and motor weakness owing to mechanical and chemical irritation of the spinal nerve root. The aim is to report atypical clinical presentation of radiculopathy secondary to neoplasia. Case report: A 62-year-old male patient was admitted with pain in the right scapular region of onset 2 months ago and progressive worsening. On patient admission, he presented isolated loss of strength in the right hand with force grade V in the proximal right upper limb and right dropped hand and living reflexes in the right upper limb. Thoracic/cervical spine magnetic resonance imaging with expansive formations in the thoracic bone marrow of neoplastic aspect, compressive fracture of the vertebral body of T1 with impairment of the thoracic cord, reduction of the vertebral canal at level C3-C4. Electroneuromyography: bilateral acute C8-T1 radiculopathy, worse right and chronic radiculopathy on the left. Subsequently, he evolved with brachial paraparesis, exalted global osteotendinous reflexes, and inexhaustible clonus in the lower limbs. C4-T5 posterior cervical arthrodesis was performed. Discussion: Cervical radiculopathy may leave the clinician perplexed by lack of clinical-radiological correlation. Of special interest is the weakness of the intrinsic hand muscles without radiological evidence for C8 radiculopathy. Overlapping with the T1 root, the C8 root innervates the finger flexors and all the intrinsic hand muscles. C8 radiculopathy is characterized by radicular neck pain, hand weakness, and sensory deficit of the ulnar fingers and medial forearm. Conclusion: The lack of clinical-radiological correlation should not mislead the clinician from the correct diagnosis, and should not delay the surgical decompression of the cord and the roots.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70951667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis causing bilateral optic perineuritis","authors":"R. Maffei, A. Barbosa, A. Amorim, Gabriel Pinheiro Martins de Almeida e Souza, P. Fraiman, J. Ferrer, V. Faria, M. Lima, Ruan Gambardella Rosalina de Azevedo, S. Matas","doi":"10.5327/1516-3180.141s1.568","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.568","url":null,"abstract":"Introduction: Optic perineuritis is a rare disorder with multiple possible etiologies, including systemic autoimmune or infectious syndromes and, more rarely, neurosyphilis. The aim of this report is to describe an uncommon manifestation of this reemerging infectious disease. Case report based on a retrospective analysis of the medical records of the patient. Case report: A previously healthy 35-year-old female presented to the hospital with a seven-day history of progressive right eye vision loss and pain on extraocular movement, with development of a pink maculopapular rash on the trunk. On the sixth day of her disease, similar symptoms appeared in the contralateral eye. Physical examination showed reduced fotomotor reflex and finger counting at 50 cm in both eyes. Magnetic resonance imaging revealed bilateral and circumferential thickening with enhancement of the optic nerve sheath, suggesting bilateral optic nerve perineuritis. Serum Venereal Disease Research Laboratory (VDRL) was 1/64 and cerebrospinal fluid (CSF) showed 440 cells (86% lymphocytes), proteins 97 mg/dL, glucose 47 mg/dL, lactate 21 mg/dL and VDRL 1/4. She was treated with IV crystalline penicillin for 21 days and had partial improvement of bilateral vision within two months. At follow-up, her visual acuity was 20/40 in the right eye and 20/100 in the left; her CSF normalized, with nonreactive VDRL. Conclusion: Neurosyphilis is a treatable cause of optic perineuritis, and its recognition is important to establish the right antibiotic treatment.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70953507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of neurology in São Paulo at the first half of the 20th century: a systematic review","authors":"M. Costa, João Pedro de Sá Pereira, Laura Victória Miranda Silveira","doi":"10.5327/1516-3180.141s1.611","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.611","url":null,"abstract":"Neurology in São Paulo was initiated at the beginning of the XX century, with the creation of the Paulista School of Medicine. This article aims to analyze the emergence of Neurology in the state of São Paulo and the influences it received. To this end, we conducted a systematic search in an electronic database, Scielo. In this context, in the 20th century, neurology studied in São Paulo was greatly influenced by the science practiced in France, since in 1882 the specialty was initiated at the University of Paris. Discussions about the diseases in this area were discussed at the Santa Casa de Misericórdia in São Paulo. Another important place for the development of neurology in São Paulo was the creation of the neuropathology and cerebrospinal fluid laboratory, in 1924, at the Hospital de Juqueri. In the 1920s, the teaching of clinical neurology was created at the Faculty of Medicine by Enjolras Vampré, known as the father of neurology in São Paulo. In the 1930s, there were major changes in the areas of brain pathology, diagnosis of diseases that affect the central nervous system, and therapy. All of this was used at Hospital de Juqueri and Faculdade Paulista de Medicina. Among the prominent methods used were pneumoencephalography, cerebral arteriography, and cerebral leucotomy. Some literary works were fundamental for the dissemination of knowledge of Neurology in the society of São Paulo, namely “Memories of the Hospital of Juqueri” from 1924 and “Archives of Assistance to Psychopaths” from 1936. Neurology underwent a major evolution at the end of the first half of the twentieth century, however, it became expensive and inaccessible to a large part of the population, especially at a time before the creation of the Unified Health System, making the poorest marginalized concerning the treatment of neurological diseases that affected the society of São Paulo at the time.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70954321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}