Sao Paulo Medical Journal最新文献

{"title":"Associations between selected genetic variants and lipid profile variability in response to statins in Alzheimer's disease: a prospective observational study.","authors":"Fabricio Ferreira de Oliveira, Sandro Soares de Almeida, Elizabeth Suchi Chen, Paulo Henrique Ferreira Bertolucci, Marilia Cardoso Smith","doi":"10.1590/1516-3180.2024.0160.27112024","DOIUrl":"10.1590/1516-3180.2024.0160.27112024","url":null,"abstract":"<p><strong>Background: </strong>Lipid profiles are largely determined by genetic variants, and lipid metabolism plays a crucial role in Alzheimer's disease.</p><p><strong>Objective: </strong>To investigate whether lipid profile variability in response to diverse statins could be affected by cholesterol metabolism-related genetic variants in Alzheimer's disease..</p><p><strong>Design and setting: </strong>This prospective observational pharmacogenetic study was conducted at the Universidade Federal de São Paulo (Unifesp), Brazil.</p><p><strong>Methods: </strong>Consecutive outpatients were prospectively followed for lipid profile variations over one year, estimated by the associations between statin therapy and the following variants: rs2695121 (NR1H2), rs3846662 (HMGCR), rs11669576 (LDLR8), rs5930 (LDLR10), rs5882 and rs708272 (CETP), rs7412 and rs429358 (APOE), and ACE insertion/deletion polymorphism.</p><p><strong>Results: </strong>All polymorphisms in the 189 patients were in Hardy-Weinberg equilibrium. Statins resulted in lower total cholesterol and LDL cholesterol levels, whereas the effects on HDL cholesterol varied according to the statin used. Atorvastatin resulted in lower triglyceride level variations than simvastatin. APOE-ε4 carriers showed a better response to atorvastatin in elevating HDL-cholesterol than APOE-ε4 non-carriers. Carriers of the ACE insertion allele had cumulatively lower total cholesterol and LDL-cholesterol levels, regardless of statin therapy, but lower triglyceride levels when using atorvastatin. Carriers of rs11669576-G had lower total cholesterol and LDL-cholesterol levels when using simvastatin, and lower total cholesterol and triglycerides when using atorvastatin. Concerning CETP haplotypes, carriers of rs5882-A and rs708272-A benefitted the most from statins, which lowered total cholesterol and increased HDL-cholesterol levels, and from atorvastatin lowering triglycerides; however, the effects of atorvastatin lowering total cholesterol and LDL-cholesterol were more pronounced for carriers of rs5882-GG/rs708272-GG.</p><p><strong>Conclusion: </strong>Lipid profile variations may be pharmacogenetically mediated in Alzheimer's disease, thus, confirming their high heritability.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024160"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between soft drink consumption and cardiovascular disease risk among Brazilian adults: a cross-sectional study.","authors":"Karla Cordeiro Gonçalves, Luís Antônio Batista Tonaco, Guilherme Augusto Veloso, Alexandra Dias Moreira, Mariana Santos Felisbino-Mendes, Deborah Carvalho Malta, Gustavo Velasquez-Melendez","doi":"10.1590/1516-3180.2023.0433.R1.29112024","DOIUrl":"10.1590/1516-3180.2023.0433.R1.29112024","url":null,"abstract":"<p><strong>Background: </strong>Inadequate diet is considered a major risk factor for chronic noncommunicable diseases and mortality. Among the ultra-processed foods, sweetened soft drinks are significant contributors to high-calorie diets and are associated with adverse health outcomes.</p><p><strong>Objective: </strong>To estimate the association between soft drink consumption and the risk of cardiovascular events.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted using data of adults aged ≥ 18 years from the 2013 National Health Survey.</p><p><strong>Methods: </strong>The explanatory variable was the daily consumption of sugar-sweetened soft drinks. Cardiovascular risk (CVR) was calculated using the Framingham score. Multinomial logistic regression was used for the analyses. Two models were used: one adjusted for age and body mass index and the other for age and waist circumference. Both models were applied to the general population and stratified by race and educational attainment.</p><p><strong>Results: </strong>The study sample consisted of 8,391 participants. Individuals with sugary soda consumption ≥ 0.4 cups/day were associated with a higher CVR, which escalated with increasing consumption of soft drinks.</p><p><strong>Conclusions: </strong>CVR was observed across all consumption categories and difference in risk was based on the intake quantity.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2023433"},"PeriodicalIF":1.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout and resilience among intensive care workers facing the end of the COVID-19 pandemic: a cross-sectional study.","authors":"Ana Irene Carlos de Medeiros, Elizabeth De Francisco Daher, Xinaida Taligare Vasconcelos Lima, Antonio George de Matos Cavalcante, Marcelo Alcântara Holanda, Eanes Delgado Pereira","doi":"10.1590/1516-3180.2024.0244.R1.07032025","DOIUrl":"10.1590/1516-3180.2024.0244.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Burnout is a global problem, and resilience may support the well-being of healthcare workers (HCWs) in stressful conditions.</p><p><strong>Objectives: </strong>This study aimed to evaluate the association between burnout and resilience among HCWs in intensive care units (ICU) during the coronavirus disease 2019 (COVID-19) pandemic.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted in the ICU of four public hospitals in Fortaleza, Brazil.</p><p><strong>Methods: </strong>A face-to-face survey was conducted among HCWs in the ICUs of four public hospitals in Fortaleza between January and August 2023. The participants completed questionnaires on burnout and resilience.</p><p><strong>Results: </strong>A total of 194 professionals, including physichians (24%), nurses (29%), nursing technicians (25%), and physiotherapists (22%), completed questionnaires on burnout and resilience through face-toface interviews. Most professionals (62%) presented with overall burnout symptoms, and an inverse association was observed between resilience and burnout. However, 16 of the 44 (34%) HCWs with the highest resilience scores experienced burnout. Furthermore, younger age and higher workload were associated with a higher prevalence of burnout.</p><p><strong>Conclusion: </strong>Determinants of burnout were identified among ICU staff members during the last year of the COVID-19 pandemic. Resilience helped HCWs cope with burnout. However, some of the most resilient HCWs presented with high levels of burnout. Efforts are necessary to implement resilience-building tools, yet public health policies to improve ICU organizational issues are more important and urgent for promoting sustainable well-being among professionals, particularly during challenges such as pandemics. Introducing resilience-building tools and implementing public health policies are necessary to improve ICU management and promote sustainable well-being among healthcare workers in high workload settings.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 5","pages":"e2024244"},"PeriodicalIF":1.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified stapled hemorrhoidectomy technique to optimize mucosectomy specimen and improve outcomes.","authors":"Fábio Guilherme Campos, Paula Gabriela Melo Moraes, Pablo Veloso Martins, Leonardo Alfonso Bustamante-Lopez, Carlos Augusto Real Martinez","doi":"10.1590/1516-3180.2023.0435.R1.29112024","DOIUrl":"10.1590/1516-3180.2023.0435.R1.29112024","url":null,"abstract":"<p><strong>Background: </strong>Surgical treatment of hemorrhoidal disease has undergone numerous modifications in recent decades. Among the technical options, stapled hemorrhoidopexy is currently considered an optimal alternative because it provides a less painful recovery. However, many reports have associated this technique with higher recurrence rates than excisional techniques.</p><p><strong>Objectives: </strong>This manuscript presents a technical modification that aims to provide more extensive mucosectomy with mechanical hemorrhoidopexy.</p><p><strong>Design and setting: </strong>The present technical modification was developed and has been recently used in two hospitals in São Paulo (SP), Brazil.</p><p><strong>Methods: </strong>To achieve this, we placed a circumferential submucosal suture at the 3 o'clock position in the clockwise direction. When the left lateral position (9 o'clock) was reached, a loop of 2-0 non-absorbable suture thread was passed around the continuous suture and retracted to the left. Subsequently, the original suture progressed towards the point on the right lateral side, where it was started.</p><p><strong>Results: </strong>Specifically, the modification consists of establishing two traction points from the pursestring suture; thus, the rectal mucosa entering the stapler head will be more uniform, and the retrieved mucosal strip will present a greater height. These features may play a role in effectively reducing mucosal prolapse and alleviating the symptoms.</p><p><strong>Conclusions: </strong>The proposed modification of the original operative technique is simple and aims to improve postoperative results by increasing the height of the mucosal specimen to be resected, thereby reducing long-term recurrence. In the future, this hypothesis will be tested in a randomized study comparing the mucosectomy height and postoperative outcomes of both technical options (classical and present).</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2023435"},"PeriodicalIF":1.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward an algorithm of percutaneous microelectrolysis: a randomized clinical trial on invasive techniques.","authors":"Carlos Eduardo Girasol, Nathaly Escobar Durán, Santiago Marcelo D'Almeida, Oscar Ariel Ronzio","doi":"10.1590/1516-3180.2024.0164.R1.07032025","DOIUrl":"10.1590/1516-3180.2024.0164.R1.07032025","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous microelectrolysis (MEP) is a minimally invasive technique used for pain relief, inflammation control, and tissue repair. However, the optimal treatment protocol remains under debate.</p><p><strong>Objective: </strong>To compare the effects of dry needling and MEP, with and without a treatment algorithm, on pain in individuals with active myofascial trigger points (MTrPs) in the upper trapezius muscle. Design and setting: Randomized controlled trial conducted at Maimónides University, Buenos Aires.</p><p><strong>Methods: </strong>Eighty-eight participants with MTrPs in the upper trapezius muscle were enrolled. The presence of MTrPs was confirmed through physical examination and algometric measurement before intervention. Participants were randomly assigned to one of six groups: Sham, dynamic dry needling, static dry needling, dynamic MEP, static MEP, or algorithmic MEP. Active treatments were administered using 0.30 mm × 40 mm acupuncture needles. Pain was assessed using two tools: the Numerical Pain Rating Scale (NPRS) and the Pressure Pain Threshold (PPT). Both measures were recorded with participants at rest before the intervention and again at 10 min, 24 h, 48 h, and 7 days post-intervention.</p><p><strong>Results: </strong>Significant post-intervention differences in NPRS scores were observed in all groups except dynamic dry needling when compared to Sham. The algorithmic MEP group achieved complete pain relief by day 7. In terms of PPT, the threshold values in the MEP groups were lower than those in the other groups.</p><p><strong>Conclusions: </strong>All needling techniques demonstrated analgesic effects on myofascial trigger points, with the algorithm-enhanced MEP showing the most notable improvement in self-reported pain. However, MEP was not superior to other methods in improving pressure pain thresholds.</p><p><strong>Clinical trials: </strong>NCT05478928.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 5","pages":"e2024164"},"PeriodicalIF":1.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brazilian version of the High-Activity Arthroplasty Score: psychometric property evaluation in hip replacement patients.","authors":"Nathalia Sundin Palmeira de Oliveira, Julia Ribeiro Soares, Danúbia da Cunha de Sá Caputo, Gustavo Leporace, Luiz Alberto Batista, Themis Moura Cardinot, Liszt Palmeira de Oliveira","doi":"10.1590/1516-3180.2024.0176.27112025","DOIUrl":"10.1590/1516-3180.2024.0176.27112025","url":null,"abstract":"<p><strong>Background: </strong>The High-Activity Arthroplasty Score (HAAS) is a reliable and valid self-administered questionnaire that was developed in British English and was designed to determine the level of physical activity in patients after lower limb arthroplasty (hip and/or knee). The Brazilian version (HAAS-Brazil) was developed after a cross-cultural adaptation in 2023.</p><p><strong>Objective: </strong>To evaluate the psychometric properties of HAAS-Brazil in patients after hip arthroplasty.</p><p><strong>Design and setting: </strong>A cross-sectional quantitative and qualitative study was conducted in an orthopedic outpatient setting.</p><p><strong>Methods: </strong>Evidence for the validity of HAAS-Brazil was assessed via psychometric testing, which followed the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN).</p><p><strong>Results: </strong>A total of 112 patients with a mean age of 56 years were included as participants; of these patients, 50.9% were female, with 44.6% being overweight and 85.7% being engaged in physical activity. HAAS-Brazil provided satisfactory evidence of content validity (CVC > 0.9), structural validity (AISP = 1; Hi > 0.3; VIMon = 0; VIIIO = 0), construct validity (ρ HOS-SP = 0.696; ρ SF-12 PSC = 0.554; ρ SF-1 MSC = 0.338), no ceiling or floor effect, acceptable internal consistency (Mokken ρ = 0.707; Cronbach α = 0.663), and good reliability (ICC(3,K) = 0.840 ; P < 0.001).</p><p><strong>Conclusion: </strong>The HAAS-Brazil provided satisfactory validation evidence in patients who underwent hip arthroplasty.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024176"},"PeriodicalIF":1.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-perception of health and quality of life in patients on renal replacement therapy undergoing hemodialysis: a case-control study.","authors":"Diego José Gambin, Felipe Gomes Dallepiane, Leonardo Saraiva, Marciele Cristiane Spanenberg Führ, Fabiana Piovesan, Caroline Mirek, João Paulo De Carli, Micheline Sandini Trentin","doi":"10.1590/1516-3180.2024.0144.R1.14042025","DOIUrl":"10.1590/1516-3180.2024.0144.R1.14042025","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) presents challenges to human health and quality of life, with care primarily focusing on renal function and comorbidity management. Several studies confirm the relationship between oral and systemic conditions of patients. Therefore, CKD and periodontal disease can be related because they are both inflammatory conditions that further increase the risk of other pathologies. The impact of CKD on oral health and overall quality of life is an area of interest.</p><p><strong>Objectives: </strong>To evaluate patients with CKD undergoing renal replacement therapy regarding the levels of self-perception of oral health and quality of life.</p><p><strong>Design setting: </strong>This case-control study was conducted jointly at the Universidade de Passo Fundo and Hospital São Vicente de Paulo, Brazil.</p><p><strong>Methods: </strong>This study included two patient groups: 1) Case group with CKD (CGA) comprising 116 patients; 2) Control group without CKD (CGO) composed of 124 patients. We used a structured questionnaire and the Oral Health Impact Profile (OHIP-14). We used the Chi-square and Wilcoxon-Mann-Whitney tests as well as an analysis of variance measure (P < 0.05).</p><p><strong>Results: </strong>The systemic diseases most prevalent among our patient cohort included hypertension (16.9% CGO and 75.9% CGA) and diabetes mellitus (8.9% CGO and 38.8% CGA). The systemic health perception was good in 66.9% of the CGO group and average in 42.2% of CGA group members. Oral health perception was good in 46% of CGO and 50% of CGA group members. Results of the self-assessment for quality of life showed a statistically significant difference between the groups for physical domain, physical disability, and social disadvantage. A comparison between the control and case (CKD) groups, based on the OHIP-14 score, showed statistically significant differences in the functionality (P < 0.006), physical disability (P < 0.042), and social disadvantage (P < 0.031) domains for the CKD group.</p><p><strong>Conclusion: </strong>Patients with CKD have lower rates of self-perception of oral health and quality of life than individuals without CKD.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024144"},"PeriodicalIF":1.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Residency - where we are and future challenges.","authors":"Alfredo Inácio Fiorelli, Paulo Manuel Pêgo-Fernandes","doi":"10.1590/1516-3180.2025.1434.14042025","DOIUrl":"10.1590/1516-3180.2025.1434.14042025","url":null,"abstract":"","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e20251434"},"PeriodicalIF":1.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cross-cultural adaptation and validation of the Weight Management Questionnaire in the Brazilian population: a cross-sectional study.","authors":"Brígida Rodrigues da Costa, Almir Vieira Dibai-Filho, Aldair Darlan Santos-de-Araújo, Fábio Henrique Ferreira Pereira, Daniela Bassi-Dibai, Adriana Sousa Rêgo","doi":"10.1590/1516-3180.2024.0149.R2.10042025","DOIUrl":"10.1590/1516-3180.2024.0149.R2.10042025","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of obesity has increased considerably worldwide, and it has become an important risk factor for chronic non-communicable diseases.</p><p><strong>Bjective: </strong>To translate, cross-culturally adapt, and validate the Weight Management Questionnaire (WMQ) to evaluate weight control practices for health monitoring and intervention in Brazil.</p><p><strong>Design and setting: </strong>This was a quantitative cross-sectional study.</p><p><strong>Methods: </strong>Obese and physically active lean individuals aged 18-59 years were included in this study. The tool used as an adaptation was the WMQ. The cross-cultural adaptation was conducted in five phases. For structural validity, confirmatory factor analysis (CFA) was used to verify the internal structure considering two domains: diet and physical activity. To determine construct validity, a comparison was performed between different groups (lean versus obese). Reliability was assessed using the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The short version of the WMQ after CFA presented eight items. Thus, the structure with two domains presented adequate fit indices: chi-square/degree of freedom = 1.66, comparative fit index = 0.996, Tucker-Lewis index = 0.994, root mean square error of approximation = 0.057, and standardized root mean square residual = 0.047. For construct validity, a significant difference was observed between the groups (P < 0.05) in both domains. We observed adequate reliability for both domains (ICC ≥ 0.854).</p><p><strong>Conclusions: </strong>The WMQ can be used for the Brazilian population, as it is reliable and has adequate internal structure, supporting its use in future research.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 4","pages":"e2024149"},"PeriodicalIF":1.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.","authors":"Gabriela Garcia de Carvalho Laguna, Isadora Bagues Rodrigues, Sara Emanuelle Dos Santos Neves, David Santos Libarino, Fernanda Beatriz Melo Maciel, Antônio Gonçalves Pessoa, Leticia Defensor da Silva Santos, Nilia Maria de Brito Lima Prado","doi":"10.1590/1516-3180.2024.0324.R1.14042025","DOIUrl":"10.1590/1516-3180.2024.0324.R1.14042025","url":null,"abstract":"<p><strong>Background: </strong>People with Autism Spectrum Disorder (ASD) experience phases of life beyond childhood, which increase the difficulties inherent in each cycle. In contrast, the scientific literature lacks broad reviews of developmental strategies regarding quality of life, even though ASD encompasses changes in social, communicative, and behavioral skills.</p><p><strong>Objective: </strong>This study aimed to identify strategies for promoting and maintaining quality of life among adults diagnosed with autism.</p><p><strong>Design and setting: </strong>This integrative review was conducted in Brazil.</p><p><strong>Methods: </strong>This review searched the Scopus and Web of Science databases, from strategies that combined the descriptors (\"Autism Spectrum Disorder\"), (\"Autism\"), (\"Aging\"), and (\"Quality of life\"). Original studies with the full text available in English published between 2018 and 2023 were included, if they responded to the eligibility criteria.</p><p><strong>Results: </strong>In total, 3,098 studies were identified, of which 44 were selected to compose the bibliographic sample of this review. The population sample included 184,653 participants diagnosed with ASD, aged on average 43.5 years old. The following were described for adults with autism: 1) cognitive aspects, 2) aspects related to suffering/mental illness, and 3) strategies to promote quality of life.</p><p><strong>Conclusion: </strong>This research contributes to basic clinical practice and promotes responsible care that attends to the health needs of people with autism throughout life. Early interventions in autistic adults and the availability of support throughout life are essential for maintaining cognitive health and quality of life.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"143 5","pages":"e2024324"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}