Sao Paulo Medical Journal最新文献

{"title":"Cut-off points of neck and waist circumference as predictors of obstructive sleep apnea in the Colombian population: a comparison with polysomnography.","authors":"Sandra Brigitte Amado Garzon, Oscar Mauricio Muñoz-Velandia, Alvaro J Ruiz, Patricia Hidalgo Martínez, Liliana Otero","doi":"10.1590/1516-3180.2022.0415.R2.310523","DOIUrl":"10.1590/1516-3180.2022.0415.R2.310523","url":null,"abstract":"<p><strong>Background: </strong>Neck circumference (NC) is a useful anthropometric measure for predicting obstructive sleep apnea (OSA). Ethnicity and sex also influence obesity phenotypes. NC cut-offs for defining OSA have not been established for the Latin American population.</p><p><strong>Objectives: </strong>To evaluate NC, waist circumference (WC), and body mass index (BMI) as predictors of OSA in the Colombian population and to determine optimal cut-off points.</p><p><strong>Design and setting: </strong>Diagnostic tests were conducted at the Javeriana University, Bogota.</p><p><strong>Methods: </strong>Adults from three cities in Colombia were included. NC, WC, and BMI were measured, and a polysomnogram provided the reference standard. The discrimination capacity and best cut-off points for diagnosing OSA were calculated.</p><p><strong>Results: </strong>964 patients were included (57.7% men; median age, 58 years) and 43.4% had OSA. The discrimination capacity of NC was similar for men and women (area under curve, AUC 0.63 versus 0.66, P = 0.39) but better for women under 60 years old (AUC 0.69 versus 0.57, P < 0.05). WC had better discrimination capacity for women (AUC 0.69 versus 0.57, P < 0.001). There were no significant differences in BMI. Optimal NC cut-off points were 36.5 cm for women (sensitivity [S]: 71.7%, specificity [E]: 55.3%) and 41 cm for men (S: 56%, E: 62%); and for WC, 97 cm for women (S: 65%, E: 69%) and 99 cm for men (S: 53%, E: 58%).</p><p><strong>Conclusions: </strong>NC and WC have moderate discrimination capacities for diagnosing OSA. The cut-off values suggest differences between Latin- and North American as well as Asian populations.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 3","pages":"e2022415"},"PeriodicalIF":1.3,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10703493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of hemodialysis on intracranial pressure waveform in patients with chronic kidney disease: an observational study.","authors":"Mariana Schechtel Koch, Bianca Drewnowski, Cristiane Rickli, Fábio André Dos Santos, Gilberto Baroni, José Carlos Rebuglio Vellosa","doi":"10.1590/1516-3180.2023.0068.R1.07072023","DOIUrl":"10.1590/1516-3180.2023.0068.R1.07072023","url":null,"abstract":"<p><strong>Background: </strong>Among the complications related to chronic kidney disease (CKD), those of a neurological nature stand out, and for a better quality of life for patients, the diagnosis and treatment of these complications is fundamental.</p><p><strong>Objectives: </strong>This study aimed to assess the effect of hemodialysis on intracranial pressure waveform (ICPw) in patients with chronic kidney disease undergoing hemodialysis and those who are not yet undergoing substitutive therapy.</p><p><strong>Design and setting: </strong>An observational study was conducted in two stages at a kidney replacement therapy center in Brazil. The first was a longitudinal study and the second was a cross-sectional study.</p><p><strong>Methods: </strong>Forty-two patients on hemodialysis were included in the first stage of the study. In the second stage, 226 participants were included. Of these, 186 were individuals with chronic kidney disease (who were not undergoing substitutive therapy), and 40 did not have the disease (control group). The participants' intracranial compliance was assessed using the non-invasive Brain4care method, and the results were compared between the groups.</p><p><strong>Results: </strong>There was a significant difference between the hemodialysis and non-hemodialysis groups, with the former having better ICPw conditions.</p><p><strong>Conclusions: </strong>Hemodialysis influenced the improvement in ICPw, probably due to the decrease in the patients' extra-and intracellular volumes. Furthermore, ICPw monitoring can be a new parameter to consider when defining the moment to start substitutive therapy.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 3","pages":"e2023068"},"PeriodicalIF":1.3,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving breastfeeding among adolescent mothers: a prospective cohort.","authors":"Maira Pinho-Pompeu, Renan Massao Nakamura, Erika Zambrano, Fernanda Garanhani Surita","doi":"10.1590/1516-3180.2022.0647.R1.260723","DOIUrl":"10.1590/1516-3180.2022.0647.R1.260723","url":null,"abstract":"<p><strong>Background: </strong>Exclusive breastfeeding is recommended for the first six months, and mother's age impact early weaning. Educational support and relevant information can increase breastfeeding rates.</p><p><strong>Objective: </strong>To determine whether antenatal education enhances the maintenance, intention, and confidence in breastfeeding among adolescents.</p><p><strong>Design and setting: </strong>A prospective cohort study involving primiparous adolescents who gave birth at the Woman's Hospital (CAISM), Universidade Estadual de Campinas, Brazil.</p><p><strong>Methods: </strong>Adolescent mothers were categorized into two groups based on the location of prenatal care: those at the Woman's Hospital (WH) who received antenatal education, and at the Primary Care (PC) who did not receive antenatal education. All adolescents received breastfeeding orientation during their postpartum hospital stay. The groups were compared using the Student's t-test, Mann-Whitney U test, and chi-squared test. Log-binomial models were used to compare the groups at different time intervals.</p><p><strong>Results: </strong>The study included 132 adolescents: 59 in the WH group and 73 in the PC group. Six months postpartum, adolescents in the WH group demonstrated higher engagement in breastfeeding (P < 0.005) and exclusive breastfeeding (P = 0.04) than PC group. PC group showed greater lack of confidence in breastfeeding (P = 0.02) and felt less prepared (P = 0.01). Notably, all WH adolescents reported a stronger desire to breastfeed after antenatal education.</p><p><strong>Conclusion: </strong>Antenatal education significantly improves the maintenance, intention, and confidence of breastfeeding among adolescents. This education approach can be implemented across all healthcare levels and should be made accessible to all women throughout the pregnancy and postpartum period.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 3","pages":"e2022647"},"PeriodicalIF":1.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive abilities and medical students' practice of physical exams: A quasi-experimental study.","authors":"Lucas Moura Yamamoto, Matheus Landi Pavin, Giordano Bruno Duarte de Souza, Julio Lamartine Hayne Bastos de Oliveira, Raphael Raniere de Oliveira Costa, Adriano Yacubian Fernandes, Alessandra Mazzo","doi":"10.1590/1516-3180.2022.0564.R1.10042023","DOIUrl":"10.1590/1516-3180.2022.0564.R1.10042023","url":null,"abstract":"<p><strong>Background: </strong>To highlight the importance of clinical simulations and simulated laboratories for student training, especially in physical examination teaching.</p><p><strong>Objective: </strong>To evaluate the gains obtained by medical students in their cognitive and practical performance of physical examinations (abdominal, cardiological, and pulmonary), as well as satisfaction and self-confidence in what they have learned, after concentrated practice developed in a skills and simulation laboratory.</p><p><strong>Design and setting: </strong>A quantitative and quasi-experimental study in which 48 students were evaluated at the Faculdade de Odontologia de Bauru, São Paulo, Brazil.</p><p><strong>Methods: </strong>A quantitative and descriptive study was conducted with regularly enrolled 2nd year medical students over 18 years of age who had content prior to data collection regarding anamnesis and physical examination remotely taught in a Moodle virtual learning environment. For data collection, the participants were subjected to a concentrated period of skill training (abdominal, cardiological, and pulmonary). Every day after the skill training session, they were subjected to a practical evaluation and completed a theoretical test before and after the practical activities. At the end of all activities, they answered the instrument to assess the simulated practices (self-confidence and satisfaction).</p><p><strong>Results: </strong>Among the 49 students evaluated, positive and significant theoretical and practical gains were identified in all three components (abdominal, cardiological, and pulmonary) (P = 0.000), as well as in the general evaluation (Theoretical 1 and Theoretical 2) (P = 0.000), satisfaction, and self-confidence (P = 0.000).</p><p><strong>Conclusion: </strong>Concentrated laboratory practice resulted in positive improvements in students' physical examination skills.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"141 6","pages":"e2022564"},"PeriodicalIF":1.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic surgery training.","authors":"Pedro Henrique Xavier Nabuco de Araujo,&nbsp;Paulo Manuel Pêgo-Fernandes","doi":"10.1590/1516-3180.2022.1415310823","DOIUrl":"https://doi.org/10.1590/1516-3180.2022.1415310823","url":null,"abstract":"Robot-assisted surgery emerged in the 2000s and has grown almost exponentially in the last decade. The use of robotic-assisted surgery has increased 10–40-fold more than that of laparoscopic surgery for general routine procedures. 1 The continuous improvement of robotic platforms has allowed surgeons to overcome the limitations of conventional laparoscopy, such as 2D visualization and long instruments that do not accurately reproduce human wrist movements. Robotic systems provide high-definition 3D visualization, giving control of the camera to the surgeon. Robotic platforms have surgical instruments with intracavitary joints that reduce tremors, reproducing the movements of the surgeon on the console with great accuracy. Combined with these technical advantages, the clinical results consistently demonstrated in scientific articles seem to corroborate the great growth of robotic surgery in several specialties. 2 The increasing use of robotic systems has raised concerns about the safety of patients operated on by surgeons on a learning curve. This demand resulted in a standardized curriculum for training new surgeons. A few years ago, robotic training was controlled and certified by Intuitive, the company that manufactured the only robotic platforms then available in Brazil. The significantly increased demand for robotic surgery led the Brazilian Medical Association (AMB), the Specialty Societies, and the Federal Council of Medicine (CFM) to regulate robotic surgery in Brazil, establishing a structured training curriculum 3,4 consisting of a basic and an advanced stage. The basic or pre-clinical stage includes acquiring theoretical knowledge about robotic equipment and how the robot works, online training on the fundamentals of robotic surgery, watching videos and attending some robotic surgeries in person, training on a robotic simulator, and training on the robot console simulating real surgery movements and procedures (in-service training","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"141 5","pages":"e20231415"},"PeriodicalIF":1.4,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of cardiopulmonary exercise test indices and conditions of overweight patients with obstructive sleep apnea: a retrospective study.","authors":"Ying Huang,&nbsp;Chunyan Ruan,&nbsp;Peng Wu,&nbsp;Qian Cai,&nbsp;Yu Chen,&nbsp;Changcai Xie,&nbsp;Jianying Lang,&nbsp;Jiqiang Li,&nbsp;Hai Chen","doi":"10.1590/1516-3180.2022.0264.R2.010623","DOIUrl":"10.1590/1516-3180.2022.0264.R2.010623","url":null,"abstract":"<p><strong>Background: </strong>The cardiopulmonary function of patients with obstructive sleep apnea (OSA) is significantly lower than that of patients with simple snoring and is significantly related to the severity of OSA. Currently, only a few studies have been conducted on cardiopulmonary exercise testing in overweight patients with OSA.</p><p><strong>Objective: </strong>To analyze the correlation between cardiopulmonary exercise test (CPET) indices and the condition of overweight patients with OSA.</p><p><strong>Design and setting: </strong>Retrospective study in Guangdong Provincial Hospital of Chinese Medicine.</p><p><strong>Methods: </strong>This study included 73 hospitalized overweight patients. The patients were divided into no, mild, moderate, and severe OSA groups. Differences in the CPET indices among the four groups were compared. The correlation between the CPET indices and conditions was analyzed.</p><p><strong>Results: </strong>No, mild, moderate, and severe OSA groups had 18 men and 5 women, 11 men and 3 women, 12 men and 2 women, and 21 men and 1 woman, respectively (P > 0.05). No significant difference was observed in resting pulmonary function among the four groups (P > 0.05). In the CPET, the anaerobic threshold, maximum oxygen uptake, and oxygen pulse were significantly lower in the severe OSA group than those in the normal OSA group (P < 0.05). Moreover, CPET indices negatively correlated with the apnea-hypopnea index.</p><p><strong>Conclusion: </strong>Changes in CPET indices occurred earlier than changes in resting pulmonary function in patients with OSA. CPET might be a potential method for evaluating the severity of OSA combined with overweight status.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 3","pages":"e2022264"},"PeriodicalIF":1.4,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and calibration of the Food Consumption Frequency Questionnaire for pregnant women.","authors":"Sheila Monteiro Brito,&nbsp;Jerusa da Mota Santana,&nbsp;Marcos Pereira,&nbsp;Djanilson Barbosa Santos,&nbsp;Ana Marlucia Oliveira","doi":"10.1590/1516-3180.2023.0059.R2.190523","DOIUrl":"10.1590/1516-3180.2023.0059.R2.190523","url":null,"abstract":"<p><strong>Background: </strong>Few food frequency questionnaires (FFQ) have been validated for pregnant women, particularly those in small- and medium-sized cities in different regions of Brazil.</p><p><strong>Objectives: </strong>To validate and calibrate a semiquantitative FFQ for pregnant women.</p><p><strong>Design and setting: </strong>The study was validated with a sample of 50 pregnant women (≥ 18 years) enrolled in Brazilian prenatal services.</p><p><strong>Methods: </strong>An FFQ and a 24-hour recall were used to evaluate dietary intake. Dietary variables were tested for normality and log-converted when asymmetrical. Pearson's Correlation Coefficient was used to validate the questionnaire. Linear regression was applied to extract calibration factors. All variables underlying the consumption analysis were adjusted for energy.</p><p><strong>Results: </strong>The mean age of the pregnant women was 26 years ± 6.2 years; 58% were in their first trimester, and 30% were identified as overweight/obese. The Pearson correlation analysis results indicated that the FFQ overestimated energy and nutrient intake, whose coefficients ranged from -0.15 (monounsaturated fat) to 0.50 (carbohydrate). Adjusting for energy reduced the mean values of intake coefficients, which now ranged from -0.33 (sodium) to 0.96 (folate). The calibration analysis results indicated variation in the coefficients from -0.23 (sodium) to 1.00 (folate). Calibration produced satisfactory coefficients for the FFQ compared with the reference standard for energy, macronutrients, monounsaturated fat, cholesterol, vitamins B12/C, folate, sodium, iron, and calcium.</p><p><strong>Conclusions: </strong>After validating and calibrating tests, we observed that the FFQ was adequately accurate for assessing the food consumption of the pregnant women in this study.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 2","pages":"e2023059"},"PeriodicalIF":1.4,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10564392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41217836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug use among medical students in São Paulo, Brazil: a cross-sectional study during the coronavirus disease 2019 pandemic.","authors":"Pedro Lemos-Santos,&nbsp;Lukas Blumrich,&nbsp;Jordi Blanes Debia,&nbsp;João Mauricio Castaldelli-Maia,&nbsp;Paulo Jeng Chian Suen,&nbsp;André Malbergier","doi":"10.1590/1516-3180.2022.0493.R1.150623","DOIUrl":"10.1590/1516-3180.2022.0493.R1.150623","url":null,"abstract":"<p><strong>Background: </strong>Medical students demonstrate higher rates of substance use than other university students and the general population. The challenges imposed by the coronavirus disease 2019 (COVID-19) pandemic raised significant concerns about mental health and substance use.</p><p><strong>Objectives: </strong>Assess the current prevalence of substance use among medical students at the University of São Paulo and evaluate the impact of the COVID-19 pandemic on drug consumption.</p><p><strong>Design and setting: </strong>A cross-sectional study was conducted on 275 medical students from the University of São Paulo Medical School (São Paulo, Brazil) in August 2020.</p><p><strong>Methods: </strong>Substance use (lifetime, previous 12 months, and frequency of use before and during the COVID-19 pandemic) and socioeconomic data were assessed using an online self-administered questionnaire. Symptoms of depression were assessed using the Patient Health Questionnaire-9.</p><p><strong>Results: </strong>Alcohol was the most consumed substance in their lifetime (95.6%), followed by illicit drugs (61.1%), marijuana (60%), and tobacco (57.5%). The most commonly consumed substances in the previous year were alcohol (82.9%), illicit drugs (44.7%), marijuana (42.5%), and tobacco (36%). Students in the first two academic years consumed fewer substances than those from higher years. There was a decreasing trend in the prevalence of most substances used after the COVID-19 pandemic among sporadic users. However, frequent users maintained their drug use patterns.</p><p><strong>Conclusion: </strong>The prevalence of substance use was high in this population and increased from the basic to the clinical cycle. The COVID-19 pandemic may have affected the frequency of drug use and prevalence estimates.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 2","pages":"e2022493"},"PeriodicalIF":1.4,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10259995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omics profile of iPSC-derived astrocytes from Progressive Supranuclear Palsy (PSP) patients.","authors":"F. Ravagnani, H. Valerio, J. Maués, Arthur N. de Oliveira, R. Puga, Karina Griesi-Oliveira, F. Picosse, H. Ferraz, R. Catharino, G. Ronsein, Patrícia de Carvalho Aguiar","doi":"10.5327/1516-3180.141s1.414","DOIUrl":"https://doi.org/10.5327/1516-3180.141s1.414","url":null,"abstract":"INTRODUCTION\u0000Progressive Supranuclear Palsy (PSP) is a neurodegenerative tauopathy and, to date, the pathophysiological mechanisms in PSP that lead to Tau hyperphosphorylation and neurodegeneration are not clear. In some brain areas, Tau pathology in glial cells appears to precede Tau aggregation in neurons. The development of a model using astrocyte cell lines derived from patients has the potential to identify molecules and pathways that contribute to early events of neurodegeneration. We developed a model of induced pluripotent stem cells (iPSC)-derived astrocytes to investigate the pathophysiology of PSP, particularly early events that might contribute to Tau hyperphosphorylation, applying omics approach to detect differentially expressed genes, metabolites, and proteins, including those from the secretome.\u0000\u0000\u0000METHODS\u0000Skin fibroblasts from PSP patients (without MAPT mutations) and controls were reprogrammed to iPSCs, further differentiated into neuroprogenitor cells (NPCs) and astrocytes. In the 5th passage, astrocytes were harvested for total RNA sequencing. Intracellular and secreted proteins were processed for proteomics experiments. Metabolomics profiling was obtained from supernatants only.\u0000\u0000\u0000RESULTS\u0000We identified hundreds of differentially expressed genes. The main networks were related to cell cycle re-activation in PSP. Several proteins were found exclusively secreted by the PSP group. The cellular processes related to the cell cycle and mitotic proteins, TriC/CCT pathway, and redox signaling were enriched in the secretome of PSP. Moreover, we found distinct sets of metabolites between PSP and controls.\u0000\u0000\u0000CONCLUSION\u0000Our iPSC-derived astrocyte model can provide distinct molecular signatures for PSP patients and it is useful to elucidate the initial stages of PSP pathogenesis.","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"116 1","pages":"105847"},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70949516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitual physical activity and sedentary behavior as predictors of dynapenia in older adults: a cross-sectional study.","authors":"Lucas Dos Santos,&nbsp;Cláudio Bispo de Almeida,&nbsp;Paulo da Fonseca Valença Neto,&nbsp;Rizia Rocha Silva,&nbsp;Isaac Costa Santos,&nbsp;Cezar Augusto Casotti","doi":"10.1590/1516-3180.2023.0070.R1.190523","DOIUrl":"10.1590/1516-3180.2023.0070.R1.190523","url":null,"abstract":"<p><strong>Background: </strong>Dynapenia is a risk factor of mortality. Therefore, the development of low-cost and easy-to-apply tools is essential to optimize the health surveillance actions of older people.</p><p><strong>Objectives: </strong>To compare the time spent on habitual physical activity (HPA) and sedentary behavior (SB) among dynapenic and non-dynapenic older adults and ascertain the predictive ability of these behaviors on outcome.</p><p><strong>Design and setting: </strong>A cross-sectional population epidemiological survey was conducted involving 208 older adults.</p><p><strong>Methods: </strong>HPA and SB were quantified using the International Physical Activity Questionnaire, and dynapenia was identified by handgrip strength (women: 18.37 kgf; men: 26.75 kgf).</p><p><strong>Results: </strong>The prevalence was 24.50%. In both sexes, dynapenic individuals reported a HPA median time of 70.00 minutes/week (min/wk), while non-dynapenic women and men reported HPA median times of 240.00 and 280.00 min/wk, respectively (P < 0.05). For SB among dynapenic individuals, a median of 388.75 min/day was observed in women and 428.57 min/d in men. In contrast, non-dynapenic women and men had 291.42 and 274.28 min/day in SB (P < 0.05), respectively. The best cutoff HPA to discriminate the outcome was 150.00 min/wk in women (sensitivity: 73.30%; specificity: 60.67%) and 140.00 min/wk in men (sensitivity, 71.43%; specificity, 61.54%). The best cutoff SB was 381.43 min/day in women (sensitivity, 53.30%; specificity, 84.80%) and 351.43 min/day in men (sensitivity, 71.43%; specificity, 73.85%).</p><p><strong>Conclusion: </strong>Older individuals with dynapenia spent less time on HPA and more time in SB. Furthermore, HPA was found to be a better discriminator of dynapenic individuals, and SB better discriminated non-dynapenic individuals.</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":"142 1","pages":"e2023070"},"PeriodicalIF":1.4,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}