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Abstract PR-010: Collateral amplification of the KRAS linked gene PTHLH governs pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability PR-010: KRAS相关基因PTHLH的侧支扩增控制胰腺癌的生长和转移，揭示了一种新的治疗易感性
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-pr-010
Jason R. Pitarresi, Robert J. Norgard, Anna M. Chiarella, Kensuke Suzuki, R. Kremer, B. Stanger, A. Rustgi
{"title":"Abstract PR-010: Collateral amplification of the KRAS linked gene PTHLH governs pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability","authors":"Jason R. Pitarresi, Robert J. Norgard, Anna M. Chiarella, Kensuke Suzuki, R. Kremer, B. Stanger, A. Rustgi","doi":"10.1158/1538-7445.panca21-pr-010","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-pr-010","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"77 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76833464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-088: Classification based on efficiency of mRNA translation reveals a metabolically-dependent subtype of pancreatic cancer PO-088:基于mRNA翻译效率的分类揭示了胰腺癌的代谢依赖亚型
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-088
Sauyeun Shin, R. Nicolle, Mehdi Liauzun, Jacobo Solórzano, A. Brunel, C. Jean, R. Samain, J. Raffenne, C. Neuzillet, Carine Joffre, Stephane Rocci, J. Iovanna, N. Dusetti, O. Larsson, S. Pyronnet, C. Bousquet, Y. Martineau
{"title":"Abstract PO-088: Classification based on efficiency of mRNA translation reveals a metabolically-dependent subtype of pancreatic cancer","authors":"Sauyeun Shin, R. Nicolle, Mehdi Liauzun, Jacobo Solórzano, A. Brunel, C. Jean, R. Samain, J. Raffenne, C. Neuzillet, Carine Joffre, Stephane Rocci, J. Iovanna, N. Dusetti, O. Larsson, S. Pyronnet, C. Bousquet, Y. Martineau","doi":"10.1158/1538-7445.panca21-po-088","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-088","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"45 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87462891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-086: Exploring therapeutic strategies against pancreatic ductal adenocarcinoma (PDAC) PO-086:胰腺导管腺癌(PDAC)的治疗策略探索
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-086
Vasiliki Liaki
{"title":"Abstract PO-086: Exploring therapeutic strategies against pancreatic ductal adenocarcinoma (PDAC)","authors":"Vasiliki Liaki","doi":"10.1158/1538-7445.panca21-po-086","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-086","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"19 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90261718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PR-011: Loss of compensatory feedback mechanism involving splicing factor SRSF1 accelerates KrasG12D-mediated pancreatic cancer initiation PR-011:剪接因子SRSF1代偿反馈机制缺失加速krasg12d介导的胰腺癌起始
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-pr-011
Ledong Wan, Kuan-Ting Lin, M. Rahman, Zhikai Wang, Youngkyu Park, D. Tuveson, A. Krainer
{"title":"Abstract PR-011: Loss of compensatory feedback mechanism involving splicing factor SRSF1 accelerates KrasG12D-mediated pancreatic cancer initiation","authors":"Ledong Wan, Kuan-Ting Lin, M. Rahman, Zhikai Wang, Youngkyu Park, D. Tuveson, A. Krainer","doi":"10.1158/1538-7445.panca21-pr-011","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-pr-011","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"75 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80427174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification 摘要PR-008: Kdm6去甲基化酶是胰腺癌发生、进展和亚型分化的关键调控因子
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-pr-008
Laura Leonhardt, Lucia Y. Li, David I. Berrios, Sudipta Ashe, A. M. Hendley, Grace E. Kim, M. Hebrok
{"title":"Abstract PR-008: Kdm6 demethylases are critical regulators of pancreatic cancer initiation, progression and subtype specification","authors":"Laura Leonhardt, Lucia Y. Li, David I. Berrios, Sudipta Ashe, A. M. Hendley, Grace E. Kim, M. Hebrok","doi":"10.1158/1538-7445.panca21-pr-008","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-pr-008","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"46 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85462785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-089: Identification of a LAMC2-regulated network featuring targetable effectors for dual therapies in pancreatic cancer PO-089:鉴定一个lamc2调控的网络，具有靶向效应，可用于胰腺癌的双重治疗
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-089
Shruthi Narayanan, O. Erice, Iker Feliu, C. Vicentini, Rodrigo Entrialgo-Cadierno, K. Valencia, E. Guruceaga, P. Khatri, Vicenzo Corbo, Silvestre Vicent Cambra, M. Ponz-Sarvisé
{"title":"Abstract PO-089: Identification of a LAMC2-regulated network featuring targetable effectors for dual therapies in pancreatic cancer","authors":"Shruthi Narayanan, O. Erice, Iker Feliu, C. Vicentini, Rodrigo Entrialgo-Cadierno, K. Valencia, E. Guruceaga, P. Khatri, Vicenzo Corbo, Silvestre Vicent Cambra, M. Ponz-Sarvisé","doi":"10.1158/1538-7445.panca21-po-089","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-089","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"36 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78887455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-093: JNK2 suppresses the growth and invasion of pancreatic cancer and is opposed by JNK1 PO-093: JNK2抑制胰腺癌的生长和侵袭，被JNK1拮抗
IF 7.3 1区 生物学
Science Signaling Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-093
Jingwei Shi, X. Tian, M. Kornmann, B. Traub
{"title":"Abstract PO-093: JNK2 suppresses the growth and invasion of pancreatic cancer and is opposed by JNK1","authors":"Jingwei Shi, X. Tian, M. Kornmann, B. Traub","doi":"10.1158/1538-7445.panca21-po-093","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-093","url":null,"abstract":"","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"97 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76983073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling. TLR5-鞭毛蛋白复合物的结构：病原体检测的新模式，保守的受体二聚化信号传导。
IF 7.3 1区 生物学
Science Signaling Pub Date : 2012-05-08
Jinghua Lu, Peter D Sun
{"title":"The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling.","authors":"Jinghua Lu, Peter D Sun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Knowledge about how Toll-like receptors (TLRs) recognize pathogenic ligands is critical to understanding how these receptors are activated and to designing therapeutic compounds that target this family of receptors for inflammatory diseases. The crystal structure of TLR5 in complex with its bacterial ligand flagellin revealed that the ligand-binding mode for TLR5 is distinct from that of previously characterized TLRs. Nevertheless, like other TLRs, TLR5 forms a dimer in response to ligand binding. This work contributes to our current knowledge of TLR function and further demonstrates the ability of TLRs to couple versatile ligand recognition to a conserved receptor signaling mechanism.</p>","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"5 223","pages":"pe11"},"PeriodicalIF":7.3,"publicationDate":"2012-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727914/pdf/nihms-492373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30708100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular signaling and the origins of the sensations of itch and pain. 细胞内信号传导和痒痛感觉的起源。
IF 7.3 1区 生物学
Science Signaling Pub Date : 2011-08-23
Sang-Kyou Han, Melvin I Simon
{"title":"Intracellular signaling and the origins of the sensations of itch and pain.","authors":"Sang-Kyou Han,&nbsp;Melvin I Simon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The skin is the largest sensory organ of the body. It is innervated by a diverse array of primary sensory neurons, including a heterogeneous subset of unmyelinated afferents called C fibers. C fibers, sometimes classified as nociceptors, can detect various painful stimuli, including temperature extremes. However, it is increasingly evident that these afferents respond to various pruritic stimuli and transmit information to the brain that is perceived as itch; this can subsequently drive scratching behavior. Although itch and pain are distinct sensations, they are closely related and can, under certain circumstances, antagonize each other. However, it is not clear precisely when, where, and how the processes generating these two sensations originate and how they are dissociated. Clues have come from the analysis of the activities of specific ligands and their receptors. New data indicate that specific pruritic ligands carrying both itch and pain information are selectively recognized by different G protein–coupled receptors (GPCRs), and this information may be transduced through different intracellular circuits in the same neuron. These findings raise questions about the intracellular mechanisms that preprocess and perhaps encode GPCR-mediated signals.</p>","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"4 187","pages":"er3"},"PeriodicalIF":7.3,"publicationDate":"2011-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30187058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wiping Out Memories 清除记忆
IF 7.3 1区 生物学
Science Signaling Pub Date : 2010-11-19 DOI: 10.1126/SCIENCE.330.6007.1019-A
P. Stern
{"title":"Wiping Out Memories","authors":"P. Stern","doi":"10.1126/SCIENCE.330.6007.1019-A","DOIUrl":"https://doi.org/10.1126/SCIENCE.330.6007.1019-A","url":null,"abstract":"The subunit composition of AMPA receptors at lateral amygdala synapses changes after the acquisition of associative fear. Inhibition of fear responses can be unexpectedly reversed even when a subject is perfectly safe. This can lead to inappropriate reactions to a fear-associated trigger, such as a bright light or loud noise. This type of reaction appears to underpin posttraumatic stress disorder, but there is little understanding of when training to inhibit fear may fail or succeed. Using a combination of electrophysiology and behavioral training in mice, Clem and Huganir observed that fear conditioning increased synaptic transmission by calcium-permeable AMPA receptors into the part of the brain that controls emotional responses (the amygdala). This effect lasted for about a week, during which the fearful memories could be erased if the animals were trained to reduce conditioned fear responses. Postmortem brain slices showed that the fear-induced synaptic changes also reversed, except in transgenic mice with a mutant subunit of the AMPA receptor. R. L. Clem, R. L. Huganir, Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science 330, 1108–1112 (2010). [Abstract] [Full Text]","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":"10 1","pages":"ec361 - ec361"},"PeriodicalIF":7.3,"publicationDate":"2010-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78184061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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