Science Signaling最新文献_第3页

The structure of the TLR5-flagellin complex: a new mode of pathogen detection, conserved receptor dimerization for signaling. TLR5-鞭毛蛋白复合物的结构：病原体检测的新模式，保守的受体二聚化信号传导。

IF 7.3 1区生物学

Science Signaling Pub Date : 2012-05-08

Jinghua Lu, Peter D Sun

引用次数: 0

Intracellular signaling and the origins of the sensations of itch and pain. 细胞内信号传导和痒痛感觉的起源。

IF 7.3 1区生物学

Science Signaling Pub Date : 2011-08-23

Sang-Kyou Han, Melvin I Simon

{"title":"Intracellular signaling and the origins of the sensations of itch and pain.","authors":"Sang-Kyou Han, Melvin I Simon","doi":"","DOIUrl":"","url":null,"abstract":"The skin is the largest sensory organ of the body. It is innervated by a diverse array of primary sensory neurons, including a heterogeneous subset of unmyelinated afferents called C fibers. C fibers, sometimes classified as nociceptors, can detect various painful stimuli, including temperature extremes. However, it is increasingly evident that these afferents respond to various pruritic stimuli and transmit information to the brain that is perceived as itch; this can subsequently drive scratching behavior. Although itch and pain are distinct sensations, they are closely related and can, under certain circumstances, antagonize each other. However, it is not clear precisely when, where, and how the processes generating these two sensations originate and how they are dissociated. Clues have come from the analysis of the activities of specific ligands and their receptors. New data indicate that specific pruritic ligands carrying both itch and pain information are selectively recognized by different G protein–coupled receptors (GPCRs), and this information may be transduced through different intracellular circuits in the same neuron. These findings raise questions about the intracellular mechanisms that preprocess and perhaps encode GPCR-mediated signals.","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2011-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30187058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wiping Out Memories 清除记忆

IF 7.3 1区生物学

Science Signaling Pub Date : 2010-11-19 DOI: 10.1126/SCIENCE.330.6007.1019-A

P. Stern

引用次数: 0

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. 从特定生化物种的多重摄动测量推断信号通路拓扑结构。

IF 7.3 1区生物学

Science Signaling Pub Date : 2010-01-01

Tian-Rui Xu, Vladislav Vyshemirsky, Amélie Gormand, Alex von Kriegsheim, Mark Girolami, George S Baillie, Dominic Ketley, Allan J Dunlop, Graeme Milligan, Miles D Houslay, Walter Kolch

{"title":"Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.","authors":"Tian-Rui Xu, Vladislav Vyshemirsky, Amélie Gormand, Alex von Kriegsheim, Mark Girolami, George S Baillie, Dominic Ketley, Allan J Dunlop, Graeme Milligan, Miles D Houslay, Walter Kolch","doi":"","DOIUrl":"","url":null,"abstract":"The specification of biological decisions by signaling pathways is encoded by the interplay between activation dynamics and network topologies. Although we can describe complex networks, we cannot easily determine which topology the cell actually uses to transduce a specific signal. Experimental testing of all plausible topologies is infeasible because of the combinatorially large number of experiments required to explore the complete hypothesis space. Here, we demonstrate that Bayesian inference-based modeling provides an approach to explore and constrain this hypothesis space,permitting the rational ranking of pathway models. Our approach can use measurements of a limited number of biochemical species when combined with multiple perturbations. As proof of concept, we examined the activation of the extracellular signal-regulated kinase (ERK) pathway by epidermal growth factor. The predicted and experimentally validated model shows that both Raf-1 and, unexpectedly,B-Raf are needed to fully activate ERK in two different cell lines. Thus, our formal methodology rationally infers evidentially supported pathway topologies even when a limited number of biochemical and kinetic measurements are available.","PeriodicalId":49560,"journal":{"name":"Science Signaling","volume":null,"pages":null},"PeriodicalIF":7.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29205816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making Memories Last 让回忆永存

IF 7.3 1区生物学

Science Signaling Pub Date : 2009-08-25 DOI: 10.1126/science.325_919e

P. Stern

引用次数: 1