RHOA 司机在胃癌患者中另辟蹊径。

IF 7.3 1区生物学

Science Signaling Pub Date : 2023-12-19 DOI:10.1126/scisignal.adk9171

Dorothy Benton, Jonathan Chernoff

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引用次数: 0

摘要

致癌的小鸟苷三磷酸酶（GTP酶）通常以一组影响其内在生化功能的有限激活突变为特征，但在胃癌中经常发生突变的RHOA似乎并没有阅读说明书。Schaefer 等人之前研究了胃癌中的 Y42C RHOA 突变，在本期的《科学信号》（Science Signaling）杂志上，他们研究了稍不常见的 L57V 突变，发现单个 RHOA 突变会产生不同的、不可预测的信号转导结果。

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RHOA drivers take alternate routes in gastric cancer.

Oncogenic small guanosine triphosphatases (GTPases) are often characterized by a limited set of activating mutations that affect their intrinsic biochemical function, but RHOA-which is frequently mutated in gastric cancer-appears not to have read the instruction manual. Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling, Schaefer et al. take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes.

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来源期刊

Science Signaling Biochemistry, Genetics and Molecular Biology-Molecular Biology

自引率

0.00%

发文量

148

期刊介绍： Science Signaling is a weekly, online multidisciplinary journal dedicated to the life sciences. Our editorial team's mission is to publish studies that elucidate the fundamental mechanisms underlying biological processes across various organisms. We prioritize research that offers novel insights into physiology, elucidates aberrant mechanisms leading to disease, identifies potential therapeutic targets and strategies, and characterizes the effects of drugs both in vitro and in vivo.