Seminars in Diagnostic Pathology最新文献_第5页

The differential diagnosis of lymphoepithelial lesion of the salivary gland 唾液腺淋巴上皮病变的鉴别诊断。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.04.004

Makoto Urano , Masato Nakaguro

引用次数: 0

Review of immunohistochemistry techniques: Applications, current status, and future perspectives 免疫组化技术综述：应用、现状和未来展望。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.05.001

Dinku Yigzaw Mebratie , Gashaw Getaneh Dagnaw

{"title":"Review of immunohistochemistry techniques: Applications, current status, and future perspectives","authors":"Dinku Yigzaw Mebratie , Gashaw Getaneh Dagnaw","doi":"10.1053/j.semdp.2024.05.001","DOIUrl":"10.1053/j.semdp.2024.05.001","url":null,"abstract":"<div><p>The Hematoxylin and Eosin stain is a cornerstone in histopathology that facilitates the microscopic examination of tissue samples for identifying infections and tumors. However, challenges arise from the similar appearances of diseases and cells, prompting the emergence of Immunohistochemistry (IHC) as an important technique. This review summarizes the principles, procedures, and applications and future perspectives of IHC, a prevalent immunostaining method allowing the detection of specific proteins in tissue sections. The multistep IHC process involves fixation, embedding, sectioning, antigen retrieval, blocking, detection, counterstaining, mounting, and visualization, with interpretation relying on factors such as microanatomic distribution and staining intensity. Common errors in IHC such as non-specific staining, tissue artifacts, inadequately inactivation of endogenous peroxidase activity and cross-reactivity, can substantially affect the accuracy and reliability of results, thereby impacting the interpretation of biological findings. Serving diagnostic, prognostic, predictive, and therapeutic roles in various conditions, including tumors, infectious diseases, neurodegenerative disorders, and muscle diseases, IHC remains pivotal despite its intricate nature. The adoption of digital pathology emerges as a progressive enhancement, addressing limitations and ensuring more accurate analyses in histopathology.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Pages 154-160"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00034-0

引用次数: 0

Aggressive Mediastinal Lymphomas 侵袭性纵隔淋巴瘤

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2021.06.010

Xiaoqiong Wang , Wei Wang , Francisco Vega , Andres E. Quesada

引用次数: 0

Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors Birt-Hogg-Dubé 综合征全貌：聚焦肾肿瘤的临床病理前景

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.01.008

Jialong Wu , Jian Lu , Chin-Lee Wu , Min Lu

{"title":"Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors","authors":"Jialong Wu , Jian Lu , Chin-Lee Wu , Min Lu","doi":"10.1053/j.semdp.2024.01.008","DOIUrl":"10.1053/j.semdp.2024.01.008","url":null,"abstract":"<div><p><span><span>Birt-Hogg-Dubé syndrome (BHD) represents a rare autosomal dominant<span> tumor predisposition syndrome characterized by skin lesions, </span></span>lung cysts<span>, and renal tumors<span><span>. The predominant histological subtypes of BHD-related renal tumors include hybrid oncocytoma-chromophobe tumors, oncocytomas, and chromophobe renal cell carcinomas, all exhibiting eosinophilic/oncocytic features. </span>Immunohistochemistry staining for KIT (CD117) and </span></span></span>CK7<span> exhibits variability in these tumor types. Germline mutations<span><span> in FLCN have been consistently identified. Generally, patients with BHD demonstrate a favorable prognosis with minimal metastatic potential. Nonetheless, the comprehensive elucidation of pathological characteristics of BHD remains incomplete, particularly in BHD-associated renal tumors that deviate from the previously identified subtypes, thereby complicating the differential diagnosis. In this review, we provide a comprehensive overview of BHD encompassing epidemiology, clinical manifestations, genetic and </span>molecular pathogenesis, as well as clinical diagnostic modalities. Emphasis is placed on clinicopathological features, specifically focusing on BHD-associated renal tumors. Collectively, this review aims to present the latest insights into BHD which benefits in the early detection, therapeutic decision-making, and prognosis prediction in BHD cases, and deepen the understanding of sporadic renal tumors.</span></span></p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Pages 119-124"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Playing editorial catch up 在编辑方面迎头赶上。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.05.002

Justin A. Bishop

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00032-7

引用次数: 0

Pathology of hereditary renal cell carcinoma syndromes 遗传性肾细胞癌综合征病理学

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.01.010

Chin-Lee Wu

引用次数: 0

A review of prognostic factors in squamous cell carcinoma of the vulva: Evidence from the last decade 外阴鳞状细胞癌预后因素综述：过去十年的证据。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2020.09.009

Julia Chen , Hoang LN

引用次数: 0

High-grade salivary carcinomas: A current insight on diagnostic pathology and the key to clinical decision making 高级别唾液腺癌：病理诊断的最新见解和临床决策的关键。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-04-17 DOI: 10.1053/j.semdp.2024.04.002

Yoshitaka Utsumi , Masato Nakaguro , Yuichiro Tada , Toshitaka Nagao

{"title":"High-grade salivary carcinomas: A current insight on diagnostic pathology and the key to clinical decision making","authors":"Yoshitaka Utsumi , Masato Nakaguro , Yuichiro Tada , Toshitaka Nagao","doi":"10.1053/j.semdp.2024.04.002","DOIUrl":"10.1053/j.semdp.2024.04.002","url":null,"abstract":"<div><p>High-grade carcinomas of the salivary glands are a group of several tumor entities with highly malignant histologic appearances, and have an aggressive biological behavior accompanied by poor a prognosis. In general, they require more intensive treatment than low- or intermediate-grade carcinomas. High-grade salivary carcinomas are rare and the microscopic features often overlap between different tumor types, making an appropriate diagnosis challenging in daily practice settings. However, with recent rapid advances in molecular pathology and molecular-targeted therapy in this field, there is a growing need to properly classify tumors, rather than just diagnosing the cases as “high-grade carcinomas”. This leads to specific treatment strategies. In this article, we review representative high-grade salivary gland carcinomas, including salivary duct carcinoma and its histologic subtypes, high-grade mucoepidermoid carcinoma, solid-type adenoid cystic carcinoma, and high-grade transformation of low- or intermediate-grade carcinomas, and discuss their differential diagnoses and clinical implications. Other rare entities, such as neuroendocrine carcinoma, NUT carcinoma, and metastatic carcinoma, should also be considered before diagnosing high-grade carcinoma, NOS. Of these tumors, salivary duct carcinoma has received the most attention because of its strong association with androgen deprivation and anti-HER2 therapies. Other tumor-type-specific treatments include anti-TRK therapy for high-grade transformation of secretory carcinoma, but further therapeutic options are expected to be developed in the future. It should be emphasized that detailed histological evaluation with adequate sampling, in addition to the effective use of molecular ancillary tests, is of the utmost importance for a suitable diagnosis.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 197-206"},"PeriodicalIF":2.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0