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Seminars in Diagnostic Pathology最新文献

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The basaloid-spectrum of salivary gland tumors: A focused review with practical diagnostic considerations 唾液腺肿瘤的基底细胞谱：重点回顾与实际诊断考虑。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-06-13 DOI: 10.1053/j.semdp.2024.06.003
Doreen N. Palsgrove
{"title":"The basaloid-spectrum of salivary gland tumors: A focused review with practical diagnostic considerations","authors":"Doreen N. Palsgrove","doi":"10.1053/j.semdp.2024.06.003","DOIUrl":"10.1053/j.semdp.2024.06.003","url":null,"abstract":"<div><p>Basaloid salivary gland neoplasms are a diverse and varied group of benign and malignant tumors. The term ‘basaloid’ is broadly used in reference to cells with elevated nuclear to cytoplasmic ratio, sparse cytoplasm, and hyperchromatic nuclei. However, a subset may also fit within the “small round blue cell tumor” morphologic category or the “biphasic” salivary gland tumor category. Furthermore, there are no established thresholds for the proportion of basaloid tumor cells needed to consider a tumor within the basaloid spectrum. Given the implicit variability in what is considered a basaloid salivary gland tumor, one may question the inclusion of certain entities (canalicular adenoma, <em>HMGA2</em>::<em>WIF1</em> pleomorphic adenoma, polymorphous adenocarcinoma) in this review based on classic morphologic features. However, salivary gland tumors with even minor basaloid components may appear ‘basaloid’ in small biopsy specimens and, thus, a choice was made to focus on common and uncommon diagnostic differentials with this in mind.</p><p>Entities that will be covered in this review also include basal cell adenoma and basal cell adenocarcinoma, adenoid cystic carcinoma, lymphoepithelial carcinoma, sialoblastoma, adamantinoma-like Ewing Sarcoma, NUT carcinoma, and carcinoma showing thymus-like differentiation.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 173-181"},"PeriodicalIF":2.9,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clearing the clouds of uncertainty: Foreword for the special issue “Diagnostic pitfalls of salivary gland tumor pathology” 拨开不确定性的云雾：涎腺肿瘤病理学诊断陷阱 "特刊前言
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-06-08 DOI: 10.1053/j.semdp.2024.06.002
Masato Nakaguro
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引用次数: 0
Mucin-rich salivary gland tumors 富含粘液蛋白的唾液腺肿瘤。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-06-08 DOI: 10.1053/j.semdp.2024.06.001
Justin A. Bishop
{"title":"Mucin-rich salivary gland tumors","authors":"Justin A. Bishop","doi":"10.1053/j.semdp.2024.06.001","DOIUrl":"10.1053/j.semdp.2024.06.001","url":null,"abstract":"<div><p>Salivary gland neoplasms characterized by abundant mucin production are rare but have long been recognized. Due to their scarcity, precise classification has long eluded these mucin-rich tumors. Recent molecular discoveries, however, have shed considerable light on the genetic underpinnings of mucin-rich salivary gland neoplasms. This manuscript will review the most up-to-date information on this fascinating group of salivary gland neoplasms.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 165-172"},"PeriodicalIF":2.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic clues and pitfalls in salivary gland fine-needle aspiration cytology 唾液腺细针穿刺细胞学的诊断线索和误区。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-03 DOI: 10.1053/j.semdp.2024.04.003
Masato Nakaguro
{"title":"Diagnostic clues and pitfalls in salivary gland fine-needle aspiration cytology","authors":"Masato Nakaguro","doi":"10.1053/j.semdp.2024.04.003","DOIUrl":"10.1053/j.semdp.2024.04.003","url":null,"abstract":"<div><p>Salivary gland tumors (SGT) display morphological diversity and pose diagnostic challenges. Preoperative fine needle aspiration cytology (FNAC) is a minimally invasive and efficient diagnostic test. However, due to the limited sample size, the final diagnosis may not be established based on FNAC alone. Although cytomorphology and architecture are usually preserved on FNAC, morphologic changes specific to FNAC can complicate the diagnosis. The Milan System for Reporting Salivary Gland Cytopathology categorizes complex FNAC interpretations. Because the cytological diagnosis is closely linked to the histological diagnosis, a multidimensional approach considering the possibility of several differential diagnoses is necessary. From the standpoint of treatment, distinguishing high-grade malignancy from low-grade malignancy is more important than distinguishing malignancy from benign tumors.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 207-211"},"PeriodicalIF":2.9,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasm” Seminars in Diagnostic Pathology 31 (2014) 66-88 增生性、修复性和反应性良性骨病变在诊断上可能与真正的骨肿瘤相混淆 "病理诊断研讨会 31 (2014) 66-88 的更正。
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2020.07.002
Mark R. Wick MD , Michael B. McDermott MB, MRCPath , Paul E. Swanson MD
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引用次数: 0
MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00033-9
{"title":"MASTHEAD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(24)00033-9","DOIUrl":"https://doi.org/10.1053/S0740-2570(24)00033-9","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Page IFC"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TABLE OF CONTENTS (p/u from previous issue w/updates) 目 录（上期内容，有更新）
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00035-2
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(24)00035-2","DOIUrl":"https://doi.org/10.1053/S0740-2570(24)00035-2","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Page ii"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257024000352/pdfft?md5=2c80d06250b385fb74ca619080690cb9&pid=1-s2.0-S0740257024000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The differential diagnosis of lymphoepithelial lesion of the salivary gland 唾液腺淋巴上皮病变的鉴别诊断。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.04.004
Makoto Urano , Masato Nakaguro
{"title":"The differential diagnosis of lymphoepithelial lesion of the salivary gland","authors":"Makoto Urano ,&nbsp;Masato Nakaguro","doi":"10.1053/j.semdp.2024.04.004","DOIUrl":"10.1053/j.semdp.2024.04.004","url":null,"abstract":"<div><p>The differential diagnosis of salivary gland lesions with epithelial components and lymphoid stroma is often challenging. Salivary gland carcinoma with tumor-associated lymphoid proliferation, tumors composed of both epithelial and lymphoid components, lymphoid neoplasms in the salivary gland, and inflammatory lesions are all included in this category. It encompasses inflammatory lesions and neoplastic lesions. With the exception of Warthin tumors, these lesions are rare, making them more difficult to diagnose. Carcinoma showing thymus-like elements has recently been reported in the salivary gland. Similar to thymic carcinoma, tumor cells are positive for CD5 and are accompanied by T lymphocytes.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 190-196"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of immunohistochemistry techniques: Applications, current status, and future perspectives 免疫组化技术综述：应用、现状和未来展望。
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.05.001
Dinku Yigzaw Mebratie , Gashaw Getaneh Dagnaw
{"title":"Review of immunohistochemistry techniques: Applications, current status, and future perspectives","authors":"Dinku Yigzaw Mebratie ,&nbsp;Gashaw Getaneh Dagnaw","doi":"10.1053/j.semdp.2024.05.001","DOIUrl":"10.1053/j.semdp.2024.05.001","url":null,"abstract":"<div><p>The Hematoxylin and Eosin stain is a cornerstone in histopathology that facilitates the microscopic examination of tissue samples for identifying infections and tumors. However, challenges arise from the similar appearances of diseases and cells, prompting the emergence of Immunohistochemistry (IHC) as an important technique. This review summarizes the principles, procedures, and applications and future perspectives of IHC, a prevalent immunostaining method allowing the detection of specific proteins in tissue sections. The multistep IHC process involves fixation, embedding, sectioning, antigen retrieval, blocking, detection, counterstaining, mounting, and visualization, with interpretation relying on factors such as microanatomic distribution and staining intensity. Common errors in IHC such as non-specific staining, tissue artifacts, inadequately inactivation of endogenous peroxidase activity and cross-reactivity, can substantially affect the accuracy and reliability of results, thereby impacting the interpretation of biological findings. Serving diagnostic, prognostic, predictive, and therapeutic roles in various conditions, including tumors, infectious diseases, neurodegenerative disorders, and muscle diseases, IHC remains pivotal despite its intricate nature. The adoption of digital pathology emerges as a progressive enhancement, addressing limitations and ensuring more accurate analyses in histopathology.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Pages 154-160"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00034-0
{"title":"EDITORIAL BOARD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(24)00034-0","DOIUrl":"https://doi.org/10.1053/S0740-2570(24)00034-0","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Page i"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257024000340/pdfft?md5=e8cb2039794ff6bf25db07c8b30b89c6&pid=1-s2.0-S0740257024000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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