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Seminars in Diagnostic Pathology最新文献

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Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma 探讨罕见性：混合型韧带增生-丛状成釉细胞瘤的临床观察与组织病理学多样性。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.12.001
Dr. Sakshi Deorah (Junior Resident), Dr. Shalini Gupta (Professor and Head)
{"title":"Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma","authors":"Dr. Sakshi Deorah (Junior Resident),&nbsp;Dr. Shalini Gupta (Professor and Head)","doi":"10.1053/j.semdp.2024.12.001","DOIUrl":"10.1053/j.semdp.2024.12.001","url":null,"abstract":"<div><div>Ameloblastoma represents a rare and locally aggressive odontogenic neoplasm, notable for its histopathological diversity. Among its subtypes, the desmoplastic and plexiform variants are relatively rare, with the hybrid form, encompassing both architectural patterns, representing an even more exceptional entity. This article delineates the clinical, radiological, and histopathological profile of a 45-year-old male presenting with pain persisting over the past month in the right posterior maxillary region. Radiographic imaging displayed a mixed radiolucent-radiopaque lesion with poorly demarcated margins, indicative of an aggressive pathology. Histopathological examination revealed a hybrid ameloblastoma, juxtaposing desmoplastic zones with densely fibrotic stroma and classic plexiform sections with epithelial strands in a reticular configuration. This unique hybrid variant underscores the complexity of ameloblastomas and necessitates comprehensive histopathological assessment, as radiological interpretations may prove insufficient for accurate diagnosis. Such detailed analysis contributes to understanding the biological behavior of this rare form, underscoring the need for heightened clinical awareness and continued investigative focus.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 22-24"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating controversies in primary intraosseous carcinoma: A comprehensive literature review concerning the odontogenic origin and diagnostic challenges 原发性骨内癌的争议：关于牙源性起源和诊断挑战的综合文献综述。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2025.01.001
Ayushi Jain , Sharon John , Saloni Verma , Shalini Gupta
{"title":"Navigating controversies in primary intraosseous carcinoma: A comprehensive literature review concerning the odontogenic origin and diagnostic challenges","authors":"Ayushi Jain ,&nbsp;Sharon John ,&nbsp;Saloni Verma ,&nbsp;Shalini Gupta","doi":"10.1053/j.semdp.2025.01.001","DOIUrl":"10.1053/j.semdp.2025.01.001","url":null,"abstract":"<div><div>Primary intraosseous carcinoma (PIOC) is a rare and challenging jawbone malignancy often linked to odontogenic cysts. With minimal connection to oral mucosa and a low incidence rate, PIOC presents significant diagnostic difficulties, often mimicking other odontogenic lesions. Histogenesis and the correct classification of the lesion remains debated, with theories suggesting origins from odontogenic epithelium or cysts. Chronic inflammation may contribute to malignant transformation, though genetic predispositions could also play a role in the pathogenesis. This review underscores the current knowledge of the lesion with the need for standardized diagnostic markers and an enhanced understanding of PIOC origin to improve diagnostic accuracy and treatment outcomes.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 50-54"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications 乳腺唾液腺样肿瘤：具有临床意义的组织病理学和遗传学特征。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.003
Christopher J. Schwartz , Gregor Krings
{"title":"Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications","authors":"Christopher J. Schwartz ,&nbsp;Gregor Krings","doi":"10.1053/j.semdp.2024.10.003","DOIUrl":"10.1053/j.semdp.2024.10.003","url":null,"abstract":"<div><div>Salivary gland-like tumors of the breast are rare neoplasms that share morphologic, immunophenotypic, and/or genetic features with their salivary gland counterparts, highlighting a shared underlying histopathogenesis in most cases. Salivary gland-like carcinomas included in the World Health Organization classification of breast tumors are adenoid cystic carcinoma, secretory carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, and the exceedingly rare polymorphous adenocarcinoma. These carcinomas are usually triple negative for estrogen receptor and progesterone receptor expression and HER2 overexpression, yet generally have favorable prognosis, in contrast to high-grade triple negative carcinomas of no special type. On the other hand, a small subset, such as solid-basaloid adenoid cystic carcinoma, rare high-grade carcinomas, and those associated with transformation to other types of high-grade invasive carcinoma can behave more aggressively. Other salivary gland-like tumors of the breast, such as pleomorphic adenoma and adenomyoepithelioma, are usually benign but can rarely undergo malignant transformation. Although clinical experience with salivary gland-like breast tumors is overall limited, their recognition and accurate classification has important implications for prognosis and clinical management, especially to avoid overtreatment of salivary gland-like carcinomas. The identification of characteristic genetic alterations and/or immunohistochemical surrogates in many of these tumors has practical applications to establishing an accurate diagnosis and directing clinical management. This review highlights the histopathologic and genetic characteristics of salivary gland-like breast tumors and the implications of the diagnosis for current clinical management.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 272-284"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00094-7
{"title":"MASTHEAD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(24)00094-7","DOIUrl":"10.1053/S0740-2570(24)00094-7","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Page IFC"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current challenges in breast pathology 当前乳腺病理学面临的挑战。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.004
Raza S. Hoda, Patrick J. McIntire
{"title":"Current challenges in breast pathology","authors":"Raza S. Hoda,&nbsp;Patrick J. McIntire","doi":"10.1053/j.semdp.2024.10.004","DOIUrl":"10.1053/j.semdp.2024.10.004","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Page 251"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer: A review emphasizing clinical concepts pathologists need to know 乳腺癌患者前哨淋巴结的术中评估：强调病理学家需要了解的临床概念的综述。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.06.004
Andrew Sciallis
{"title":"Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer: A review emphasizing clinical concepts pathologists need to know","authors":"Andrew Sciallis","doi":"10.1053/j.semdp.2024.06.004","DOIUrl":"10.1053/j.semdp.2024.06.004","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 285-292"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00095-9
{"title":"EDITORIAL BOARD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(24)00095-9","DOIUrl":"10.1053/S0740-2570(24)00095-9","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Page i"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TABLE OF CONTENTS (p/u from previous issue w/updates) 目 录（上期内容，有更新）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00096-0
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(24)00096-0","DOIUrl":"10.1053/S0740-2570(24)00096-0","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Page ii"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Lobular lesions of the breast: From the classic to the variants" "乳腺小叶病变：从经典到变异"。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.002
Erinn Downs , H. Evin Gulbahce
{"title":"\"Lobular lesions of the breast: From the classic to the variants\"","authors":"Erinn Downs ,&nbsp;H. Evin Gulbahce","doi":"10.1053/j.semdp.2024.10.002","DOIUrl":"10.1053/j.semdp.2024.10.002","url":null,"abstract":"<div><div>The aim of this review is to provide the surgical pathologist an overview of lobular lesions, from <em>in situ</em> to invasive carcinoma and the variants, by discussing the epidemiology, clinical characteristics, morphology, immunohistochemistry, known molecular data as well as the treatment recommendations. The recognition of histologic variants of both <em>in situ</em> and invasive lobular carcinoma has expanded the differential diagnosis. Awareness of these different entities is important as treatment recommendations continue to evolve.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 258-271"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative evaluation of surgical margins in breast cancer 乳腺癌手术边缘的术中评估。
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.06.005
Lauren Kopicky , Betty Fan , Stephanie A. Valente
{"title":"Intraoperative evaluation of surgical margins in breast cancer","authors":"Lauren Kopicky ,&nbsp;Betty Fan ,&nbsp;Stephanie A. Valente","doi":"10.1053/j.semdp.2024.06.005","DOIUrl":"10.1053/j.semdp.2024.06.005","url":null,"abstract":"<div><div>Achieving clear resection margins at the time of lumpectomy is essential for optimal patient outcomes. Margin status is traditionally determined by pathologic evaluation of the specimen and often is difficult or impossible for the surgeon to definitively know at the time of surgery, resulting in the need for re-operation to obtain clear surgical margins. Numerous techniques have been investigated to enhance the accuracy of intraoperative margin and are reviewed in this manuscript.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 293-300"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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