Seminars in Diagnostic Pathology最新文献

Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma.

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-12-14 DOI: 10.1053/j.semdp.2024.12.001

Dr Sakshi Deorah, Dr Shalini Gupta

{"title":"Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma.","authors":"Dr Sakshi Deorah, Dr Shalini Gupta","doi":"10.1053/j.semdp.2024.12.001","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.12.001","url":null,"abstract":"Ameloblastoma represents a rare and locally aggressive odontogenic neoplasm, notable for its histopathological diversity. Among its subtypes, the desmoplastic and plexiform variants are relatively rare, with the hybrid form, encompassing both architectural patterns, representing an even more exceptional entity. This article delineates the clinical, radiological, and histopathological profile of a 45-year-old male presenting with pain persisting over the past month in the right posterior maxillary region. Radiographic imaging displayed a mixed radiolucent-radiopaque lesion with poorly demarcated margins, indicative of an aggressive pathology. Histopathological examination revealed a hybrid ameloblastoma, juxtaposing desmoplastic zones with densely fibrotic stroma and classic plexiform sections with epithelial strands in a reticular configuration. This unique hybrid variant underscores the complexity of ameloblastomas and necessitates comprehensive histopathological assessment, as radiological interpretations may prove insufficient for accurate diagnosis. Such detailed analysis contributes to understanding the biological behavior of this rare form, underscoring the need for heightened clinical awareness and continued investigative focus.","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intricacies of plexiform unicystic ameloblastoma: A rare intraluminal journey in the jaw. 丛状单囊釉母细胞瘤的复杂性：一种罕见的颌骨腔内病变。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-07 DOI: 10.1053/j.semdp.2024.11.001

Dr Sakshi Deorah, Dr Sharon John, Dr Shalini Gupta

{"title":"Intricacies of plexiform unicystic ameloblastoma: A rare intraluminal journey in the jaw.","authors":"Dr Sakshi Deorah, Dr Sharon John, Dr Shalini Gupta","doi":"10.1053/j.semdp.2024.11.001","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.11.001","url":null,"abstract":"Ameloblastoma is a true benign odontogenic epithelial tumor, primarily arising in the jaw, and ranks as the second most prevalent odontogenic neoplasm following odontoma. Known for its diverse clinical, radiographic, and histological manifestations, ameloblastoma encompasses a wide spectrum of presentations. Unicystic ameloblastomas (UAs), a less common and generally less aggressive variant, appear as cystic lesions that can mimic ordinary jaw cysts in their clinical and radiologic features. However, histological examination reveals a distinctive odontogenic epithelium lining the cyst cavities, with some cases exhibiting luminal and mural growth. This article presents a unique case involving a 40-year-old female patient who experienced swelling in the right posterior maxilla for four months. Initially presumed to be a routine ameloblastoma, subsequent histopathological analysis identified it as an intraluminal type of UA with rare plexiform changes. It is characterized by a cystic space lined with ameloblast-like cells in a plexiform arrangement, setting it apart from other UA subtypes. Imaging often reveals a unilocular cystic appearance, which may obscure differential diagnosis by closely resembling other odontogenic cysts. The variations within ameloblastoma have always sparked considerable discussion, and we aim to elucidate the reasons behind this specific transformation and its distinctive characteristics.","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targetoid hemosiderotic hemangioma: A review article. 靶形血蜘蛛网状血管瘤：综述文章。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-05 DOI: 10.1053/j.semdp.2024.11.002

Toan Bui, Laura M Rezac, C Alexis Noble, Ariel R Velasquez-Evers, Robert T Brodell

{"title":"Targetoid hemosiderotic hemangioma: A review article.","authors":"Toan Bui, Laura M Rezac, C Alexis Noble, Ariel R Velasquez-Evers, Robert T Brodell","doi":"10.1053/j.semdp.2024.11.002","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.11.002","url":null,"abstract":"Background: Targetoid hemosiderotic hemangioma (THH), also known as hobnail lymphatic malformation (HLL) or hobnail hemangioma, is an uncommon, acquired vascular lesion with a dynamic presentation and an unclear etiology. It predominantly affects adults with an age range from 9 to 78 years and has no gender predilection. The lesion is thought to arise from trauma, leading to micro-shunts between small lesional capillaries and adjacent lymphatic vessels.Methods: This review article examines the clinical, histologic, and immunohistochemical characteristics of THH, and explores its differential diagnoses, including Kaposi's sarcoma, solitary angiokeratoma, retiform hemangioendothelioma, and Dabska tumor.Results: THH presents clinically as asymptomatic, well-circumscribed lesions with a central red-blue and/or brown papule surrounded by a peripheral ecchymotic ring, giving a \"bull's-eye\" or targetoid appearance. Histologically, THH exhibits dilated vascular channels lined by hobnail endothelial cells, red blood cell extravasation, hemosiderin deposition, and mild lymphohistiocytic infiltrates. Immunohistochemistry is positive for D2-40, a lymphatic endothelial marker.Conclusions: Heightened awareness of the clinical appearance of these solitary targetoid lesions is important. Without clinical-pathologic correlation, the branching telangiectatic vessels and purpura seen in THH could suggest more concerning vascular lesions like Kaposi sarcoma.","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications 乳腺唾液腺样肿瘤：具有临床意义的组织病理学和遗传学特征。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.003

Christopher J. Schwartz , Gregor Krings

{"title":"Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications","authors":"Christopher J. Schwartz , Gregor Krings","doi":"10.1053/j.semdp.2024.10.003","DOIUrl":"10.1053/j.semdp.2024.10.003","url":null,"abstract":"<div><div>Salivary gland-like tumors of the breast are rare neoplasms that share morphologic, immunophenotypic, and/or genetic features with their salivary gland counterparts, highlighting a shared underlying histopathogenesis in most cases. Salivary gland-like carcinomas included in the World Health Organization classification of breast tumors are adenoid cystic carcinoma, secretory carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, and the exceedingly rare polymorphous adenocarcinoma. These carcinomas are usually triple negative for estrogen receptor and progesterone receptor expression and HER2 overexpression, yet generally have favorable prognosis, in contrast to high-grade triple negative carcinomas of no special type. On the other hand, a small subset, such as solid-basaloid adenoid cystic carcinoma, rare high-grade carcinomas, and those associated with transformation to other types of high-grade invasive carcinoma can behave more aggressively. Other salivary gland-like tumors of the breast, such as pleomorphic adenoma and adenomyoepithelioma, are usually benign but can rarely undergo malignant transformation. Although clinical experience with salivary gland-like breast tumors is overall limited, their recognition and accurate classification has important implications for prognosis and clinical management, especially to avoid overtreatment of salivary gland-like carcinomas. The identification of characteristic genetic alterations and/or immunohistochemical surrogates in many of these tumors has practical applications to establishing an accurate diagnosis and directing clinical management. This review highlights the histopathologic and genetic characteristics of salivary gland-like breast tumors and the implications of the diagnosis for current clinical management.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 272-284"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00094-7

引用次数: 0

Current challenges in breast pathology 当前乳腺病理学面临的挑战。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.004

Raza S. Hoda, Patrick J. McIntire

引用次数: 0

Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer: A review emphasizing clinical concepts pathologists need to know 乳腺癌患者前哨淋巴结的术中评估：强调病理学家需要了解的临床概念的综述。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.06.004

Andrew Sciallis

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00095-9

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录（上期内容，有更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00096-0

引用次数: 0

"Lobular lesions of the breast: From the classic to the variants" "乳腺小叶病变：从经典到变异"。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.002

Erinn Downs , H. Evin Gulbahce

引用次数: 0