Seminars in Diagnostic Pathology最新文献

Frozen section evaluation of deceased donor kidney biopsies: A field guide

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-20 DOI: 10.1016/j.semdp.2025.150900

Andrea R. Lightle

{"title":"Frozen section evaluation of deceased donor kidney biopsies: A field guide","authors":"Andrea R. Lightle","doi":"10.1016/j.semdp.2025.150900","DOIUrl":"10.1016/j.semdp.2025.150900","url":null,"abstract":"<div><div>The demand for donated kidneys is steadily increasing, making it critical that the transplant community maximizes the use of organs procured from deceased donors. When a donated kidney becomes available, a transplant program evaluates the suitability of the organ for their patients and will choose whether to decline or accept. A pre-implantation biopsy may be performed if the transplant center is unsure about the suitability of the organ. More than half of deceased donor kidneys are biopsied prior to implantation, and “biopsy findings” is the most commonly cited reason for a kidney not being accepted for transplantation. This is despite the fact that retrospective analyses at multiple centers have revealed that the results of kidney pre-implantation biopsies are poorly reproducible, inaccurate, and do not correlate with clinical outcomes. A prospective study comparing the scores of paraffin-embedded pre-implantation biopsies given by on-call pathologists to scores given by experienced renal pathologists found that only the evaluation by the renal pathologist was significantly associated with graft function and survival. In 2023, the Organ Procurement and Transplantation Network implemented the Standardized Kidney Biopsy Reporting and Data Collection policy, specifying how kidney pre-implantation biopsies should be scored and reported. This article aims to increase awareness of the reporting criteria for kidney pre-implantation biopsies, thereby increasing the accuracy and reproducibility of the results and decreasing the number of deceased donor kidneys that are inappropriately discarded.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 3","pages":"Article 150900"},"PeriodicalIF":2.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frozen sections in gastrointestinal, pancreatobiliary and hepatic pathology: A review

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-12 DOI: 10.1016/j.semdp.2025.150894

Tony El Jabbour , Kisong Kim , Mohamad Besher Ourfali , Hwajeong Lee

引用次数: 0

An update on mixed phenotype acute leukemia

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-11 DOI: 10.1016/j.semdp.2025.150893

Olga K Weinberg , Bo Zhang , Sharon K Germans, Weina Chen

{"title":"An update on mixed phenotype acute leukemia","authors":"Olga K Weinberg , Bo Zhang , Sharon K Germans, Weina Chen","doi":"10.1016/j.semdp.2025.150893","DOIUrl":"10.1016/j.semdp.2025.150893","url":null,"abstract":"<div><div>Mixed phenotype acute leukemias (MPALs) are a heterogeneous group of acute leukemias that show differentiation along more than one lineage. MPAL are rare and account for <5 % of all acute leukemias and demonstrate an inferior prognosis compared with standard acute lymphoblastic or myeloid leukemias. Historically, due to the limited understanding of its underlying pathogenesis, there were no well-established classification schemes, leading to difficulty in both diagnosis and treatment. With the advent of new nomenclature and algorithms, including the European Group for the Immunological Characterization of Leukemias (EGIL) scoring system, World Health Organization (WHO) tumor classification, and International Consensus Classification (ICC), these entities are better defined and there have been significant changes in clinical management. Additionally, an increasing variety of molecular and cytogenetic abnormalities have been recognized, which have improved the diagnostic classifications and may represent important potential therapeutic targets. However, due to its rarity, current evidence and recommendations on the clinical approach to MPAL are largely based on retrospective studies with relatively small cohorts, and it remains a diagnostic and therapeutic dilemma. In this review, we discuss the most updated classifications, genomic complexity, and diagnostic and therapeutic strategies for MPAL.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 3","pages":"Article 150893"},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive Lobular Neoplasia: Review and Updates.

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-04 DOI: 10.1016/j.semdp.2025.150883

Youley Tjendra, Barbara Susnik

{"title":"Non-invasive Lobular Neoplasia: Review and Updates.","authors":"Youley Tjendra, Barbara Susnik","doi":"10.1016/j.semdp.2025.150883","DOIUrl":"https://doi.org/10.1016/j.semdp.2025.150883","url":null,"abstract":"<p><p>Non-invasive lobular neoplasia (LN) encompasses atypical lobular hyperplasia (ALH), classic lobular carcinoma in situ (CLCIS), florid lobular carcinoma in situ (FLCIS), and pleomorphic lobular carcinoma in situ (PLCIS). Lobular neoplasia is a neoplastic epithelial proliferation of the terminal duct lobular unit. A defining feature is discohesion due to the loss of E-cadherin, a protein that facilitates cell-to-cell adhesion. Lobular neoplasia is both a risk factor and a non-obligate precursor of invasive breast carcinoma. Classic LN, characterized by small, non-cohesive monomorphic cells, includes ALH and classic LCIS. While classic LN is usually not seen on imaging and, therefore, is diagnosed incidentally, FLCIS and PLCIS are typically the imaging targets, most often manifesting as calcifications. Unlike classic LN, which is typically hormone receptor-positive and HER2-negative, FLCIS and PLCIS may present with less favorable phenotypes. While ALH and CLCIS diagnosed on concordant core biopsy are generally managed with surveillance with or without chemoprevention, complete surgical excision is recommended for FLCIS and PLCIS due to high upgrade rates to invasive carcinoma. Accurate classification of non-invasive breast neoplastic lesions is essential for guiding treatment. This review provides an overview of the clinical features, pathology, and management of lobular neoplasia, emphasizing the importance of accurate diagnosis and individualized patient care.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":"150883"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The history of the microscope reflects advances in science and medicine 显微镜的历史反映了科学和医学的进步

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/j.semdp.2024.01.002

Caitlin A. Noble , Andrew P. Biesemier , Sarah F. McClees , Aljunaid M. Alhussain , Stephen E. Helms , Robert T. Brodell

引用次数: 0

Mark Wick contributions to pathology of the mediastinum 马克-维克对纵隔病理学的贡献

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/j.semdp.2024.01.006

Horacio Maluf

{"title":"Mark Wick contributions to pathology of the mediastinum","authors":"Horacio Maluf","doi":"10.1053/j.semdp.2024.01.006","DOIUrl":"10.1053/j.semdp.2024.01.006","url":null,"abstract":"<div><div><span><span><span>Mark Wick made a wide range of contributions to the field of mediastinal pathology. Early papers amplified the spectrum of neuroendocrine carcinomas<span><span> of the thymus and brought attention to the aggressive nature of this tumor, also highlighting the occurrence of coexisting </span>carcinoid tumor and </span></span>small cell carcinoma<span> of this organ. The controversial issue of thymoma<span> classification was addressed in several papers and editorial comments, while also reporting a case of metastatic thymoma. A series of thymic carcinomas<span> as well a report on the unusual clear cell variant bear his name as one of the authors. He summarized the topic of mediastinal cyst in a review published in 2005. </span></span></span></span>Sarcomas arising in </span>mediastinal germ cell tumors<span> were also within the purview of his interests, with a publication of series of seven cases. He reviewed the topic of inflammatory myofibroblastic tumor of the heart and added a case to the existing literature. Two books dedicated to different aspect of mediastinal pathology also carry his name in the front cover in association with Drs Taazelar in one and Marchevsky in the other.</span></div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150835"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical-pathologic correlation: The impact of grossing at the bedside 临床与病理相关性：床旁大体检查的影响

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/j.semdp.2024.01.007

C. Alexis Noble , Chinmoy Bhate , Buu T. Duong , Allison R. Cruse , Robert T. Brodell , Riley C. Hanus

{"title":"Clinical-pathologic correlation: The impact of grossing at the bedside","authors":"C. Alexis Noble , Chinmoy Bhate , Buu T. Duong , Allison R. Cruse , Robert T. Brodell , Riley C. Hanus","doi":"10.1053/j.semdp.2024.01.007","DOIUrl":"10.1053/j.semdp.2024.01.007","url":null,"abstract":"<div><div><span>The unenlightened clinician may submit a skin specimen to the lab and expect an “answer.” The experienced clinician knows that in performing skin biopsies, it is critical to select the most appropriate: 1) anatomic location for the biopsy</span><span><span><sup>1</sup></span></span><sup>,</sup><span><span><sup>2</sup></span></span>; 2) type of biopsy<span><span><sup>1</sup></span></span><sup>,</sup><span><span><sup>2</sup></span></span><span><span>; 3) depth and breadth of the biopsy; and 4) medium for hematoxylin and </span>eosin<span> staining (formalin) or direct immunofluorescence (Michel's Transport Medium or normal saline).</span></span><span><span><sup>2</sup></span></span> Demographic information, anatomic location, clinical context, and differential diagnosis are all critical components of a properly completed requisition form.<span><span>3</span></span>, <span><span>4</span></span>, <span><span>5</span></span><span> Proper biopsy design and appropriate grossing of the tissue at the bedside should be added to this list. In this article, we review the basics of gross pathologic examination and then provide four examples to demonstrate that optimal clinical-pathologic correlation requires the clinician consider the needs of the pathologist when tissue is presented to the lab.</span></div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150836"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/S0740-2570(25)00022-X

引用次数: 0

Targetoid hemosiderotic hemangioma: A review article 靶形血蜘蛛网状血管瘤：综述文章。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/j.semdp.2024.11.002

Toan Bui , Laura M. Rezac , C. Alexis Noble , Ariel R. Velasquez-Evers , Robert T. Brodell

{"title":"Targetoid hemosiderotic hemangioma: A review article","authors":"Toan Bui , Laura M. Rezac , C. Alexis Noble , Ariel R. Velasquez-Evers , Robert T. Brodell","doi":"10.1053/j.semdp.2024.11.002","DOIUrl":"10.1053/j.semdp.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Targetoid hemosiderotic hemangioma (THH), also known as hobnail lymphatic malformation (HLL) or hobnail hemangioma, is an uncommon, acquired vascular lesion with a dynamic presentation and an unclear etiology. It predominantly affects adults with an age range from 9 to 78 years and has no gender predilection. The lesion is thought to arise from trauma, leading to micro-shunts between small lesional capillaries and adjacent lymphatic vessels.</div></div><div><h3>Methods</h3><div>This review article examines the clinical, histologic, and immunohistochemical characteristics of THH, and explores its differential diagnoses, including Kaposi's sarcoma, solitary angiokeratoma, retiform hemangioendothelioma, and Dabska tumor.</div></div><div><h3>Results</h3><div>THH presents clinically as asymptomatic, well-circumscribed lesions with a central red-blue and/or brown papule surrounded by a peripheral ecchymotic ring, giving a \"bull's-eye\" or targetoid appearance. Histologically, THH exhibits dilated vascular channels lined by hobnail endothelial cells, red blood cell extravasation, hemosiderin deposition, and mild lymphohistiocytic infiltrates. Immunohistochemistry is positive for D2-40, a lymphatic endothelial marker.</div></div><div><h3>Conclusions</h3><div>Heightened awareness of the clinical appearance of these solitary targetoid lesions is important. Without clinical-pathologic correlation, the branching telangiectatic vessels and purpura seen in THH could suggest more concerning vascular lesions like Kaposi sarcoma.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 2","pages":"Article 150869"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-01 DOI: 10.1053/S0740-2570(25)00021-8

引用次数: 0