Seminars in Diagnostic Pathology最新文献

Intricacies of plexiform unicystic ameloblastoma: A rare intraluminal journey in the jaw 丛状单囊釉母细胞瘤的复杂性：一种罕见的颌骨腔内病变。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.11.001

Dr. Sakshi Deorah , Dr. Sharon John , Dr. Shalini Gupta

{"title":"Intricacies of plexiform unicystic ameloblastoma: A rare intraluminal journey in the jaw","authors":"Dr. Sakshi Deorah , Dr. Sharon John , Dr. Shalini Gupta","doi":"10.1053/j.semdp.2024.11.001","DOIUrl":"10.1053/j.semdp.2024.11.001","url":null,"abstract":"<div><div>Ameloblastoma is a true benign odontogenic epithelial tumor, primarily arising in the jaw, and ranks as the second most prevalent odontogenic neoplasm following odontoma. Known for its diverse clinical, radiographic, and histological manifestations, ameloblastoma encompasses a wide spectrum of presentations. Unicystic ameloblastomas (UAs), a less common and generally less aggressive variant, appear as cystic lesions that can mimic ordinary jaw cysts in their clinical and radiologic features. However, histological examination reveals a distinctive odontogenic epithelium lining the cyst cavities, with some cases exhibiting luminal and mural growth. This article presents a unique case involving a 40-year-old female patient who experienced swelling in the right posterior maxilla for four months. Initially presumed to be a routine ameloblastoma, subsequent histopathological analysis identified it as an intraluminal type of UA with rare plexiform changes. It is characterized by a cystic space lined with ameloblast-like cells in a plexiform arrangement, setting it apart from other UA subtypes. Imaging often reveals a unilocular cystic appearance, which may obscure differential diagnosis by closely resembling other odontogenic cysts. The variations within ameloblastoma have always sparked considerable discussion, and we aim to elucidate the reasons behind this specific transformation and its distinctive characteristics.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 18-21"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates)

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/S0740-2570(25)00004-8

引用次数: 0

Sclerosing Odontogenic Carcinoma: UPLIFTS and pitfalls 硬化性牙源性癌：UPLIFTS 和陷阱。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.09.004

Arushi Tomar , Sharon John , Shalini Gupta

{"title":"Sclerosing Odontogenic Carcinoma: UPLIFTS and pitfalls","authors":"Arushi Tomar , Sharon John , Shalini Gupta","doi":"10.1053/j.semdp.2024.09.004","DOIUrl":"10.1053/j.semdp.2024.09.004","url":null,"abstract":"<div><div>Sclerosing Odontogrenic Carcinoma (SOC) is a recent addition to the category of odontogenic tumours, which was first described by Koutlas <em>et al</em>. in 2008. It was described as primary intraosseous carcinoma with bland cytology, sclerotic stroma with presence of local infiltration showing aggressive behaviour. Following its discovery and the presentation of first case, only a handful of cases have been reported till date, which may be due to underreporting of the cases or inclusion of the case to other diagnosis since the features of this tumour overlaps with many other lesions of the oral cavity. Due to this factor, the pathogenesis of this category of tumours still remains enigmatic. The clinical features as a result of this factor are also not reported of the consistent type and overlaps with the already existing clinical features of other lesions. This lesion has only appeared till date twice in WHO classification of Odontogenic Cysts and Tumours. Thereby, the literature on this category is still in paucity. Therefore, the present review takes into account all of the features, diagnostic criteria and the markers discovered for this lesion and would provide an insight into whether this lesion is justified as a malignant lesion or should not be considered as a separate category of odontogenic tumour.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 29-32"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemangiomatous ameloblastoma; A separate entity?”

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2025.01.003

Roshna Sankar , Sharon John , Priya Devi , Saloni Verma , Priyanka Singh , Shalini Gupta

引用次数: 0

Calcifying odontogenic cysts: A novel outlook on classification, diagnosis and management 牙源性钙化囊肿：关于分类、诊断和管理的新观点。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.08.006

Sharon John, Priya Devi, Kriti Sharma, Roshna Sankar, Shalini Gupta

{"title":"Calcifying odontogenic cysts: A novel outlook on classification, diagnosis and management","authors":"Sharon John, Priya Devi, Kriti Sharma, Roshna Sankar, Shalini Gupta","doi":"10.1053/j.semdp.2024.08.006","DOIUrl":"10.1053/j.semdp.2024.08.006","url":null,"abstract":"<div><h3>Background</h3><div>The Calcifying Odontogenic Cysts (COC) displays a wide range of clinical and histopathological variations as well as diverse biological behaviors. This diversity has led to confusion and disagreement regarding the terminology and classification of this lesion. The previous classification attempts to categorize COC into two concepts. The first concept, termed \"monistic,\" suggests that all COCs are neoplastic despite the majority being cystic in structure and seemingly non-neoplastic. The second concept, known as \"dualistic,\" posits that COC comprises two distinct entities: a cyst and a neoplasm. This research discusses various previous classifications of COC found in the literature and proposes a new, straightforward universal classification based solely on histopathology, aiming to facilitate understanding for surgeons.</div></div><div><h3>Material and methods</h3><div>Fifteen cases of COC have been collected with clinicopathological parameters including detailed information regarding patient demographics, symptoms, anatomical site, radiological characteristics, duration of evolution, recurrence, and types of histopathology according to the proposed classification.</div></div><div><h3>Result</h3><div>A total of fifteen cases of COC were analyzed. According to the histological analysis of the proposed classification Type 1: 5 (33.3), Type II: 4 (26.6), Type III: 3(20), and Type IV:3(20) and recurrence in 3 (20 %) of cases.</div></div><div><h3>Conclusion</h3><div>It simplifies the complexities arising from variations in the cystic linings of type IV of COC, which can be overlooked and have caused recurrence in the current research. Therefore, the key requirement for arriving at a validated and practical conclusion lies in the accurate histological classification of calcifying odontogenic cysts and their impact on treatment.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 1-4"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual presentation of calcifying odontogenic cyst with literature review 牙源性钙化囊肿的不寻常表现及文献综述。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.09.003

Priya Devi , Sharon John , Saloni Verma , Roshna Sankar , Rajeev Kumar Singh , Shalini Gupta

{"title":"An unusual presentation of calcifying odontogenic cyst with literature review","authors":"Priya Devi , Sharon John , Saloni Verma , Roshna Sankar , Rajeev Kumar Singh , Shalini Gupta","doi":"10.1053/j.semdp.2024.09.003","DOIUrl":"10.1053/j.semdp.2024.09.003","url":null,"abstract":"<div><div>The calcifying odontogenic cyst (COC) is an uncommon developmental odontogenic cyst, the oral counterpart of Malherbe's cutaneous calcifying epithelioma (pilomatricoma). This article presents two unique cases of calcifying odontogenic cysts each exhibiting distinctive histopathological features and its literature review. One case with an unexpected finding of cholesterol granuloma (CG), a rare occurrence in non-inflammatory cysts within an unusual location between two maxillary central incisors. One more instance involves the presence of a compound odontome in conjunction with COC. The cases underscore the clinical and histopathological diversity of COC and highlight the importance of radiological and histopathological assessments for accurate diagnosis. The unexpected association of COC with cholesterol granuloma challenges traditional diagnostic expectations. Additionally, the second case suggests that COCs may warrant sub-categorization to better understand their varied presentations and biological behavior. This article contributes to the expanding knowledge of COC, emphasizing the significance of documenting rare cases to enhance comprehension of its nature, pathogenesis, and oral cavity origin.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 33-36"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MASTHEAD (p/u from previous issue)

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/S0740-2570(25)00005-X

引用次数: 0

Calcifying cystic odontogenic tumour: Dilemma and pitfalls 钙化性囊性牙源性肿瘤：困境与陷阱

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.09.005

Arushi Tomar, Sharon John, Saloni Verma, Shalini Gupta

{"title":"Calcifying cystic odontogenic tumour: Dilemma and pitfalls","authors":"Arushi Tomar, Sharon John, Saloni Verma, Shalini Gupta","doi":"10.1053/j.semdp.2024.09.005","DOIUrl":"10.1053/j.semdp.2024.09.005","url":null,"abstract":"<div><div>Odontogenic lesions are a category of lesions, which are found to be arising from the remnants of the tooth-bearing tissues of the body, that can be cystic in nature as a result of degeneration or as a result of excessive proliferation of these cells, can result in the formation of odontogenic tumours which are found in gnathic bones in the body. Since their discovery in literature and the explanation provided for their pathogenesis, these lesions have been the subject of debate and controversy amongst researchers as well as practitioners. Thereby, this review has taken into consideration one such odontogenic tumour, Calcifying Cystic Odontogenic Tumour (CCOT), which first were included under the namesake (Calcifying odontogenic cyst) as a sperate subheading under this cyst, but now has been designated under the category of tumours along with various histologic subtypes classified and described henceforth. Although the lesion has been removed in the recent classification, a wide variety of lesions in biphasic form has been reported in the past. Therefore, this present review takes a sneak-peek into this lesion with insight into its presentation, incidence, aetiology, pathogenesis, histopathology and all the controversies surrounding this category of lesion and the current literature about this lesion with proving the fact that this needs to be considered again in the category of odontogenic tumours.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 25-28"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the debates surrounding keratoameloblastoma: An in-depth review of an emerging entity 探讨围绕角膜成釉细胞瘤的争论：对一个新兴实体的深入回顾。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2025.01.002

Saloni Verma, Ayushi Jain, Sharon John, Prashasti Chundawat, Shalini Gupta

引用次数: 0

Molecular insights into hybrid tumors: Exploring the heterogeneity in plexiform ameloblastoma 混合瘤的分子研究：探索丛状母细胞瘤的异质性。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.09.002

Dr. Sharon John , Dr. Arushi Tomar , Dr. Ayushi Jain , Dr. Shalini Gupta

{"title":"Molecular insights into hybrid tumors: Exploring the heterogeneity in plexiform ameloblastoma","authors":"Dr. Sharon John , Dr. Arushi Tomar , Dr. Ayushi Jain , Dr. Shalini Gupta","doi":"10.1053/j.semdp.2024.09.002","DOIUrl":"10.1053/j.semdp.2024.09.002","url":null,"abstract":"<div><div>For many years, odontogenic tumors have been known to present both clinical and histopathological challenges due to their origins in the epithelial, ectomesenchymal, and/or mesenchymal components of tooth-forming tissues. Gaining a comprehensive understanding of both common and rare odontogenic tumors is crucial for their effective study and clinical management. One particularly puzzling tumor is the \"plexiform ameloblastoma,\" a variant of the solid multicystic ameloblastoma. This term describes a distinct pattern of epithelial proliferation within the cystic cavity. Numerous studies have emphasized the variability of the stromal component, further highlighting the enigmatic nature of ameloblastoma. The presence of unique and rare features, such as primitive, mature desmoplastic, hemangiomatous, or ghost cells within the stroma of plexiform ameloblastoma, underscores the differentiation potential of the neoplastic odontogenic epithelium and offers significant insights into the tissue reactions associated with this condition. This case review discusses four instances of plexiform ameloblastoma, illustrating various atypical stromal changes and their influence on patient prognosis. It also provides important criteria for analyzing stromal alterations related to this complex odontogenic tumor.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 5-12"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0