Seminars in Diagnostic Pathology最新文献

Intraoperative examination in bone and soft tissue pathology 术中骨及软组织病理检查

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-17 DOI: 10.1016/j.semdp.2025.150904

Ali Alani , Julio A. Diaz-Perez

引用次数: 0

An adapted & improved validation protocol for digital pathology implementation 一种适应和改进的数字病理学实施验证协议

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-15 DOI: 10.1016/j.semdp.2025.150905

Ying-Han R. Hsu , Iman Ahmed , Juliana Phlamon , Charlotte Carment-Baker , Joyce Yin Tung Chan , Ioannis Prassas , Karen Weiser , Shaza Zeidan , Blaise Clarke , George M. Yousef

{"title":"An adapted & improved validation protocol for digital pathology implementation","authors":"Ying-Han R. Hsu , Iman Ahmed , Juliana Phlamon , Charlotte Carment-Baker , Joyce Yin Tung Chan , Ioannis Prassas , Karen Weiser , Shaza Zeidan , Blaise Clarke , George M. Yousef","doi":"10.1016/j.semdp.2025.150905","DOIUrl":"10.1016/j.semdp.2025.150905","url":null,"abstract":"<div><div>Digital Pathology (DP) is transforming disease diagnosis by providing rapid and efficient analysis of tissue samples. However, ensuring the accuracy and reliability of diagnoses is crucial. This manuscript outlines University Health Network (UHN)'s journey towards the development of a customized validation protocol for implementing a digital workflow for primary clinical assessment. Drawing on guidelines from the Royal College of Pathologists (RCPath) UK and the College of American Pathologists (CAP), UHN has tailored its approach to accommodate the unique needs of its 14 subspecialty groups. Our protocol emphasizes pathologist-led self-validation, integration of diverse subspecialty cases, and a phased rollout with continuous monitoring. Additionally, the use of change management principles inspired by Leeds University (CCP) played a critical role in guiding the process, ensuring pathologists’ comfort with digital workflows, and addressing subspecialty-specific challenges. This comprehensive validation protocol supports UHN’s broader goals of leveraging DP for clinical practice while ensuring patient safety and data integrity.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150905"},"PeriodicalIF":2.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frozen section analysis in community settings: Diagnostic challenges and key considerations 冰冻切片分析在社区设置：诊断的挑战和关键考虑

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-15 DOI: 10.1016/j.semdp.2025.150903

Rashna Meunier, Kisong Kim, Noureldien Darwish, Syed M. Gilani

引用次数: 0

The importance of frozen section analysis in head, neck, and endocrine pathology 冰冻切片分析在头颈部及内分泌病理中的重要性

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-08 DOI: 10.1016/j.semdp.2025.150902

Noureldien Darwish, Syed M. Gilani

引用次数: 0

Intraoperative frozen section diagnosis of lung specimens: An updated review 术中肺标本冰冻切片诊断：最新综述

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-01 DOI: 10.1016/j.semdp.2025.150901

Yuchen Han , Guoping Cai

{"title":"Intraoperative frozen section diagnosis of lung specimens: An updated review","authors":"Yuchen Han , Guoping Cai","doi":"10.1016/j.semdp.2025.150901","DOIUrl":"10.1016/j.semdp.2025.150901","url":null,"abstract":"<div><div>Intraoperative frozen section (FS) diagnosis is a critical step in the management of patients with pulmonary lesions, which provides guidance for surgical resection procedures. Intraoperative FS diagnosis requires a comprehensive approach that integrates clinical information, imaging findings, and histopathological evaluation. Effective communication between pathologists and surgeons is vital for achieving the best practice result. Intraoperative FS diagnosis faces new challenges in the era of new lung cancer screening strategy, changes in histological tumor classification and addition of new lung tumor entities. Below we discuss the challenges in pre-intraoperative assessment and intraoperative diagnosis of pulmonary nodules. Key considerations include clinical information and CT imaging findings. Multiple nodules require strategic sampling, focusing on the most malignant-appearing lesion. Intraoperative FS diagnosis involves recognizing growth patterns and cellular atypia that help distinction of preinvasive lesions, minimal invasive, and invasive tumor although it might be challenging. Distinguishing benign from malignant tumors is also discussed, with emphasis on histological and imaging features. Special considerations include spread through air spaces (STAS), margin assessment, lymphoproliferative disorders, infectious diseases, and benign or uncertain-behavior tumors.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 3","pages":"Article 150901"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathology Intraoperative Consultation 术中会诊

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-21 DOI: 10.1016/j.semdp.2025.150899

Nalin Leelatian , Declan McGuone

引用次数: 0

Frozen section evaluation of deceased donor kidney biopsies: A field guide 冷冻切片评估已故供体肾活检：现场指南

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-20 DOI: 10.1016/j.semdp.2025.150900

Andrea R. Lightle

{"title":"Frozen section evaluation of deceased donor kidney biopsies: A field guide","authors":"Andrea R. Lightle","doi":"10.1016/j.semdp.2025.150900","DOIUrl":"10.1016/j.semdp.2025.150900","url":null,"abstract":"<div><div>The demand for donated kidneys is steadily increasing, making it critical that the transplant community maximizes the use of organs procured from deceased donors. When a donated kidney becomes available, a transplant program evaluates the suitability of the organ for their patients and will choose whether to decline or accept. A pre-implantation biopsy may be performed if the transplant center is unsure about the suitability of the organ. More than half of deceased donor kidneys are biopsied prior to implantation, and “biopsy findings” is the most commonly cited reason for a kidney not being accepted for transplantation. This is despite the fact that retrospective analyses at multiple centers have revealed that the results of kidney pre-implantation biopsies are poorly reproducible, inaccurate, and do not correlate with clinical outcomes. A prospective study comparing the scores of paraffin-embedded pre-implantation biopsies given by on-call pathologists to scores given by experienced renal pathologists found that only the evaluation by the renal pathologist was significantly associated with graft function and survival. In 2023, the Organ Procurement and Transplantation Network implemented the Standardized Kidney Biopsy Reporting and Data Collection policy, specifying how kidney pre-implantation biopsies should be scored and reported. This article aims to increase awareness of the reporting criteria for kidney pre-implantation biopsies, thereby increasing the accuracy and reproducibility of the results and decreasing the number of deceased donor kidneys that are inappropriately discarded.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 3","pages":"Article 150900"},"PeriodicalIF":2.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frozen sections in gastrointestinal, pancreatobiliary and hepatic pathology: A review 胃肠道、胰胆管和肝脏病理的冰冻切片：综述

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-12 DOI: 10.1016/j.semdp.2025.150894

Tony El Jabbour , Kisong Kim , Mohamad Besher Ourfali , Hwajeong Lee

引用次数: 0

An update on mixed phenotype acute leukemia 混合表型急性白血病的最新进展。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-11 DOI: 10.1016/j.semdp.2025.150893

Olga K Weinberg , Bo Zhang , Sharon K Germans, Weina Chen

{"title":"An update on mixed phenotype acute leukemia","authors":"Olga K Weinberg , Bo Zhang , Sharon K Germans, Weina Chen","doi":"10.1016/j.semdp.2025.150893","DOIUrl":"10.1016/j.semdp.2025.150893","url":null,"abstract":"<div><div>Mixed phenotype acute leukemias (MPALs) are a heterogeneous group of acute leukemias that show differentiation along more than one lineage. MPAL are rare and account for <5 % of all acute leukemias and demonstrate an inferior prognosis compared with standard acute lymphoblastic or myeloid leukemias. Historically, due to the limited understanding of its underlying pathogenesis, there were no well-established classification schemes, leading to difficulty in both diagnosis and treatment. With the advent of new nomenclature and algorithms, including the European Group for the Immunological Characterization of Leukemias (EGIL) scoring system, World Health Organization (WHO) tumor classification, and International Consensus Classification (ICC), these entities are better defined and there have been significant changes in clinical management. Additionally, an increasing variety of molecular and cytogenetic abnormalities have been recognized, which have improved the diagnostic classifications and may represent important potential therapeutic targets. However, due to its rarity, current evidence and recommendations on the clinical approach to MPAL are largely based on retrospective studies with relatively small cohorts, and it remains a diagnostic and therapeutic dilemma. In this review, we discuss the most updated classifications, genomic complexity, and diagnostic and therapeutic strategies for MPAL.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 3","pages":"Article 150893"},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive Lobular Neoplasia: Review and Updates. 非侵袭性小叶肿瘤：回顾和最新进展。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-03-04 DOI: 10.1016/j.semdp.2025.150883

Youley Tjendra, Barbara Susnik

{"title":"Non-invasive Lobular Neoplasia: Review and Updates.","authors":"Youley Tjendra, Barbara Susnik","doi":"10.1016/j.semdp.2025.150883","DOIUrl":"https://doi.org/10.1016/j.semdp.2025.150883","url":null,"abstract":"<p><p>Non-invasive lobular neoplasia (LN) encompasses atypical lobular hyperplasia (ALH), classic lobular carcinoma in situ (CLCIS), florid lobular carcinoma in situ (FLCIS), and pleomorphic lobular carcinoma in situ (PLCIS). Lobular neoplasia is a neoplastic epithelial proliferation of the terminal duct lobular unit. A defining feature is discohesion due to the loss of E-cadherin, a protein that facilitates cell-to-cell adhesion. Lobular neoplasia is both a risk factor and a non-obligate precursor of invasive breast carcinoma. Classic LN, characterized by small, non-cohesive monomorphic cells, includes ALH and classic LCIS. While classic LN is usually not seen on imaging and, therefore, is diagnosed incidentally, FLCIS and PLCIS are typically the imaging targets, most often manifesting as calcifications. Unlike classic LN, which is typically hormone receptor-positive and HER2-negative, FLCIS and PLCIS may present with less favorable phenotypes. While ALH and CLCIS diagnosed on concordant core biopsy are generally managed with surveillance with or without chemoprevention, complete surgical excision is recommended for FLCIS and PLCIS due to high upgrade rates to invasive carcinoma. Accurate classification of non-invasive breast neoplastic lesions is essential for guiding treatment. This review provides an overview of the clinical features, pathology, and management of lobular neoplasia, emphasizing the importance of accurate diagnosis and individualized patient care.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":"150883"},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0