Seminars in Diagnostic Pathology最新文献

Bridging Perspectives: Integrating urologist and cytopathologist insights of urine cytology 桥梁观点：整合泌尿科医生和细胞病理学家的尿细胞学见解

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-10-10 DOI: 10.1016/j.semdp.2025.150960

Nikka Khorsandi , Sima Porten , Christopher J. VandenBussche , Nancy Greenland , Poonam Vohra

{"title":"Bridging Perspectives: Integrating urologist and cytopathologist insights of urine cytology","authors":"Nikka Khorsandi , Sima Porten , Christopher J. VandenBussche , Nancy Greenland , Poonam Vohra","doi":"10.1016/j.semdp.2025.150960","DOIUrl":"10.1016/j.semdp.2025.150960","url":null,"abstract":"<div><div>In this comprehensive review, we explore the integration of both cytopathologic and urologic perspectives around interpretation of urine cytology under the Paris System for Reporting Urinary Cytology (TPS) and clinical management. Urine cytology is a pivotal diagnostic tool for urologists, especially in the detection and management of high-grade urothelial carcinoma (HGUC). The review highlights how TPS has standardized urine cytology interpretations through consistent diagnostic criteria and reduced atypical diagnoses. This standardization aids in communication between pathologists and clinicians. There is an educational need to foster more effective collaboration between urologists and cytopathologists. Clinicians are not formally educated about TPS, and guidelines do not exist for how TPS diagnostic categories should impact patient treatment/management. Therefore, as TPS continues to evolve, it is important for pathologists to understand how urologists perceive TPS and use its diagnostic categories. This review addresses the clinical management of various diagnostic categories under TPS, illustrating how urologists integrate urine cytology results with endoscopic and radiologic data to monitor recurrence, progression, and metastasis of bladder cancer. It also covers the adjunctive use of urinary biomarkers and advanced cystoscopic techniques to enhance diagnostic accuracy. By bridging cytopathologic insights with urologic clinical applications, this review provides a holistic understanding of the diagnostic and management strategies for bladder cancer, underscoring the indispensable role of urine cytology in urologic practice.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 6","pages":"Article 150960"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145327168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表（p/u来自上一期，更新）

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-25 DOI: 10.1053/S0740-2570(25)00090-5

引用次数: 0

MASTHEAD (p/u from previous issue) 报头（p/u从上一期）

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-25 DOI: 10.1053/S0740-2570(25)00088-7

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（p/u来自上一期，并有更新）

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-25 DOI: 10.1053/S0740-2570(25)00087-5

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（p/u自上期）

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-25 DOI: 10.1053/S0740-2570(25)00089-9

引用次数: 0

Differential diagnosis of multiple myeloma. 多发性骨髓瘤的鉴别诊断。

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-07 DOI: 10.1016/j.semdp.2025.150944

Miguel Dario Cantu, Weina Chen

{"title":"Differential diagnosis of multiple myeloma.","authors":"Miguel Dario Cantu, Weina Chen","doi":"10.1016/j.semdp.2025.150944","DOIUrl":"https://doi.org/10.1016/j.semdp.2025.150944","url":null,"abstract":"<p><p>Distinguishing multiple myeloma from B-cell lymphomas can be a diagnostic challenge. There can be significant morphologic, immunophenotypic and clinical overlap that may require additional molecular genetic ancillary studies and careful clinical review to render an accurate diagnosis. The focus of this review will be on the differential diagnosis of multiple myeloma with an emphasis on low-grade B-cell lymphomas with plasmacytic differentiation and aggressive B-cell lymphomas with plasmablastic morphology that can mimic true plasma cell neoplasms. Diagnostic approaches to plasmablastic neoplasms, including extramedullary plasmablastic plasmacytoma and distinguishing features of B-cell lymphomas with plasmablastic morphology are discussed. Low-grade B-cell lymphomas with plasmacytic differentiation, including lymphoplasmacytic lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and other low-grade B-cell lymphomas that less frequently exhibit plasmacytic differentiation such as follicular lymphoma and mantle cell lymphoma are also included. Multiple myeloma with CCND1:IGH, which can mimic low-grade B-cell lymphomas and post-treatment plasmacytic proliferations following treatment for B-cell lymphomas with plasmacytic differentiation are also discussed.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":"150944"},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrahepatic cholangiocarcinoma: Current concepts in histopathology, immunohistochemistry, and molecular diagnostics. 肝外胆管癌：组织病理学、免疫组织化学和分子诊断的最新概念。

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-07 DOI: 10.1016/j.semdp.2025.150949

Jared Beyersdorf, M Lisa Zhang

{"title":"Extrahepatic cholangiocarcinoma: Current concepts in histopathology, immunohistochemistry, and molecular diagnostics.","authors":"Jared Beyersdorf, M Lisa Zhang","doi":"10.1016/j.semdp.2025.150949","DOIUrl":"https://doi.org/10.1016/j.semdp.2025.150949","url":null,"abstract":"<p><p>Cholangiocarcinoma (CCA) makes up a diverse group of malignancies that originate from the biliary epithelium. Despite its rarity, this is a highly aggressive group of diseases with a high mortality, which has been increasing on a global scale. Classification of CCA is based on the anatomical site of origin and consists of intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA) cholangiocarcinoma. The pathologic diagnosis of CCA can be challenging from multiple standpoints, including tissue acquisition and interpretation. Surgery is the only curative treatment, but patients often present at late stages, which may not be amenable to surgical treatment. Novel therapies are emerging for CCA, and early genetic testing is essential to identify candidate patients. There is a need for further developments in immunohistochemistry and molecular characterization of CCA to enable earlier diagnosis, especially from limited samples. This review provides a concise overview of current concepts in the pathology of CCA, focusing on diagnostic challenges, histology, staging, immunohistochemistry, and evolving molecular features.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":"150949"},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expanding family of ALK-rearranged Mesenchymal Neoplasms alk重排间充质肿瘤的扩大家族。

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-06 DOI: 10.1016/j.semdp.2025.150947

Abbas Agaimy

{"title":"The expanding family of ALK-rearranged Mesenchymal Neoplasms","authors":"Abbas Agaimy","doi":"10.1016/j.semdp.2025.150947","DOIUrl":"10.1016/j.semdp.2025.150947","url":null,"abstract":"<div><div>The increasing use of next generation sequencing (NGS) technologies has resulted in a rapid increase in molecularly defined mesenchymal entities and enabled molecular characterization of existing phenotypically defined entities. These recent developments have expanded the clinicopathological spectrum of <em>ALK</em>-rearranged neoplasia, at same time highlighting a wide array of non-<em>ALK</em> fusions in many ALK immunoreactive neoplasms. This led to emergence of an “<em>ALK</em> vs. <em>non-ALK fusion</em>” concept among ALK immunoreactive neoplasms. The <em>ALK</em> fusion category includes morphologically defined entities (inflammatory myofibroblastic tumor and related neoplasms and epithelioid fibrous histiocytoma) as well as emerging fibro-/myxoid (“fibroblastic”) neoplasms of skin/ superficial soft tissue and vocal cords and ALK+ (mostly pediatric) histiocytoses. Lastly, diverse categories of unclassified <em>ALK</em> fusion neoplasms have been reported that display tyrosine kinase-like phenotype (CD34+/ S100+), foamy cell/ pseudolipogenic features and unclassified high-grade morphology. On the other hand, the “non-<em>ALK</em> fusion” category expands to include entities with regular/ frequent ALK reactivity (angiomatoid fibrous histiocytoma with <em>EWSR1/FUS::CREB</em>, spindle/ epithelioid cell rhabdomyosarcoma with <em>EWSR1/FUS::TFCP2</em> and unclassified sarcomas with <em>EWSR1/FUS::CREB</em> fusions). The latter category has challenged the value of IHC and/ or FISH alone to confirm or rule out <em>ALK</em> alterations, underlining the pivotal role of NGS to verify the exact driver fusion. Under circumstances, identification of the exact fusion may have therapeutic and/ or prognostic implications. This overview discusses the main <em>ALK</em> fusion entities with emphasis on differential diagnosis.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150947"},"PeriodicalIF":3.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NCOA1/2/3-rearranged low-grade fibroblastic/myofibroblastic spindle cell tumors: including emerging entities beyond the WHO 5th edition of Bone and Soft Tissue Tumors - a systematic review. 重排低级别纤维母细胞/肌纤维母细胞梭形细胞肿瘤：包括WHO第5版骨和软组织肿瘤以外的新兴实体-系统综述

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-06 DOI: 10.1016/j.semdp.2025.150945

Rayan Sibira, Josephine K Dermawan

引用次数: 0

Histopathological and genetic landscape of pancreatic ductal adenocarcinoma and its variants 胰腺导管腺癌及其变异的组织病理学和遗传学研究

IF 3.5 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-08-05 DOI: 10.1016/j.semdp.2025.150948

Nicholas J. Caldwell, M. Lisa Zhang

引用次数: 0