Seminars in Diagnostic Pathology最新文献

Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms 骨髓微环境在多发性骨髓瘤中的作用：生态位对耐药机制的影响

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-22 DOI: 10.1016/j.semdp.2025.150916

Lijie Wang , Mingyue Shi , Andrew Y. Sung , C Cameron Yin , Yanliang Bai , Mingyi Chen

{"title":"Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms","authors":"Lijie Wang , Mingyue Shi , Andrew Y. Sung , C Cameron Yin , Yanliang Bai , Mingyi Chen","doi":"10.1016/j.semdp.2025.150916","DOIUrl":"10.1016/j.semdp.2025.150916","url":null,"abstract":"<div><div>Multiple myeloma (MM) is a blood cancer characterized by the uncontrolled growth of plasma cells in the bone marrow. These malignant plasma cells can proliferate locally and spread to other tissues and organs. The M-protein they produce can lead to various clinical symptoms, including anemia, hypercalcemia, bone pain, bone destruction, and kidney dysfunction. Despite significant advancements in treatment over the past two decades that have improved survival and outcomes for many patients, drug resistance remains a significant therapeutic challenge. This resistance is largely driven by the complex interactions between MM cells and the bone marrow microenvironment (BMME), making long-term disease control difficult. To improve treatment outcomes, it is essential to understand how the BMME supports MM cell growth and survival, as well as how these cells evade therapies. Investigating these processes will help identify key mechanisms behind drug resistance, offering a pathway to develop targeted therapies that can overcome this challenge. This review will explore the intricate relationship between MM cells and the BMME, focusing on how both cellular and non-cellular components of the microenvironment contribute to resistance mechanisms and prompt disease progression. These insights aim to inform future therapeutic strategies to enhance treatment options for MM patients.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150916"},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory rhabdomyoblastic tumor: A review and update 炎性横纹肌母细胞瘤：综述与最新进展

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-20 DOI: 10.1016/j.semdp.2025.150917

Andrew L. Folpe

引用次数: 0

Cytogenetic and molecular aberrations at diagnosis and in prognosis of multiple myeloma 细胞遗传学和分子畸变在多发性骨髓瘤诊断和预后中的作用

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-17 DOI: 10.1016/j.semdp.2025.150915

Beenu Thakral , Anjanaa Vijayanarayanan , L. Jeffrey Medeiros, Pei Lin

{"title":"Cytogenetic and molecular aberrations at diagnosis and in prognosis of multiple myeloma","authors":"Beenu Thakral , Anjanaa Vijayanarayanan , L. Jeffrey Medeiros, Pei Lin","doi":"10.1016/j.semdp.2025.150915","DOIUrl":"10.1016/j.semdp.2025.150915","url":null,"abstract":"<div><div>Multiple myeloma accounts for ∼10 % of all hematologic malignancies. It is genetically a highly heterogeneous disease. Cytogenetic aberrations can be found in only one-third of myeloma cases by karyotyping, in contrast to >90 % by interphase fluorescence in situ hybridization analysis, especially when performed on CD138-enriched plasma cells. Next generation sequencing has shown that mutations affecting the MAP kinase pathway, including <em>KRAS, NRAS</em> and <em>BRAF</em> are the most frequent driver mutations in myeloma detected in up to 40 % of cases. Biallelic <em>TP53</em> inactivation is one of the most important high-risk factor that is associated with poor survival, frequency of which increases in relapsed/refractory myeloma and is rare in MGUS and SMM. <em>De novo</em> plasma cell leukemia is associated with frequent <em>MYC</em> translocations and t(11;14) while plasma cell leukemia associated with a pre-existing myeloma (so-called secondary plasma cell leukemia) more commonly harbors del(17p). Early or primary cytogenetic alterations (such as trisomies and/or one of the <em>IGH</em> translocation) lead to formation of a founder clone which over time expands, and evolves by acquiring additional genetic abnormalities such as copy number and epigenetic changes and secondary mutations contributing to intratumoral heterogeneity seen in myeloma. Thus, presence of clonal heterogeneity at baseline, subsequent linear and branching clonal evolution that occurs with disease progression and therapeutic selection of resistant mutant clones underscores the need for a comprehensive cytogenetic and molecular testing over time. This testing allows for a better understanding of disease pathogenesis and can inform therapeutic options for better patient care and outcomes.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150915"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（p/u来自上一期，并有更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-01 DOI: 10.1053/S0740-2570(25)00043-7

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表（p/u来自上一期，更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-01 DOI: 10.1053/S0740-2570(25)00046-2

引用次数: 0

MASTHEAD (p/u from previous issue) 报头（p/u从上一期）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-01 DOI: 10.1053/S0740-2570(25)00044-9

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（p/u自上期）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-05-01 DOI: 10.1053/S0740-2570(25)00045-0

引用次数: 0

Breast Pathology Through the Digital Lens 数字镜头下的乳腺病理学

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-24 DOI: 10.1016/j.semdp.2025.150914

Alexis Heller, Lakshmi Kowtha, Kriti Tiwari, Malini Harigopal

{"title":"Breast Pathology Through the Digital Lens","authors":"Alexis Heller, Lakshmi Kowtha, Kriti Tiwari, Malini Harigopal","doi":"10.1016/j.semdp.2025.150914","DOIUrl":"10.1016/j.semdp.2025.150914","url":null,"abstract":"<div><div>Digital pathology (DP) has significantly transformed breast pathology at Mount Sinai Hospital by enhancing diagnostic accuracy, collaboration, and education. The institution has integrated the Philips IntelliSite Pathology Solution (PIPS) for primary diagnostic use, which allows for high-resolution whole slide imaging (WSI) of surgical pathology slides. The workflow involves the scanning of glass slides to create digital images, which are then reviewed and annotated by pathologists. Key benefits of this workflow include immediate slide sharing with colleagues, efficient sign-outs, improved detection of low-positive immunohistochemical staining, and detailed measurements of tumors and margins. The ability to access a digital archive for retrospective case reviews further enhances diagnostic capabilities. However, limitations persist, including challenges in visualizing small calcium oxalate crystals and the need for manual interpretation of certain stains. Although the process of digitizing slides initially increased turnaround times, this has been mitigated by increased staffing and scanner availability. Additionally, the transition to DP has already paved the way for artificial intelligence, serving as a benchmark to develop algorithms for prognostic and predictive biomarkers, predict immunotherapy response, and thus transform cancer care. The overall impact of DP on breast pathology is overwhelmingly positive, with continued efforts to address its limitations.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150914"},"PeriodicalIF":2.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of frozen section in gynecologic pathology 冷冻切片在妇科病理中的作用

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-23 DOI: 10.1016/j.semdp.2025.150913

Harsimar Kaur, Minhua Wang

{"title":"The role of frozen section in gynecologic pathology","authors":"Harsimar Kaur, Minhua Wang","doi":"10.1016/j.semdp.2025.150913","DOIUrl":"10.1016/j.semdp.2025.150913","url":null,"abstract":"<div><div>Intraoperative consultation using frozen sections in gynecologic surgery aids in determining the scope of the surgery. The main indications are to evaluate the presence of malignancy, determine the primary site, histologic type, and grade of the tumor, and assess the extent of local tumor invasion and distant spread.</div><div>A thorough gross examination of submitted specimens helps identify critical features such as specimen integrity, tumor size, serosa and ovarian surface involvement, myometrial involvement, and lymph node status. Uterine endometrial carcinomas are classified based on histologic type and grade, with attention to features such as myometrial invasion, cervical stromal involvement, and gross tumor size. Correct evaluation of uterine mesenchymal tumors, ovarian epithelial tumors, sex-cord stromal tumors, and germ cell tumors is essential to guide the decision between conservative and extensive surgical staging. It is challenging but essential to distinguish primary ovarian tumors from metastatic neoplasms. Prompt and clear communication with the operating surgeon is crucial for successful consultation. Providing definitive diagnoses on frozen sections can sometimes be difficult; however, understanding the management algorithm and maintaining an open dialogue with the surgeon about differential diagnoses can help in offering the necessary information for subsequent management steps.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150913"},"PeriodicalIF":2.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative examination in bone and soft tissue pathology 术中骨及软组织病理检查

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-04-17 DOI: 10.1016/j.semdp.2025.150904

Ali Alani , Julio A. Diaz-Perez

引用次数: 0