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Seminars in Diagnostic Pathology最新文献

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Flow cytometry in the diagnosis and prognosis of multiple myeloma 流式细胞术在多发性骨髓瘤诊断和预后中的应用
IF 3.5 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-07-25 DOI: 10.1016/j.semdp.2025.150942
Adam C. Seegmiller
{"title":"Flow cytometry in the diagnosis and prognosis of multiple myeloma","authors":"Adam C. Seegmiller","doi":"10.1016/j.semdp.2025.150942","DOIUrl":"10.1016/j.semdp.2025.150942","url":null,"abstract":"<div><div>Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discusses the immunophenotype of normal plasma cells and how this can be used to distinguish them from neoplastic plasma cells. The prognostic impact of particular immunophenotypic aberrancies is reviewed. Finally, it describes approaches to post-treatment monitoring myeloma by flow cytometry, including measurable residual disease detection and its impact on disease outcomes.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150942"},"PeriodicalIF":3.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NUT-rearranged sarcoma NUT-rearranged肉瘤
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-26 DOI: 10.1016/j.semdp.2025.150941
Sintawat Wangsiricharoen , Jeanne M. Meis , Wendong Yu
{"title":"NUT-rearranged sarcoma","authors":"Sintawat Wangsiricharoen ,&nbsp;Jeanne M. Meis ,&nbsp;Wendong Yu","doi":"10.1016/j.semdp.2025.150941","DOIUrl":"10.1016/j.semdp.2025.150941","url":null,"abstract":"<div><div><em>NUT</em>-rearranged sarcoma is an emerging group of soft tissue sarcomas defined by <em>NUT</em> rearrangement. It is distinct from NUT carcinoma. These sarcomas show a predilection for somatic soft tissue, the thoracic region, the gastrointestinal tract, and body cavities, and affect a wide age range. Histologically, they display one or multiple growth patterns within the tumor, including fibrosarcomatous, round cell, epithelioid/rhabdoid, and hyalinized/nested patterns. Tumor cells invariably express NUT (with the exception of tumors harboring <em>NUTM2</em>) and may have aberrant expression of other markers. Molecularly, <em>NUT</em>-rearranged sarcoma typically involves genes in the MAD transcription family. Those NUT-rearranged sarcomas seem to have distinct clinical and pathologic features. While BET inhibitors are effective in NUT carcinoma, they may not be effective in <em>NUT</em>-rearranged sarcoma.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150941"},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratocystoma: Molecular insights and diagnostic challenges in a rare salivary gland tumor 角化细胞瘤：一种罕见唾液腺肿瘤的分子见解和诊断挑战
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-24 DOI: 10.1016/j.semdp.2025.150940
Yoshitaka Utsumi , Masato Nakaguro , Justin A. Bishop , Toshitaka Nagao
{"title":"Keratocystoma: Molecular insights and diagnostic challenges in a rare salivary gland tumor","authors":"Yoshitaka Utsumi ,&nbsp;Masato Nakaguro ,&nbsp;Justin A. Bishop ,&nbsp;Toshitaka Nagao","doi":"10.1016/j.semdp.2025.150940","DOIUrl":"10.1016/j.semdp.2025.150940","url":null,"abstract":"<div><div>Keratosytoma is a rare, benign salivary gland tumor designated as a new entity by Nagao et al. in 2002. Recently, the discovery of <em>RUNX2</em> gene rearrangement as a characteristic genetic alteration has established its classification as a distinct neoplasm, solidifying the inclusion of keratocystoma in the 5th edition of the WHO classification of Head and Neck Tumors. Clinically, keratocystoma occurs across a broad age range but is most prevalent among younger individuals, with no significant sex predilection. It typically presents as a slow-growing parotid mass. Histologically, the tumor is characterized by a multilocular cystic lesion lined by stratified squamous epithelium without atypia and lacks a granular cell layer. In addition to cyst formation, nests of squamous epithelium enclosed within fibrous stroma are also observed, sometimes along with salivary ducts with squamous metaplasia-like processes. Immunohistochemically, similar to normal squamous epithelium, tumor cells are positive for p63 and negative for myoepithelial markers, including SMA, calponin, and S-100. The Ki-67 labeling index is low, and p53 expression exhibits a wild-type pattern. The differential diagnosis encompasses a wide spectrum of conditions, ranging from non-neoplastic lesions to benign and malignant tumors composed of squamous epithelium. These include squamous cell carcinoma, mucoepidermoid carcinoma, metaplastic Warthin tumor, pleomorphic adenoma with squamous differentiation, dermoid cyst, epidermal cyst/cholesteatoma, and necrotizing sialometaplasia. Although a detailed histomorphological examination is essential for the diagnosis, testing for <em>RUNX2</em> gene rearrangement is expected to play a pivotal role in the differential diagnosis of keratocystoma. More cases are necessary to better understand this rare salivary gland tumor.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150940"},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acral fibrochondromyxoid tumor – A review of the literature 肢端纤维软骨粘液样瘤-文献综述
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-17 DOI: 10.1016/j.semdp.2025.150938
Carina A. Dehner , John S.A. Chrisinger
{"title":"Acral fibrochondromyxoid tumor – A review of the literature","authors":"Carina A. Dehner ,&nbsp;John S.A. Chrisinger","doi":"10.1016/j.semdp.2025.150938","DOIUrl":"10.1016/j.semdp.2025.150938","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150938"},"PeriodicalIF":2.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratin-positive giant cell-rich tumor review 角蛋白阳性富巨细胞肿瘤综述
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-12 DOI: 10.1016/j.semdp.2025.150939
John S.A. Chrisinger , Carina A. Dehner
{"title":"Keratin-positive giant cell-rich tumor review","authors":"John S.A. Chrisinger ,&nbsp;Carina A. Dehner","doi":"10.1016/j.semdp.2025.150939","DOIUrl":"10.1016/j.semdp.2025.150939","url":null,"abstract":"<div><div>Keratin-positive giant cell-rich tumor is a recently described mesenchymal neoplasm, which occurs predominantly in young women and often arises in the subcutis or bone. Histologically, tumors vary from giant cell tumor-like to xanthogranulomatous, or a mixture of both patterns. Tumors with predominantly xanthogranulomatous infiltrate and scattered mononuclear cells with bright eosinophilic cytoplasm were originally described as xanthogranulomatous epithelial tumor, a lesion which was subsequently found to be on a morphologic spectrum with keratin-positive giant cell-rich tumor. Most cases express keratin, characteristically with demonstration of dendritic-like cytoplasmic projections, and harbor HMGA2::NCOR2 fusions. High level expression of CSF1, in the absence of CSF1 gene alterations, is also frequently observed. Data on the clinical behavior of keratin-positive giant cell-rich tumor is limited. The course is often indolent, however rare cases are aggressive.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150939"},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cutaneous dedifferentiated and undifferentiated melanoma 原发性皮肤去分化和未分化黑色素瘤
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-11 DOI: 10.1016/j.semdp.2025.150937
Ingrid Ferreira , Thomas Brenn
{"title":"Primary cutaneous dedifferentiated and undifferentiated melanoma","authors":"Ingrid Ferreira ,&nbsp;Thomas Brenn","doi":"10.1016/j.semdp.2025.150937","DOIUrl":"10.1016/j.semdp.2025.150937","url":null,"abstract":"<div><div>The diagnosis of melanoma remains challenging due to its wide clinical, histopathologic and molecular spectrum. While melanomas typically display a melanocytic phenotype by immunohistochemistry, staining for the conventional markers of melanocytic differentiation (e.g. S100, SOX10, Melan A and HMB45) may be absent in rare instances. This phenomenon is most frequently encountered in the metastatic setting but is increasingly recognized also in primary cutaneous and mucosal melanomas. These tumors are referred to as dedifferentiated melanoma when arising in the background of a conventional melanoma precursor, either morphologically or by immunohistochemistry. Undifferentiated melanomas pose a particular diagnostic challenge as they present in the absence of a recognizable melanoma precursor component. This manuscript outlines the clinical, histopathological and molecular features of these rare tumors to facilitate recognition and allow for more confident diagnosis.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150937"},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MASTHEAD (p/u from previous issue) 报头（p/u从上一期）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-07 DOI: 10.1053/S0740-2570(25)00064-4
{"title":"MASTHEAD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(25)00064-4","DOIUrl":"10.1053/S0740-2570(25)00064-4","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150928"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表（p/u来自上一期，更新）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-07 DOI: 10.1053/S0740-2570(25)00066-8
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(25)00066-8","DOIUrl":"10.1053/S0740-2570(25)00066-8","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150930"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EDITORIAL BOARD (p/u from previous issue) 编辑委员会（p/u自上期）
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-06-07 DOI: 10.1053/S0740-2570(25)00065-6
{"title":"EDITORIAL BOARD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(25)00065-6","DOIUrl":"10.1053/S0740-2570(25)00065-6","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150929"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms 骨髓微环境在多发性骨髓瘤中的作用：生态位对耐药机制的影响
IF 2.9 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2025-05-22 DOI: 10.1016/j.semdp.2025.150916
Lijie Wang , Mingyue Shi , Andrew Y. Sung , C Cameron Yin , Yanliang Bai , Mingyi Chen
{"title":"Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms","authors":"Lijie Wang ,&nbsp;Mingyue Shi ,&nbsp;Andrew Y. Sung ,&nbsp;C Cameron Yin ,&nbsp;Yanliang Bai ,&nbsp;Mingyi Chen","doi":"10.1016/j.semdp.2025.150916","DOIUrl":"10.1016/j.semdp.2025.150916","url":null,"abstract":"<div><div>Multiple myeloma (MM) is a blood cancer characterized by the uncontrolled growth of plasma cells in the bone marrow. These malignant plasma cells can proliferate locally and spread to other tissues and organs. The M-protein they produce can lead to various clinical symptoms, including anemia, hypercalcemia, bone pain, bone destruction, and kidney dysfunction. Despite significant advancements in treatment over the past two decades that have improved survival and outcomes for many patients, drug resistance remains a significant therapeutic challenge. This resistance is largely driven by the complex interactions between MM cells and the bone marrow microenvironment (BMME), making long-term disease control difficult. To improve treatment outcomes, it is essential to understand how the BMME supports MM cell growth and survival, as well as how these cells evade therapies. Investigating these processes will help identify key mechanisms behind drug resistance, offering a pathway to develop targeted therapies that can overcome this challenge. This review will explore the intricate relationship between MM cells and the BMME, focusing on how both cellular and non-cellular components of the microenvironment contribute to resistance mechanisms and prompt disease progression. These insights aim to inform future therapeutic strategies to enhance treatment options for MM patients.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 4","pages":"Article 150916"},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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