多发性骨髓瘤的鉴别诊断。

IF 3.5 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Miguel Dario Cantu, Weina Chen
{"title":"多发性骨髓瘤的鉴别诊断。","authors":"Miguel Dario Cantu, Weina Chen","doi":"10.1016/j.semdp.2025.150944","DOIUrl":null,"url":null,"abstract":"<p><p>Distinguishing multiple myeloma from B-cell lymphomas can be a diagnostic challenge. There can be significant morphologic, immunophenotypic and clinical overlap that may require additional molecular genetic ancillary studies and careful clinical review to render an accurate diagnosis. The focus of this review will be on the differential diagnosis of multiple myeloma with an emphasis on low-grade B-cell lymphomas with plasmacytic differentiation and aggressive B-cell lymphomas with plasmablastic morphology that can mimic true plasma cell neoplasms. Diagnostic approaches to plasmablastic neoplasms, including extramedullary plasmablastic plasmacytoma and distinguishing features of B-cell lymphomas with plasmablastic morphology are discussed. Low-grade B-cell lymphomas with plasmacytic differentiation, including lymphoplasmacytic lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and other low-grade B-cell lymphomas that less frequently exhibit plasmacytic differentiation such as follicular lymphoma and mantle cell lymphoma are also included. Multiple myeloma with CCND1:IGH, which can mimic low-grade B-cell lymphomas and post-treatment plasmacytic proliferations following treatment for B-cell lymphomas with plasmacytic differentiation are also discussed.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":"150944"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Differential diagnosis of multiple myeloma.\",\"authors\":\"Miguel Dario Cantu, Weina Chen\",\"doi\":\"10.1016/j.semdp.2025.150944\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Distinguishing multiple myeloma from B-cell lymphomas can be a diagnostic challenge. There can be significant morphologic, immunophenotypic and clinical overlap that may require additional molecular genetic ancillary studies and careful clinical review to render an accurate diagnosis. The focus of this review will be on the differential diagnosis of multiple myeloma with an emphasis on low-grade B-cell lymphomas with plasmacytic differentiation and aggressive B-cell lymphomas with plasmablastic morphology that can mimic true plasma cell neoplasms. Diagnostic approaches to plasmablastic neoplasms, including extramedullary plasmablastic plasmacytoma and distinguishing features of B-cell lymphomas with plasmablastic morphology are discussed. Low-grade B-cell lymphomas with plasmacytic differentiation, including lymphoplasmacytic lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and other low-grade B-cell lymphomas that less frequently exhibit plasmacytic differentiation such as follicular lymphoma and mantle cell lymphoma are also included. Multiple myeloma with CCND1:IGH, which can mimic low-grade B-cell lymphomas and post-treatment plasmacytic proliferations following treatment for B-cell lymphomas with plasmacytic differentiation are also discussed.</p>\",\"PeriodicalId\":49548,\"journal\":{\"name\":\"Seminars in Diagnostic Pathology\",\"volume\":\" \",\"pages\":\"150944\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Diagnostic Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.semdp.2025.150944\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Diagnostic Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.semdp.2025.150944","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

区分多发性骨髓瘤和b细胞淋巴瘤可能是一个诊断挑战。可能存在显著的形态学、免疫表型和临床重叠,这可能需要额外的分子遗传学辅助研究和仔细的临床审查才能做出准确的诊断。本综述的重点是多发性骨髓瘤的鉴别诊断,重点是具有浆细胞分化的低级别b细胞淋巴瘤和具有浆母细胞形态的侵袭性b细胞淋巴瘤,可以模拟真正的浆细胞肿瘤。讨论了质母细胞瘤的诊断方法,包括髓外质母细胞瘤和具有质母细胞形态的b细胞淋巴瘤的区别特征。伴有浆细胞分化的低级别b细胞淋巴瘤,包括淋巴浆细胞淋巴瘤、边缘带淋巴瘤、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤,以及其他较少表现浆细胞分化的低级别b细胞淋巴瘤,如滤泡性淋巴瘤和套细胞淋巴瘤。我们还讨论了CCND1:IGH多发性骨髓瘤,它可以模拟低级别b细胞淋巴瘤,以及治疗后浆细胞分化b细胞淋巴瘤后的浆细胞增殖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differential diagnosis of multiple myeloma.

Distinguishing multiple myeloma from B-cell lymphomas can be a diagnostic challenge. There can be significant morphologic, immunophenotypic and clinical overlap that may require additional molecular genetic ancillary studies and careful clinical review to render an accurate diagnosis. The focus of this review will be on the differential diagnosis of multiple myeloma with an emphasis on low-grade B-cell lymphomas with plasmacytic differentiation and aggressive B-cell lymphomas with plasmablastic morphology that can mimic true plasma cell neoplasms. Diagnostic approaches to plasmablastic neoplasms, including extramedullary plasmablastic plasmacytoma and distinguishing features of B-cell lymphomas with plasmablastic morphology are discussed. Low-grade B-cell lymphomas with plasmacytic differentiation, including lymphoplasmacytic lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and other low-grade B-cell lymphomas that less frequently exhibit plasmacytic differentiation such as follicular lymphoma and mantle cell lymphoma are also included. Multiple myeloma with CCND1:IGH, which can mimic low-grade B-cell lymphomas and post-treatment plasmacytic proliferations following treatment for B-cell lymphomas with plasmacytic differentiation are also discussed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.80
自引率
0.00%
发文量
69
审稿时长
71 days
期刊介绍: Each issue of Seminars in Diagnostic Pathology offers current, authoritative reviews of topics in diagnostic anatomic pathology. The Seminars is of interest to pathologists, clinical investigators and physicians in practice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信