Seminars in Diagnostic Pathology最新文献_第2页

Intraoperative evaluation of surgical margins in breast cancer 乳腺癌手术边缘的术中评估。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.06.005

Lauren Kopicky , Betty Fan , Stephanie A. Valente

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00093-5

引用次数: 0

Spectrum of atypical ductal hyperplasia (ADH) and ductal carcinoma in-situ (DCIS): Diagnostic challenges 非典型导管增生（ADH）和导管原位癌（DCIS）的谱系：诊断难题。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.09.001

Philip Bomeisl , Hannah Gilmore

{"title":"Spectrum of atypical ductal hyperplasia (ADH) and ductal carcinoma in-situ (DCIS): Diagnostic challenges","authors":"Philip Bomeisl , Hannah Gilmore","doi":"10.1053/j.semdp.2024.09.001","DOIUrl":"10.1053/j.semdp.2024.09.001","url":null,"abstract":"<div><div>Breast specimens are some of the more common specimens sent to the pathology laboratory for diagnosis. From a clinical perspective, the diagnoses fall into three broad categories: benign, atypical and malignant with patients then being managed according to established guidelines. However, the pathologic diagnosis can sometimes be challenging, and the distinction between these categories is sometimes far more subtle and subjective than non-pathologist may understand. One recurring diagnostic challenge in breast pathology is the diagnosis of atypical ductal hyperplasia (ADH) versus ductal carcinoma in situ (DCIS). While many cases are straightforward, others are quite borderline and challenging to classify consistently with significant interobserver variation amongst pathologists. The distinction between ADH and DCIS is critical from a clinical management perspective because one is treated as a risk factor, and the other as a malignancy that will be completely surgically excised and may require radiation therapy. This review will address the spectrum of ADH and DCIS with the associated diagnostic challenges in the real-world setting from presentation at core needle biopsy to surgery.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 252-257"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence. 腺样绒毛膜母细胞瘤再探：对其组织学二元论、分子畸变和临床复发的辨证探索。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-10-08 DOI: 10.1053/j.semdp.2024.10.001

Dr Sakshi Deorah, Dr Shalini Gupta

{"title":"Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence.","authors":"Dr Sakshi Deorah, Dr Shalini Gupta","doi":"10.1053/j.semdp.2024.10.001","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.10.001","url":null,"abstract":"<p><p>Adenoid ameloblastoma (AA) is a rare benign but locally aggressive odontogenic tumor originating from the remnants of the dental lamina or enamel organ. It was newly incorporated into the 2022 WHO classification of odontogenic lesions, standing as the sole novel entity in this update. AA is also regarded as a hybrid tumor because of the combination of histological characteristics observed in both adenomatoid odontogenic tumors and ameloblastoma. Clinically, it presents similarly to other ameloblastoma variants, with patients typically exhibiting a painless, slow-growing jaw swelling. However, this subtype is noted for its more aggressive behavior, including a higher recurrence rate and greater local invasiveness. Histopathologically, AA is distinguished by an intricate arrangement of epithelial islands, cords, and strands, generating a cribriform architectural pattern, with peripheral palisading and central stellate reticulum-like formations. Immunohistochemical profiling reveals the expression of epithelial differentiation markers, including cytokeratins, and proliferative markers such as Ki-67, further corroborating its aggressive phenotype. While its precise etiopathogenesis remains obscure, the unique histological characteristics imply a potentially distinct underlying molecular pathway. Due to its aggressive nature, AA necessitates meticulous clinical and histopathological evaluation and tailored therapeutic strategies to mitigate recurrence risks and optimize patient prognoses. Furthermore, this review integrates histological and molecular insights from recent studies conducted after its inclusion in the updated WHO classification.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcifying cystic odontogenic tumour: Dilemma and pitfalls. 钙化性囊性牙源性肿瘤：困境与陷阱

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-19 DOI: 10.1053/j.semdp.2024.09.005

Arushi Tomar, Sharon John, Saloni Verma, Shalini Gupta

{"title":"Calcifying cystic odontogenic tumour: Dilemma and pitfalls.","authors":"Arushi Tomar, Sharon John, Saloni Verma, Shalini Gupta","doi":"10.1053/j.semdp.2024.09.005","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.09.005","url":null,"abstract":"<p><p>Odontogenic lesions are a category of lesions, which are found to be arising from the remnants of the tooth-bearing tissues of the body, that can be cystic in nature as a result of degeneration or as a result of excessive proliferation of these cells, can result in the formation of odontogenic tumours which are found in gnathic bones in the body. Since their discovery in literature and the explanation provided for their pathogenesis, these lesions have been the subject of debate and controversy amongst researchers as well as practitioners. Thereby, this review has taken into consideration one such odontogenic tumour, Calcifying Cystic Odontogenic Tumour (CCOT), which first were included under the namesake (Calcifying odontogenic cyst) as a sperate subheading under this cyst, but now has been designated under the category of tumours along with various histologic subtypes classified and described henceforth. Although the lesion has been removed in the recent classification, a wide variety of lesions in biphasic form has been reported in the past. Therefore, this present review takes a sneak-peek into this lesion with insight into its presentation, incidence, aetiology, pathogenesis, histopathology and all the controversies surrounding this category of lesion and the current literature about this lesion with proving the fact that this needs to be considered again in the category of odontogenic tumours.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sclerosing Odontogenic Carcinoma: UPLIFTS and pitfalls. 硬化性牙源性癌：UPLIFTS 和陷阱。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-16 DOI: 10.1053/j.semdp.2024.09.004

Arushi Tomar, Sharon John, Shalini Gupta

{"title":"Sclerosing Odontogenic Carcinoma: UPLIFTS and pitfalls.","authors":"Arushi Tomar, Sharon John, Shalini Gupta","doi":"10.1053/j.semdp.2024.09.004","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.09.004","url":null,"abstract":"<p><p>Sclerosing Odontogrenic Carcinoma (SOC) is a recent addition to the category of odontogenic tumours, which was first described by Koutlas et al. in 2008. It was described as primary intraosseous carcinoma with bland cytology, sclerotic stroma with presence of local infiltration showing aggressive behaviour. Following its discovery and the presentation of first case, only a handful of cases have been reported till date, which may be due to underreporting of the cases or inclusion of the case to other diagnosis since the features of this tumour overlaps with many other lesions of the oral cavity. Due to this factor, the pathogenesis of this category of tumours still remains enigmatic. The clinical features as a result of this factor are also not reported of the consistent type and overlaps with the already existing clinical features of other lesions. This lesion has only appeared till date twice in WHO classification of Odontogenic Cysts and Tumours. Thereby, the literature on this category is still in paucity. Therefore, the present review takes into account all of the features, diagnostic criteria and the markers discovered for this lesion and would provide an insight into whether this lesion is justified as a malignant lesion or should not be considered as a separate category of odontogenic tumour.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual presentation of calcifying odontogenic cyst with literature review. 牙源性钙化囊肿的不寻常表现及文献综述。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-13 DOI: 10.1053/j.semdp.2024.09.003

Priya Devi, Sharon John, Saloni Verma, Roshna Sankar, Rajeev Kumar Singh, Shalini Gupta

{"title":"An unusual presentation of calcifying odontogenic cyst with literature review.","authors":"Priya Devi, Sharon John, Saloni Verma, Roshna Sankar, Rajeev Kumar Singh, Shalini Gupta","doi":"10.1053/j.semdp.2024.09.003","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.09.003","url":null,"abstract":"<p><p>The calcifying odontogenic cyst (COC) is an uncommon developmental odontogenic cyst, the oral counterpart of Malherbe's cutaneous calcifying epithelioma (pilomatricoma). This article presents two unique cases of calcifying odontogenic cysts each exhibiting distinctive histopathological features and its literature review. One case with an unexpected finding of cholesterol granuloma (CG), a rare occurrence in non-inflammatory cysts within an unusual location between two maxillary central incisors. One more instance involves the presence of a compound odontome in conjunction with COC. The cases underscore the clinical and histopathological diversity of COC and highlight the importance of radiological and histopathological assessments for accurate diagnosis. The unexpected association of COC with cholesterol granuloma challenges traditional diagnostic expectations. Additionally, the second case suggests that COCs may warrant sub-categorization to better understand their varied presentations and biological behavior. This article contributes to the expanding knowledge of COC, emphasizing the significance of documenting rare cases to enhance comprehension of its nature, pathogenesis, and oral cavity origin.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights into hybrid tumors: Exploring the heterogeneity in plexiform ameloblastoma. 混合瘤的分子研究：探索丛状母细胞瘤的异质性。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-12 DOI: 10.1053/j.semdp.2024.09.002

Dr Sharon John, Dr Arushi Tomar, Dr Ayushi Jain, Dr Shalini Gupta

{"title":"Molecular insights into hybrid tumors: Exploring the heterogeneity in plexiform ameloblastoma.","authors":"Dr Sharon John, Dr Arushi Tomar, Dr Ayushi Jain, Dr Shalini Gupta","doi":"10.1053/j.semdp.2024.09.002","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.09.002","url":null,"abstract":"<p><p>For many years, odontogenic tumors have been known to present both clinical and histopathological challenges due to their origins in the epithelial, ectomesenchymal, and/or mesenchymal components of tooth-forming tissues. Gaining a comprehensive understanding of both common and rare odontogenic tumors is crucial for their effective study and clinical management. One particularly puzzling tumor is the \"plexiform ameloblastoma,\" a variant of the solid multicystic ameloblastoma. This term describes a distinct pattern of epithelial proliferation within the cystic cavity. Numerous studies have emphasized the variability of the stromal component, further highlighting the enigmatic nature of ameloblastoma. The presence of unique and rare features, such as primitive, mature desmoplastic, hemangiomatous, or ghost cells within the stroma of plexiform ameloblastoma, underscores the differentiation potential of the neoplastic odontogenic epithelium and offers significant insights into the tissue reactions associated with this condition. This case review discusses four instances of plexiform ameloblastoma, illustrating various atypical stromal changes and their influence on patient prognosis. It also provides important criteria for analyzing stromal alterations related to this complex odontogenic tumor.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Goblet cell adenocarcinoma 上皮细胞腺癌

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.003

Jula Veerapong, Mojgan Hosseini

引用次数: 0

Appendiceal adenocarcinoma: Current concepts & challenges 阑尾腺癌：当前的概念与挑战。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.005

Phoenix D. Bell

{"title":"Appendiceal adenocarcinoma: Current concepts & challenges","authors":"Phoenix D. Bell","doi":"10.1053/j.semdp.2024.08.005","DOIUrl":"10.1053/j.semdp.2024.08.005","url":null,"abstract":"<div><p>Appendiceal adenocarcinoma (ApAC) is a rare malignancy, comprising less than 1 % of all gastrointestinal tumors. The current World Health Organization classifies ApAC as mucinous or nonmucinous. Mucinous ApAC are composed of pools of mucin lined by cells with low- and high-grade cytology and areas of infiltrative invasion. Nonmucinous ApAC histologically resemble conventional colorectal adenocarcinomas and have a worse prognosis than their mucinous counterpart. Unfortunately, the nomenclature and histologic classification of ApAC, specifically the mucinous subtype, has changed several times throughout the years, contributing to diagnostic confusion for pathologists. The treatment for mucinous ApAC differs from that of other appendiceal mucinous neoplasms, thus accurate diagnosis is key to patient management and outcome. This review discusses the current classification and staging of ApAC with a particular emphasis on the mucinous subtype and peritoneal disease, as these areas are the most challenging for practicing surgical pathologists.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 5","pages":"Pages 213-221"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257024000704/pdfft?md5=39f03b1d3dfa4cae71f84dc71896b7ce&pid=1-s2.0-S0740257024000704-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0