Seminars in Diagnostic Pathology最新文献_第2页

Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence 腺样绒毛膜母细胞瘤再探：对其组织学二元论、分子畸变和临床复发的辨证探索。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.10.001

Dr. Sakshi Deorah, Dr. Shalini Gupta

{"title":"Adenoid ameloblastoma revisited: A discursive exploration of its histological dualism, molecular aberrations, and clinical recurrence","authors":"Dr. Sakshi Deorah, Dr. Shalini Gupta","doi":"10.1053/j.semdp.2024.10.001","DOIUrl":"10.1053/j.semdp.2024.10.001","url":null,"abstract":"<div><div>Adenoid ameloblastoma (AA) is a rare benign but locally aggressive odontogenic tumor originating from the remnants of the dental lamina or enamel organ. It was newly incorporated into the 2022 WHO classification of odontogenic lesions, standing as the sole novel entity in this update. AA is also regarded as a hybrid tumor because of the combination of histological characteristics observed in both adenomatoid odontogenic tumors and ameloblastoma. Clinically, it presents similarly to other ameloblastoma variants, with patients typically exhibiting a painless, slow-growing jaw swelling. However, this subtype is noted for its more aggressive behavior, including a higher recurrence rate and greater local invasiveness. Histopathologically, AA is distinguished by an intricate arrangement of epithelial islands, cords, and strands, generating a cribriform architectural pattern, with peripheral palisading and central stellate reticulum-like formations. Immunohistochemical profiling reveals the expression of epithelial differentiation markers, including cytokeratins, and proliferative markers such as Ki-67, further corroborating its aggressive phenotype. While its precise etiopathogenesis remains obscure, the unique histological characteristics imply a potentially distinct underlying molecular pathway. Due to its aggressive nature, AA necessitates meticulous clinical and histopathological evaluation and tailored therapeutic strategies to mitigate recurrence risks and optimize patient prognoses. Furthermore, this review integrates histological and molecular insights from recent studies conducted after its inclusion in the updated WHO classification.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 13-17"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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TABLE OF CONTENTS (p/u from previous issue w/updates)

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/S0740-2570(25)00007-3

引用次数: 0

EDITORIAL BOARD (p/u from previous issue)

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/S0740-2570(25)00006-1

引用次数: 0

Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma 探讨罕见性：混合型韧带增生-丛状成釉细胞瘤的临床观察与组织病理学多样性。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2024.12.001

Dr. Sakshi Deorah (Junior Resident), Dr. Shalini Gupta (Professor and Head)

{"title":"Exploring the Rarity: Clinical insights and histopathological diversity of hybrid desmoplastic-plexiform ameloblastoma","authors":"Dr. Sakshi Deorah (Junior Resident), Dr. Shalini Gupta (Professor and Head)","doi":"10.1053/j.semdp.2024.12.001","DOIUrl":"10.1053/j.semdp.2024.12.001","url":null,"abstract":"<div><div>Ameloblastoma represents a rare and locally aggressive odontogenic neoplasm, notable for its histopathological diversity. Among its subtypes, the desmoplastic and plexiform variants are relatively rare, with the hybrid form, encompassing both architectural patterns, representing an even more exceptional entity. This article delineates the clinical, radiological, and histopathological profile of a 45-year-old male presenting with pain persisting over the past month in the right posterior maxillary region. Radiographic imaging displayed a mixed radiolucent-radiopaque lesion with poorly demarcated margins, indicative of an aggressive pathology. Histopathological examination revealed a hybrid ameloblastoma, juxtaposing desmoplastic zones with densely fibrotic stroma and classic plexiform sections with epithelial strands in a reticular configuration. This unique hybrid variant underscores the complexity of ameloblastomas and necessitates comprehensive histopathological assessment, as radiological interpretations may prove insufficient for accurate diagnosis. Such detailed analysis contributes to understanding the biological behavior of this rare form, underscoring the need for heightened clinical awareness and continued investigative focus.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 1","pages":"Pages 22-24"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Navigating controversies in primary intraosseous carcinoma: A comprehensive literature review concerning the odontogenic origin and diagnostic challenges

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI: 10.1053/j.semdp.2025.01.001

Ayushi Jain , Sharon John , Saloni Verma , Shalini Gupta

引用次数: 0

Targetoid hemosiderotic hemangioma: A review article. 靶形血蜘蛛网状血管瘤：综述文章。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-05 DOI: 10.1053/j.semdp.2024.11.002

Toan Bui, Laura M Rezac, C Alexis Noble, Ariel R Velasquez-Evers, Robert T Brodell

{"title":"Targetoid hemosiderotic hemangioma: A review article.","authors":"Toan Bui, Laura M Rezac, C Alexis Noble, Ariel R Velasquez-Evers, Robert T Brodell","doi":"10.1053/j.semdp.2024.11.002","DOIUrl":"https://doi.org/10.1053/j.semdp.2024.11.002","url":null,"abstract":"<p><strong>Background: </strong>Targetoid hemosiderotic hemangioma (THH), also known as hobnail lymphatic malformation (HLL) or hobnail hemangioma, is an uncommon, acquired vascular lesion with a dynamic presentation and an unclear etiology. It predominantly affects adults with an age range from 9 to 78 years and has no gender predilection. The lesion is thought to arise from trauma, leading to micro-shunts between small lesional capillaries and adjacent lymphatic vessels.</p><p><strong>Methods: </strong>This review article examines the clinical, histologic, and immunohistochemical characteristics of THH, and explores its differential diagnoses, including Kaposi's sarcoma, solitary angiokeratoma, retiform hemangioendothelioma, and Dabska tumor.</p><p><strong>Results: </strong>THH presents clinically as asymptomatic, well-circumscribed lesions with a central red-blue and/or brown papule surrounded by a peripheral ecchymotic ring, giving a \"bull's-eye\" or targetoid appearance. Histologically, THH exhibits dilated vascular channels lined by hobnail endothelial cells, red blood cell extravasation, hemosiderin deposition, and mild lymphohistiocytic infiltrates. Immunohistochemistry is positive for D2-40, a lymphatic endothelial marker.</p><p><strong>Conclusions: </strong>Heightened awareness of the clinical appearance of these solitary targetoid lesions is important. Without clinical-pathologic correlation, the branching telangiectatic vessels and purpura seen in THH could suggest more concerning vascular lesions like Kaposi sarcoma.</p>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications 乳腺唾液腺样肿瘤：具有临床意义的组织病理学和遗传学特征。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.003

Christopher J. Schwartz , Gregor Krings

{"title":"Salivary gland-like tumors of the breast: Histopathologic and genetic features with clinical implications","authors":"Christopher J. Schwartz , Gregor Krings","doi":"10.1053/j.semdp.2024.10.003","DOIUrl":"10.1053/j.semdp.2024.10.003","url":null,"abstract":"<div><div>Salivary gland-like tumors of the breast are rare neoplasms that share morphologic, immunophenotypic, and/or genetic features with their salivary gland counterparts, highlighting a shared underlying histopathogenesis in most cases. Salivary gland-like carcinomas included in the World Health Organization classification of breast tumors are adenoid cystic carcinoma, secretory carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, and the exceedingly rare polymorphous adenocarcinoma. These carcinomas are usually triple negative for estrogen receptor and progesterone receptor expression and HER2 overexpression, yet generally have favorable prognosis, in contrast to high-grade triple negative carcinomas of no special type. On the other hand, a small subset, such as solid-basaloid adenoid cystic carcinoma, rare high-grade carcinomas, and those associated with transformation to other types of high-grade invasive carcinoma can behave more aggressively. Other salivary gland-like tumors of the breast, such as pleomorphic adenoma and adenomyoepithelioma, are usually benign but can rarely undergo malignant transformation. Although clinical experience with salivary gland-like breast tumors is overall limited, their recognition and accurate classification has important implications for prognosis and clinical management, especially to avoid overtreatment of salivary gland-like carcinomas. The identification of characteristic genetic alterations and/or immunohistochemical surrogates in many of these tumors has practical applications to establishing an accurate diagnosis and directing clinical management. This review highlights the histopathologic and genetic characteristics of salivary gland-like breast tumors and the implications of the diagnosis for current clinical management.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 272-284"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00094-7

引用次数: 0

Current challenges in breast pathology 当前乳腺病理学面临的挑战。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.10.004

Raza S. Hoda, Patrick J. McIntire

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Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer: A review emphasizing clinical concepts pathologists need to know 乳腺癌患者前哨淋巴结的术中评估：强调病理学家需要了解的临床概念的综述。

IF 2.9 3区医学