Seminars in Diagnostic Pathology最新文献_第10页

MASTHEAD (p/u from previous issue) 报头(p/u从上一期)

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00102-8

引用次数: 0

Diagnostic work-up of hematological malignancies with underlying germline predisposition disorders (GPD) 血液病伴潜在生殖系易感性疾病(GPD)的诊断检查

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.11.004

Rashmi Kanagal-Shamanna , Kristian T. Schafernak , Katherine R. Calvo

{"title":"Diagnostic work-up of hematological malignancies with underlying germline predisposition disorders (GPD)","authors":"Rashmi Kanagal-Shamanna , Kristian T. Schafernak , Katherine R. Calvo","doi":"10.1053/j.semdp.2023.11.004","DOIUrl":"10.1053/j.semdp.2023.11.004","url":null,"abstract":"<div>Hematological malignancies with underlying germline predisposition disorders have been recognized by the World Health Organization 5th edition and International Consensus Classification (ICC) classification systems. The list of genes and the associated phenotypes are expanding and involve both pediatric and adult populations. While the clinical presentation and underlying molecular pathogenesis are relatively well described, the knowledge regarding the bone marrow morphologic features, the landscape of somatic aberrations associated with progression to hematological malignancies is limited. These pose challenges in the diagnosis of low-grade myelodysplastic syndrome (MDS) to hematopathologists which carries direct implication for various aspects of clinical management of the patient, donor selection for transplantation, and family members. Here in, we provide a focused review on the diagnostic work-up of hematological malignancies with underlying germline predisposition disorders with emphasis on the spectrum of hematological malignancies associated with each entity, and characteristic bone marrow morphologic, somatic cytogenetic and molecular alterations at the time of diagnosis of hematological malignancies. We also review the key clinical, morphologic, and molecular features, that should initiate screening for these entities.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 443-456"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135610315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classic Hodgkin lymphoma in young people 年轻人的典型霍奇金淋巴瘤

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.005

Srishti Gupta, Jeffrey W. Craig

{"title":"Classic Hodgkin lymphoma in young people","authors":"Srishti Gupta, Jeffrey W. Craig","doi":"10.1053/j.semdp.2023.06.005","DOIUrl":"10.1053/j.semdp.2023.06.005","url":null,"abstract":"<div>Classic Hodgkin lymphoma (CHL) is a unique form of lymphoid cancer featuring a heterogeneous tumor microenvironment and a relative paucity of malignant Hodgkin and Reed-Sternberg (HRS) cells with characteristic phenotype. Younger individuals (children, adolescents and young adults) are affected as often as the elderly, producing a peculiar bimodal age-incidence profile that has generated immense interest in this disease and its origins. Decades of epidemiological investigations have documented the populations most susceptible and identified multiple risk factors that can be broadly categorized as either biological or environmental in nature. Most risk factors result in overt immunodeficiency or confer more subtle alterations to baseline health, physiology or immune function. Epstein Barr virus, however, is both a risk factor and well-established driver of lymphomagenesis in a significant subset of cases. Epigenetic changes, along with the accumulation of somatic driver mutations and cytogenetic abnormalities are required for the malignant transformation of germinal center-experienced HRS cell precursors. Chromosomal instability and the influence of endogenous mutational processes are critical in this regard, by impacting genes involved in key signaling pathways that promote the survival and proliferation of HRS cells and their escape from immune destruction. Here we review the principal features, known risk factors and lymphomagenic mechanisms relevant to newly diagnosed CHL, with an emphasis on those most applicable to young people.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 379-391"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A personalized approach to lymphoproliferations in patients with inborn errors of immunity 先天性免疫缺陷患者淋巴细胞增生的个体化治疗方法

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.07.001

Shachar Naor , Etai Adam , Ginette Schiby , Dita Gratzinger

引用次数: 0

Post-transplant lymphoproliferative disorders (PTLD) in adolescents and young adults: A category in need of definition 青少年和年轻人移植后淋巴细胞增生性疾病(PTLD):一个需要定义的类别

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.07.002

Amy Chadburn

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会(p/u自上期)

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00103-X

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表(p/u来自上一期，更新)

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00104-1

引用次数: 0

Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist 遗传性骨髓衰竭综合征和种系对骨髓瘤的易感性:病理学家的实用方法

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.006

Jingwei Li , Jacob R. Bledsoe

{"title":"Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist","authors":"Jingwei Li , Jacob R. Bledsoe","doi":"10.1053/j.semdp.2023.06.006","DOIUrl":"10.1053/j.semdp.2023.06.006","url":null,"abstract":"<div>The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to myeloid malignancy is complex and involves correlation between clinical findings, laboratory and genetic studies, and bone marrow histopathology. The rarity of these disorders and the overlap of clinical and pathologic features between primary and secondary causes of bone marrow failure, acquired aplastic anemia, and myelodysplastic syndrome may result in diagnostic uncertainty. With an emphasis on the pathologist's perspective, we review diagnostically useful features of germline disorders including Fanconi anemia, Shwachman-Diamond syndrome, telomere biology disorders, severe congenital neutropenia, GATA2 deficiency, SAMD9/SAMD9L diseases, Diamond-Blackfan anemia, and acquired aplastic anemia. We discuss the distinction between baseline morphologic and genetic findings of these disorders and features that raise concern for the development of myelodysplastic syndrome.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 429-442"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The changing landscape of pediatric histiocytoses: Birth, life, and transdifferentiation of pediatric histiocytes 儿童组织细胞增多的变化:儿童组织细胞的出生、生命和转分化

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.003

Aaron Auerbach , Nadine S. Aguilera

引用次数: 0

Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma 儿童人群中的反应性淋巴结病，重点是潜在的淋巴瘤模拟物

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.004

Rachel A. Mariani , Elizabeth L. Courville

引用次数: 0