Seminars in Diagnostic Pathology最新文献_第10页

Histopathologic clues to the etiopathogenesis of orbital inflammatory disease: Idiopathic, IgG4-related, neoplastic, autoimmune and beyond 眼眶炎症性疾病发病机制的组织病理学线索：特发性、IgG4 相关性、肿瘤性、自身免疫性及其他疾病

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2024.01.011

Anna M. Stagner

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Autoimmune pancreatitis: Biopsy interpretation and differential diagnosis 自身免疫性胰腺炎：活检解读与鉴别诊断

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2024.01.001

Yoh Zen

{"title":"Autoimmune pancreatitis: Biopsy interpretation and differential diagnosis","authors":"Yoh Zen","doi":"10.1053/j.semdp.2024.01.001","DOIUrl":"10.1053/j.semdp.2024.01.001","url":null,"abstract":"<div>Autoimmune pancreatitis (AIP) is classified into type 1 (IgG4-related) and type 2 (IgG4-unrelated) and the interpretation of pancreatic biopsy findings plays a crucial role in their diagnosis. Needle biopsy of type 1 AIP in the acute or subacute phase shows a diffuse lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phlebitis, and the infiltration of many IgG4-positive plasma cells. In a later phase, changes become less inflammatory and more fibrotic, making interpretations more challenging. Confirmation of the lack of ‘negative’ findings that are unlikely to occur in type 1 AIP (e.g., neutrophilic infiltration, abscess) is important to avoid an overdiagnosis. The number of IgG4-positive plasma cells increases to >10 cells/high-power field (hpf), and the IgG4/IgG-positive plasma cell ratio exceeds 40 %. However, these are minimal criteria and typical cases show >30 positive cells/hpf and a ratio >70 % even in biopsy specimens. Therefore, cases with a borderline increase in this number or ratio need to be diagnosed with caution. In cases of ductal adenocarcinoma, the upstream pancreas rarely shows type 1 AIP-like changes; however, the ratio of IgG4/IgG-positive plasma cells is typically <40 %. Although the identification of a granulocytic epithelial lesion (GEL) is crucial for type 2 AIP, this finding needs to be interpreted in conjunction with a background dense lymphoplasmacytic infiltrate. An isolated neutrophilic duct injury can occur in peritumoral or obstructive pancreatitis. Drug-induced pancreatitis in patients with inflammatory bowel disease often mimics type 2 AIP clinically and pathologically. IL-8 and PD-L1 are potential ancillary immunohistochemical markers for type 2 AIP, requiring validation studies.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 79-87"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139095341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary succinate dehydrogenase-deficient renal cell carcinoma 遗传性琥珀酸脱氢酶缺陷肾细胞癌

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/j.semdp.2023.11.001

Joanna Rogala , Ming Zhou

{"title":"Hereditary succinate dehydrogenase-deficient renal cell carcinoma","authors":"Joanna Rogala , Ming Zhou","doi":"10.1053/j.semdp.2023.11.001","DOIUrl":"10.1053/j.semdp.2023.11.001","url":null,"abstract":"<div>Succinate dehydrogenase (SDH), formed by four subunits SDHA, SDHB, SDHC, SDHD, and an assembly factor SDHAF2, functions as a key respiratory enzyme. Biallelic inactivation of genes encoding any of the components, almost always in the presence of a germline mutation, causes loss of function of the entire enzyme complex (so-called SDH deficiency) and subsequent development of SDH-deficient neoplasms which include pheochromocytoma/paraganglioma, gastrointestinal stromal tumor, and renal cell carcinoma (RCC). These tumors may occur in the same patient or kindred. SDH-deficient RCC shows distinctive morphological features with vacuolated eosinophilic cytoplasm due to distinctive cytoplasmatic inclusions containing flocculent material. The diagnosis is confirmed by loss of SDHB on immunohistochemistry with positive internal control. The majority of tumors occur in the setting of germline mutations in one of the SDH genes, most commonly SDHB. The prognosis is excellent for low-grade tumors but worse for high-grade tumors with high-grade nuclei, sarcomatoid change, or coagulative necrosis. Awareness of the morphological features and low-threshold for applying SDHB immunohistochemistry help identify patients with SDH-deficient RCC and hereditary SDH-deficient tumor syndromes. In this review we summarize recent development on the clinical and genetic features, diagnostic approach, and pitfalls of SDH-deficient syndrome, focusing on SDH-deficient renal cell carcinomas.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 1","pages":"Pages 32-41"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135516526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录（上期内容，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/S0740-2570(24)00015-7

引用次数: 0

Hereditary papillary renal cell carcinoma 遗传性乳头状肾细胞癌

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/j.semdp.2023.12.002

Isa Mulingbayan Jacoba, Zhichun Lu

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Pathology of hereditary renal cell carcinoma syndromes: Tuberous sclerosis complex (TSC) 遗传性肾细胞癌综合征的病理学：结节性硬化综合征（TSC）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/j.semdp.2023.09.001

Miranda E. Machacek, Chin-Lee Wu, Kristine M. Cornejo

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COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/S0740-2570(24)00012-1

引用次数: 0

MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/S0740-2570(24)00013-3

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von Hippel–Lindau disease-related neoplasia with an emphasis on renal manifestations 冯-希佩尔-林道病相关肿瘤，重点是肾脏表现

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/j.semdp.2023.11.003

Burak Tekin, Lori A. Erickson, Sounak Gupta

{"title":"von Hippel–Lindau disease-related neoplasia with an emphasis on renal manifestations","authors":"Burak Tekin, Lori A. Erickson, Sounak Gupta","doi":"10.1053/j.semdp.2023.11.003","DOIUrl":"10.1053/j.semdp.2023.11.003","url":null,"abstract":"<div>von Hippel–Lindau (VHL) disease is characterized by biallelic inactivation of the VHL gene leading to abnormal or absent VHL protein function, and constitutive activation of hypoxia-inducible factors (HIF) that leads to pro-tumorigenic signaling. Individuals with VHL disease develop numerous cysts and tumors involving multiple organs including the kidneys, central nervous system, endolymphatic sac, lungs, pancreatobiliary system, adrenal glands, epididymis, and/or broad ligament. On histologic examination, these lesions show morphologic overlap as they are frequently characterized by cells with clear cytoplasm and prominent vascularity. In addition to distinguishing non-renal tumors from metastatic clear cell renal cell carcinoma, understanding site-specific histopathologic and immunophenotypic features of these tumors has several applications. This includes distinguishing VHL-related tumors from those that arise sporadically and lack VHL gene alterations, guiding further genetic workup, and helping distinguish between different genetic predisposition syndromes. In this context, immunohistochemical studies for markers such as paired box 8 (PAX-8), carbonic anhydrase 9 (CA9), and glucose transporter 1 (GLUT-1) have an important role in routine clinical practice and represent cost-effective diagnostic tools. The recent development of targeted therapeutics directed against HIF-mediated signaling represents a significant milestone in the management of VHL disease and highlights the importance of accurately diagnosing and characterizing the wide spectrum of VHL disease-associated lesions.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 1","pages":"Pages 20-27"},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-01-01 DOI: 10.1053/S0740-2570(24)00014-5

引用次数: 0