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Seminars in Diagnostic Pathology最新文献

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Post-transplant lymphoproliferative disorders (PTLD) in adolescents and young adults: A category in need of definition 青少年和年轻人移植后淋巴细胞增生性疾病(PTLD):一个需要定义的类别
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.07.002
Amy Chadburn
{"title":"Post-transplant lymphoproliferative disorders (PTLD) in adolescents and young adults: A category in need of definition","authors":"Amy Chadburn","doi":"10.1053/j.semdp.2023.07.002","DOIUrl":"10.1053/j.semdp.2023.07.002","url":null,"abstract":"<div><p>Post-transplant lymphoproliferative disorders are a well-recognized complication of solid organ and stem cell transplantation<span>. Much data has accumulated with respect to the pathobiology and clinical behavior of these lesions in the general post-transplant population as well as in the pediatric and adult age groups. However, information as to these lesions in the adolescent and young adult populations, which bridge the pediatric and adult groups, is limited. In this review, the focus is on this unique population of PTLD patients and their proliferations.</span></p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 401-407"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EDITORIAL BOARD (p/u from previous issue) 编辑委员会(p/u自上期)
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00103-X
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引用次数: 0
TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表(p/u来自上一期，更新)
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00104-1
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(23)00104-1","DOIUrl":"https://doi.org/10.1053/S0740-2570(23)00104-1","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Page ii"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257023001041/pdfft?md5=8777bdaf6e6611d4094c440b552fb405&pid=1-s2.0-S0740257023001041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138395618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist 遗传性骨髓衰竭综合征和种系对骨髓瘤的易感性:病理学家的实用方法
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.006
Jingwei Li , Jacob R. Bledsoe
{"title":"Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist","authors":"Jingwei Li ,&nbsp;Jacob R. Bledsoe","doi":"10.1053/j.semdp.2023.06.006","DOIUrl":"10.1053/j.semdp.2023.06.006","url":null,"abstract":"<div><p><span><span>The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to </span>myeloid malignancy<span><span><span><span> is complex and involves correlation between clinical findings, laboratory and genetic studies, and bone marrow histopathology. The rarity of these disorders and the overlap of clinical and pathologic features between primary and secondary causes of bone marrow failure, acquired </span>aplastic anemia<span>, and myelodysplastic syndrome may result in diagnostic uncertainty. With an emphasis on the pathologist's perspective, we review diagnostically useful features of germline disorders including </span></span>Fanconi anemia<span>, Shwachman-Diamond syndrome, telomere biology disorders, </span></span>severe congenital neutropenia<span>, GATA2 deficiency, </span></span></span><em>SAMD9/SAMD9L</em> diseases, Diamond-Blackfan anemia, and acquired aplastic anemia. We discuss the distinction between baseline morphologic and genetic findings of these disorders and features that raise concern for the development of myelodysplastic syndrome.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 429-442"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom 儿童和年轻人的侵袭性非霍奇金淋巴瘤;诊断和分子的智慧之珠
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.002
Amrit Singh, Ifeyinwa E. Obiorah
{"title":"Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom","authors":"Amrit Singh,&nbsp;Ifeyinwa E. Obiorah","doi":"10.1053/j.semdp.2023.06.002","DOIUrl":"10.1053/j.semdp.2023.06.002","url":null,"abstract":"<div><p><span><span>Mature non-Hodgkin lymphomas (NHLs) of the pediatric and young adults(PYA), including </span>Burkitt lymphoma<span><span> (BL), diffuse large B cell lymphoma<span> (DLBCL), high-grade B cell lymphoma (HGBCL), primary mediastinal large B cell lymphoma (PMBL) and anaplastic large cell lymphoma (ALCL), generally have excellent prognosis compared to the adult population. BL, </span></span>DLBCL and </span></span>HGBCL<span><span><span> are usually of germinal center (GCB) origin in the PYA population. PMBL neither belongs to the GCB nor the activated B cell subtype and is associated with a poorer outcome than BL or DLBCL of comparable stage. Anaplastic large cell lymphoma is the most frequent </span>peripheral T cell lymphoma occurring in the PYA and accounts for 10–15% of childhood NHL. Most pediatric ALCL, unlike in the adult, demonstrate expression of </span>anaplastic lymphoma kinase<span> (ALK). In recent years, the understanding of the biology and molecular features of these aggressive lymphomas has increased tremendously. This has led to reclassification of newer PYA entities including Burkitt-like lymphoma with 11q aberration.</span></span></p><p>In this review, we will discuss the current progress discovered in frequently encountered aggressive NHLs in the PYA, highlighting the clinical, pathologic and molecular features that aid in the diagnosis of these aggressive lymphomas. We will be updating the new concepts and terminologies used in the new classification systems.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 392-400"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changing landscape of pediatric histiocytoses: Birth, life, and transdifferentiation of pediatric histiocytes 儿童组织细胞增多的变化:儿童组织细胞的出生、生命和转分化
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.003
Aaron Auerbach , Nadine S. Aguilera
{"title":"The changing landscape of pediatric histiocytoses: Birth, life, and transdifferentiation of pediatric histiocytes","authors":"Aaron Auerbach ,&nbsp;Nadine S. Aguilera","doi":"10.1053/j.semdp.2023.05.003","DOIUrl":"10.1053/j.semdp.2023.05.003","url":null,"abstract":"<div><p><span>Histiocytic neoplasms in the children are very rare, and histiocytoses can occur in the perinatal period<span>. The presumed origins and presentation of specific histiocytoses in the pediatric age group are described. Common and newly described histiocytoses are presented including </span></span>Langerhans cell histiocytosis<span>, Rosai-Dorfman disease, histiocytic sarcoma<span>, ALK positive histiocytosis, and hemophagocytic lymphohistiocytosis. Molecular findings common to pediatric histiocytoses are also discussed.</span></span></p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 420-428"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9551883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma 儿童人群中的反应性淋巴结病，重点是潜在的淋巴瘤模拟物
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.004
Rachel A. Mariani , Elizabeth L. Courville
{"title":"Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma","authors":"Rachel A. Mariani ,&nbsp;Elizabeth L. Courville","doi":"10.1053/j.semdp.2023.05.004","DOIUrl":"10.1053/j.semdp.2023.05.004","url":null,"abstract":"<div><p><span>Benign lymphadenopathy<span> is common in the pediatric population and may be clinically striking. As in adults, lymph node evaluation in pediatric patients requires careful morphologic and immunohistochemical assessment and clinical contextualization of the findings. It is important for the </span></span>pathologist<span> to be familiar with benign and reactive conditions that may mimic malignancy<span>. This review presents non-neoplastic or indolent processes or patterns of lymphoid hyperplasia that may be confused with or raise the differential of lymphoma, with a focus on those more commonly encountered in the pediatric/adolescent population.</span></span></p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 371-378"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9599381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small biopsies in the head and neck: Bone and soft tissue 头颈部小活检：骨和软组织
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-09-01 DOI: 10.1053/j.semdp.2023.06.003
Aarti E Sharma , Darcy A Kerr , Nicole A Cipriani
{"title":"Small biopsies in the head and neck: Bone and soft tissue","authors":"Aarti E Sharma ,&nbsp;Darcy A Kerr ,&nbsp;Nicole A Cipriani","doi":"10.1053/j.semdp.2023.06.003","DOIUrl":"10.1053/j.semdp.2023.06.003","url":null,"abstract":"<div><p><span>Bone and soft tissue lesions in the head and neck encompass not only a broad morphologic spectrum but also significant inherent clinicopathologic overlap. Epidemiology<span><span>, radiology, and location – similar to the diagnostic assessment in other sites – are especially important considerations in the context of an established mesenchymal proliferation. Herein, the approach towards diagnosis is stratified by morphology (spindle, </span>sarcomatoid, epithelioid, round cell), cellular lineage (fibroblastic, </span></span>nerve sheath, rhabdomyogenic), and tumor grade (benign, low- to high-grade malignant) as the basis of further immunohistochemical or molecular investigation.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 5","pages":"Pages 353-370"},"PeriodicalIF":2.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10102032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MASTHEAD (p/u from previous issue) MASTHEAD（上一期的p/u）
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-09-01 DOI: 10.1053/S0740-2570(23)00082-5
{"title":"MASTHEAD (p/u from previous issue)","authors":"","doi":"10.1053/S0740-2570(23)00082-5","DOIUrl":"https://doi.org/10.1053/S0740-2570(23)00082-5","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 5","pages":"Page IFC"},"PeriodicalIF":2.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50189861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary gland neoplasms in small biopsies and fine needle aspirations 小活检和细针穿刺中的涎腺肿瘤
IF 2.3 3区 医学
Seminars in Diagnostic Pathology Pub Date : 2023-09-01 DOI: 10.1053/j.semdp.2023.04.010
Jalal B. Jalaly, Zubair W. Baloch
{"title":"Salivary gland neoplasms in small biopsies and fine needle aspirations","authors":"Jalal B. Jalaly,&nbsp;Zubair W. Baloch","doi":"10.1053/j.semdp.2023.04.010","DOIUrl":"10.1053/j.semdp.2023.04.010","url":null,"abstract":"<div><p><span><span>Salivary gland neoplasms are rare and represent a diverse group of </span>head and neck tumors. Their diagnosis in limited cellularity specimens can be challenging as many of these have overlapping clinical, radiological presentation, and pathologic features. </span>Fine needle aspiration and/or core biopsies are more of a norm than rarity to be performed preoperatively to provide invaluable information that can guide clinical management including surgery. Even though these limited specimens may not always provide a definitive diagnosis; they have high sensitivity in confirming primary neoplasia, assessing the tumor grade, and ruling out non-surgical disease. An algorithmic pattern based approach can help narrow the differential diagnosis; leading to a definitive diagnosis with the help of specific ancillary studies.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 5","pages":"Pages 340-348"},"PeriodicalIF":2.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10040917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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