Seminars in Diagnostic Pathology最新文献_第9页

Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis 淋巴母细胞白血病/淋巴瘤分类和最小/可测量残留疾病分析的最新进展。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.10.001

Alexandra E. Kovach , Brent L. Wood

{"title":"Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis","authors":"Alexandra E. Kovach , Brent L. Wood","doi":"10.1053/j.semdp.2023.10.001","DOIUrl":"10.1053/j.semdp.2023.10.001","url":null,"abstract":"<div>Lymphoblastic leukemia/lymphoma (ALL/LBL), especially certain subtypes, continues to confer morbidity and mortality despite significant therapeutic advances. The pathologic classification of ALL/LBL, especially that of B-ALL, has recently substantially expanded with the identification of several distinct and prognostically important genetic drivers. These discoveries are reflected in both current classification systems, the World Health Organization (WHO) 5th edition and the new International Consensus Classification (ICC). In this article, novel subtypes of B-ALL are reviewed, including DUX4, MEF2D and ZNF384-rearranged B-ALL; the rare pediatric entity B-ALL with TLF3::HLF, now added to the classifications, is discussed; updates to the category of B-ALL with BCR::ABL1-like features (Ph-like B-ALL) are summarized; and emerging genetic subtypes of T-ALL are presented. The second half of the article details current approaches to minimal/measurable residual disease (MRD) detection in B-ALL and T-ALL and presents anticipated challenges to current approaches in the burgeoning era of antigen-directed immunotherapy.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 457-471"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classic Hodgkin lymphoma in young people 年轻人的典型霍奇金淋巴瘤

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.005

Srishti Gupta, Jeffrey W. Craig

{"title":"Classic Hodgkin lymphoma in young people","authors":"Srishti Gupta, Jeffrey W. Craig","doi":"10.1053/j.semdp.2023.06.005","DOIUrl":"10.1053/j.semdp.2023.06.005","url":null,"abstract":"<div>Classic Hodgkin lymphoma (CHL) is a unique form of lymphoid cancer featuring a heterogeneous tumor microenvironment and a relative paucity of malignant Hodgkin and Reed-Sternberg (HRS) cells with characteristic phenotype. Younger individuals (children, adolescents and young adults) are affected as often as the elderly, producing a peculiar bimodal age-incidence profile that has generated immense interest in this disease and its origins. Decades of epidemiological investigations have documented the populations most susceptible and identified multiple risk factors that can be broadly categorized as either biological or environmental in nature. Most risk factors result in overt immunodeficiency or confer more subtle alterations to baseline health, physiology or immune function. Epstein Barr virus, however, is both a risk factor and well-established driver of lymphomagenesis in a significant subset of cases. Epigenetic changes, along with the accumulation of somatic driver mutations and cytogenetic abnormalities are required for the malignant transformation of germinal center-experienced HRS cell precursors. Chromosomal instability and the influence of endogenous mutational processes are critical in this regard, by impacting genes involved in key signaling pathways that promote the survival and proliferation of HRS cells and their escape from immune destruction. Here we review the principal features, known risk factors and lymphomagenic mechanisms relevant to newly diagnosed CHL, with an emphasis on those most applicable to young people.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 379-391"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A personalized approach to lymphoproliferations in patients with inborn errors of immunity 先天性免疫缺陷患者淋巴细胞增生的个体化治疗方法

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.07.001

Shachar Naor , Etai Adam , Ginette Schiby , Dita Gratzinger

引用次数: 0

Post-transplant lymphoproliferative disorders (PTLD) in adolescents and young adults: A category in need of definition 青少年和年轻人移植后淋巴细胞增生性疾病(PTLD):一个需要定义的类别

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.07.002

Amy Chadburn

引用次数: 0

EDITORIAL BOARD (p/u from previous issue) 编辑委员会(p/u自上期)

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00103-X

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录表(p/u来自上一期，更新)

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/S0740-2570(23)00104-1

引用次数: 0

Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist 遗传性骨髓衰竭综合征和种系对骨髓瘤的易感性:病理学家的实用方法

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.006

Jingwei Li , Jacob R. Bledsoe

{"title":"Inherited bone marrow failure syndromes and germline predisposition to myeloid neoplasia: A practical approach for the pathologist","authors":"Jingwei Li , Jacob R. Bledsoe","doi":"10.1053/j.semdp.2023.06.006","DOIUrl":"10.1053/j.semdp.2023.06.006","url":null,"abstract":"<div>The diagnostic work up and surveillance of germline disorders of bone marrow failure and predisposition to myeloid malignancy is complex and involves correlation between clinical findings, laboratory and genetic studies, and bone marrow histopathology. The rarity of these disorders and the overlap of clinical and pathologic features between primary and secondary causes of bone marrow failure, acquired aplastic anemia, and myelodysplastic syndrome may result in diagnostic uncertainty. With an emphasis on the pathologist's perspective, we review diagnostically useful features of germline disorders including Fanconi anemia, Shwachman-Diamond syndrome, telomere biology disorders, severe congenital neutropenia, GATA2 deficiency, SAMD9/SAMD9L diseases, Diamond-Blackfan anemia, and acquired aplastic anemia. We discuss the distinction between baseline morphologic and genetic findings of these disorders and features that raise concern for the development of myelodysplastic syndrome.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 429-442"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom 儿童和年轻人的侵袭性非霍奇金淋巴瘤;诊断和分子的智慧之珠

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.06.002

Amrit Singh, Ifeyinwa E. Obiorah

{"title":"Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom","authors":"Amrit Singh, Ifeyinwa E. Obiorah","doi":"10.1053/j.semdp.2023.06.002","DOIUrl":"10.1053/j.semdp.2023.06.002","url":null,"abstract":"<div>Mature non-Hodgkin lymphomas (NHLs) of the pediatric and young adults(PYA), including Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL), high-grade B cell lymphoma (HGBCL), primary mediastinal large B cell lymphoma (PMBL) and anaplastic large cell lymphoma (ALCL), generally have excellent prognosis compared to the adult population. BL, DLBCL and HGBCL are usually of germinal center (GCB) origin in the PYA population. PMBL neither belongs to the GCB nor the activated B cell subtype and is associated with a poorer outcome than BL or DLBCL of comparable stage. Anaplastic large cell lymphoma is the most frequent peripheral T cell lymphoma occurring in the PYA and accounts for 10–15% of childhood NHL. Most pediatric ALCL, unlike in the adult, demonstrate expression of anaplastic lymphoma kinase (ALK). In recent years, the understanding of the biology and molecular features of these aggressive lymphomas has increased tremendously. This has led to reclassification of newer PYA entities including Burkitt-like lymphoma with 11q aberration.In this review, we will discuss the current progress discovered in frequently encountered aggressive NHLs in the PYA, highlighting the clinical, pathologic and molecular features that aid in the diagnosis of these aggressive lymphomas. We will be updating the new concepts and terminologies used in the new classification systems.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"40 6","pages":"Pages 392-400"},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9749630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The changing landscape of pediatric histiocytoses: Birth, life, and transdifferentiation of pediatric histiocytes 儿童组织细胞增多的变化:儿童组织细胞的出生、生命和转分化

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.003

Aaron Auerbach , Nadine S. Aguilera

引用次数: 0

Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma 儿童人群中的反应性淋巴结病，重点是潜在的淋巴瘤模拟物

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2023-11-01 DOI: 10.1053/j.semdp.2023.05.004

Rachel A. Mariani , Elizabeth L. Courville

引用次数: 0