Seminars in Diagnostic Pathology最新文献_第6页

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/S0740-2570(24)00093-5

引用次数: 0

Spectrum of atypical ductal hyperplasia (ADH) and ductal carcinoma in-situ (DCIS): Diagnostic challenges 非典型导管增生（ADH）和导管原位癌（DCIS）的谱系：诊断难题。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-11-01 DOI: 10.1053/j.semdp.2024.09.001

Philip Bomeisl , Hannah Gilmore

{"title":"Spectrum of atypical ductal hyperplasia (ADH) and ductal carcinoma in-situ (DCIS): Diagnostic challenges","authors":"Philip Bomeisl , Hannah Gilmore","doi":"10.1053/j.semdp.2024.09.001","DOIUrl":"10.1053/j.semdp.2024.09.001","url":null,"abstract":"<div><div>Breast specimens are some of the more common specimens sent to the pathology laboratory for diagnosis. From a clinical perspective, the diagnoses fall into three broad categories: benign, atypical and malignant with patients then being managed according to established guidelines. However, the pathologic diagnosis can sometimes be challenging, and the distinction between these categories is sometimes far more subtle and subjective than non-pathologist may understand. One recurring diagnostic challenge in breast pathology is the diagnosis of atypical ductal hyperplasia (ADH) versus ductal carcinoma in situ (DCIS). While many cases are straightforward, others are quite borderline and challenging to classify consistently with significant interobserver variation amongst pathologists. The distinction between ADH and DCIS is critical from a clinical management perspective because one is treated as a risk factor, and the other as a malignancy that will be completely surgically excised and may require radiation therapy. This review will address the spectrum of ADH and DCIS with the associated diagnostic challenges in the real-world setting from presentation at core needle biopsy to surgery.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 6","pages":"Pages 252-257"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Goblet cell adenocarcinoma 上皮细胞腺癌

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.003

Jula Veerapong, Mojgan Hosseini

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Appendiceal adenocarcinoma: Current concepts & challenges 阑尾腺癌：当前的概念与挑战。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.005

Phoenix D. Bell

{"title":"Appendiceal adenocarcinoma: Current concepts & challenges","authors":"Phoenix D. Bell","doi":"10.1053/j.semdp.2024.08.005","DOIUrl":"10.1053/j.semdp.2024.08.005","url":null,"abstract":"<div><p>Appendiceal adenocarcinoma (ApAC) is a rare malignancy, comprising less than 1 % of all gastrointestinal tumors. The current World Health Organization classifies ApAC as mucinous or nonmucinous. Mucinous ApAC are composed of pools of mucin lined by cells with low- and high-grade cytology and areas of infiltrative invasion. Nonmucinous ApAC histologically resemble conventional colorectal adenocarcinomas and have a worse prognosis than their mucinous counterpart. Unfortunately, the nomenclature and histologic classification of ApAC, specifically the mucinous subtype, has changed several times throughout the years, contributing to diagnostic confusion for pathologists. The treatment for mucinous ApAC differs from that of other appendiceal mucinous neoplasms, thus accurate diagnosis is key to patient management and outcome. This review discusses the current classification and staging of ApAC with a particular emphasis on the mucinous subtype and peritoneal disease, as these areas are the most challenging for practicing surgical pathologists.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 5","pages":"Pages 213-221"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257024000704/pdfft?md5=39f03b1d3dfa4cae71f84dc71896b7ce&pid=1-s2.0-S0740257024000704-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/S0740-2570(24)00074-1

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A practical guide to serrated appendiceal lesions 阑尾锯齿状病变实用指南

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.07.001

Domenika Ortiz Requena, Rhonda K. Yantiss

{"title":"A practical guide to serrated appendiceal lesions","authors":"Domenika Ortiz Requena, Rhonda K. Yantiss","doi":"10.1053/j.semdp.2024.07.001","DOIUrl":"10.1053/j.semdp.2024.07.001","url":null,"abstract":"<div><p>Several neoplastic and non-neoplastic proliferations of the appendix can show varying degrees of serrated epithelial architecture. Of these, diffuse mucosal hyperplasia is most common, followed in frequency by low-grade mucinous and serrated neoplasms. It is important to distinguish serrated appendiceal neoplasms from their potential mimics because these entities may be managed differently. Diffuse mucosal hyperplasia is a non-neoplastic change that usually develops in the setting of resolving appendicitis and requires no further therapy or surveillance, and serrated neoplasms confined to the mucosa are adequately treated by appendectomy alone. On the other hand, low-grade appendiceal mucinous neoplasms may require surveillance, and those with extra-appendiceal spread differ from adenocarcinomas arising from serrated neoplasms with respect to both treatment and prognosis. Low-grade mucinous neoplasms in the peritoneum are frequently amenable to peritoneum-directed therapies alone, while adenocarcinomas derived from serrated neoplasms often spread to both regional lymph nodes and the peritoneum, potentially requiring right colectomy and systemic chemotherapy. The purpose of this review is to summarize the literature regarding the clinical and pathologic features of appendiceal lesions that show epithelial serration and provide the reader with helpful tips to distinguish serrated neoplasms from their mimics.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 5","pages":"Pages 243-249"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录（上期内容，有更新）

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/S0740-2570(24)00076-5

引用次数: 0

Well-differentiated neuroendocrine tumors of the appendix: Diagnosis, differentials, and disease progression 阑尾分化良好的神经内分泌肿瘤：诊断、鉴别和疾病进展。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.001

Pooja Navale , Raul S. Gonzalez

{"title":"Well-differentiated neuroendocrine tumors of the appendix: Diagnosis, differentials, and disease progression","authors":"Pooja Navale , Raul S. Gonzalez","doi":"10.1053/j.semdp.2024.08.001","DOIUrl":"10.1053/j.semdp.2024.08.001","url":null,"abstract":"<div><p>Well-differentiated neuroendocrine tumors are the most common neoplasm of the appendix. They are graded and staged using World Health Organization and American Joint Committee on Cancer criteria, respectively. They may be invisible grossly or form rounded yellow nodules, sometimes in the appendiceal tip. They show classic neuroendocrine tumor features microscopically, forming nests and cords of monotonous cells with salt-and-pepper chromatin and amphophilic cytoplasm. They are positive for neuroendocrine markers by immunohistochemistry, but their molecular characteristics are not well defined. pT-category staging relies primarily on tumor size, though higher-stage cases may involve the subserosa or mesoappendix. Few entities enter the differential diagnosis, but lesions such as goblet cell adenocarcinoma, poorly differentiated neuroendocrine carcinoma, and mixed neuroendocrine-non-neuroendocrine neoplasm may be considered. Appendiceal neuroendocrine tumors may metastasize to regional lymph nodes, but farther spread is rare. The most consistently proven risk factor for such spread is tumor size, though different studies have proposed different cutoffs. Other potential risk factors include lymphovascular invasion and margin positivity. Tumors smaller than 1 cm can be treated by appendectomy, while hemicolectomy is recommended for tumors larger than 2 cm. Proper treatment for cases measuring 1–2 cm remains a matter of debate.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 5","pages":"Pages 236-242"},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Exploring the mysterious mucinous appendiceal neoplasm 探索神秘的粘液性阑尾肿瘤

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.002

Erika Hissong

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Updates in appendiceal neoplasms 阑尾肿瘤的最新进展。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-09-01 DOI: 10.1053/j.semdp.2024.08.004

Phoenix D. Bell

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