Seminars in Diagnostic Pathology最新文献_第6页

Expanding the cytological and architectural spectrum of mucoepidermoid carcinoma: The key to solving diagnostic problems in morphological variants 扩展粘液表皮样癌的细胞学和结构谱：解决形态变异诊断问题的关键

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-04-03 DOI: 10.1053/j.semdp.2024.04.001

Shinnichi Sakamoto, Kentaro Kikuchi

{"title":"Expanding the cytological and architectural spectrum of mucoepidermoid carcinoma: The key to solving diagnostic problems in morphological variants","authors":"Shinnichi Sakamoto, Kentaro Kikuchi","doi":"10.1053/j.semdp.2024.04.001","DOIUrl":"10.1053/j.semdp.2024.04.001","url":null,"abstract":"<div>Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Varying sized cysts and sheets composed of three cell types (epidermoid, intermediate, and mucous cells) with varying degrees of atypia form the characteristic histological appearance of MEC. MEC frequently contains a wide variety of modified tumor cells and can be entirely cystic or completely solid. Under these circumstances, MEC requires critical differentiation from many mimickers, ranging from simple cysts and benign tumors to high-grade carcinomas. Tumor-associated lymphoid proliferation and sclerotic changes in the stroma also contribute to diagnostic difficulties. Several well-known diagnostically challenging variants (oncocytic, clear cell, spindle cell, and sclerosing) exist in MEC. With the advent of studies on specific CRTC1/3::MAML2 fusion genes in MEC, newly proposed subtypes have emerged, including Warthin-like and non-sebaceous lymphadenoma-like MECs. In addition to the recently defined mucoacinar variant with a serous cell phenotype, MEC devoid of squamous differentiation has also been reported, implying the need to reconsider this basic concept. In this article, we outline the general clinical features and MAML2 status of conventional MEC and review the cytoarchitectural subtypes, with an emphasis on a pitfall in the interpretation of this histologically diverse single entity.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 182-189"},"PeriodicalIF":2.9,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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TABLE OF CONTENTS (p/u from previous issue w/updates) 目录（上期内容，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/S0740-2570(24)00024-8

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Differential diagnosis of IgG4-positive plasma cells in the lung 肺igg4阳性浆细胞的鉴别诊断。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2023.11.006

Sanjay Mukhopadhyay

{"title":"Differential diagnosis of IgG4-positive plasma cells in the lung","authors":"Sanjay Mukhopadhyay","doi":"10.1053/j.semdp.2023.11.006","DOIUrl":"10.1053/j.semdp.2023.11.006","url":null,"abstract":"<div>The recognition of immunoglobulin G4-related disease (IgG4-RD) as an entity in the pancreaticobiliary tract was followed by a slew of papers describing inflammation and fibrosis containing IgG4-positive plasma cells in a variety of sites including the respiratory tract, leading to the hypothesis that these abnormalities were attributable to IgG4-RD. Predictably, pathologists began to see requests from clinicians to perform IgG4 immunohistochemistry in lung biopsies “to rule out IgG4-RD”. Several years later, the notion that IgG4-RD would prove to be the underlying cause of a wide array of fibroinflammatory lesions in the lung has not panned out as promised. To the contrary, it has become clear that IgG4-positive plasma cells are not specific for IgG4-RD, and that large numbers of IgG4-positive plasma cells can be encountered in other well-defined entities, including inflammatory myofibroblastic tumor and nodular lymphoid hyperplasia, as well as in lymphoplasmacytic infiltrates in other entities, including connective tissue disease and idiopathic forms of interstitial lung disease. It has also become clear that raised serum IgG4 levels can occur in settings other than IgG4-RD. These observations suggest that true IgG4-RD of the lung is far less common than previously surmised. Pathologists must familiarize themselves with mimics of IgG4-RD in the lung and exercise caution before attributing lymphoplasmacytic infiltrates in the lung to IgG4-RD.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 72-78"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2023.12.001

Sarwat I. Gilani , Alessia Buglioni , Lynn D. Cornell

{"title":"IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics","authors":"Sarwat I. Gilani , Alessia Buglioni , Lynn D. Cornell","doi":"10.1053/j.semdp.2023.12.001","DOIUrl":"10.1053/j.semdp.2023.12.001","url":null,"abstract":"<div>IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial nephritis (IgG4-TIN), and then IgG4-related membranous glomerulonephritis (IgG4-MGN), we now recognize additional patterns of interstitial nephritis, glomerular disease, and vascular disease that can be seen as part of IgG4-RKD. The clinical presentation is variable and can include acute or chronic kidney injury, proteinuria or nephrotic syndrome, mass lesion(s), and obstruction. While usually associated with other organ involvement by IgG4-RD, kidney-alone involvement is present in approximately 20 % of IgG4-RKD. Compared to IgG4-RD overall, patients with IgG4-RKD are more likely to show increased serum IgG4 or IgG, and more likely to have hypocomplementemia. In this review, we extensively cover other types of autoimmune and plasma cell-rich interstitial nephritis, mass forming inflammatory diseases of the kidney, and other mimics of IgG4-TIN, in particular ANCA-associated disease.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 88-94"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138821355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unraveling the complexities of IgG4-related disease: Musings from a histopathologist 解读 IgG4 相关疾病的复杂性：组织病理学家的思考

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2024.01.004

Vikram Deshpande

引用次数: 0

Challenges and pitfalls in the diagnosis of IgG4-related disease igg4相关疾病诊断的挑战和缺陷

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2023.11.005

Adrian C. Bateman , Emma L. Culver

{"title":"Challenges and pitfalls in the diagnosis of IgG4-related disease","authors":"Adrian C. Bateman , Emma L. Culver","doi":"10.1053/j.semdp.2023.11.005","DOIUrl":"10.1053/j.semdp.2023.11.005","url":null,"abstract":"<div>IgG4-related disease (IgG4-RD) is a relatively novel fibroinflammatory condition characterized typically by dense lymphoplasmacytic inflammation, storiform fibrosis and obliterative venulitis, together with prominent IgG4+ plasma cells and an IgG4+/IgG+ plasma cell ratio of >40 %. The diagnosis is usually made on a combination of clinical and serological features together with characteristic radiological and histological appearances. The condition may be limited to a single tissue/organ (e.g., autoimmune pancreatitis) or may be multicentric in nature – four clinical ‘patterns’ of disease distribution have recently been described. The diagnosis of IgG4-RD can be challenging, particularly when the clinical presentation is unusual and/or when the histological features are not typical. A diagnosis of IgG4-RD may still be achieved in these situations, after careful clinicopathological discussion e.g., at a specialist multidisciplinary team meeting. However, a wide range of other conditions (neoplastic and non-neoplastic) can mimic IgG4-RD, clinically and/or on histological examination. The relationship between IgG4-RD and non-IgG4-RD associated conditions in some clinical situations is particularly complex. This review describes the role of histological examination in the diagnosis of IgG4-RD, discusses some of the practical difficulties that may be encountered and provides an insight into the range of non-IgG4-RD associated conditions that can mimic IgG4-RD on clinical and/or histological grounds. The requirement for interpretation of histological features in the context of the global clinical picture of the patient is highlighted and emphasized.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 45-53"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/S0740-2570(24)00021-2

引用次数: 0

Mimickers of immunoglobulin G4-related hepatobiliary disease on biopsy 活组织检查中免疫球蛋白 G4 相关肝胆疾病的模拟物

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2024.01.009

Byoung Uk Park, Hee Eun Lee, Lizhi Zhang

{"title":"Mimickers of immunoglobulin G4-related hepatobiliary disease on biopsy","authors":"Byoung Uk Park, Hee Eun Lee, Lizhi Zhang","doi":"10.1053/j.semdp.2024.01.009","DOIUrl":"10.1053/j.semdp.2024.01.009","url":null,"abstract":"<div>With the growing recognition of IgG4-related hepatobiliary disease, establishing a definitive diagnosis relies mainly on a combination of clinical findings, serological markers, and imaging modalities. However, the role of histopathological evaluation remains indispensable, particularly in cases necessitating differential diagnosis or malignancy exclusion. While diagnosing IgG4-related hepatobiliary disease through surgical resection specimens is often straightforward, pathologists encounter substantial challenges when evaluating biopsies. The increasing rarity of surgical interventions exacerbates this due to improved disease recognition and suspicion. Numerous confounding factors, including the absence of the characteristic histologic features, limited tissue sample size, biopsy artifacts, and the limited value of IgG4 counts, further complicate the diagnostic process. Additionally, many other disorders exhibit clinical and histological features that overlap with IgG4-related disease, intensifying the complexity of interpreting biopsy specimens. This article explores the clinical and histomorphologic features of IgG4-related hepatobiliary disease and its potential mimickers. It offers valuable insights for pathologists and clinicians when confronted with biopsy specimens from hepatobiliary organs.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 95-107"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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EDITORIAL BOARD (p/u from previous issue) 编辑委员会（上期增刊）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/S0740-2570(24)00023-6

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MASTHEAD (p/u from previous issue) MASTHEAD （P/U 自上期起）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/S0740-2570(24)00022-4

引用次数: 0