Seminars in Diagnostic Pathology最新文献_第6页

Aggressive Mediastinal Lymphomas 侵袭性纵隔淋巴瘤

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2021.06.010

Xiaoqiong Wang , Wei Wang , Francisco Vega , Andres E. Quesada

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Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors Birt-Hogg-Dubé 综合征全貌：聚焦肾肿瘤的临床病理前景

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.01.008

Jialong Wu , Jian Lu , Chin-Lee Wu , Min Lu

{"title":"Birt-Hogg-Dubé syndrome in an overall view: Focus on the clinicopathological prospects in renal tumors","authors":"Jialong Wu , Jian Lu , Chin-Lee Wu , Min Lu","doi":"10.1053/j.semdp.2024.01.008","DOIUrl":"10.1053/j.semdp.2024.01.008","url":null,"abstract":"<div>Birt-Hogg-Dubé syndrome (BHD) represents a rare autosomal dominant tumor predisposition syndrome characterized by skin lesions, lung cysts, and renal tumors. The predominant histological subtypes of BHD-related renal tumors include hybrid oncocytoma-chromophobe tumors, oncocytomas, and chromophobe renal cell carcinomas, all exhibiting eosinophilic/oncocytic features. Immunohistochemistry staining for KIT (CD117) and CK7 exhibits variability in these tumor types. Germline mutations in FLCN have been consistently identified. Generally, patients with BHD demonstrate a favorable prognosis with minimal metastatic potential. Nonetheless, the comprehensive elucidation of pathological characteristics of BHD remains incomplete, particularly in BHD-associated renal tumors that deviate from the previously identified subtypes, thereby complicating the differential diagnosis. In this review, we provide a comprehensive overview of BHD encompassing epidemiology, clinical manifestations, genetic and molecular pathogenesis, as well as clinical diagnostic modalities. Emphasis is placed on clinicopathological features, specifically focusing on BHD-associated renal tumors. Collectively, this review aims to present the latest insights into BHD which benefits in the early detection, therapeutic decision-making, and prognosis prediction in BHD cases, and deepen the understanding of sporadic renal tumors.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Pages 119-124"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Playing editorial catch up 在编辑方面迎头赶上。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.05.002

Justin A. Bishop

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COVER (PMS 180&K) (p/u from previous issue w/updates) 封面（PMS 180&K）（上一期的原版，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/S0740-2570(24)00032-7

引用次数: 0

Pathology of hereditary renal cell carcinoma syndromes 遗传性肾细胞癌综合征病理学

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2024.01.010

Chin-Lee Wu

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A review of prognostic factors in squamous cell carcinoma of the vulva: Evidence from the last decade 外阴鳞状细胞癌预后因素综述：过去十年的证据。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-05-01 DOI: 10.1053/j.semdp.2020.09.009

Julia Chen , Hoang LN

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High-grade salivary carcinomas: A current insight on diagnostic pathology and the key to clinical decision making 高级别唾液腺癌：病理诊断的最新见解和临床决策的关键。

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-04-17 DOI: 10.1053/j.semdp.2024.04.002

Yoshitaka Utsumi , Masato Nakaguro , Yuichiro Tada , Toshitaka Nagao

{"title":"High-grade salivary carcinomas: A current insight on diagnostic pathology and the key to clinical decision making","authors":"Yoshitaka Utsumi , Masato Nakaguro , Yuichiro Tada , Toshitaka Nagao","doi":"10.1053/j.semdp.2024.04.002","DOIUrl":"10.1053/j.semdp.2024.04.002","url":null,"abstract":"<div>High-grade carcinomas of the salivary glands are a group of several tumor entities with highly malignant histologic appearances, and have an aggressive biological behavior accompanied by poor a prognosis. In general, they require more intensive treatment than low- or intermediate-grade carcinomas. High-grade salivary carcinomas are rare and the microscopic features often overlap between different tumor types, making an appropriate diagnosis challenging in daily practice settings. However, with recent rapid advances in molecular pathology and molecular-targeted therapy in this field, there is a growing need to properly classify tumors, rather than just diagnosing the cases as “high-grade carcinomas”. This leads to specific treatment strategies. In this article, we review representative high-grade salivary gland carcinomas, including salivary duct carcinoma and its histologic subtypes, high-grade mucoepidermoid carcinoma, solid-type adenoid cystic carcinoma, and high-grade transformation of low- or intermediate-grade carcinomas, and discuss their differential diagnoses and clinical implications. Other rare entities, such as neuroendocrine carcinoma, NUT carcinoma, and metastatic carcinoma, should also be considered before diagnosing high-grade carcinoma, NOS. Of these tumors, salivary duct carcinoma has received the most attention because of its strong association with androgen deprivation and anti-HER2 therapies. Other tumor-type-specific treatments include anti-TRK therapy for high-grade transformation of secretory carcinoma, but further therapeutic options are expected to be developed in the future. It should be emphasized that detailed histological evaluation with adequate sampling, in addition to the effective use of molecular ancillary tests, is of the utmost importance for a suitable diagnosis.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 197-206"},"PeriodicalIF":2.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the cytological and architectural spectrum of mucoepidermoid carcinoma: The key to solving diagnostic problems in morphological variants 扩展粘液表皮样癌的细胞学和结构谱：解决形态变异诊断问题的关键

IF 2.9 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-04-03 DOI: 10.1053/j.semdp.2024.04.001

Shinnichi Sakamoto, Kentaro Kikuchi

{"title":"Expanding the cytological and architectural spectrum of mucoepidermoid carcinoma: The key to solving diagnostic problems in morphological variants","authors":"Shinnichi Sakamoto, Kentaro Kikuchi","doi":"10.1053/j.semdp.2024.04.001","DOIUrl":"10.1053/j.semdp.2024.04.001","url":null,"abstract":"<div>Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. Varying sized cysts and sheets composed of three cell types (epidermoid, intermediate, and mucous cells) with varying degrees of atypia form the characteristic histological appearance of MEC. MEC frequently contains a wide variety of modified tumor cells and can be entirely cystic or completely solid. Under these circumstances, MEC requires critical differentiation from many mimickers, ranging from simple cysts and benign tumors to high-grade carcinomas. Tumor-associated lymphoid proliferation and sclerotic changes in the stroma also contribute to diagnostic difficulties. Several well-known diagnostically challenging variants (oncocytic, clear cell, spindle cell, and sclerosing) exist in MEC. With the advent of studies on specific CRTC1/3::MAML2 fusion genes in MEC, newly proposed subtypes have emerged, including Warthin-like and non-sebaceous lymphadenoma-like MECs. In addition to the recently defined mucoacinar variant with a serous cell phenotype, MEC devoid of squamous differentiation has also been reported, implying the need to reconsider this basic concept. In this article, we outline the general clinical features and MAML2 status of conventional MEC and review the cytoarchitectural subtypes, with an emphasis on a pitfall in the interpretation of this histologically diverse single entity.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 182-189"},"PeriodicalIF":2.9,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TABLE OF CONTENTS (p/u from previous issue w/updates) 目录（上期内容，有更新）

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/S0740-2570(24)00024-8

引用次数: 0

Differential diagnosis of IgG4-positive plasma cells in the lung 肺igg4阳性浆细胞的鉴别诊断。

IF 2.3 3区医学

Seminars in Diagnostic Pathology Pub Date : 2024-03-01 DOI: 10.1053/j.semdp.2023.11.006

Sanjay Mukhopadhyay

{"title":"Differential diagnosis of IgG4-positive plasma cells in the lung","authors":"Sanjay Mukhopadhyay","doi":"10.1053/j.semdp.2023.11.006","DOIUrl":"10.1053/j.semdp.2023.11.006","url":null,"abstract":"<div>The recognition of immunoglobulin G4-related disease (IgG4-RD) as an entity in the pancreaticobiliary tract was followed by a slew of papers describing inflammation and fibrosis containing IgG4-positive plasma cells in a variety of sites including the respiratory tract, leading to the hypothesis that these abnormalities were attributable to IgG4-RD. Predictably, pathologists began to see requests from clinicians to perform IgG4 immunohistochemistry in lung biopsies “to rule out IgG4-RD”. Several years later, the notion that IgG4-RD would prove to be the underlying cause of a wide array of fibroinflammatory lesions in the lung has not panned out as promised. To the contrary, it has become clear that IgG4-positive plasma cells are not specific for IgG4-RD, and that large numbers of IgG4-positive plasma cells can be encountered in other well-defined entities, including inflammatory myofibroblastic tumor and nodular lymphoid hyperplasia, as well as in lymphoplasmacytic infiltrates in other entities, including connective tissue disease and idiopathic forms of interstitial lung disease. It has also become clear that raised serum IgG4 levels can occur in settings other than IgG4-RD. These observations suggest that true IgG4-RD of the lung is far less common than previously surmised. Pathologists must familiarize themselves with mimics of IgG4-RD in the lung and exercise caution before attributing lymphoplasmacytic infiltrates in the lung to IgG4-RD.</div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 2","pages":"Pages 72-78"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0