{"title":"The basaloid-spectrum of salivary gland tumors: A focused review with practical diagnostic considerations","authors":"Doreen N. Palsgrove","doi":"10.1053/j.semdp.2024.06.003","DOIUrl":"10.1053/j.semdp.2024.06.003","url":null,"abstract":"<div><p>Basaloid salivary gland neoplasms are a diverse and varied group of benign and malignant tumors. The term ‘basaloid’ is broadly used in reference to cells with elevated nuclear to cytoplasmic ratio, sparse cytoplasm, and hyperchromatic nuclei. However, a subset may also fit within the “small round blue cell tumor” morphologic category or the “biphasic” salivary gland tumor category. Furthermore, there are no established thresholds for the proportion of basaloid tumor cells needed to consider a tumor within the basaloid spectrum. Given the implicit variability in what is considered a basaloid salivary gland tumor, one may question the inclusion of certain entities (canalicular adenoma, <em>HMGA2</em>::<em>WIF1</em> pleomorphic adenoma, polymorphous adenocarcinoma) in this review based on classic morphologic features. However, salivary gland tumors with even minor basaloid components may appear ‘basaloid’ in small biopsy specimens and, thus, a choice was made to focus on common and uncommon diagnostic differentials with this in mind.</p><p>Entities that will be covered in this review also include basal cell adenoma and basal cell adenocarcinoma, adenoid cystic carcinoma, lymphoepithelial carcinoma, sialoblastoma, adamantinoma-like Ewing Sarcoma, NUT carcinoma, and carcinoma showing thymus-like differentiation.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 173-181"},"PeriodicalIF":2.9,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clearing the clouds of uncertainty: Foreword for the special issue “Diagnostic pitfalls of salivary gland tumor pathology”","authors":"Masato Nakaguro","doi":"10.1053/j.semdp.2024.06.002","DOIUrl":"10.1053/j.semdp.2024.06.002","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 163-164"},"PeriodicalIF":2.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mucin-rich salivary gland tumors","authors":"Justin A. Bishop","doi":"10.1053/j.semdp.2024.06.001","DOIUrl":"10.1053/j.semdp.2024.06.001","url":null,"abstract":"<div><p>Salivary gland neoplasms characterized by abundant mucin production are rare but have long been recognized. Due to their scarcity, precise classification has long eluded these mucin-rich tumors. Recent molecular discoveries, however, have shed considerable light on the genetic underpinnings of mucin-rich salivary gland neoplasms. This manuscript will review the most up-to-date information on this fascinating group of salivary gland neoplasms.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 165-172"},"PeriodicalIF":2.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic clues and pitfalls in salivary gland fine-needle aspiration cytology","authors":"Masato Nakaguro","doi":"10.1053/j.semdp.2024.04.003","DOIUrl":"10.1053/j.semdp.2024.04.003","url":null,"abstract":"<div><p>Salivary gland tumors (SGT) display morphological diversity and pose diagnostic challenges. Preoperative fine needle aspiration cytology (FNAC) is a minimally invasive and efficient diagnostic test. However, due to the limited sample size, the final diagnosis may not be established based on FNAC alone. Although cytomorphology and architecture are usually preserved on FNAC, morphologic changes specific to FNAC can complicate the diagnosis. The Milan System for Reporting Salivary Gland Cytopathology categorizes complex FNAC interpretations. Because the cytological diagnosis is closely linked to the histological diagnosis, a multidimensional approach considering the possibility of several differential diagnoses is necessary. From the standpoint of treatment, distinguishing high-grade malignancy from low-grade malignancy is more important than distinguishing malignancy from benign tumors.</p></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 4","pages":"Pages 207-211"},"PeriodicalIF":2.9,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark R. Wick MD , Michael B. McDermott MB, MRCPath , Paul E. Swanson MD
{"title":"Corrigendum to “Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasm” Seminars in Diagnostic Pathology 31 (2014) 66-88","authors":"Mark R. Wick MD , Michael B. McDermott MB, MRCPath , Paul E. Swanson MD","doi":"10.1053/j.semdp.2020.07.002","DOIUrl":"10.1053/j.semdp.2020.07.002","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Page 161"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257020300654/pdfft?md5=e661f610c2ea3dbcaa198a5ecc47b1f0&pid=1-s2.0-S0740257020300654-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38277506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TABLE OF CONTENTS (p/u from previous issue w/updates)","authors":"","doi":"10.1053/S0740-2570(24)00035-2","DOIUrl":"https://doi.org/10.1053/S0740-2570(24)00035-2","url":null,"abstract":"","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"41 3","pages":"Page ii"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0740257024000352/pdfft?md5=2c80d06250b385fb74ca619080690cb9&pid=1-s2.0-S0740257024000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}