Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-08-13DOI: 10.1055/a-2681-6597
Hamid Ali, Ahmad Abu Qdais, Arindam Chatterjee, Mohamad Abdalkader, Eytan Raz, Thanh N Nguyen, Sami Al Kasab
{"title":"Updates in Cerebrovascular Imaging.","authors":"Hamid Ali, Ahmad Abu Qdais, Arindam Chatterjee, Mohamad Abdalkader, Eytan Raz, Thanh N Nguyen, Sami Al Kasab","doi":"10.1055/a-2681-6597","DOIUrl":"10.1055/a-2681-6597","url":null,"abstract":"<p><p>Cerebrovascular imaging has undergone significant advances, enhancing the diagnosis and management of cerebrovascular diseases such as stroke, aneurysms, and arteriovenous malformations. This chapter explores key imaging modalities, including non-contrast computed tomography, computed tomography angiography, magnetic resonance imaging (MRI), and digital subtraction angiography. Innovations such as high-resolution vessel wall imaging, artificial intelligence (AI)-driven stroke detection, and advanced perfusion imaging have improved diagnostic accuracy and treatment selection. Additionally, novel techniques like 7-T MRI, molecular imaging, and functional ultrasound provide deeper insights into vascular pathology. AI and machine learning applications are revolutionizing automated detection and prognostication, expediting treatment decisions. Challenges remain in standardization, radiation exposure, and accessibility. However, continued technological advances, multimodal imaging integration, and AI-driven automation promise a future of precise, non-invasive cerebrovascular diagnostics, ultimately improving patient outcomes.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"601-613"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-09-03DOI: 10.1055/a-2694-4877
Tyler M Schmidt, Lama Abdel Wahed
{"title":"Updates in Multiple Sclerosis Imaging.","authors":"Tyler M Schmidt, Lama Abdel Wahed","doi":"10.1055/a-2694-4877","DOIUrl":"10.1055/a-2694-4877","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) remains an integral diagnostic tool in multiple sclerosis (MS), for both making the initial diagnosis and monitoring for disease relapse and progression. Despite the applied use of MRI according to the revised McDonald's criteria in 2017, there has been persistent low diagnostic specificity, especially as it pertains to differentiating radiologically isolated syndrome from alternative diagnoses that mimic demyelination. This report will provide an overview of recent paraclinical innovations, with a focus on MRI biomarkers and parameters such as the central vein and paramagnetic rim signs. Utilizing these tools in clinical practice will hopefully improve precision in the diagnosis and monitoring of MS and reduce the risk of false-positive diagnoses.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"623-631"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-11-07DOI: 10.1055/a-2720-8868
David M Greer
{"title":"Lama Abdel Wahed, MD, and Tracey A. Cho, MD, FAAN.","authors":"David M Greer","doi":"10.1055/a-2720-8868","DOIUrl":"10.1055/a-2720-8868","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"563"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-11-11DOI: 10.1055/a-2709-6725
Bart K Chwalisz
{"title":"Clinicoradiologic Assessment of the Cranial Nerves and Skull Base: A Primer for Neurologists in 10 Clinical Pearls.","authors":"Bart K Chwalisz","doi":"10.1055/a-2709-6725","DOIUrl":"10.1055/a-2709-6725","url":null,"abstract":"<p><p>The skull base and cranial nerves are of high neurological interest. Although the anatomy is complex, a clinicoradiologic approach using modern neuroimaging informed by history taking and physical examination can be employed to elucidate many problems in skull base neurology. This review illustrates diagnostic principles and pearls in skull base medicine with illustrative case vignettes.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"614-622"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-06-30DOI: 10.1055/a-2645-2914
Prashanth Rajarajan, Carson Quinn, Kathryn B Holroyd
{"title":"Neuroimaging of Central Nervous System Infections.","authors":"Prashanth Rajarajan, Carson Quinn, Kathryn B Holroyd","doi":"10.1055/a-2645-2914","DOIUrl":"10.1055/a-2645-2914","url":null,"abstract":"<p><p>Neuroimaging plays a key role in the diagnosis of central nervous system (CNS) infections, as well as common infectious mimics. Standard imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI), as well as advanced techniques such as vessel wall imaging and MR spectroscopy, are becoming widely used in many areas of the world and are valuable tools to aid neurologists in clinical practice. This review seeks to elucidate patterns of infectious pathogen tropism in the brain and spine, detail key imaging features of specific neuroinfectious pathogens such as patterns of enhancement and formation of mass lesions, and improve understanding of the sequential development of CNS infections and their complications including stroke and hydrocephalus. Here, we focus on a clinically relevant approach, categorizing pathogens in detail based on clinical syndrome and neuroanatomical imaging findings.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"584-600"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-10-01Epub Date: 2025-10-27DOI: 10.1055/a-2716-1306
Lama Abdel Wahed, Tracey A Cho
{"title":"Updates in Neuroradiology and Cutting Edge Imaging Techniques.","authors":"Lama Abdel Wahed, Tracey A Cho","doi":"10.1055/a-2716-1306","DOIUrl":"10.1055/a-2716-1306","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"564-565"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145379534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-08-01Epub Date: 2025-04-28DOI: 10.1055/a-2576-4291
Neil A Busis, Robert Montgomery, Bruce H Cohen
{"title":"Documentation, Coding, and Billing for Neurologic Services and Procedures.","authors":"Neil A Busis, Robert Montgomery, Bruce H Cohen","doi":"10.1055/a-2576-4291","DOIUrl":"10.1055/a-2576-4291","url":null,"abstract":"<p><p>Documentation, coding, and billing (claims submission) are foundational to neurologic practice in the United States, enabling accurate reimbursement, effective communication, and data-driven advancements in patient care, research, and education. Neurologists navigate complex regulatory frameworks and evolving payer guidelines, requiring meticulous attention to diagnostic coding, evaluation and management (E/M) services, and procedure-specific requirements. This chapter examines critical aspects of neurologic billing and coding, including ICD-10-CM (International Classification of Diseases, Tenth Revision, Clinical Modification) for diagnostic accuracy, updated E/M guidelines emphasizing medical decision-making and time, and new telemedicine codes. It highlights the best practices for procedure coding and the use of digital health technologies. The challenges posed by prior authorization are explored, alongside potential solutions like artificial intelligence-driven tools and policy reform. By prioritizing precision, compliance, and technological adaptation, neurologists can enhance patient outcomes, support practice sustainability, and contribute to the broader goals of equitable, efficient, and innovative neurologic care.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"478-486"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-08-01Epub Date: 2025-06-12DOI: 10.1055/a-2632-9941
Lee Williams
{"title":"Shifting Landscapes: Evolving Practice Models in Neurology.","authors":"Lee Williams","doi":"10.1055/a-2632-9941","DOIUrl":"10.1055/a-2632-9941","url":null,"abstract":"<p><p>The practice of neurology is undergoing significant transformation due to evolving economic pressures, workforce shortages, and increasing demand for neurologic care. Lower reimbursements, increasing operating expenses, and complexity of care challenge the sustainability of existing practice models. This study outlines critical considerations for practice and staffing models in neurology, focusing on strategies to optimize access to care, contain costs for patients and the practice, and enhance operational efficiency. Key topics discussed include integrating advanced practice providers, expanding teleneurology and intravisit care, exploring value-based care models, and enhancing workflows via technology to improve patient experience and clinic efficiency. As the field continues to evolve, neurology practices must adopt agile strategies that balance clinical excellence with economic sustainability in order to meet the demands of a challenging healthcare landscape.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"503-511"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-08-01Epub Date: 2025-04-04DOI: 10.1055/a-2552-3903
Chloé E Hill, Chun Chieh Lin, Brian C Callaghan
{"title":"Ensuring Access to Neurologic Care: Challenges and Opportunities.","authors":"Chloé E Hill, Chun Chieh Lin, Brian C Callaghan","doi":"10.1055/a-2552-3903","DOIUrl":"10.1055/a-2552-3903","url":null,"abstract":"<p><p>Neurologic disorders are prevalent in the United States, with an estimated 60% of Americans experiencing at least one neurologic condition. This volume of neurologic disease requires commensurate care. In this article, we review access to neurologic care and examine challenges and opportunities across several dimensions of access. Long wait times for neurologists and evidence that neurologists see only a fraction of certain neurologic conditions suggest issues with the <i>availability</i> of care; better triage of neurologists' expertise and employment of neurology advanced practice providers may improve the supply of neurologic care. <i>Accessibility</i> of neurologic care is hindered by regional inequities and urban/rural disparities, which may be attenuated through the use of telemedicine. High out-of-pocket costs and excessive pharmaceutical prices inhibit the <i>affordability</i> of neurologic care; these obstacles may be addressed with more appropriate test utilization and more effective drug price negotiation. Lastly, innovative care models facilitated by recent technological advances have the potential to profoundly expand access to neurologic care.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"519-528"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12562551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seminars in NeurologyPub Date : 2025-08-01Epub Date: 2025-03-10DOI: 10.1055/a-2554-1069
Jacob Pellinen, Jeffrey Buchhalter
{"title":"Learning Health Systems and Improvement Science in Neurology.","authors":"Jacob Pellinen, Jeffrey Buchhalter","doi":"10.1055/a-2554-1069","DOIUrl":"10.1055/a-2554-1069","url":null,"abstract":"<p><p>Although the quality movement in healthcare in the United States has been maturing for the last several decades, neurology remains a frontier of work related to learning healthcare systems (LHS) and the science of improvement. This review describes the use of LHS models in neurology and the use of Improvement Science to advance position system changes and improve care. LHSs are broadly understandable, widely supported, and have a developing yet proven track record. However, there are distinct challenges at multiple levels in successful implementation, as well as nuances related to variability in practice patterns and institutions. This review outlines these hurdles and approaches to addressing them. There are examples of effective work currently being conducted in this emerging field, with an emphasis on two subspecialties that have been the primary early adopters of these models and methodology within neurology: stroke and epilepsy. As LHS models take shape in neurology subspecialties, there will be an ongoing need for collaboration and iterative change to support continuous improvement in systems of care and improve outcomes for patients with neurologic disease.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"457-462"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}