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Seminars in Neurology最新文献

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Management of Brain Metastases: A Review of Novel Therapies. 脑转移瘤的治疗:新疗法综述。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1055/s-0043-1776782
Shreyas Bellur, Atulya Aman Khosla, Ahmad Ozair, Rupesh Kotecha, Michael W McDermott, Manmeet S Ahluwalia
{"title":"Management of Brain Metastases: A Review of Novel Therapies.","authors":"Shreyas Bellur, Atulya Aman Khosla, Ahmad Ozair, Rupesh Kotecha, Michael W McDermott, Manmeet S Ahluwalia","doi":"10.1055/s-0043-1776782","DOIUrl":"10.1055/s-0043-1776782","url":null,"abstract":"<p><p>Brain metastases (BMs) represent the most common intracranial tumors in adults, and most commonly originate from lung, followed by breast, melanoma, kidney, and colorectal cancer. Management of BM is individualized based on the size and number of brain metastases, the extent of extracranial disease, the primary tumor subtype, neurological symptoms, and prior lines of therapy. Until recently, treatment strategies were limited to local therapies, like surgical resection and radiotherapy, the latter in the form of whole-brain radiotherapy or stereotactic radiosurgery. The next generation of local strategies includes laser interstitial thermal therapy, magnetic hyperthermic therapy, post-resection brachytherapy, and focused ultrasound. New targeted therapies and immunotherapies with documented intracranial activity have transformed clinical outcomes. Novel systemic therapies with intracranial utility include new anaplastic lymphoma kinase inhibitors like brigatinib and ensartinib; selective \"rearranged during transfection\" inhibitors like selpercatinib and pralsetinib; B-raf proto-oncogene inhibitors like encorafenib and vemurafenib; Kirsten rat sarcoma viral oncogene inhibitors like sotorasib and adagrasib; ROS1 gene rearrangement (ROS1) inhibitors, anti-neurotrophic tyrosine receptor kinase agents like larotrectinib and entrectinib; anti-human epidermal growth factor receptor 2/epidermal growth factor receptor exon 20 agent like poziotinib; and antibody-drug conjugates like trastuzumab-emtansine and trastuzumab-deruxtecan. This review highlights the modern multidisciplinary management of BM, emphasizing the integration of systemic and local therapies.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"845-858"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lynne P. Taylor, MD, FAAN, Tresa M. McGranahan, MD, PhD, and Vyshak Alva Venur, MD. Lynne P. Taylor, MD, FAAN, Tresa M. McGranahan, MD, PhD, and Vyshak Alva Venur, MD.
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-12-01 Epub Date: 2023-12-14 DOI: 10.1055/s-0043-1776768
David M Greer
{"title":"Lynne P. Taylor, MD, FAAN, Tresa M. McGranahan, MD, PhD, and Vyshak Alva Venur, MD.","authors":"David M Greer","doi":"10.1055/s-0043-1776768","DOIUrl":"https://doi.org/10.1055/s-0043-1776768","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":"43 6","pages":"807"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Management and Advances in the Treatment of Glioma. 胶质瘤的外科治疗及进展。
IF 1.8 4区 医学
Seminars in Neurology Pub Date : 2023-12-01 Epub Date: 2023-11-14 DOI: 10.1055/s-0043-1776766
Andrew A Hardigan, Joshua D Jackson, Anoop P Patel
{"title":"Surgical Management and Advances in the Treatment of Glioma.","authors":"Andrew A Hardigan, Joshua D Jackson, Anoop P Patel","doi":"10.1055/s-0043-1776766","DOIUrl":"10.1055/s-0043-1776766","url":null,"abstract":"<p><p>The care of patients with both high-grade glioma and low-grade glioma necessitates an interdisciplinary collaboration between neurosurgeons, neuro-oncologists, neurologists and other practitioners. In this review, we aim to detail the considerations, approaches and advances in the neurosurgical care of gliomas. We describe the impact of extent-of-resection in high-grade and low-grade glioma, with particular focus on primary and recurrent glioblastoma. We address advances in surgical methods and adjunct technologies such as intraoperative imaging and fluorescence guided surgery that maximize extent-of-resection while minimizing the potential for iatrogenic neurological deficits. Finally, we review surgically-mediated therapies other than resection and discuss the role of neurosurgery in emerging paradigm-shifts in inter-disciplinary glioma management such as serial tissue sampling and \"window of opportunity trials\".</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"810-824"},"PeriodicalIF":1.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuro-oncology. 神经肿瘤学
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-12-01 Epub Date: 2023-12-14 DOI: 10.1055/s-0043-1776767
Lynne P Taylor, Tresa M McGranahan, Vyshak Alva Venur
{"title":"Neuro-oncology.","authors":"Lynne P Taylor, Tresa M McGranahan, Vyshak Alva Venur","doi":"10.1055/s-0043-1776767","DOIUrl":"10.1055/s-0043-1776767","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":"43 6","pages":"808-809"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain Tumor Imaging: Review of Conventional and Advanced Techniques. 脑肿瘤成像:传统与先进技术综述。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-12-01 Epub Date: 2023-11-14 DOI: 10.1055/s-0043-1776765
Andrew Campion, Michael Iv
{"title":"Brain Tumor Imaging: Review of Conventional and Advanced Techniques.","authors":"Andrew Campion, Michael Iv","doi":"10.1055/s-0043-1776765","DOIUrl":"10.1055/s-0043-1776765","url":null,"abstract":"<p><p>Approaches to central nervous system (CNS) tumor classification and evaluation have undergone multiple iterations over the past few decades, in large part due to our growing understanding of the influence of genetics on tumor behavior and our refinement of brain tumor imaging techniques. Computed tomography and magnetic resonance imaging (MRI) both play a critical role in the diagnosis and monitoring of brain tumors, although MRI has become especially important due to its superior soft tissue resolution. The purpose of this article will be to briefly review the fundamentals of conventional and advanced techniques used in brain tumor imaging. We will also highlight the applications of these imaging tools in the context of commonly encountered tumors based on the most recently updated 2021 World Health Organization (WHO) classification of CNS tumors framework.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"867-888"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107592635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Biases and Shared Decision Making in Acute Brain Injury. 急性脑损伤的认知偏差与共同决策。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-10-04 DOI: 10.1055/s-0043-1775596
Alexis Steinberg, Baruch Fischhoff
{"title":"Cognitive Biases and Shared Decision Making in Acute Brain Injury.","authors":"Alexis Steinberg, Baruch Fischhoff","doi":"10.1055/s-0043-1775596","DOIUrl":"10.1055/s-0043-1775596","url":null,"abstract":"<p><p>Many patients hospitalized after severe acute brain injury are comatose and require life-sustaining therapies. Some of these patients make favorable recoveries with continued intensive care, while others do not. In addition to providing medical care, clinicians must guide surrogate decision makers through high-stakes, emotionally charged decisions about whether to continue life-sustaining therapies. These consultations require clinicians first to assess a patient's likelihood of recovery given continued life-sustaining therapies (i.e., prognosticate), then to communicate that prediction to surrogates, and, finally, to elicit and interpret the patient's preferences. At each step, both clinicians and surrogates are vulnerable to flawed decision making. Clinicians can be imprecise, biased, and overconfident when prognosticating after brain injury. Surrogates can misperceive the choice and misunderstand or misrepresent a patient's wishes, which may never have been communicated clearly. These biases can undermine the ability to reach choices congruent with patients' preferences through shared decision making (SDM). Decision science has extensively studied these biases. In this article, we apply that research to improving SDM for patients who are comatose after acute brain injury. After introducing SDM and the medical context, we describe principal decision science results as they relate to neurologic prognostication and end-of-life decisions, by both clinicians and surrogates. Based on research regarding general processes that can produce imprecise, biased, and overconfident prognoses, we propose interventions that could improve SDM, supporting clinicians and surrogates in making these challenging decisions.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"735-743"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Grading Scales and Neuroprognostication in Acute Brain Injury. 急性脑损伤的临床分级量表和神经诊断。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-10-03 DOI: 10.1055/s-0043-1775749
Sahily Reyes-Esteves, Monisha Kumar, Scott E Kasner, Jens Witsch
{"title":"Clinical Grading Scales and Neuroprognostication in Acute Brain Injury.","authors":"Sahily Reyes-Esteves, Monisha Kumar, Scott E Kasner, Jens Witsch","doi":"10.1055/s-0043-1775749","DOIUrl":"10.1055/s-0043-1775749","url":null,"abstract":"<p><p>Prediction of neurological clinical outcome after acute brain injury is critical because it helps guide discussions with patients and families and informs treatment plans and allocation of resources. Numerous clinical grading scales have been published that aim to support prognostication after acute brain injury. However, the development and validation of clinical scales lack a standardized approach. This in turn makes it difficult for clinicians to rely on prognostic grading scales and to integrate them into clinical practice. In this review, we discuss quality measures of score development and validation and summarize available scales to prognosticate outcomes after acute brain injury. These include scales developed for patients with coma, cardiac arrest, ischemic stroke, nontraumatic intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury; for each scale, we discuss available validation studies.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"664-674"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease-Based Prognostication: Neuro-Oncology. 基于疾病的预后：神经肿瘤学。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-09-26 DOI: 10.1055/s-0043-1775751
Kristin A Waite, Gino Cioffi, Mark G Malkin, Jill S Barnholtz-Sloan
{"title":"Disease-Based Prognostication: Neuro-Oncology.","authors":"Kristin A Waite, Gino Cioffi, Mark G Malkin, Jill S Barnholtz-Sloan","doi":"10.1055/s-0043-1775751","DOIUrl":"10.1055/s-0043-1775751","url":null,"abstract":"<p><p>Primary malignant and non-malignant brain and other central nervous system (CNS) tumors, while relatively rare, are a disproportionate source of morbidity and mortality. Here we provide a brief overview of approaches to modeling important clinical outcomes, such as overall survival, that are critical for clinical care. Because there are a large number of histologically distinct types of primary malignant and non-malignant brain and other CNS tumors, this chapter will provide an overview of prognostication considerations on the most common primary non-malignant brain tumor, meningioma, and the most common primary malignant brain tumor, glioblastoma. In addition, information on nomograms and how they can be used as individualized prognostication tools by clinicians to counsel patients and their families regarding treatment, follow-up, and prognosis is described. The current state of nomograms for meningiomas and glioblastomas are also provided.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"768-775"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury. 急性脑损伤神经诊断的血液生物标志物。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-09-26 DOI: 10.1055/s-0043-1775764
Andrew M Nguyen, Vishal Saini, H E Hinson
{"title":"Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury.","authors":"Andrew M Nguyen, Vishal Saini, H E Hinson","doi":"10.1055/s-0043-1775764","DOIUrl":"10.1055/s-0043-1775764","url":null,"abstract":"<p><p>Acute brain injury causes loss of functionality in patients that often is devastating. Predicting the degree of functional loss and overall prognosis requires a multifaceted approach to help patients, and more so their families, make important decisions regarding plans and goals of care. A variety of blood-based markers have been studied as one aspect of this determination. In this review, we discuss CNS-derived and systemic markers that have been studied for neuroprognostication purposes. We discuss the foundation of each protein, the conditions in which it has been studied, and how the literature has used these markers for interpretation. We also discuss challenges to using each marker in each section as well.</p>","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":" ","pages":"689-698"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zachary David Threlkeld, MD, and David Yi-Gin Hwang, MD, FAAN, FCCM, FNCS. Zachary David Threlkeld，医学博士和David Yi-Gin Hwang，医学博士，FAAN，FCCM，FNCS。
IF 2.7 4区 医学
Seminars in Neurology Pub Date : 2023-10-01 Epub Date: 2023-11-02 DOI: 10.1055/s-0043-1775793
David M Greer
{"title":"Zachary David Threlkeld, MD, and David Yi-Gin Hwang, MD, FAAN, FCCM, FNCS.","authors":"David M Greer","doi":"10.1055/s-0043-1775793","DOIUrl":"10.1055/s-0043-1775793","url":null,"abstract":"","PeriodicalId":49544,"journal":{"name":"Seminars in Neurology","volume":"43 5","pages":"661"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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