Armin Hirbod-Mobarakeh, Amir-Abbas Keshavarz-Akhlaghi, Fatemeh Hadi, Shayan Eghdami, Arash Hirbod-Mobarakeh, Sara Hassan Kalhori, Ali Khanipour-Kencha
{"title":"Ecological momentary interventions for bipolar disorder: a systematic review and meta-analysis.","authors":"Armin Hirbod-Mobarakeh, Amir-Abbas Keshavarz-Akhlaghi, Fatemeh Hadi, Shayan Eghdami, Arash Hirbod-Mobarakeh, Sara Hassan Kalhori, Ali Khanipour-Kencha","doi":"10.1007/s00127-025-02845-z","DOIUrl":"https://doi.org/10.1007/s00127-025-02845-z","url":null,"abstract":"<p><strong>Background and objectives: </strong>Bipolar Disorders affect 2% of the world population and ranks as the sixth leading cause of disability. Barriers such as lack of insight and limited access to healthcare result in a significant disease burden. These barriers can be mitigated by technology-delivered interventions such as ecological momentary interventions, which provide personalized, real-time treatments based on ecological momentary assessments of relevant variables. This review aimed to assess the effectiveness of ecological momentary interventions in bipolar disorder.</p><p><strong>Methods: </strong>We conducted searches across Medline, Scopus, CENTRAL, psychINFO and ProQuest without applying any filter through December 30, 2023. Two authors screened results to eliminate irrelevant and duplicate studies, and the remaining studies were independently reviewed. Data were extracted, transformed into a common rubric, and analyzed for treatment effects using Review Manager 5.</p><p><strong>Findings: </strong>We analyzed 14 studies, encompassing 1776 patients with bipolar disorder. Interventions were mostly based on psychoeducation and cognitive behavioral therapy. EMI had small to moderate effects on quality of life (SMD = 0.24; 95% CI = 0.04-0.44, P = 0.02; I² = 47%), medication adherence (SMD = 0.21; 95% CI = 0.03-0.39, P = 0.02; I² = 0%), and affective episodes (HR = 0.75; 95% CI = 0.57-0.98, P = 0.04; I² = 0%).</p><p><strong>Conclusion: </strong>Ecological momentary intervention is a novel area of research in behavioral science. The results of this systematic review based on the available literature suggest that these interventions could be beneficial for patients with bipolar disorder.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Social isolation and sarcopenia: the mediating role of physical activity and the intersocietal differences from US and China.","authors":"Sicheng Li, Lingxiao He, Ya Fang","doi":"10.1007/s00127-025-02832-4","DOIUrl":"https://doi.org/10.1007/s00127-025-02832-4","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the causal relationship between sarcopenia and social isolation. This study investigated the association between social isolation and sarcopenia and explored the mediating role of physical activity among American and Chinese older adults.</p><p><strong>Methods: </strong>Data were from the Health and Retirement Study (HRS) and China Health and Retirement Longitudinal Study (CHARLS), encompassing 3,383 American and 6,996 Chinese. Sarcopenia was defined by the European Working Group on Sarcopenia in Older People 2 and Asian Working Group for Sarcopenia 2019 criteria. Social isolation was measured by the Steptoe Social Isolation Index for American and a 5-item scale for Chinese. Logistic regression models with inverse probability weighting were conducted to explore the effect of social isolation on sarcopenia risk. Causal mediation analysis was conducted to examine direct and indirect associations.</p><p><strong>Results: </strong>Over 8-year and 4-year follow-ups, 363 Americans and 392 Chinese had sarcopenia. Social isolation was associated with higher risk of sarcopenia in HRS (OR = 1.14, 95% CI = 1.02-1.29) and CHARLS (OR = 1.24, 95% CI = 1.10-1.39). The indirect effects of social isolation on sarcopenia through physical activity were significant only in HRS, explaining 7.63% of the total effect. Handgrip strength and gait speed were significantly associated with social isolation for HRS and CHARLS, while muscle mass and chair-stand test performance were significantly associated only in CHARLS.</p><p><strong>Conclusions: </strong>Social isolation significantly increased the risk of sarcopenia. Physical activity partially mediated this association only in Americans. More attention should be paid on socially isolated older adults to prevent sarcopenia.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Major depressive episodes and diet quality among Brazilian individuals: results from the 2013 and 2019 National Health Survey.","authors":"Leonardo Pozza Santos, Jéssica Carollina Von Schusterschitz Soares Schiatti, Ludmila Correa Muniz","doi":"10.1007/s00127-025-02828-0","DOIUrl":"https://doi.org/10.1007/s00127-025-02828-0","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between major depressive episodes and diet quality among Brazilian adults and older adults.</p><p><strong>Methods: </strong>We conducted a cross-sectional, population-based study using data from the two editions of the Brazilian National Health Survey (PNS in the Portuguese acronym) conducted in 2013 and 2019. Major depressive episodes were assessed using the Patient Health Questionnaire-9 (PHQ-9) and classified in two ways: based on a cutoff point of ≥ 9 points on the scale and according to the diagnostic criteria of the Statistical Manual of Mental Disorders. Diet quality was assessed using a diet quality score that considered the week consumption of seven food items. We used linear regression models to explore the association between major depressive episodes and diet quality score. Sensitivity analysis evaluating the association between major depressive episodes and each food item that composed the diet quality score was performed.</p><p><strong>Results: </strong>In both 2013 and 2019, individuals with major depressive episodes had a diet quality score 0.20 standard deviations higher compared to their peers, indicating a worse diet quality, regardless of the criteria used to define exposure and the potential confounders. Sensitivity analysis revealed a lower prevalence of regular consumption of beans, vegetables, fruits, and milk, and a higher prevalence of regular consumption of sugar-sweetened beverages and sweets among individuals with major depressive episodes.</p><p><strong>Conclusion: </strong>Major depressive episodes appear to be linked to lower diet quality in the Brazilian population. Policymakers and public health programs should consider approaches to improve both mental health and dietary habits.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jean Tyan, Roland J Thorpe, Christine Ladd-Acosta, Aisha S Dickerson
{"title":"Associations between discriminatory experiences and dementia in the Health and Retirement Study.","authors":"Jean Tyan, Roland J Thorpe, Christine Ladd-Acosta, Aisha S Dickerson","doi":"10.1007/s00127-025-02822-6","DOIUrl":"https://doi.org/10.1007/s00127-025-02822-6","url":null,"abstract":"<p><p>Dramatic racial and ethnic disparities in dementia necessitate research into potential risk factors and points of intervention. Using data from a large sample (n = 13,733) of older US residents participating in the Health and Retirement Study between 2006 and 2016, we investigated relationships between everyday and major discrimination and development of dementia. Data on self-reported everyday and major discrimination were collected via questionnaires. Algorithmic classification of probable dementia status was determined via a battery of cognitive tests. We used logistic regression models, and analyses were stratified by race and ethnicity and sex. We found that overall, more frequent experiences of everyday discrimination were associated with higher odds of developing dementia (odds ratio (OR) = 1.18; 95% confidence interval (CI): 1.10, 1.27; p < 0.001). Estimates stratified by race similarly suggested the positive association between everyday discrimination and odds of dementia onset was highest in non-Hispanic Black participants (OR: 1.30; 95% CI: 1.13, 1.51; p < 0.001). Our results reveal a link between frequency of everyday experiences of discrimination and dementia onset and highlight the role of psychosocial exposures in health and disease. This study underlines the impact that psychosocial stressors can have on cognitive health. Interventions addressing psychosocial risk factors experienced disproportionately by historically marginalized groups may be crucial in the goal to mitigate dementia disparities and achieve dementia equity.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poor family finances, family-based adverse childhood experiences, and depressive and behavioral symptoms in adolescence.","authors":"Sondre Aasen Nilsen, Rebecca Lynn Radlick, Kristin Gärtner Askeland","doi":"10.1007/s00127-025-02824-4","DOIUrl":"https://doi.org/10.1007/s00127-025-02824-4","url":null,"abstract":"<p><strong>Purpose: </strong>Adverse childhood experiences (ACEs) are a possible pathway through which poor family finances influences adolescents' behavioral and mental health problems. However, the interrelationship between family finances, ACEs, and behavioral and mental health outcomes in adolescence has received little attention. We aimed to (1) document exposure to family-based ACEs by perceived family finances (PFF), (2) examine how PFF relates to cumulative and pattern-based approaches to ACEs, and (3) assess the direct and interactive associations between PFF and ACEs in relation with behavioral and mental health problems.</p><p><strong>Methods: </strong>Data stem from the 2017-2019 nationwide Ungdata surveys of adolescents aged 13-15 (n = 12,560). Family-based ACEs were measured by 6 items covering parental alcohol use and intoxication, and intra-familial violence and fighting. The family-based ACEs were used both as a cumulative index score and examined through latent class analysis (LCA) to identify patterns of exposures. Cluster robust linear regression analyses were used to examine additive and interactive associations between PFF, family-based ACEs, and behavioral and depressive symptoms.</p><p><strong>Results: </strong>Poor (compared to not poor) PFF was significantly associated with more depressive symptoms and behavioral problems. Cumulative and pattern based approaches to family-based ACEs partially and similarly attenuated the association between PFF and mental health outcomes. Mainly, however, PFF and family-based ACEs were independently associated with mental health outcomes and did not interact.</p><p><strong>Conclusions: </strong>Poor family finances and family-based ACEs co-occur, and both have strong associations with depressive symptoms and behavioral problems in adolescence.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Henri M Garrison-Desany, Jacquelyn L Meyers, Sarah D Linnstaedt, Karestan C Koenen, Stacey L House, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Steven E Bruce, Samuel A McLean, Christy A Denckla
{"title":"Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income.","authors":"Henri M Garrison-Desany, Jacquelyn L Meyers, Sarah D Linnstaedt, Karestan C Koenen, Stacey L House, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Steven E Bruce, Samuel A McLean, Christy A Denckla","doi":"10.1007/s00127-025-02821-7","DOIUrl":"https://doi.org/10.1007/s00127-025-02821-7","url":null,"abstract":"<p><strong>Purpose: </strong>Post-traumatic stress (PTS) symptoms are highly comorbid with substance use (i.e., alcohol, tobacco, and cannabis). Few studies have investigated potential individual-, household-, and neighborhood-level socioeconomic effect modifiers of this comorbidity in longitudinal analyses. We aim to examine interactions between this multi-level environment and PTS symptoms on future substance use behaviors.</p><p><strong>Methods: </strong>Data were drawn from the Advancing Understanding of RecOvery afteR traumA (AURORA) study, including 2943 individuals who presented to the emergency department (ED) within 72 h of a traumatic event. Frequency of tobacco, alcohol, cannabis use, and PTS symptoms were reported at 6 timepoints. Mixed effect Poisson models, clustered by state, were used to generate incidence rate ratios (IRRs) substance use, both cross-sectionally and prospectively. Moderation analysis of PTS and substance use, stratified by household income and area deprivation index (ADI), was conducted using mixed effect models and parallel process growth curves.</p><p><strong>Results: </strong>Significant associations were observed between PTS with tobacco, alcohol, and cannabis use frequency cross-sectionally, and for tobacco and alcohol and PTS exposure prospectively. Lower income (P < 0.001) and higher deprivation (P < 0.001) were associated with tobacco use, while higher income (P < 0.001) and less deprivation (P = 0.01) were associated with increased alcohol use. We found modest modification by household income for alcohol and tobacco, and little evidence of modification by neighborhood ADI.</p><p><strong>Conclusions: </strong>Household income had greater evidence of effect modification for substance use, compared to neighborhood-level ADI. Our findings demonstrate that household indicators of socioeconomic status likely modify the relationship between PTS and substance use.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.","authors":"ZhaoXuan Shang, ChunQing Fang, GuoShuai Luo, XiaoE Lang, Xiangyang Zhang","doi":"10.1007/s00127-025-02826-2","DOIUrl":"https://doi.org/10.1007/s00127-025-02826-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the gender-specific associations between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.</p><p><strong>Methods: </strong>A total of 601 patients with chronic schizophrenia were evaluated using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Positive and Negative Syndrome Scale (PANSS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation and regression analyses were performed to explore the relationships between childhood trauma and clinical symptoms and cognitive function, considering gender differences.</p><p><strong>Results: </strong>Childhood trauma prevalence showed no gender differences. In male patients, physical neglect predicted PANSS Positive symptoms (β = 0.123), and physical abuse was linked to lower Visuospatial Construction scores (β = -0.103). In female patients, emotional neglect predicted PANSS Positive (β = 0.225) and Excitement factors (β = 0.197), and emotional abuse predicted Depressive symptoms (β = 0.186). Sexual abuse was associated with lower language scores (β = -0.204), and physical neglect with deficits in Immediate (β = -0.261) and Delayed Memory (β = -0.157).</p><p><strong>Conclusion: </strong>The findings highlight distinct gender-specific patterns in the impact of childhood trauma on clinical symptoms among patients with chronic schizophrenia. This suggests the necessity for gender-specific therapeutic interventions to address these differences effectively.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Che-Yu Chiang, Su-Chen Lo, Jason W Beckstead, Chiu-Yueh Yang
{"title":"Associations between constipation risk and lifestyle, medication use, and affective symptoms in patients with schizophrenia: a multicenter cross-sectional study.","authors":"Che-Yu Chiang, Su-Chen Lo, Jason W Beckstead, Chiu-Yueh Yang","doi":"10.1007/s00127-024-02729-8","DOIUrl":"10.1007/s00127-024-02729-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between lifestyle and atypical antipsychotic drug use in patients with schizophrenia and the risk of constipation and to assess the impact of anxiety and depressive symptoms on constipation risk.</p><p><strong>Methods: </strong>Cross-sectional convenience sampling was employed, and 271 participants aged 20-65 were enrolled. Data were collected via a structured questionnaire comprising participants' demographic data, medication information, dietary behavior assessment, and the Baecke Physical Activity Questionnaire, Beck Depression Inventory-II, and Beck Anxiety Inventory. IBM SPSS 24.0 with multivariate logistic regression was used for data analysis. We performed a subgroup analysis of anticholinergic drugs via multivariate logistic regression.</p><p><strong>Results: </strong>In total, 180 participants had functional constipation; risk factors included female sex, anxiety symptoms, depressive symptoms, and quetiapine and aripiprazole use. Patients who drank more than 3,000 cc of water daily or used risperidone were less likely to have functional constipation. Depressive and anxiety symptoms were risk factors even after adjusting for sex, use of anticholinergics and laxatives, consuming two servings of fruit, consuming three servings of vegetables, consuming more than 3,000 cc of water daily, physical activity, medical comorbidity, chlorpromazine equivalent dose, and atypical antipsychotic use. Similar associations were found for two affective symptoms and functional constipation in the subgroup analysis of anticholinergic drugs.</p><p><strong>Conclusion: </strong>The prevalence of functional constipation in patients with schizophrenia was 66.4%. The risk factors included female sex, anticholinergics, aripiprazole, quetiapine, and depressive and anxiety symptoms. Risperidone users and those who drank 3000 cc of water daily were less likely to have constipation.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"427-440"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Che-Yu Chiang, Su-Chen Lo, Jason W Beckstead, Chiu-Yueh Yang
{"title":"Correction: Associations between constipation risk and lifestyle, medication use, and affective symptoms in patients with schizophrenia: a multicenter cross-sectional study.","authors":"Che-Yu Chiang, Su-Chen Lo, Jason W Beckstead, Chiu-Yueh Yang","doi":"10.1007/s00127-024-02743-w","DOIUrl":"10.1007/s00127-024-02743-w","url":null,"abstract":"","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"441"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charlotte Gayer-Anderson, Gemma Knowles, Stephanie Beards, Alice Turner, Daniel Stanyon, Sam Davis, Rachel Blakey, Katie Lowis, Lynsey Dorn, Aisha Ofori, Mar Rus-Calafell, Craig Morgan, Lucia Valmaggia
{"title":"Immersive virtual reality as a novel approach to investigate the association between adverse events and adolescent paranoid ideation.","authors":"Charlotte Gayer-Anderson, Gemma Knowles, Stephanie Beards, Alice Turner, Daniel Stanyon, Sam Davis, Rachel Blakey, Katie Lowis, Lynsey Dorn, Aisha Ofori, Mar Rus-Calafell, Craig Morgan, Lucia Valmaggia","doi":"10.1007/s00127-024-02701-6","DOIUrl":"10.1007/s00127-024-02701-6","url":null,"abstract":"<p><strong>Purpose: </strong>Paranoid ideation is common among adolescents, yet little is known about the precursors. Using a novel immersive virtual reality (VR) paradigm, we tested whether experiences of bullying, and other interpersonal/threatening events, are associated with paranoid ideation to a greater degree than other types of (i) non-interpersonal events or (ii) adverse childhood experiences.</p><p><strong>Methods: </strong>Self-reported exposure to adverse life events and bullying was collected on 481 adolescents, aged 11-15. We used mixed effects (multilevel) linear regression to estimate the magnitude of associations between risk factors and paranoid ideation, assessed by means of adolescents' reactions to ambiguously behaving avatars in a VR school canteen, adjusting for putative confounders (gender, year group, ethnicity, free school meal status, place of birth, family mental health problems).</p><p><strong>Results: </strong>Lifetime exposure to interpersonal/threatening events, but not non-interpersonal events or adverse circumstances, was associated with higher levels of state paranoid ideation, with further evidence that the effect was cumulative (1 type: ϐ<sub>adj</sub> 0.07, 95% CI -0.01-0.14; 2 types: ϐ<sub>adj</sub> 0.14, 95% CI 0.05-0.24; 3 + types: ϐ<sub>adj</sub> 0.24, 95% CI 0.12-0.36). More tentatively, for girls, but not boys, recent bullying was associated with heightened paranoid ideation with effect estimates ranging from ϐ<sub>adj</sub> 0.06 (95% CI -0.02-0.15) for physical bullying to ϐ<sub>adj</sub> 0.21 (95% CI 0.10-0.32) for cyber bullying.</p><p><strong>Conclusions: </strong>Our data suggest a degree of specificity for adversities involving interpersonal threat or hostility, i.e. those that involve unwanted interference and/or attempted control of an individual's personal boundaries being associated with heightened levels of state paranoid ideation among adolescents.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"305-318"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}