Sara A Moustafa, Salima Douhou, Hany Ibrahim Hassanin, Mohamed Azzam Abdelrahman Ali, Nesma Gamal El Sheikh, Nehal Elkholy, Heba Mohamed Tawfik, Maram Magdy Shaat, Hoda Tarek Sanad, Marian Wagieh Mansour Abdelmalak, Sara Elfarrash, Samer Salama, Abdelrahman Ewis, Omar Ahmed Hassan, Mahmoud Abdelfattah, Ahmed Sabry Mohamed, Mohamed Yasser Sayed Saif, Aziza Mahmoud Abouzied, Eman Ali MohamedMohamed, Mohamed Salama
{"title":"Validation of harmonized cognitive assessment protocol within the Egyptian context.","authors":"Sara A Moustafa, Salima Douhou, Hany Ibrahim Hassanin, Mohamed Azzam Abdelrahman Ali, Nesma Gamal El Sheikh, Nehal Elkholy, Heba Mohamed Tawfik, Maram Magdy Shaat, Hoda Tarek Sanad, Marian Wagieh Mansour Abdelmalak, Sara Elfarrash, Samer Salama, Abdelrahman Ewis, Omar Ahmed Hassan, Mahmoud Abdelfattah, Ahmed Sabry Mohamed, Mohamed Yasser Sayed Saif, Aziza Mahmoud Abouzied, Eman Ali MohamedMohamed, Mohamed Salama","doi":"10.1007/s00127-024-02783-2","DOIUrl":"10.1007/s00127-024-02783-2","url":null,"abstract":"<p><p>This study addresses the urgent need for culturally sensitive cognitive assessments in Egypt by validating an adapted version of Harmonized Cognitive Assessment Protocol (HCAP) to the Egyptian context. This version is to be used as a part of the Egyptian Aging Survey (AL-SEHA). We enrolled 300 participants aged 55 + from diverse backgrounds and meticulously adapted the HCAP for Egypt's linguistic and cultural context. Demonstrating strong reliability and validity (sensitivity 87.6%, specificity 89.2%, accuracy 89.7%), the Egyptian HCAP effectively identified cognitive impairment. Integrated into the AL-SEHA, this validated HCAP offers valuable insights on cognitive function decline in Egypt's aging population. Our findings not only contribute to global understanding of cognitive health but also set a precedent for future cross-cultural HCAP validations, informing policies and early diagnosis for dementia care.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"1227-1237"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing the psychological impact of the Shanghai lockdown on local and non-local college students: an explanatory sequential mixed method approach.","authors":"Siyao Wu, Gen Li, Andrew Wortham, Brian J Hall","doi":"10.1007/s00127-024-02790-3","DOIUrl":"10.1007/s00127-024-02790-3","url":null,"abstract":"<p><strong>Purpose: </strong>In 2022, the Shanghai municipal government enforced strict COVID-19 lockdown measures. Lockdown experiences for college students varied. Local students normally returned home and had familial support while non-local students relied more on institutional support when quarantining in dormitories. The difference could profoundly impact their access to necessary material resources and emotional support, affecting their mental health. This study compared the psychological effects of the Shanghai Lockdown on local and non-local college students using an explanatory-sequential mixed methods design.</p><p><strong>Methods: </strong>Quantitative analyses of data from 327 college students examined local and non-local students' mental health outcomes during the lockdown. Follow-up qualitative interviews (N = 12) contextualized their sources of stress and group differences.</p><p><strong>Results: </strong>Higher prevalences of probable anxiety (34.6%), depression (45.1%), and poor subjective mental well-being (65.4%) are found among non-local students compared to local students (23.7% anxiety, 29.4% depressive symptoms, and 47.9% poor well-being). Suicidal ideation was higher among local students (8.6% prevalence difference). Being a non-local college student was associated with increased odds of probable anxiety, depression, and poor well-being. Interviews identified group differences such that non-local students received more school support (i.e., food and financial) and perceived emotional support but faced poorer quarantine living environments compared to local peers.</p><p><strong>Conclusions: </strong>Non-local college students were more vulnerable to the impact of lockdown. Our findings also provide insights into the impact of familial versus institutional support on student mental health during times of crisis.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"1173-1185"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole G Hammond, Børge Sivertsen, Jens Christoffer Skogen, Simon Øverland, Ian Colman
{"title":"Correction: The gendered relationship between illicit substance use and self-harm in university students.","authors":"Nicole G Hammond, Børge Sivertsen, Jens Christoffer Skogen, Simon Øverland, Ian Colman","doi":"10.1007/s00127-025-02874-8","DOIUrl":"10.1007/s00127-025-02874-8","url":null,"abstract":"","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"1255"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vendela Husberg-Bru, Laila A Hopstock, Jens C Thimm, Torgeir Gilje Lid, Kamilla Rognmo, Catharina Elisabeth Arfwedson Wang, Kristin Gustavson
{"title":"Potentially traumatic events and the association with hazardous alcohol use in 19,128 middle aged and elderly adults: the Tromsø Study 2015-2016.","authors":"Vendela Husberg-Bru, Laila A Hopstock, Jens C Thimm, Torgeir Gilje Lid, Kamilla Rognmo, Catharina Elisabeth Arfwedson Wang, Kristin Gustavson","doi":"10.1007/s00127-024-02801-3","DOIUrl":"10.1007/s00127-024-02801-3","url":null,"abstract":"<p><strong>Purpose: </strong>The aim was to examine the association between a wide range of potentially traumatic events (PTEs) experienced in childhood, adulthood or both, and hazardous alcohol use, including the relationship between the total sum of PTEs and hazardous alcohol use in middle aged and elderly adults. Previous studies have predominantly focused on childhood PTEs or isolated PTEs and more severe alcohol problems, little focus has been given to middle aged and elderly adults with hazardous alcohol use and PTE experiences.</p><p><strong>Methods: </strong>We used logistic regression analysis to study the relation between a broad range of PTEs and hazardous alcohol defined by the alcohol use disorder identification test (AUDIT) in 19,128 women and men aged 40 years and above participating in the seventh survey of the Norwegian population-based Tromsø Study in 2015-2016. Alcohol abstainers were excluded from the analyses.</p><p><strong>Results: </strong>Experience of violence, sexual abuse, bullying, painful or frightening medical and dental treatments, and serious illness or accident by a loved one were associated with higher odds for hazardous alcohol use. Further, there were higher odds of hazardous alcohol use per additional experienced PTE (OR = 1.22, 95% CI 1.20-1.25, p ≤ 0.001).</p><p><strong>Conclusion: </strong>PTEs were prevalent among participants who had a hazardous alcohol use. Also, most of the PTEs occurring in childhood, adulthood or both were independently related to hazardous alcohol use. Moreover, the findings indicate an association in the relationship between the number of PTEs and hazardous alcohol use.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":"1099-1112"},"PeriodicalIF":3.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Return to work after sick leave due to mental illness - a qualitative study on the perspective of workplace integration managers.","authors":"Anna Pelizäus, Martina Geipel, Johannes Hamann","doi":"10.1007/s00127-025-02906-3","DOIUrl":"https://doi.org/10.1007/s00127-025-02906-3","url":null,"abstract":"<p><strong>Background and aim: </strong>Increasing numbers of people are unable to work due to mental illness and this is an increasing problem on both a personal and societal level. In Germany, a workplace integration management system (BEM) has been legally required since 2004 to support return to work (RTW). However, its uptake and success, especially regarding mental illnesses, is still unclear. This study was conducted to identify the current state of RTW after episodes of mental illnesses from the perspective of workplace integration managers and explore potential barriers and facilitators that influence the course and outcome of the BEM process.</p><p><strong>Methods: </strong>Semi-structured interviews with BEM managers (N = 14) from the greater Munich area were performed and analyzed using Thematic Analysis.</p><p><strong>Results: </strong>In their work, BEM managers tend to find themselves in a field of tension between the personal concerns of returning employees and the employer's business interests. They experience mistrust and lack of openness on the part of the returnees, while employers show little willingness to fully invest in the process. Lack of or incorrect information about BEM and on mental illness seems to promote these disruptive factors, as well as others.</p><p><strong>Conclusion: </strong>Broad education on BEM appears to be a promising means to reduce fear among returnees and to better reach the processes potential. In addition, a more open approach to mental illness could simplify the process for all involved.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica K Perrotte, Priscilla Martinez, Yessenia Castro, Miguel Pinedo, Craig A Field, Lin Tran, Ty S Schepis
{"title":"Trends in alcohol use disorder symptoms among U.S. adults disaggregated by sex, race, and age.","authors":"Jessica K Perrotte, Priscilla Martinez, Yessenia Castro, Miguel Pinedo, Craig A Field, Lin Tran, Ty S Schepis","doi":"10.1007/s00127-025-02910-7","DOIUrl":"https://doi.org/10.1007/s00127-025-02910-7","url":null,"abstract":"<p><strong>Purpose: </strong>Population-based studies of alcohol-related trends typically collapse across sex while examining race and/or age, limiting understanding of shifts in alcohol involvement at the intersection of sex, race, and age. Therefore, this study evaluated population-level trends in alcohol use and alcohol use disorder (AUD) symptoms as disaggregated within Hispanic, Black, and White female and male U.S. early and middle adults.</p><p><strong>Methods: </strong>Data were from years 2002 to 2019 of the National Survey on Drug Use and Health, Participants were 18 to 64, Hispanic, Black, or White, and consumed any alcohol. Annualized linear change estimates were computed to assess trends in past-month drinking days and AUD symptoms. Between groups analyses were also conducted to examine (a) sex differences within ethnoracial identity and (b) ethnoracial differences within sex. All analyses were further stratified across early (age 18 to 29) and middle adults (age 30 to 64).</p><p><strong>Results: </strong>Number of drinking days increased only among Black early adult females and Black middle adult females and decreased for all males except for Black middle adults, with the strongest decrease for Black early adult males. AUD symptoms decreased for all early adult males, and most strongly among Black males. Among middle adults, AUD symptoms decreased only among Hispanic males and increased among White males and females.</p><p><strong>Conclusions and relevance: </strong>National trends in alcohol use and AUD symptoms are distinct across subpopulations at the intersection of sex, race, and age. Continued disaggregated analyses across heterogeneous U.S. subpopulations are needed to better inform clinical care.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Verdaasdonk, M A Charalambides, D Baumeister, M Jackson, P A Garety, C Morgan, T Ward, E Peters
{"title":"The victimisation experience schedule: contextualising interpersonal trauma and perceived discrimination in individuals with psychotic experiences with and without a need-for-care.","authors":"I Verdaasdonk, M A Charalambides, D Baumeister, M Jackson, P A Garety, C Morgan, T Ward, E Peters","doi":"10.1007/s00127-025-02917-0","DOIUrl":"https://doi.org/10.1007/s00127-025-02917-0","url":null,"abstract":"<p><strong>Purpose: </strong>Victimisation is associated with psychotic experiences (PEs) across the psychosis continuum, yet contextual factors possibly influencing outcomes have been neglected. Building on the Unusual Experiences Enquiry study (UNIQUE) showing higher childhood trauma but lower discrimination in individuals with PEs without a need-for-care, compared to those with a need-for-care, this study utilized a novel instrument to examine victimisation-related contextual factors.</p><p><strong>Methods: </strong>Individuals from the UNIQUE study with persistent PEs with (clinical, n = 82) and without (non-clinical, n = 92) a need-for-care, and a control group without PEs (n = 83), completed the Victimisation Experiences Schedule (VES). This multidimensional instrument, comprising items from validated measures, assesses interpersonal traumas and discriminatory experiences, alongside contextual factors: impact, powerlessness, social support, age, duration, frequency, victim-perpetrator relationships, and reasons for discrimination.</p><p><strong>Results: </strong>There were no differences in lifetime interpersonal traumas between the clinical and non-clinical groups, with the latter reporting slightly more than controls. The clinical group experienced more lifetime perceived discrimination than the other groups. No differences emerged in impact and powerlessness at the time of victimisation; however, the clinical group reported lower positive social support and higher current impact and powerlessness for both types of victimisation. Discrimination occurred earlier and lasted longer in the clinical group than the other groups, often attributed to mental health and race/ethnicity, likely reflecting a higher proportion of racially minoritized individuals.</p><p><strong>Conclusion: </strong>The results suggest an interplay between risk and protective factors around victimisation that may shape outcomes, highlighting the importance of assessing contextual factors of victimisation using comprehensive tools like the VES.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dylan Johnson, Ian Colman, Katholiki Georgiades, Mark Wade
{"title":"Interactions between early-life adversity, pandemic stress, and social support on psychiatric disorders in a nationally representative sample of Canadian adults.","authors":"Dylan Johnson, Ian Colman, Katholiki Georgiades, Mark Wade","doi":"10.1007/s00127-025-02911-6","DOIUrl":"https://doi.org/10.1007/s00127-025-02911-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined how pre-existing early-life adversity (ELA) and current social support interacted with COVID-specific pandemic stressors in relation to risk of psychiatric disorders in a nationally-representative sample of Canadian adults.</p><p><strong>Methods: </strong>Participants (n = 9,409) were from the Mental Health and Access to Care Survey, a cross-sectional survey of Canadian adults during later stages of the COVID pandemic (March to July 2022). Measures included pandemic stressors (Statistics Canada), ELA (Childhood Experiences of Violence Questionnaire), social support (Social Provisions Scale), and past 12-month psychiatric problems (WHO-CIDI). Statistical analyses included two-step logistic regression models adjusted for covariates and weighted for complex survey design.</p><p><strong>Results: </strong>Higher odds of psychiatric problems were predicted by ELA (aOR = 1.24 [1.15-1.35]-aOR = 1.53 [1.39-1.69] across psychiatric disorders) and pandemic stress (aOR = 1.18 [1.12-1.25]-aOR = 1.32 [1.26-1.39] across psychiatric disorders). Significant interactions between ELA and pandemic stress for depression (aOR = 0.96 [0.93-0.98]) suggested an attenuated effect of pandemic stress at higher levels of ELA. Social support was associated with reduced psychiatric problems (aOR = 0.88 [0.86-0.91]-aOR = 0.97 [0.94-0.99]), while pandemic stress was associated with increased psychiatric problems (aOR = 1.20 [1.15-1.26]-aOR = 1.33 [1.27-1.40]). An interaction between social support and pandemic stress for suicidality (aOR = 1.02 [1.01-1.03]) indicated that higher levels of social support were associated with increased odds of suicidality in the presence of pandemic stress, though the effect was small and of questionable clinical significance.</p><p><strong>Conclusion: </strong>ELA and pandemic stress increased psychiatric disorder likelihood, while social support was protective. However, interactions indicate nuanced relationships in mental health risk during the pandemic.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorun Rugkåsa, Olav Nyttingnes, Jūratė Šaltytė Benth, Tonje Lossius Husum, Solveig Helene Høymork Kjus, Irene Wormdahl, Tore Hofstad, Trond Hatling
{"title":"Can primary mental health services impact levels of involuntary admissions? A cluster-RCT of the ReCoN intervention.","authors":"Jorun Rugkåsa, Olav Nyttingnes, Jūratė Šaltytė Benth, Tonje Lossius Husum, Solveig Helene Høymork Kjus, Irene Wormdahl, Tore Hofstad, Trond Hatling","doi":"10.1007/s00127-025-02914-3","DOIUrl":"https://doi.org/10.1007/s00127-025-02914-3","url":null,"abstract":"<p><strong>Purpose: </strong>Internationally, policies and legal changes seek to reduce the use of involuntary psychiatric admissions. Usually directed towards specialist services, these initiatives show little sustained progress. We tested whether an intervention at the level of primary mental health services has potential to reduce the use of involuntary admissions.</p><p><strong>Methods: </strong>We conducted a two-arm cluster-RCT following Zelen's design (ClinicalTrials.gov:NCT03989765). Each cluster included the primary mental health service and their local collaborators in mid-sized Norwegian municipalities with rates of involuntary admissions above the national average. Five clusters were randomised to co-create and implement a comprehensive intervention. These could not be blinded, but the five control clusters were. Our primary hypothesis was that rates of involuntary admissions would be lower in the intervention arm when comparing change over time between arms, and that this would sustain. Secondary hypotheses were that rates of referrals for involuntary admissions and rates of referrals confirmed for involuntary status after the second statutory assessment, would be lower in the intervention arm.</p><p><strong>Results: </strong>Data obtained from the Norwegian Patient Registry included all events in the study period. The difference between trial arms in changes of rates of involuntary admissions from baseline to the intervention period was 6.8 (95% CI 1.8 to 11.7; effect size (EC) 2.7), and reduced to 3.0 (95% CI -3.8 to 9.7; ES 0.9) between baseline and the post-intervention period. The difference between arms regarding changes in referral rates between the baseline and intervention period was 1.7 (95% CI -4.6 to 8.1; ES 0.5), and for changes in the rate of referrals resulting in involuntary status it was 1.3 (95% CI -3.4 to 6.0; ES 0.8).</p><p><strong>Conclusion: </strong>We found a clear difference between trial arms in our primary outcome of involuntary admissions during the intervention period, but not beyond that period, and not regarding referrals for involuntary admissions, although the consistent direction of change favoured the intervention. We interpret the results to constitute 'proof of concept' that adequately resourced primary mental health services might contribute to policy aims of reducing involuntary care. Further rigorous studies in heterogeneous contexts are required.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychiatric disorders following the clustering of family disadvantages in previous generations: a multigenerational cohort study.","authors":"Baojing Li, Can Liu, Ylva B Almquist, Lisa Berg","doi":"10.1007/s00127-025-02918-z","DOIUrl":"https://doi.org/10.1007/s00127-025-02918-z","url":null,"abstract":"<p><strong>Purpose: </strong>There is a lack of multigenerational research on the extent to which mental health is informed by transmission of multiple disadvantages across previous generations. This study aims to investigate how family socioeconomic and psychosocial disadvantages cluster and transition over grandparental and parental generations, and how this might be associated with grandchild psychiatric disorders.</p><p><strong>Methods: </strong>We utilized a cohort study with data following three generations from the Stockholm Birth Cohort Multigenerational Study, including 11,299 individuals born in 1953 (parental generation), their 22,598 parents (grandparental generation), and 24,707 adult children (grandchild generation). Family disadvantages as exposures were measured across two periods- grandparental adulthood (parental childhood) and parental adulthood (grandchild childhood), and included socioeconomic (i.e., low income, non-employment, overcrowding, and single parenthood) and psychosocial aspects (i.e., single parenthood, teenage motherhood, psychiatric disorders, and criminality of father). Psychiatric disorders in the adult grandchildren as outcome were defined by hospitalizations with a main or contributing diagnosis reflecting mental and behavioral disorders from age 18 until 2019.</p><p><strong>Results: </strong>Multiple disadvantages within the grandparental and parental generations, respectively, predicted higher probabilities of grandchild psychiatric disorders. Multigenerational transmission is evident in that grandchildren with combinations of grandparental socioeconomic disadvantages and parental psychosocial disadvantages had comparably high probabilities of psychiatric disorders. Importantly, improved socioeconomic and psychosocial circumstances across previous generations predicted comparably low probabilities of grandchild psychiatric disorders.</p><p><strong>Conclusion: </strong>Mental health of future generations is informed by the transmission of multiple disadvantages across previous generations, and the transition from grandparental socioeconomic disadvantages into parental psychosocial disadvantages is particularly important.</p>","PeriodicalId":49510,"journal":{"name":"Social Psychiatry and Psychiatric Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}