Taiwanese Journal of Obstetrics & Gynecology最新文献_第3页

Prenatal diagnosis of a familial 22q11.21 microduplication and mosaic trisomy 20 in a pregnancy with an asymptomatic father carrier and a favorable fetal outcome 一名无症状父亲携带和胎儿预后良好的孕妇，产前诊断出家族性22q11.21微复制和马赛克20三体

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.010

Chih-Ping Chen

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Low-level mosaic trisomy 12 at amniocentesis in a pregnancy associated with complete cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the aneuploid cell line and a favorable fetal outcome 妊娠期羊膜穿刺术中低水平嵌合12三体与培养羊膜细胞和未培养羊膜细胞之间的完全细胞遗传学差异、围产期非整倍体细胞系的逐渐减少和良好的胎儿结局相关

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.004

Chih-Ping Chen

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Routine transvaginal ultrasound preceding mid-pregnancy fetal anatomical screening is a feasible and valuable tool in screening for vasa previa 妊娠中期胎儿解剖筛查前常规经阴道超声是筛查前置血管的一种可行且有价值的工具

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2024.12.032

Pei-Chen Wu , Ching-Chi Hsia , Ksenia Olisova , Chang-Ching Yeh , Tung-Yao Chang

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Prenatal diagnosis and genetic counseling of a de novo 18q21.2 microdeletion associated with normal phenotype 与正常表型相关的新生18q21.2微缺失的产前诊断和遗传咨询

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2024.12.033

Yuexiang Feng , Ruijie Chang , Tianzi Wu , Wenjuan Tang

引用次数: 0

Prenatal diagnosis of a familial Xq27.1-q28 deletion with an asymptomatic mother carrier and no abnormality in the female fetus 产前诊断家族性Xq27.1-q28缺失，无症状母亲携带者，女性胎儿无异常

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.007

Chih-Ping Chen

引用次数: 0

Low-level mosaic trisomy 21 at amniocentesis in a pregnancy associated with an abnormal first-trimester maternal serum screening result, a favorable fetal outcome and postnatal decrease of the aneuploid cell line 妊娠期羊膜穿刺术中低水平镶嵌21三体与妊娠早期母体血清筛查结果异常、有利的胎儿结局和出生后非整倍体细胞系减少有关

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.05.009

Chih-Ping Chen

引用次数: 0

PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development 胎盘滋养细胞PHLDA2表达和启动子甲基化：与子痫前期发展的关系

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.01.006

Jie Chen, Youhong Zheng, Lilin Hang, Huiyan Wang

{"title":"PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development","authors":"Jie Chen, Youhong Zheng, Lilin Hang, Huiyan Wang","doi":"10.1016/j.tjog.2025.01.006","DOIUrl":"10.1016/j.tjog.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>Preeclampsia (PE) is an idiopathic and life-threatening pregnancy-related disease. Alterations to DNA methylation in imprinted genes may play a crucial role in the dysfunction of trophoblast cells and PE.</div></div><div><h3>Materials and methods</h3><div>Herein, we sought to elucidate the characteristics of PHLDA2 in placental trophoblasts and its underlying mechanisms in pregnant women with PE. Between January 2019 and December 2021, the clinical data and placental tissue samples from 15 PE cases and 15 control women who underwent obstetric examination were collected. Immunohistochemistry, qRT-PCR, WB and pyrosequencing were used to detect and compare the expression and methylation status of imprinted gene PHLDA2 in placental tissues of the two groups.</div></div><div><h3>Results</h3><div>The expression levels of PHLDA2 mRNA and protein were significantly higher in the placental tissue of PE patients than those of healthy controls during the third trimester (<em>P = 0.001)</em>. Additionally, PHLDA2 expression levels were evaluated in four trophoblast cell lines, with the JEG-3 line showing the lowest expression of PHLDA2. Notably, the JEG-3 line demonstrated a significantly faster rate of proliferation compared to the other three cell lines. When the PHLDA2 was overexpressed in JEG-3 cells, the proliferative proteins were significantly reduced, while the expression levels of apoptosis-related proteins p27 and cleaved-caspase3 were significantly increased. In addition, pyrosequencing showed that the methylation levels of the <em>PHLDA2</em> promoter region were significantly lower in PE placentas than in controls.</div></div><div><h3>Conclusion</h3><div>The hypomethylation status of the <em>PHLDA2</em> promoter is associated with its altered expression in PE placentas, suggesting a potential role in the condition's pathogenesis.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 662-670"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of motor imagery focused pelvic floor exercises and relaxation exercises for treating dysmenorrhea: A randomized controlled study 运动意象集中盆底练习和放松练习治疗痛经的比较：一项随机对照研究

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2024.12.029

Selda Koçoğlu , Ömer Şevgin , Beyzanur Dikmen Hoşbaş

{"title":"Comparison of motor imagery focused pelvic floor exercises and relaxation exercises for treating dysmenorrhea: A randomized controlled study","authors":"Selda Koçoğlu , Ömer Şevgin , Beyzanur Dikmen Hoşbaş","doi":"10.1016/j.tjog.2024.12.029","DOIUrl":"10.1016/j.tjog.2024.12.029","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the impact of integrating motor imagery-focused pelvic floor exercises (MOPEXE) and relaxation exercise (RE) on pain and menstrual symptoms in the management of dysmenorrhea.</div></div><div><h3>Materials and methods</h3><div>60 participants with dysmenorrhea were randomly allocated to MOPEXE, RE, and a combination group that included both exercises. Participants were instructed to perform the relevant exercise program 3-d per week for eight weeks. The Menstruation Attitude Questionnaire (MAQ), Functional and Emotional Dysmenorrhea Scale (FEDS), and Short-Form McGill Pain Questionnaire (SF-MPQ) were used to assess pre- and post-treatment participant-reported outcomes.</div></div><div><h3>Results</h3><div>Combination therapy revealed a significant decrease in VAS and FEDS (emotional) and an increase in MAQ (deliberating event, natural event, anticipation, and denial parameters) compared to MOPEXE. MOPEXE group demonstrated a significant increase in menstruation as a bothersome event and a decrease in FEDS (functional). In comparison with the RE group, MAQ scores were significantly higher in the combination group. A significant reduction in VAS and an increase in the denial parameter of MAQ were observed in the RE group.</div></div><div><h3>Conclusion</h3><div>Physical therapy with pelvic floor and relaxation exercises centered on motor imagery is an effective measure to reduce painful symptoms and to relieve dysmenorrhea both in terms of functional and emotional aspects.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 671-677"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for failed induction of labor: A retrospective study in a single, tertiary, perinatal-care center 引产失败的危险因素：在一个单一的，三级，围产期护理中心的回顾性研究

IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/j.tjog.2025.04.010

Maika Nariai, Osamu Wada-Hiraike, Takayuki Iriyama, Takahiro Seyama, Keiichi Kumasawa, Yasushi Hirota, Yutaka Osuga

{"title":"Risk factors for failed induction of labor: A retrospective study in a single, tertiary, perinatal-care center","authors":"Maika Nariai, Osamu Wada-Hiraike, Takayuki Iriyama, Takahiro Seyama, Keiichi Kumasawa, Yasushi Hirota, Yutaka Osuga","doi":"10.1016/j.tjog.2025.04.010","DOIUrl":"10.1016/j.tjog.2025.04.010","url":null,"abstract":"<div><h3>Objective</h3><div>To estimate the incidence and associated risk factors of failed induction of labor (IOL).</div></div><div><h3>Materials and methods</h3><div>A retrospective, case–control study was conducted on a cohort of women who underwent IOL from January 2020 to December 2023 and delivered after 34 weeks of gestation at our hospital (n = 1541). Failed IOL was defined as delivering with a cesarean section for any reason. The control group consisted of successful vaginal deliveries, including forceps and vacuum deliveries after IOL. Both primiparous and multiparous women were included in the study. We identified associated risk factors of failed IOL via multivariable logistic regression analysis.</div></div><div><h3>Results</h3><div>During the study period, 1541 of 4244 women (36.3 %) who delivered at our hospital underwent IOL. Among them, 326 women had a failed IOL, an estimated incidence of 21.2 % (95 % confidence interval [CI]: 19.1 %–23.3 %). The multivariable analysis revealed that older age (adjusted odds ratio [aOR] = 1.07 for each 1-year increase, 95 % CI: 1.04–1.11, P < 0.001), primiparity (aOR = 0.24 95 % CI: 0.16–0.35, P < 0.001), conception by using assisted reproductive technology (aOR = 1.45 95 % CI: 1.06–2.00, P = 0.021) larger birth weight (aOR = 1.05 for each 100 g increase, 95 % CI: 1.01–1.65, P = 0.023), hypertensive disorders of pregnancy (HDPs) (aOR = 2.53, 95 % CI: 1.80–3.56, P < 0.001), the lower simplified Bishop score before induction (aOR = 0.70 for each 1-point increase, 95 % CI: 0.61–0.80 P < 0.001), and the use of no epidural anesthesia (aOR = 0.42, 95 % CI: 0.31–0.57, P < 0.001) were independently associated with failed IOL.</div></div><div><h3>Conclusions</h3><div>Age, primiparity, method of conception, birth weight, HDPs, and simplified Bishop score should be considered as the predictor of failed IOL.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 4","pages":"Pages 687-692"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 2 4区医学

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-07-01 DOI: 10.1016/S1028-4559(25)00169-X

引用次数: 0